CN101070331A - 一种精制奈达铂的方法 - Google Patents
一种精制奈达铂的方法 Download PDFInfo
- Publication number
- CN101070331A CN101070331A CN 200710022407 CN200710022407A CN101070331A CN 101070331 A CN101070331 A CN 101070331A CN 200710022407 CN200710022407 CN 200710022407 CN 200710022407 A CN200710022407 A CN 200710022407A CN 101070331 A CN101070331 A CN 101070331A
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- Prior art keywords
- nedaplatin
- hours
- reifining
- alkyl
- content
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 238000000034 method Methods 0.000 title claims abstract description 25
- 229950007221 nedaplatin Drugs 0.000 title claims abstract description 18
- 190000005734 Nedaplatin Chemical compound 0.000 title claims abstract 10
- 239000000047 product Substances 0.000 claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 20
- 238000002425 crystallisation Methods 0.000 claims abstract description 12
- 230000008025 crystallization Effects 0.000 claims abstract description 12
- 238000001816 cooling Methods 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 6
- 239000012043 crude product Substances 0.000 claims abstract description 5
- 239000000706 filtrate Substances 0.000 claims abstract description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 238000001291 vacuum drying Methods 0.000 claims description 16
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 14
- -1 alkyl ketone Chemical class 0.000 claims description 10
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims description 9
- 125000005233 alkylalcohol group Chemical group 0.000 claims description 3
- 238000001914 filtration Methods 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 238000003756 stirring Methods 0.000 description 30
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 20
- 229910052709 silver Inorganic materials 0.000 description 20
- 239000004332 silver Substances 0.000 description 20
- 239000007791 liquid phase Substances 0.000 description 17
- 238000010521 absorption reaction Methods 0.000 description 16
- 238000004587 chromatography analysis Methods 0.000 description 16
- 238000005374 membrane filtration Methods 0.000 description 16
- 239000007787 solid Substances 0.000 description 15
- ZAXCMPAWRCMABN-UHFFFAOYSA-N azane;2-hydroxyacetic acid;platinum Chemical compound N.N.[Pt].OCC(O)=O ZAXCMPAWRCMABN-UHFFFAOYSA-N 0.000 description 9
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Substances [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 8
- 229910052697 platinum Inorganic materials 0.000 description 7
- 238000007670 refining Methods 0.000 description 3
- 206010008342 Cervix carcinoma Diseases 0.000 description 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 description 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 description 2
- 230000000118 anti-neoplastic effect Effects 0.000 description 2
- 201000010881 cervical cancer Diseases 0.000 description 2
- 238000001311 chemical methods and process Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 201000004101 esophageal cancer Diseases 0.000 description 2
- 201000010536 head and neck cancer Diseases 0.000 description 2
- 208000014829 head and neck neoplasm Diseases 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 231100000419 toxicity Toxicity 0.000 description 2
- 230000001988 toxicity Effects 0.000 description 2
- 206010005003 Bladder cancer Diseases 0.000 description 1
- 206010065553 Bone marrow failure Diseases 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 231100000371 dose-limiting toxicity Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 231100000053 low toxicity Toxicity 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000003039 myelosuppressive effect Effects 0.000 description 1
- 231100000417 nephrotoxicity Toxicity 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 208000002154 non-small cell lung carcinoma Diseases 0.000 description 1
- 150000003057 platinum Chemical class 0.000 description 1
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 210000001550 testis Anatomy 0.000 description 1
- 206010043554 thrombocytopenia Diseases 0.000 description 1
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 description 1
- 201000005112 urinary bladder cancer Diseases 0.000 description 1
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Description
Claims (5)
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007100224074A CN100494210C (zh) | 2007-05-17 | 2007-05-17 | 一种精制奈达铂的方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CNB2007100224074A CN100494210C (zh) | 2007-05-17 | 2007-05-17 | 一种精制奈达铂的方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN101070331A true CN101070331A (zh) | 2007-11-14 |
CN100494210C CN100494210C (zh) | 2009-06-03 |
Family
ID=38897760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2007100224074A Active CN100494210C (zh) | 2007-05-17 | 2007-05-17 | 一种精制奈达铂的方法 |
Country Status (1)
Country | Link |
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CN (1) | CN100494210C (zh) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101865894A (zh) * | 2010-06-28 | 2010-10-20 | 江苏奥赛康药业有限公司 | 一种奈达铂冻干粉针剂的杂质检测方法 |
CN102352516A (zh) * | 2011-10-26 | 2012-02-15 | 南京工业大学 | 一种奈达铂的精制方法 |
CN102417522A (zh) * | 2011-10-20 | 2012-04-18 | 南京工业大学 | 一种含银量极低的奈达铂的制备方法 |
-
2007
- 2007-05-17 CN CNB2007100224074A patent/CN100494210C/zh active Active
Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101865894A (zh) * | 2010-06-28 | 2010-10-20 | 江苏奥赛康药业有限公司 | 一种奈达铂冻干粉针剂的杂质检测方法 |
CN102417522A (zh) * | 2011-10-20 | 2012-04-18 | 南京工业大学 | 一种含银量极低的奈达铂的制备方法 |
CN102417522B (zh) * | 2011-10-20 | 2014-11-26 | 南京工业大学 | 一种奈达铂的制备方法 |
CN102352516A (zh) * | 2011-10-26 | 2012-02-15 | 南京工业大学 | 一种奈达铂的精制方法 |
Also Published As
Publication number | Publication date |
---|---|
CN100494210C (zh) | 2009-06-03 |
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C06 | Publication | ||
PB01 | Publication | ||
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SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
ASS | Succession or assignment of patent right |
Owner name: NANJING SIMCERE DONGYUAN PHARMACEUTICAL CO., LTD. Free format text: FORMER OWNER: DONGJIE PHARMACY CO., LTD., NANJING Effective date: 20100827 |
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COR | Change of bibliographic data |
Free format text: CORRECT: ADDRESS; FROM: 211800 NO.12, JIANGYUAN ROAD, ECONOMIC DEVELOPMENT ZONE, PUKOU DISTRICT, NANJING CITY, JIANGSU PROVINCE TO: 211800 NO.8, XINGLONG ROAD, ECONOMIC DEVELOPMENT ZONE, PUKOU DISTRICT, NANJING CITY, JIANGSU PROVINCE |
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TR01 | Transfer of patent right |
Effective date of registration: 20100827 Address after: 211800, No. 8, prosperous road, Pukou Economic Development Zone, Nanjing, Jiangsu Patentee after: NANJING SIMCERE DONGYUAN PHARMACEUTICA Co.,Ltd. Address before: Jiang Yuan Lu, Pukou District Economic Development Zone Nanjing City, Jiangsu province 211800 No. 12 Patentee before: Nanjing Dongjie Pharmaceutical Co.,Ltd. |
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CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: No.99, Huakang Road, Jiangbei new district, Nanjing, Jiangsu Province, 210000 Patentee after: SIMCERE PHARMACEUTICAL Co.,Ltd. Address before: 211800, No. 8, prosperous road, Pukou Economic Development Zone, Nanjing, Jiangsu Patentee before: NANJING SIMCERE DONGYUAN PHARMACEUTICA Co.,Ltd. |
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TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20230428 Address after: No. 20 Yaogu Yiheng Road, Xiuying District, Haikou City, Hainan Province, 570311 Patentee after: Xiansheng Zaiming Pharmaceutical Co.,Ltd. Address before: 210000 No.99, Huakang Road, Jiangbei new district, Nanjing City, Jiangsu Province Patentee before: SIMCERE PHARMACEUTICAL Co.,Ltd. |
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CP03 | Change of name, title or address | ||
CP03 | Change of name, title or address |
Address after: No. 20 Yaogu Yiheng Road, Xiuying District, Haikou City, Hainan Province, 570311 Patentee after: Hainan Xiansheng Zaiming Pharmaceutical Co.,Ltd. Country or region after: China Address before: No. 20 Yaogu Yiheng Road, Xiuying District, Haikou City, Hainan Province, 570311 Patentee before: Xiansheng Zaiming Pharmaceutical Co.,Ltd. Country or region before: China |