CN101043888B - 制备异噻唑衍生物的方法 - Google Patents

制备异噻唑衍生物的方法 Download PDF

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Publication number
CN101043888B
CN101043888B CN2005800284337A CN200580028433A CN101043888B CN 101043888 B CN101043888 B CN 101043888B CN 2005800284337 A CN2005800284337 A CN 2005800284337A CN 200580028433 A CN200580028433 A CN 200580028433A CN 101043888 B CN101043888 B CN 101043888B
Authority
CN
China
Prior art keywords
formula
isothiazole
chemical compound
methyl
benzyloxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN2005800284337A
Other languages
English (en)
Chinese (zh)
Other versions
CN101043888A (zh
Inventor
大卫·B·达蒙
布赖恩·P·琼斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Ltd Great Britain
OSI Pharmaceuticals LLC
Original Assignee
PFIZER Ltd
Pfizer Products Inc
OSI Pharmaceuticals LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PFIZER Ltd, Pfizer Products Inc, OSI Pharmaceuticals LLC filed Critical PFIZER Ltd
Publication of CN101043888A publication Critical patent/CN101043888A/zh
Application granted granted Critical
Publication of CN101043888B publication Critical patent/CN101043888B/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
CN2005800284337A 2004-08-26 2005-08-02 制备异噻唑衍生物的方法 Expired - Fee Related CN101043888B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60454204P 2004-08-26 2004-08-26
US60/604,542 2004-08-26
PCT/US2005/027398 WO2006026034A2 (en) 2004-08-26 2005-08-02 Processes for the preparation of isothiazole derivatives

Publications (2)

Publication Number Publication Date
CN101043888A CN101043888A (zh) 2007-09-26
CN101043888B true CN101043888B (zh) 2010-08-11

Family

ID=36000502

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800284337A Expired - Fee Related CN101043888B (zh) 2004-08-26 2005-08-02 制备异噻唑衍生物的方法

Country Status (21)

Country Link
US (2) US8884025B2 (https=)
EP (1) EP1784183B1 (https=)
JP (2) JP5100390B2 (https=)
KR (1) KR100893977B1 (https=)
CN (1) CN101043888B (https=)
AR (1) AR050613A1 (https=)
AT (1) ATE542533T1 (https=)
AU (1) AU2005280451B2 (https=)
BR (1) BRPI0514667A (https=)
CA (1) CA2578023C (https=)
DK (1) DK1784183T3 (https=)
ES (1) ES2378994T3 (https=)
IL (1) IL181063A0 (https=)
MX (1) MX2007002246A (https=)
NO (1) NO20071319L (https=)
PL (1) PL1784183T3 (https=)
PT (1) PT1784183E (https=)
RU (1) RU2349588C2 (https=)
TW (1) TWI361688B (https=)
WO (1) WO2006026034A2 (https=)
ZA (1) ZA200701016B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1784183E (pt) 2004-08-26 2012-03-09 Pfizer Processos para a preparação de derivados de isotiazole
ES2623652T3 (es) 2011-12-28 2017-07-11 Allergan, Inc. Derivados de 3-fenil-5-ureidoisotiazol-4-carboximida y 3-amino-5-fenilisotiazol como inhibidores de cinasa
CN103833665B (zh) * 2014-02-24 2015-09-23 杰达维（上海）医药科技发展有限公司 一种新的合成异噻唑的方法
US9353093B2 (en) 2014-10-07 2016-05-31 Allergan, Inc. Indole-1-carboxamides as kinase inhibitors
US9403803B2 (en) 2014-10-08 2016-08-02 Allergan, Inc. Indole-3-carboxamides as kinase inhibitors
US9359336B2 (en) 2014-10-09 2016-06-07 Allergan, Inc. Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
US9371314B2 (en) 2014-10-09 2016-06-21 Allergan, Inc. Pyridyl benzothiophenes as kinase inhibitors
AU2023416218A1 (en) * 2022-12-28 2025-07-10 Beyang Therapeutics Co., Ltd. Protein tyrosine kinase inhibitor and medical use thereof
WO2026002126A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂及其眼用制剂
WO2026002137A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂游离碱的晶型

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235764B1 (en) * 1998-06-04 2001-05-22 Pfizer Inc. Isothiazole derivatives useful as anticancer agents

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408234A1 (de) * 1974-02-21 1975-09-04 Celamerck Gmbh & Co Kg Isothiazolylharnstoffe
US4059433A (en) * 1976-06-18 1977-11-22 Fmc Corporation 3-Alkoxyisothiazole derivatives as herbicides
IL72093A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives
HN2000000051A (es) * 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
GB0010188D0 (en) * 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
EP1527071A1 (en) * 2002-07-25 2005-05-04 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
US20060035954A1 (en) * 2004-08-11 2006-02-16 Sharma Padam N Ammonolysis process for the preparation of intermediates for DPP IV inhibitors
PT1784183E (pt) 2004-08-26 2012-03-09 Pfizer Processos para a preparação de derivados de isotiazole

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6235764B1 (en) * 1998-06-04 2001-05-22 Pfizer Inc. Isothiazole derivatives useful as anticancer agents
US6548526B2 (en) * 1998-06-04 2003-04-15 Pfizer Inc Isothiazole derivatives useful as anticancer agents

Also Published As

Publication number Publication date
ES2378994T3 (es) 2012-04-19
JP5100390B2 (ja) 2012-12-19
WO2006026034A3 (en) 2006-06-29
CN101043888A (zh) 2007-09-26
PL1784183T3 (pl) 2012-07-31
AR050613A1 (es) 2006-11-08
AU2005280451B2 (en) 2009-02-05
CA2578023C (en) 2012-05-15
WO2006026034A2 (en) 2006-03-09
JP5498524B2 (ja) 2014-05-21
US9371298B2 (en) 2016-06-21
NO20071319L (no) 2007-05-29
EP1784183B1 (en) 2012-01-25
DK1784183T3 (da) 2012-04-02
KR20070070158A (ko) 2007-07-03
IL181063A0 (en) 2007-07-04
BRPI0514667A (pt) 2008-06-17
US8884025B2 (en) 2014-11-11
EP1784183A2 (en) 2007-05-16
US20150065726A1 (en) 2015-03-05
ATE542533T1 (de) 2012-02-15
US20090023924A1 (en) 2009-01-22
CA2578023A1 (en) 2006-03-09
RU2349588C2 (ru) 2009-03-20
JP2008510841A (ja) 2008-04-10
PT1784183E (pt) 2012-03-09
KR100893977B1 (ko) 2009-04-20
MX2007002246A (es) 2007-04-20
HK1111359A1 (en) 2008-08-08
ZA200701016B (en) 2008-05-28
AU2005280451A1 (en) 2006-03-09
EP1784183A4 (en) 2009-12-09
JP2012153705A (ja) 2012-08-16
TW200621241A (en) 2006-07-01
TWI361688B (en) 2012-04-11
RU2007106847A (ru) 2008-08-27

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