CN101098888A - Tnf拮抗剂 - Google Patents
Tnf拮抗剂 Download PDFInfo
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- CN101098888A CN101098888A CNA2005800464293A CN200580046429A CN101098888A CN 101098888 A CN101098888 A CN 101098888A CN A2005800464293 A CNA2005800464293 A CN A2005800464293A CN 200580046429 A CN200580046429 A CN 200580046429A CN 101098888 A CN101098888 A CN 101098888A
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- seq
- leu
- lys
- ala
- thr
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Images
Landscapes
- Peptides Or Proteins (AREA)
Abstract
Description
SEQ ID NO | 氨基酸序列 |
1 | KRWSRYF |
SEQ ID NO | 氨基酸序列 |
2 | PXPXN |
3 | XPXPXNX |
4 | ELPQHAQPDPSNW |
5 | EHSSDAQPDPSNW |
6 | RETTDAQPDPSNW |
7 | GRKEDAQPDPSNW |
8 | KLPQHANPSPSNW |
9 | LLPQHANPNPSNW |
10 | KLPQHAHPEPSNW |
11 | ALPQHASPSPSNW |
12 | MLEKDAQPDPSNW |
13 | GRKEDAQPDPSNW |
14 | ARTQDAQPDPSNW |
15 | ERNRDAQPDPSNW |
16 | VRQRDAQPDPSNW |
17 | ERPEDAQPDPSNW |
18 | SRQEDAQPDPSNW |
19 | ERLRDSQPDPSNW |
20 | ASMKDAQPDPSNW |
21 | QLPQHADPAPSNW |
22 | LLPQHEQPEPSNW |
23 | ELASDAQPDPANW |
24 | ELIRDAQPDPANW |
25 | ELLSDAQPDPVNW |
26 | ERRQDAQPDPSNW |
27 | ERLADAQPDPFNW |
28 | EGIEWAQPDPTNF |
单体克隆 | SEQ ID NO | 环1序列 | 环3/4序列 | 其它突变a |
TN3-2-B1-C22 | 29 | KRWSRYF | ELPQHAQPDPSNW | D165G |
TN3-2-B1-C31 | 30 | KRWSRYF | EHSSDAQPDPSNW | D165G |
TN3-2-B1-C24 | 31 | KRWSRYF | ERTTDAQPDPSNW | D165G |
TN3-2-B1-C22-7 | 32 | KRWSRYF | GRKEDAQPDPSNW | D165G |
TN3-2-B1-c22-1 | 33 | KRWSRYF | KLPQHANPSPSNW | D165G |
TN3-2-B1-c22-2 | 34 | KRWSRYF | LLPQHANPNPSNW | D165G |
TN3-2-B1-c22-3 | 35 | KRWSRYF | KLPQHAHPEPSNW | D165G |
TN3-2-B1-c22-4 | 36 | KRWSRYF | ALPQHASPSPSNW | D165G |
TN3-2-B1-c22-6 | 37 | KRWSRYF | MLEKDAQPDPSNW | D165G |
TN3-2-B1-c22-7 | 38 | KRWSRYF | GRKEDAQPDPSNW | D165G |
TN3-2-B1-c22-8 | 39 | KRWSRYF | ARTQDAQPDPSNW | D165G |
TN3-2-B1-c22-9 | 40 | KRWSRYF | ERNRDAQPDPSNW | D165G |
TN3-2-B1-c22-10 | 41 | KRWSRYF | VRQRDAQPDPSNW | D165G |
TN3-2-B1-c22-11 | 42 | KRWSRYF | ERPEDAQPDPSNW | D165G |
TN3-2-B1-c22-12 | 43 | KRWSRYF | SRQEDAQPDPSNW | D165G |
TN3-2-B1-c22-13 | 44 | KRWSRYF | ERLRDSQPDPSNW | D165G |
TN3-2-B1-c22-14 | 45 | KRWSRYF | ASMKDAQPDPSNW | D165G |
TN3-2-B1-c22-15 | 46 | KRWSRYF | QLPQHADPAPSNW | D165G |
TN3-2-B1-c22-16 | 47 | KRWSRYF | LLPQHEQPEPSNW | D165G |
TN3-2-B1-c7 | 48 | KRWSRYF | ELASDAQPDPANW | D165G |
TN3-2-B1-C19 | 49 | KRWSRYF | ELIRDAQPDPANW | D165G |
TN3-2-B1-C1 | 50 | KRWSRYF | ELLSDAQPDPVNW | D165G |
TN3-2-B1-C20 | 51 | KRWSRYF | ERRQDAQPDPSNW | D165G |
TN3-2-B1-C53 | 52 | KRWSRYF | ERLADAQPDPFNW | D165G |
TN3-2-B1-C29 | 53 | KRWSRYF | EGIEWAQPDPTNF | D165G |
三聚体克隆 | SEQ ID NO | 相应的单聚体克隆 |
TN2-2-B1-C22 | 54 | TN3-2-B1-C22 |
TN2-2-B1-C31 | 55 | TN3-2-B1-C31 |
TN2-2-B1-C24 | 56 | TN3-2-B1-C24 |
TN2-2-B1-C22-7 | 57 | TN3-2-B1-C22-7 |
TN2-2-B1-c22-1 | 58 | TN3-2-B1-c22-1 |
TN2-2-B1-c22-2 | 59 | TN3-2-B1-c22-2 |
TN2-2-B1-c22-3 | 60 | TN3-2-B1-c22-3 |
TN2-2-B1-c22-4 | 61 | TN3-2-B1-c22-4 |
TN2-2-B1-c22-6 | 62 | TN3-2-B1-c22-6 |
TN2-2-B1-c22-7 | 63 | TN3-2-B1-c22-7 |
TN2-2-B1-c22-8 | 64 | TN3-2-B1-c22-8 |
TN2-2-B1-c22-9 | 65 | TN3-2-B1-c22-9 |
TN2-2-B1-c22-10 | 66 | TN3-2-B1-c22-10 |
TN2-2-B1-c22-11 | 67 | TN3-2-B1-c22-11 |
TN2-2-B1-c22-12 | 68 | TN3-2-B1-c22-12 |
TN2-2-B1-c22-13 | 69 | TN3-2-B1-c22-13 |
TN2-2-B1-c22-14 | 70 | TN3-2-B1-c22-14 |
TN2-2-B1-c22-15 | 71 | TN3-2-B1-c22-15 |
TN2-2-B1-c22-16 | 72 | TN3-2-B1-c22-16 |
TN2-2-B1-c7 | 73 | TN3-2-B1-c7 |
TN2-2-B1-C19 | 74 | TN3-2-B1-C19 |
TN2-2-B1-C1 | 75 | TN3-2-B1-C1 |
TN2-2-B1-C20 | 76 | TN3-2-B1-C20 |
TN2-2-B1-C53 | 77 | TN3-2-B1-C53 |
TN2-2-B1-C29 | 78 | TN3-2-B1-C29 |
Claims (26)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DKPA200401813 | 2004-11-22 | ||
DKPA200401813 | 2004-11-22 | ||
US60/629,343 | 2004-11-22 |
Publications (1)
Publication Number | Publication Date |
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CN101098888A true CN101098888A (zh) | 2008-01-02 |
Family
ID=39012076
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2005800464293A Pending CN101098888A (zh) | 2004-11-22 | 2005-11-21 | Tnf拮抗剂 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN101098888A (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101747414B (zh) * | 2008-12-19 | 2012-01-25 | 华中科技大学 | TNF-α结合肽和TNFR1封闭肽及其在治疗TNF相关疾病中的应用 |
CN103172746A (zh) * | 2011-12-26 | 2013-06-26 | 财团法人工业技术研究院 | 三聚体Fc融合蛋白及其用途 |
CN103739714A (zh) * | 2013-12-30 | 2014-04-23 | 江苏众红生物工程创药研究院有限公司 | TNFα与DC-SIGN的融合蛋白及其应用 |
-
2005
- 2005-11-21 CN CNA2005800464293A patent/CN101098888A/zh active Pending
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101747414B (zh) * | 2008-12-19 | 2012-01-25 | 华中科技大学 | TNF-α结合肽和TNFR1封闭肽及其在治疗TNF相关疾病中的应用 |
CN103172746A (zh) * | 2011-12-26 | 2013-06-26 | 财团法人工业技术研究院 | 三聚体Fc融合蛋白及其用途 |
CN103172746B (zh) * | 2011-12-26 | 2016-09-21 | 财团法人工业技术研究院 | 三聚体Fc融合蛋白及其用途 |
CN103739714A (zh) * | 2013-12-30 | 2014-04-23 | 江苏众红生物工程创药研究院有限公司 | TNFα与DC-SIGN的融合蛋白及其应用 |
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C02 | Deemed withdrawal of patent application after publication (patent law 2001) | ||
WD01 | Invention patent application deemed withdrawn after publication |
Open date: 20080102 |