CN101098873A - 作为激酶抑制剂的1,4-取代的吡唑并嘧啶 - Google Patents

作为激酶抑制剂的1,4-取代的吡唑并嘧啶 Download PDF

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Publication number
CN101098873A
CN101098873A CNA2005800464109A CN200580046410A CN101098873A CN 101098873 A CN101098873 A CN 101098873A CN A2005800464109 A CNA2005800464109 A CN A2005800464109A CN 200580046410 A CN200580046410 A CN 200580046410A CN 101098873 A CN101098873 A CN 101098873A
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China
Prior art keywords
phenyl
pyrazolo
amine
pyrimidine
methyl
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Pending
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CNA2005800464109A
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Chinese (zh)
Inventor
N·施密德伯格
P·菲雷
P·因巴赫
P·霍尔策
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Novartis AG
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Novartis AG
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Vascular Medicine (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
CNA2005800464109A 2004-11-12 2005-11-10 作为激酶抑制剂的1,4-取代的吡唑并嘧啶 Pending CN101098873A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0425035A GB0425035D0 (en) 2004-11-12 2004-11-12 Organic compounds
GB0425035.3 2004-11-12

Publications (1)

Publication Number Publication Date
CN101098873A true CN101098873A (zh) 2008-01-02

Family

ID=33523649

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CNA2005800464109A Pending CN101098873A (zh) 2004-11-12 2005-11-10 作为激酶抑制剂的1,4-取代的吡唑并嘧啶

Country Status (15)

Country Link
US (1) US20080096868A1 (https=)
EP (1) EP1812441A1 (https=)
JP (1) JP2008519790A (https=)
KR (1) KR20070084191A (https=)
CN (1) CN101098873A (https=)
AR (1) AR051485A1 (https=)
AU (1) AU2005303965A1 (https=)
BR (1) BRPI0517803A (https=)
CA (1) CA2585660A1 (https=)
GB (1) GB0425035D0 (https=)
GT (1) GT200500325A (https=)
MX (1) MX2007005644A (https=)
RU (1) RU2007121846A (https=)
TW (1) TW200621783A (https=)
WO (1) WO2006050946A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102471335A (zh) * 2009-07-10 2012-05-23 大鹏药品工业株式会社 氮杂二环式化合物或其盐
CN109912599A (zh) * 2009-07-15 2019-06-21 英特利凯恩有限责任公司 化学实体、组合物和方法
CN110734437A (zh) * 2018-07-19 2020-01-31 金秋 吡唑并嘧啶化合物和药物组合物及其应用

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