CN101039938A - 作为flap抑制剂的二苯基取代的烷烃 - Google Patents

作为flap抑制剂的二苯基取代的烷烃 Download PDF

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Publication number
CN101039938A
CN101039938A CNA2005800354414A CN200580035441A CN101039938A CN 101039938 A CN101039938 A CN 101039938A CN A2005800354414 A CNA2005800354414 A CN A2005800354414A CN 200580035441 A CN200580035441 A CN 200580035441A CN 101039938 A CN101039938 A CN 101039938A
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China
Prior art keywords
phenyl
methyl
compound
pyridine
dimethyl
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Pending
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CNA2005800354414A
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English (en)
Chinese (zh)
Inventor
L·楚
I·E·科普卡
B·李
A·K·奥加瓦
F·乌贾恩沃拉
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Merck and Co Inc
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Merck and Co Inc
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Publication of CN101039938A publication Critical patent/CN101039938A/zh
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

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  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Biomedical Technology (AREA)
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  • Reproductive Health (AREA)
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  • Hematology (AREA)
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  • Endocrinology (AREA)
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  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pregnancy & Childbirth (AREA)
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  • Oncology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Transplantation (AREA)
  • Toxicology (AREA)
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  • Hospice & Palliative Care (AREA)
CNA2005800354414A 2004-10-18 2005-10-14 作为flap抑制剂的二苯基取代的烷烃 Pending CN101039938A (zh)

Applications Claiming Priority (2)

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US61975204P 2004-10-18 2004-10-18
US60/619,752 2004-10-18

Publications (1)

Publication Number Publication Date
CN101039938A true CN101039938A (zh) 2007-09-19

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ID=36084258

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CNA2005800354414A Pending CN101039938A (zh) 2004-10-18 2005-10-14 作为flap抑制剂的二苯基取代的烷烃

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US (2) US20070287736A1 (https=)
EP (1) EP1814877B1 (https=)
JP (1) JP2008516968A (https=)
CN (1) CN101039938A (https=)
AT (1) ATE425158T1 (https=)
AU (1) AU2005295646B2 (https=)
CA (1) CA2584262A1 (https=)
DE (1) DE602005013272D1 (https=)
WO (1) WO2006044602A2 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103180314A (zh) * 2010-08-16 2013-06-26 贝林格尔.英格海姆国际有限公司 抑制白三烯产生的*二唑类抑制剂

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TW200716536A (en) * 2005-06-09 2007-05-01 Chugai Pharmaceutical Co Ltd Vitamin D compounds
WO2007056210A2 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Diphenylmethane derivatives as inhibitors of leukotriene biosynthesis
US7977359B2 (en) 2005-11-04 2011-07-12 Amira Pharmaceuticals, Inc. 5-lipdxygenase-activating protein (FLAP) inhibitors
GB2431927B (en) 2005-11-04 2010-03-17 Amira Pharmaceuticals Inc 5-Lipoxygenase-activating protein (FLAP) inhibitors
US8399666B2 (en) 2005-11-04 2013-03-19 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
WO2007120574A2 (en) * 2006-04-11 2007-10-25 Merck & Co., Inc. Diaryl substituted alkanes
ATE543810T1 (de) 2006-09-01 2012-02-15 Merck Sharp & Dohme Hemmer des 5-lipoxygenase aktivierenden proteins (flap)
WO2008097930A1 (en) * 2007-02-05 2008-08-14 Amira Pharmaceuticals, Inc. Reverse indoles as 5-lipoxygenase-activating protein (flap) inhibitors
EP2170065A4 (en) * 2007-06-20 2011-11-23 Merck Sharp & Dohme DIPHENYL SUBSTITUTED ALKANES
US20110003815A1 (en) * 2007-10-10 2011-01-06 Merck & Co., Inc. Diphenyl substituted cycloalkanes
JP5324082B2 (ja) * 2007-12-20 2013-10-23 大阪瓦斯株式会社 ９，９−ビス（カルボキシアリール）フルオレン類およびそのエステルの製造方法
MX2010012814A (es) 2008-05-23 2010-12-20 Amira Pharmaceuticals Inc Inhibidor de proteina activadora de 5-lipoxigenasa.
US8618300B2 (en) 2008-09-04 2013-12-31 Boehringer Ingelheim International Gmbh Indolizine inhibitors of leukotriene production
US8546431B2 (en) 2008-10-01 2013-10-01 Panmira Pharmaceuticals, Llc 5-lipoxygenase-activating protein (FLAP) inhibitors
US8420655B2 (en) 2009-12-04 2013-04-16 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
JP5862669B2 (ja) 2010-08-26 2016-02-16 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
CA2812449A1 (en) 2010-09-23 2012-03-29 Boehringer Ingelheim International Gmbh Oxadiazole inhibitors of leukotriene production
JP5828188B2 (ja) 2010-09-23 2015-12-02 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン産生のオキサジアゾール阻害剤
JP5928958B2 (ja) 2010-10-29 2016-06-01 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のベンゾイミダゾールインヒビター
WO2012061169A1 (en) 2010-11-01 2012-05-10 Boehringer Ingelheim International Gmbh Benzimidazole inhibitors of leukotriene production
JP6097998B2 (ja) * 2010-12-16 2017-03-22 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ロイコトリエン生成のビアリールアミドインヒビター
WO2013116182A1 (en) * 2012-01-31 2013-08-08 Boehringer Ingelheim International Gmbh Heterocyclic compounds as inhibitors of leukotriene production
AR089853A1 (es) 2012-02-01 2014-09-24 Boehringer Ingelheim Int Inhibidores de oxadiazol de la produccion de leucotrienos para terapia de combinacion, composicion farmaceutica, uso
EP3380970B1 (en) 2015-11-24 2023-01-04 Sanford Burnham Prebys Medical Discovery Institute Novel azole derivatives as apelin receptor agonist

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US4853398A (en) * 1987-04-13 1989-08-01 Eli Lilly And Company Leukotriene antagonists and use thereas
US5795900A (en) * 1995-10-03 1998-08-18 Abbott Laboratories Symmetrical bis-heteroaryl-methoxy-phenylalkyl carboxylates as inhibitors of leukotriene biosynthesis
PL351470A1 (en) * 1999-04-28 2003-04-22 Aventis Pharma Gmbh Tri-aryl acid derivatives as ppar receptor ligands
CN1829519A (zh) * 2003-07-24 2006-09-06 默克公司 二苯基取代的环烷烃类,含有它们的组合物和应用的方法
EP1858513A4 (en) 2005-03-09 2009-06-03 Merck & Co Inc DIPHENYL-SUBSTITUTED CYCLOALCANES, COMPOSITIONS CONTAINING SUCH COMPOUNDS AND METHOD FOR THEIR USE

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103180314A (zh) * 2010-08-16 2013-06-26 贝林格尔.英格海姆国际有限公司 抑制白三烯产生的*二唑类抑制剂

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WO2006044602A9 (en) 2006-06-08
US8729104B2 (en) 2014-05-20
AU2005295646B2 (en) 2008-11-20
WO2006044602A2 (en) 2006-04-27
US20110190346A1 (en) 2011-08-04
US20070287736A1 (en) 2007-12-13
EP1814877A2 (en) 2007-08-08
ATE425158T1 (de) 2009-03-15
WO2006044602A3 (en) 2006-08-10
CA2584262A1 (en) 2006-04-27
AU2005295646A1 (en) 2006-04-27
DE602005013272D1 (de) 2009-04-23
EP1814877B1 (en) 2009-03-11

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