CN101085277A - Traditional Chinese medicine composition for curing chronic renal failure - Google Patents

Abstract

The invention relates to a Chinese medicinal composition for treating chronic renal failure which is prepared from more than ten kinds of Chinese medicinal herbs including raw astragalus root, corn stigma, leech and coix seed.

Description

A kind of Chinese medicine composition of treatment chronic kidney hypofunction

Technical field

The present invention relates to treat a kind of Chinese medicine composition of chronic kidney hypofunction, is that a kind of chronic kidney hypofunction for the treatment of is the Chinese medicine preparation of raw material with the Chinese herbal medicine.Belong to the field of Chinese medicines.

Background technology

Chronic renal failure (chronic kidney hypofunction) is because the result of kidney damage that a variety of causes causes and the deterioration of carrying out property, body is at the excretion metabolism product, regulate water, electrolyte, acid-base balance, and the clinical syndrome that gets muddled of aspects such as the generation of some endocrine activity material and deactivation.Chronic kidney hypofunction belongs to categories such as " difficulty in urination ", " obstruction and rejection ", " edema ", " asthenia " in the traditional Chinese medical science.Chronic kidney hypofunction can be by multiple kidney disease development such as edema, stranguria, hematuria.The traditional Chinese medical science thinks that with the passing of time various nephropathy, undermine each function, and based on the spleen damage of suffering from a deficiency of the kidney, the state of an illness progressively develops and aggravates disease, and causes the positive deficiency of vital energy to decline at last, and turbid pathogen, blood stasis are stopped up the kidney network that stagnates, cause kidney to lose out entire function, the retention of turbid damp uremic is in body, and the initiation primary disease.The traditional Chinese medical science is divided disease type Coryza Treated by Syndrome Differentiation such as spleen deficiency of kidney-QI, deficiency of spleen-YANG and kidneyYANG, the hepatic and renal YIN deficiency, deficiency of both YIN and YANG clinically, obtains very good effect.The research of Chinese medicine chronic kidney hypofunction has had bigger progress.Theoretical side, vital QI being weakened and pathogen being violent, the pathogenic characteristic of carrying throughout must be known together.Differential diagnosis in tcm opinion control Chinese medicine decoction in the delaying chronic kidney hypofunction progress, improve clinical symptoms and cooperate hemodialysis, reduce the dialysis complication, improve dialysis patient life quality aspect and all obtained certain effect.Invent a kind of not only safety but also effective Chinese medicine preparation, be significant.

Summary of the invention

The present invention develops in conjunction with the latest modern technological scientific achievement on the basis of traditional tcm syndrome differentiation and treatment.The purpose of this invention is to provide a kind of Chinese medicine preparation for the treatment of chronic kidney hypofunction.Have determined curative effect, safe ready, have no side effect, cheap characteristics.

The present invention is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Radix Rehmanniae of 2.5～10 parts of Poria of Stigma Maydis

0.1～2 part of 1.0～4 portions of Semen Plantaginis of 1.5～6 portions of Rhizoma Dioscoreaes of Radix Astragali

0.1～1 part of 1.0～4 portions of Hirudo of 1.0～4 parts of Folium Pyrrosiaes of 0.1～2 part of Semen Coicis of 1.0～4 parts of Cortexs Eucommiae of 1.5～6 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae.

The weight proportion of each raw material of optimization formula of the present invention is:

1.5～2.5 parts of 1.5～2.5 parts of Radix Rehmanniae of 4.5～5.5 parts of Poria of Stigma Maydis

0.5～1.5 part of 1.5～2.5 portions of Semen Plantaginis of 2.5～3.5 portions of Rhizoma Dioscoreaes of Radix Astragali

0.5～1.5 part of 1.5～2.5 parts of Cortex Eucommiae of 2.5～3.5 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae

0.3～0.7 part of 1.5～2.5 portions of Hirudo of 1.5～2.5 parts of Folium Pyrrosiaes of Semen Coicis.

The weight proportion of each raw material of optimum formula of the present invention is:

2 parts of 2 parts of Radix Rehmanniae of 5 parts of Poria of Stigma Maydis

1 part of 2 portions of Semen Plantaginis of 3 portions of Rhizoma Dioscoreaes of Radix Astragali

1 part of 2 parts of Cortex Eucommiae of 3 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae

0.5 part of 2 portions of Hirudo of 2 parts of Folium Pyrrosiaes of Semen Coicis.

Drug action mechanism among the present invention is as follows:

The Stigma Maydis property of medicine is sweet, light, and is flat.Return kidney, stomach, liver, gallbladder meridian.Has inducing diuresis to remove edema, the effect of liver heat removing function of gallbladder promoting.Can treat edema, stranguria, nebulousurine is quenched one's thirst, jaundice, cholecystitis, cholelithiasis, hypertension, acute mastitis, galactostasis etc.(the 777th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Astragali property of medicine is sweet, warm.Return lung, spleen channel.Has benefiting qi and raising yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, the effect of promoting pus discharge and tissue regeneration strengthening.Can treat the card of all Qi and blood deficiencies, as diarrhea due to hypofunction of the spleen, the cough due to deficiency of the lung, proctoptosis, uterine prolapse, spontaneous perspiration, night sweat, edema, arthralgia due to stagnation of blood, carbuncle is difficult bursts or bursts for a long time and do not hold back etc.(the 2813rd page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Radix Salviae Miltiorrhizae property of medicine hardship is slightly cold.GUIXIN, pericardium, Liver Channel.Have blood circulation promoting and blood stasis dispelling, menstruction regulating and pain relieving, relieving restlessness is calmed the nerves, the effect of removing heat from blood eliminating carbuncle.Can treat menoxenia, dysmenorrhea, amenorrhea, the stasis of blood stagnated and suffered from abdominal pain puerperal, trusted subordinate's pain, lumps in the chest and abdomen, pyretic arthralgia swells and ache, traumatic injury, heat is gone into nutrient blood, dysphoria, vexed insomnia, carbuncle pyogenic infections from tumour or sore etc.(the 647th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Semen Coicis property of medicine is sweet, light, is slightly cold.Return spleen, stomach, lung meridian.Has the dampness removing spleen invigorating, arthralgia relieving by relaxing muscles and tendons, the effect of clearing away heat and discharging pus.Can treat edema, beriberi, dribbling urination, damp-warm diseases is had loose bowels, leukorrhagia, rheumatic arthralgia, the contracture of muscle arteries and veins, lung abscess, acute appendicitis, verruca plana etc.(the 3725th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Poria property of medicine is sweet, light, and is flat.GUIXIN, spleen, lung, kidney channel.Has promoting diuresis to eliminate damp pathogen, invigorating the spleen and regulating the stomach, the effect of mind tranquilizing and the heart calming.Can treat dysuria, the edema distension, is had loose bowels at phlegm retention cough with dyspnea, vomiting, insufficiency of the spleen lack of appetite, palpitation and restlessness, insomnia forgetfulness, seminal emission nebulousurine etc.(the 2154th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Dioscoreae property of medicine is sweet, flat.Return spleen, lung, kidney channel.Have spleen reinforcing, support lung, reinforce the kidney, the effect that benefit is smart.Can treat diarrhea due to hypofunction of the spleen, the lack of appetite edema, cough and asthma due to lung deficiency is quenched one's thirst, seminal emission, leukorrhagia, the frequent micturition of suffering from a deficiency of the kidney.Carbuncle is controlled in external, scrofula etc.(the 218th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Rhizoma Alismatis property of medicine is sweet, light, and is cold.Return kidney, urinary bladder channel.Have promoting diuresis to eliminate damp pathogen, treating stranguria effect expels the heat-evil.Can treat dysuria, the puckery pain of pyretic stranguria, the edema distension is had loose bowels, dizziness due to fluid-retention, seminal emission etc.(the 2067th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Folium Pyrrosiae property of medicine hardship, sweet, cold.Return lung, kidney, urinary bladder channel.Has relieving stranguria by diuresis, removing heat from the lung and dissipating phlegm, the effect of cooling blood for hemostasis.Can treat stranguria, edema, dysuria, the expectorant heat syndrome cough is breathed heavily, and spitting of blood is spitted blood epistaxis, metrorrhagia and traumatic hemorrhage etc.(the 811st page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Radix Rehmanniae nature and flavor are sweet, cold.GUIXIN, liver, kidney channel.Has clearing away heat and cooling blood, yin nourishing, the effect of promoting the production of body fluid.Can treat that calentura crimson tongue excessive thirst, interior-heat caused by deficiency of YIN, hectic fever due to YIN-deficiency consumptive fever, interior-heat are quenched one's thirst, haematemesis, epistaxis, send out speckle dermexanthesis etc.(Ji Yubin chief editor " Chinese medicine medicine for preventing pharmacology and application " Heilungkiang science tech publishing house 1999 version the 514th page).

The Semen Plantaginis property of medicine is sweet, light, is slightly cold.Return lung, liver, kidney, urinary bladder channel.Have heat clearing away, diuresis makes eye bright, the expectorant effect.Can treat urinary obstruction, stranguria with turbid discharge, leukorrhagia, edema, the heat-damp in summer dysentery, conjunctival congestion is hidden from view, and the expectorant heat syndrome cough is breathed heavily etc.(the 539th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

Sweet, the little suffering of the Cortex Eucommiae property of medicine, temperature.Return liver, kidney channel.Has invigorating the liver and kidney, bone and muscle strengthening, antiabortive effect.Can treat soreness of waist and knee joint, sexual impotence, frequent micturition, dribbling urination, rheumatic arthralgia, frequent fetal movement, habitual abortion etc.(the 1514th page of Shanghai science tech publishing house second edition write by " Chinese medicine voluminous dictionary " Nanjing University of Traditional Chinese Medicine).

The Hirudo nature and flavor are salty, bitter, and are flat; Slightly poisonous.Return Liver Channel.Has removing blood stasis, removing blood stasis, the effect of stimulating the menstrual flow.Ke Zhi Liao mass in the abdomen mass in the abdomen, blood stasis amenorrhea, injury from falling down etc.(the 63rd page of Chemical Industry Press of Pharmacopoeia of the People's Republic of China version in 2000 is compiled by Chinese Pharmacopoeia Commission).

The present invention follows the principles of formulating prescriptions of the traditional Chinese medical science " monarch ", is monarch drug with Stigma Maydis, Radix Astragali and Radix Salviae Miltiorrhizae; With Semen Coicis, Poria, Rhizoma Dioscoreae, Rhizoma Alismatis, Folium Pyrrosiae, Radix Rehmanniae and Hirudo is ministerial drug; With the Semen Plantaginis and the Cortex Eucommiae is adjuvant.All medicines are harmonious, and the tool kidney tonifying is invigorated blood circulation the effect of promoting diuresis to eliminate damp pathogen altogether.The treatment chronic kidney hypofunction has determined curative effect, has no side effect taking convenience, cheap characteristics.

Clinical drug of the present invention uses the result to show that following advantage is arranged:

1, the Chinese herbal medicine each component selected for use of the present invention meets the regulation of Pharmacopoeia of People's Republic of China, utilizes the comprehensive function treatment chronic kidney hypofunction of the Chinese medicine of respectively distinguishing the flavor of, and is nontoxic to human body.Show that through the acute and chronic toxicity test of animal the animal of being tested does not see any toxic reaction, its main organs does not have tangible change yet, and safety of medicine is reliable.

2, rich in proteins in the medicine of the present invention, glucose, glucuronic acid, volatile oil, pectin, fructose, organic acid, lecithin, vitamin, aminoacid also contains various trace elements such as Saponin, plant sterol and calcium, is beneficial to absorption of human body, health invigorating.

3, the present invention not only can effectively treat chronic kidney hypofunction, and the prevention of chronic kidney hypofunction is also had good effect, and the treatment chronic kidney hypofunction has determined curative effect, has no side effect taking convenience, cheap characteristics.

For showing the therapeutic effect of medicine of the present invention, as follows through clinical test results to the treatment chronic kidney hypofunction; Treatment chronic kidney hypofunction patient 20 examples.Take the embodiment decoction, each 1 bag, two to three times on the one, take half an hour ante cibum.Three months is a course of treatment, take continuously three the course of treatment observe the curative effect.Produce effects 7 examples account for 35%, and effective 9 examples account for 45%, and invalid 4 examples account for 20%, and total effective rate reaches 80%.After three course of therapy, patient does not have any untoward reaction, and three big routine tests and hepatic and renal function detect no abnormal.

The specific embodiment

The embodiment decoction takes by weighing raw material by following weight:

2 parts of 2 parts of Radix Rehmanniae of 5 parts of Poria of Stigma Maydis

1 part of 2 portions of Semen Plantaginis of 3 portions of Rhizoma Dioscoreaes of Radix Astragali

1 part of 2 parts of Cortex Eucommiae of 3 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae

0.5 part of 2 portions of Hirudo of 2 parts of Folium Pyrrosiaes of Semen Coicis.

Preparation method is to get above-mentioned raw materials to clean roguing, dries, and is ground into granule, soaks 1 hour, puts and decocts with water secondary in the multi-function extractor, adds up the water of 10 times of amounts of medical material for the first time, decocts 1.5～2 hours, gets decocting liquid, filters.Add up for the second time the water of 7 times of amounts of medical material, decocted 1～1.2 hour, get decocting liquid twice, filter, in the heat-sealing bag, 105 ℃ of high temperature sterilizes, packing is promptly.The decoction of the treatment chronic kidney hypofunction that the present invention makes is that plastic packaging is packed, and every bag of 210ml is oral, one time one bag, every day two to three times.Three months is a course of treatment.

Claims (3)

1, a kind of Chinese medicine composition of treatment chronic kidney hypofunction is characterized in that it is made by the following weight proportion raw material:

1.0～4 parts of 1.0～4 parts of Radix Rehmanniae of 2.5～10 parts of Poria of Stigma Maydis

0.1～2 part of 1.0～4 portions of Semen Plantaginis of 1.5～6 portions of Rhizoma Dioscoreaes of Radix Astragali

0.1～2 part of 1.0～4 parts of Cortex Eucommiae of 1.5～6 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae

0.1～1 part of 1.0～4 portions of Hirudo of 1.0～4 parts of Folium Pyrrosiaes of Semen Coicis.

2, a kind of Chinese medicine composition of treatment chronic kidney hypofunction according to claim 1, wherein the weight proportion of each raw material is:

1.5～2.5 parts of 1.5～2.5 parts of Radix Rehmanniae of 4.5～5.5 parts of Poria of Stigma Maydis

0.5～1.5 part of 1.5～2.5 portions of Semen Plantaginis of 2.5～3.5 portions of Rhizoma Dioscoreaes of Radix Astragali

0.5～1.5 part of 1.5～2.5 parts of Cortex Eucommiae of 2.5～3.5 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae

0.3～0.7 part of 1.5～2.5 portions of Hirudo of 1.5～2.5 parts of Folium Pyrrosiaes of Semen Coicis.

3, a kind of Chinese medicine composition of treatment chronic kidney hypofunction according to claim 1, wherein the weight proportion of each raw material is:

2 parts of 2 parts of Radix Rehmanniae of 5 parts of Poria of Stigma Maydis

1 part of 2 portions of Semen Plantaginis of 3 portions of Rhizoma Dioscoreaes of Radix Astragali

1 part of 2 parts of Cortex Eucommiae of 3 portions of Rhizoma Alismatis of Radix Salviae Miltiorrhizae

0.5 part of 2 portions of Hirudo of 2 parts of Folium Pyrrosiaes of Semen Coicis.