CN101061131B - 吉西他滨衍生物纳微粒 - Google Patents
吉西他滨衍生物纳微粒 Download PDFInfo
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- CN101061131B CN101061131B CN2005800218778A CN200580021877A CN101061131B CN 101061131 B CN101061131 B CN 101061131B CN 2005800218778 A CN2005800218778 A CN 2005800218778A CN 200580021877 A CN200580021877 A CN 200580021877A CN 101061131 B CN101061131 B CN 101061131B
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- gemcitabine
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- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/542—Carboxylic acids, e.g. a fatty acid or an amino acid
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P31/12—Antivirals
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- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y30/00—Nanotechnology for materials or surface science, e.g. nanocomposites
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
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- C07H19/073—Pyrimidine radicals with 2-deoxyribosyl as the saccharide radical
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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Abstract
Description
在最后悬浮液中SQgem浓度(mg/ml) | 平均流体动力学直径(nm) | 标准偏差 | 多分散性指数 |
1 | 126.2 | 43.5 | 0.26 |
2 | 150.4 | 37.7 | 0.09 |
4 | 171.3 | 40.8 | 0.08 |
Claims (18)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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FR0451365 | 2004-06-30 | ||
FR0451365A FR2874016B1 (fr) | 2004-06-30 | 2004-06-30 | Nanoparticules de derives de la gemcitabine |
PCT/FR2005/050488 WO2006090029A1 (fr) | 2004-06-30 | 2005-06-23 | Nanoparticules de derives de la gemcitabine |
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CN201110251937.2A Division CN102335436B (zh) | 2004-06-30 | 2005-06-23 | 吉西他滨衍生物纳微粒 |
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CN101061131A CN101061131A (zh) | 2007-10-24 |
CN101061131B true CN101061131B (zh) | 2011-10-05 |
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CN201110251937.2A Active CN102335436B (zh) | 2004-06-30 | 2005-06-23 | 吉西他滨衍生物纳微粒 |
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CN201110251937.2A Active CN102335436B (zh) | 2004-06-30 | 2005-06-23 | 吉西他滨衍生物纳微粒 |
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US (2) | US7704972B2 (zh) |
EP (3) | EP1761551B1 (zh) |
JP (2) | JP4927726B2 (zh) |
CN (2) | CN101061131B (zh) |
AT (2) | ATE519773T1 (zh) |
CA (2) | CA2805761C (zh) |
DK (2) | DK2055711T3 (zh) |
ES (2) | ES2372141T3 (zh) |
FR (1) | FR2874016B1 (zh) |
PT (2) | PT1761551E (zh) |
WO (1) | WO2006090029A1 (zh) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2648099C (en) * | 2006-03-31 | 2012-05-29 | The Brigham And Women's Hospital, Inc | System for targeted delivery of therapeutic agents |
FR2924024B1 (fr) * | 2007-11-27 | 2012-08-17 | Centre Nat Rech Scient | Nanoparticules d'actifs therapeutiques de faible solubilite aqueuse |
FR2931152B1 (fr) * | 2008-05-16 | 2010-07-30 | Centre Nat Rech Scient | Nouveau systeme de transfert d'acide nucleique |
WO2010039039A1 (en) * | 2008-10-03 | 2010-04-08 | Clavis Pharma Asa | Oral formulations of gemcitabine derivatives |
FR2937549B1 (fr) * | 2008-10-29 | 2011-04-01 | Centre Nat Rech Scient | Nanoparticules de derives beta-lactamine |
FR2937537A1 (fr) * | 2008-10-29 | 2010-04-30 | Centre Nat Rech Scient | Nanoparticules de statine |
EP2344277B1 (en) * | 2008-10-31 | 2018-06-27 | Hitachi Koki CO., LTD. | Centrifuge |
WO2010063080A1 (en) | 2008-12-05 | 2010-06-10 | Commonwealth Scientific And Industrial Research Organisation | Amphiphile prodrugs |
FR2968662B1 (fr) | 2010-12-10 | 2013-11-22 | Roussy Inst Gustave | Nouveaux derives d'oxazaphosphorines pre-activees, utilisation et methode de preparation |
JP6049712B2 (ja) | 2011-07-08 | 2016-12-21 | ザ ユニバーシティ オブ ノース カロライナ アット チャペル ヒルThe University Of North Carolina At Chapel Hill | 抗癌治療及び画像化並びに骨障害治療のための金属ビスホスホネートナノ粒子 |
FR2988092B1 (fr) * | 2012-03-16 | 2014-04-25 | Centre Nat Rech Scient | Complexes de vitamine c, nanoparticules desdits complexes, procedes pour leur preparation, leurs compositions, leurs utilisations cosmetiques et procede de traitement cosmetique |
US8956613B2 (en) | 2012-11-13 | 2015-02-17 | BoYen Therapeutics, Inc. | Gemcitabine prodrugs and uses thereof |
EP2742955A1 (en) | 2012-12-12 | 2014-06-18 | Centre National De La Recherche Scientifique | Nanoparticles based on bioconjugate of GAG |
JP6083770B2 (ja) * | 2013-09-13 | 2017-02-22 | 板井 昭子 | 水溶液製剤及びその製造方法 |
CN105873569B (zh) | 2013-11-06 | 2020-07-28 | 芝加哥大学 | 用于化疗剂、核酸和光敏剂的递送或共递送的纳米级载体 |
CN103599073A (zh) * | 2013-11-15 | 2014-02-26 | 无锡中科光远生物材料有限公司 | 一种负载有靶向抗癌药物的plga微米颗粒的制备方法 |
JP6212831B2 (ja) | 2013-12-04 | 2017-10-18 | 杭州源昶医薬科技有限公司 | ゲムシタビン誘導体、該誘導体を含む組成物及び該誘導体の製薬用途 |
WO2015116782A1 (en) | 2014-01-29 | 2015-08-06 | Board Of Regents, The University Of Texas System | Nucleobase analogue derivatives and their applications |
CN105030682B (zh) * | 2015-06-24 | 2018-02-09 | 广州复大医疗股份有限公司 | 一种纳米微粒胶体及其制备方法与用途 |
US11246877B2 (en) | 2016-05-20 | 2022-02-15 | The University Of Chicago | Nanoparticles for chemotherapy, targeted therapy, photodynamic therapy, immunotherapy, and any combination thereof |
TWI719182B (zh) * | 2017-03-29 | 2021-02-21 | 國立交通大學 | 奈米組成物、其製造方法及其用途 |
CN111491634A (zh) | 2017-07-31 | 2020-08-04 | 詹纽瑞治疗公司 | 有机磷酸酯衍生物 |
JP7364552B2 (ja) | 2017-08-02 | 2023-10-18 | ザ ユニバーシティ オブ シカゴ | X線誘起光線力学療法、放射線療法、放射線力学療法、化学療法、免疫療法、及びそれらの任意の組み合わせのための、ナノスケール金属有機層及び金属有機ナノプレート |
EP3758495A4 (en) * | 2018-03-02 | 2021-12-01 | January Therapeutics, Inc. | COMPOSITIONS OF NANOPARTICLES |
WO2019204869A1 (en) * | 2018-04-26 | 2019-10-31 | NanoMed Holdings Pty Ltd | Gemcitabine amphiphile prodrugs |
EP3628735A1 (en) | 2018-09-25 | 2020-04-01 | Centre National De La Recherche Scientifique | Antisense rna targeting pmp22 for the treatment of charcot-marie-tooth 1a disease |
WO2020247912A1 (en) * | 2019-06-06 | 2020-12-10 | Board Of Regents, The University Of Texas System | Lipid nanoparticles containing pharmaceutical and/or nutraceutical agents and methods thereof |
US11708637B2 (en) | 2019-08-13 | 2023-07-25 | The Regents Of The University Of California | Methods of supporting a graphene sheet disposed on a frame support |
FR3110427B1 (fr) | 2020-05-20 | 2023-07-14 | Laboratoires Eriger | Conjugué terpenique de couplage |
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EP0693077A1 (en) * | 1993-04-05 | 1996-01-24 | Norsk Hydro A/S | Antiviral compounds |
WO1998032762A1 (en) * | 1997-01-24 | 1998-07-30 | Norsk Hydro Asa | Gemcitabine derivatives |
US6524595B1 (en) * | 2000-05-12 | 2003-02-25 | Coletica | Cyclodextrins preferentially substituted on their primary face by acid or amine functions |
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2004
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- 2005-06-23 JP JP2007518660A patent/JP4927726B2/ja active Active
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- 2005-06-23 PT PT09152764T patent/PT2055711E/pt unknown
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- 2005-06-23 EP EP08100379A patent/EP1925624A1/fr not_active Withdrawn
- 2005-06-23 AT AT05857322T patent/ATE519773T1/de active
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- 2005-06-23 AT AT09152764T patent/ATE520703T1/de active
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- 2005-06-23 US US11/631,075 patent/US7704972B2/en active Active
- 2005-06-23 CN CN201110251937.2A patent/CN102335436B/zh active Active
- 2005-06-23 CA CA2572380A patent/CA2572380C/fr active Active
- 2005-06-23 WO PCT/FR2005/050488 patent/WO2006090029A1/fr active Application Filing
- 2005-06-23 ES ES05857322T patent/ES2371411T3/es active Active
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EP0693077A1 (en) * | 1993-04-05 | 1996-01-24 | Norsk Hydro A/S | Antiviral compounds |
WO1998032762A1 (en) * | 1997-01-24 | 1998-07-30 | Norsk Hydro Asa | Gemcitabine derivatives |
US6384019B1 (en) * | 1997-01-24 | 2002-05-07 | Norsk Hydro Asa | Gemcitabine derivatives |
US6524595B1 (en) * | 2000-05-12 | 2003-02-25 | Coletica | Cyclodextrins preferentially substituted on their primary face by acid or amine functions |
Also Published As
Publication number | Publication date |
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EP1761551A1 (fr) | 2007-03-14 |
CA2805761C (fr) | 2016-10-04 |
DK2055711T3 (da) | 2011-12-12 |
US7704972B2 (en) | 2010-04-27 |
JP2012102107A (ja) | 2012-05-31 |
CN102335436A (zh) | 2012-02-01 |
FR2874016B1 (fr) | 2006-11-24 |
CA2572380C (fr) | 2013-11-19 |
ES2372141T3 (es) | 2012-01-16 |
CN102335436B (zh) | 2014-10-08 |
EP1925624A1 (fr) | 2008-05-28 |
ES2371411T3 (es) | 2012-01-02 |
ATE520703T1 (de) | 2011-09-15 |
FR2874016A1 (fr) | 2006-02-10 |
EP2055711A1 (fr) | 2009-05-06 |
DK1761551T3 (da) | 2011-11-28 |
PT2055711E (pt) | 2011-12-07 |
CN101061131A (zh) | 2007-10-24 |
ATE519773T1 (de) | 2011-08-15 |
CA2572380A1 (fr) | 2006-08-31 |
JP2008504353A (ja) | 2008-02-14 |
EP2055711B1 (fr) | 2011-08-17 |
US20100160249A1 (en) | 2010-06-24 |
PT1761551E (pt) | 2011-11-24 |
EP1761551B1 (fr) | 2011-08-10 |
WO2006090029A1 (fr) | 2006-08-31 |
JP5552473B2 (ja) | 2014-07-16 |
US8044034B2 (en) | 2011-10-25 |
CA2805761A1 (fr) | 2006-08-31 |
JP4927726B2 (ja) | 2012-05-09 |
US20090130214A1 (en) | 2009-05-21 |
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