BRPI0514667A - processos para a preparação de derivados de isotiazol - Google Patents

processos para a preparação de derivados de isotiazol

Info

Publication number
BRPI0514667A
BRPI0514667A BRPI0514667-4A BRPI0514667A BRPI0514667A BR PI0514667 A BRPI0514667 A BR PI0514667A BR PI0514667 A BRPI0514667 A BR PI0514667A BR PI0514667 A BRPI0514667 A BR PI0514667A
Authority
BR
Brazil
Prior art keywords
processes
preparation
isothiazole derivatives
derivatives
isothiazole
Prior art date
Application number
BRPI0514667-4A
Other languages
English (en)
Portuguese (pt)
Inventor
David B Damon
Original Assignee
Pfizer Prod Inc
Osi Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc, Osi Pharm Inc filed Critical Pfizer Prod Inc
Publication of BRPI0514667A publication Critical patent/BRPI0514667A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D275/00—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings
    • C07D275/02—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings
    • C07D275/03—Heterocyclic compounds containing 1,2-thiazole or hydrogenated 1,2-thiazole rings not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Diabetes (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Obesity (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
BRPI0514667-4A 2004-08-26 2005-08-02 processos para a preparação de derivados de isotiazol BRPI0514667A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US60454204P 2004-08-26 2004-08-26
PCT/US2005/027398 WO2006026034A2 (en) 2004-08-26 2005-08-02 Processes for the preparation of isothiazole derivatives

Publications (1)

Publication Number Publication Date
BRPI0514667A true BRPI0514667A (pt) 2008-06-17

Family

ID=36000502

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0514667-4A BRPI0514667A (pt) 2004-08-26 2005-08-02 processos para a preparação de derivados de isotiazol

Country Status (21)

Country Link
US (2) US8884025B2 (https=)
EP (1) EP1784183B1 (https=)
JP (2) JP5100390B2 (https=)
KR (1) KR100893977B1 (https=)
CN (1) CN101043888B (https=)
AR (1) AR050613A1 (https=)
AT (1) ATE542533T1 (https=)
AU (1) AU2005280451B2 (https=)
BR (1) BRPI0514667A (https=)
CA (1) CA2578023C (https=)
DK (1) DK1784183T3 (https=)
ES (1) ES2378994T3 (https=)
IL (1) IL181063A0 (https=)
MX (1) MX2007002246A (https=)
NO (1) NO20071319L (https=)
PL (1) PL1784183T3 (https=)
PT (1) PT1784183E (https=)
RU (1) RU2349588C2 (https=)
TW (1) TWI361688B (https=)
WO (1) WO2006026034A2 (https=)
ZA (1) ZA200701016B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1784183E (pt) 2004-08-26 2012-03-09 Pfizer Processos para a preparação de derivados de isotiazole
ES2623652T3 (es) 2011-12-28 2017-07-11 Allergan, Inc. Derivados de 3-fenil-5-ureidoisotiazol-4-carboximida y 3-amino-5-fenilisotiazol como inhibidores de cinasa
CN103833665B (zh) * 2014-02-24 2015-09-23 杰达维（上海）医药科技发展有限公司 一种新的合成异噻唑的方法
US9353093B2 (en) 2014-10-07 2016-05-31 Allergan, Inc. Indole-1-carboxamides as kinase inhibitors
US9403803B2 (en) 2014-10-08 2016-08-02 Allergan, Inc. Indole-3-carboxamides as kinase inhibitors
US9359336B2 (en) 2014-10-09 2016-06-07 Allergan, Inc. Heterocycle-substituted pyridyl benzothiophenes as kinase inhibitors
US9371314B2 (en) 2014-10-09 2016-06-21 Allergan, Inc. Pyridyl benzothiophenes as kinase inhibitors
AU2023416218A1 (en) * 2022-12-28 2025-07-10 Beyang Therapeutics Co., Ltd. Protein tyrosine kinase inhibitor and medical use thereof
WO2026002126A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂及其眼用制剂
WO2026002137A1 (zh) * 2024-06-27 2026-01-02 苏州必扬医药科技有限公司 一种蛋白酪氨酸激酶抑制剂游离碱的晶型

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2408234A1 (de) * 1974-02-21 1975-09-04 Celamerck Gmbh & Co Kg Isothiazolylharnstoffe
US4059433A (en) * 1976-06-18 1977-11-22 Fmc Corporation 3-Alkoxyisothiazole derivatives as herbicides
IL72093A0 (en) * 1983-06-20 1984-10-31 Lilly Co Eli N'-substituted(3-alkyl-5-isothiazolyl)urea derivatives
UA60365C2 (uk) * 1998-06-04 2003-10-15 Пфайзер Продактс Інк. Похідні ізотіазолу, спосіб їх одержання, фармацевтична композиція та спосіб лікування гіперпроліферативного захворювання у ссавця
HN2000000051A (es) * 1999-05-19 2001-02-02 Pfizer Prod Inc Derivados heterociclicos utiles como agentes anticancerosos
GB0010188D0 (en) * 2000-04-26 2000-06-14 Ferring Bv Inhibitors of dipeptidyl peptidase IV
EP1527071A1 (en) * 2002-07-25 2005-05-04 Pfizer Products Inc. Isothiazole derivatives useful as anticancer agents
US20060035954A1 (en) * 2004-08-11 2006-02-16 Sharma Padam N Ammonolysis process for the preparation of intermediates for DPP IV inhibitors
PT1784183E (pt) 2004-08-26 2012-03-09 Pfizer Processos para a preparação de derivados de isotiazole

Also Published As

Publication number Publication date
ES2378994T3 (es) 2012-04-19
JP5100390B2 (ja) 2012-12-19
WO2006026034A3 (en) 2006-06-29
CN101043888A (zh) 2007-09-26
PL1784183T3 (pl) 2012-07-31
AR050613A1 (es) 2006-11-08
AU2005280451B2 (en) 2009-02-05
CA2578023C (en) 2012-05-15
WO2006026034A2 (en) 2006-03-09
JP5498524B2 (ja) 2014-05-21
US9371298B2 (en) 2016-06-21
NO20071319L (no) 2007-05-29
EP1784183B1 (en) 2012-01-25
DK1784183T3 (da) 2012-04-02
KR20070070158A (ko) 2007-07-03
IL181063A0 (en) 2007-07-04
US8884025B2 (en) 2014-11-11
EP1784183A2 (en) 2007-05-16
US20150065726A1 (en) 2015-03-05
ATE542533T1 (de) 2012-02-15
US20090023924A1 (en) 2009-01-22
CA2578023A1 (en) 2006-03-09
RU2349588C2 (ru) 2009-03-20
JP2008510841A (ja) 2008-04-10
PT1784183E (pt) 2012-03-09
KR100893977B1 (ko) 2009-04-20
MX2007002246A (es) 2007-04-20
HK1111359A1 (en) 2008-08-08
ZA200701016B (en) 2008-05-28
AU2005280451A1 (en) 2006-03-09
EP1784183A4 (en) 2009-12-09
JP2012153705A (ja) 2012-08-16
TW200621241A (en) 2006-07-01
TWI361688B (en) 2012-04-11
CN101043888B (zh) 2010-08-11
RU2007106847A (ru) 2008-08-27

Similar Documents

Publication Publication Date Title
NO20083434L (no) Benzamid- og heteroarenderivater
BRPI0520870B8 (pt) compostos intermediários para a preparação de alfa-mercaptoacetanilidas de s-triazolila
CR10968A (es) Nuevos derivados de 3-amino-pirrolo[3,4-c]pirazol -5(1h, 4h, 6h) carbaldehido
MY153971A (en) Sulfonamides as trpm8 modulators
CR9954A (es) Derivados de pirazina
UY31468A1 (es) Derivados bis-(sulfonilamino) en terapia 065
BRPI0715579A2 (pt) "composto, composição farmacêutica e uso de um composto"
WO2006023515A3 (en) Novel thiazole inhibitors of fructose 1,6-bisphosphatase
PH12013500745A1 (en) Azaadamantane derivatives and methods of use
IL183237A0 (en) Polymorphs of memantine hydrochloride
MX2007005694A (es) Nuevos derivados de betulina, preparacion y uso de los mismos.
EA201000413A1 (ru) Способ получения производных лактамида, новые производные лактамида и препараты, содержащие производные лактамида
DK1981874T3 (da) Aminophenylderivater som nye inhibitorer af histondeacetylase
MY151986A (en) Adamantyl diamide derivatives and uses of same
MX2009011579A (es) Pirimidinonas como moduladores de caseina cinasa ii (ck2).
TW201129564A (en) Diphenylpyrazolopyridine derivatives, preparation thereof and therapeutic use thereof
WO2007147771A3 (en) Tetralin and indane derivatives and uses thereof
CR10206A (es) Acidos4-fenil-tiazol-5-carboxilicos amidas de acidos 4-fenil-tiazol-5-carboxilicos como inhibidores de la plk1
NO20071319L (no) Fremgangsmate for fremstilling av isotiazolderivater.
BRPI0507903A (pt) derivados de quinazolina e composição farmacêutica compreendendo os mesmos
NO20092690L (no) Aminderivater og deres anvendelse i beta-2-adrenoreseptormedierte sykdommer
UY27803A1 (es) Derivados de benzoxazina y usos de los mismos.
TW200942529A (en) Pyrrolidinyl derivatives and uses thereof
NO20054135L (no) Kipolinon/benzoksazin derivater og anvendelser derav
BRPI0408205A (pt) derivado de anilina substituìdo, composição farmacêutica, e, uso de uma composição farmacêutica

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: OSI PHARMACEUTICALS, INC. (US) , PFIZER INC. (US)

Free format text: TRANSFERIDO DE: PFIZER PRODUCTS INC.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]
B11E Dismissal acc. art. 34 of ipl - requirements for examination incomplete
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B11T Dismissal of application maintained [chapter 11.20 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]