CN101035782A - Mif抑制剂 - Google Patents

Mif抑制剂 Download PDF

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Publication number
CN101035782A
CN101035782A CNA2005800342065A CN200580034206A CN101035782A CN 101035782 A CN101035782 A CN 101035782A CN A2005800342065 A CNA2005800342065 A CN A2005800342065A CN 200580034206 A CN200580034206 A CN 200580034206A CN 101035782 A CN101035782 A CN 101035782A
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CN
China
Prior art keywords
benzo
dihydro
oxazin
compound
mif
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CNA2005800342065A
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English (en)
Chinese (zh)
Inventor
A·比利希
P·莱尔
H·格斯塔西
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
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Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
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Application filed by Novartis AG filed Critical Novartis AG
Publication of CN101035782A publication Critical patent/CN101035782A/zh
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/18—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 2
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Communicable Diseases (AREA)
  • Rheumatology (AREA)
  • Immunology (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Endocrinology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Pain & Pain Management (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Dermatology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Otolaryngology (AREA)
  • Obesity (AREA)
  • AIDS & HIV (AREA)
CNA2005800342065A 2004-10-21 2005-10-19 Mif抑制剂 Pending CN101035782A (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB0423405.0 2004-10-21
GBGB0423405.0A GB0423405D0 (en) 2004-10-21 2004-10-21 Organic compounds

Publications (1)

Publication Number Publication Date
CN101035782A true CN101035782A (zh) 2007-09-12

Family

ID=33484961

Family Applications (1)

Application Number Title Priority Date Filing Date
CNA2005800342065A Pending CN101035782A (zh) 2004-10-21 2005-10-19 Mif抑制剂

Country Status (17)

Country Link
US (1) US7378416B2 (https=)
EP (1) EP1805170B1 (https=)
JP (1) JP2008517020A (https=)
KR (1) KR100875767B1 (https=)
CN (1) CN101035782A (https=)
AT (1) ATE464307T1 (https=)
AU (1) AU2005298923B2 (https=)
BR (1) BRPI0516981A (https=)
CA (1) CA2581981A1 (https=)
DE (1) DE602005020666D1 (https=)
ES (1) ES2344655T3 (https=)
GB (1) GB0423405D0 (https=)
MX (1) MX2007004738A (https=)
PL (1) PL1805170T3 (https=)
PT (1) PT1805170E (https=)
RU (1) RU2383541C2 (https=)
WO (1) WO2006045505A1 (https=)

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GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds
BRPI0616344A2 (pt) 2005-09-26 2011-06-14 Avigen Inc mÉtodo para o tratamento de dependÊncia quÍmica e comportamental
US20070281924A1 (en) * 2006-05-31 2007-12-06 Gaeta Federico C MIF inhibitors for treating neuropathic pain and associated syndromes
CA2653345A1 (en) 2006-05-31 2007-12-13 Avigen, Inc. Ibudilast for inhibiting macrophage migration inhibitory factor (mif) activity
US9643922B2 (en) * 2008-08-18 2017-05-09 Yale University MIF modulators
PE20110368A1 (es) 2008-08-18 2011-06-13 Univ Yale Moduladores de mif
US9540322B2 (en) 2008-08-18 2017-01-10 Yale University MIF modulators
EP2198879A1 (en) 2008-12-11 2010-06-23 Institut Curie CD74 modulator agent for regulating dendritic cell migration and device for studying the motility capacity of a cell
WO2014200872A1 (en) 2013-06-09 2014-12-18 Rjs Biologics Llc Pharmaceutical compounds targeted by mif affinity-tethered moieties
US9617212B2 (en) 2013-12-17 2017-04-11 Controlled Chemicals, Inc. Isoindolin-1-ones as macrophage migration inhibitory factor (MIF) inhibitors
EP2944310B1 (en) 2014-05-16 2018-03-21 Mifcare MIF inhibitors for the acute or chronic treatment of pulmonary hypertension
US10899739B2 (en) 2017-11-15 2021-01-26 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same
US11465991B2 (en) 2018-03-15 2022-10-11 Yale University Pyrazole-containing macrophage migration inhibitory factor inhibitors
WO2019199621A1 (en) * 2018-04-09 2019-10-17 Yale University Bi-functional molecules to degrade circulating proteins
US20230097887A1 (en) 2018-04-09 2023-03-30 Yale University Bi-functional Molecules to Degrade Circulating Proteins
US12485178B2 (en) 2018-04-09 2025-12-02 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
US12364766B2 (en) 2018-04-09 2025-07-22 Yale University Bifunctional small molecules to target the selective degradation of circulating proteins
CN113301925A (zh) 2018-12-19 2021-08-24 小利兰·斯坦福大学理事会 用于溶酶体靶向的双官能分子以及相关的组合物和方法
WO2022093817A1 (en) * 2020-10-26 2022-05-05 Yale University Macrophage migration inhibitory factor inhibitors, and methods of making and using same
EP4237002A4 (en) * 2020-10-28 2025-02-12 University Health Network METHODS OF TREATING SPONDYLOARTHRITIS OR SYMPTOMS THEREOF
AU2022310356A1 (en) 2021-07-14 2024-01-25 Lycia Therapeutics, Inc. Asgpr cell surface receptor binding compounds and conjugates

Family Cites Families (4)

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JPS6081182A (ja) * 1983-10-12 1985-05-09 Kissei Pharmaceut Co Ltd チオフエン誘導体及びその製造方法
US5696117A (en) * 1995-11-07 1997-12-09 Ortho Pharmaceutical Corporation Benzoxazine antimicrobial agents
JP4403305B2 (ja) * 2001-09-03 2010-01-27 武田薬品工業株式会社 １，３−ベンゾチアジノン誘導体および用途
GB0507695D0 (en) * 2005-04-15 2005-05-25 Novartis Ag Organic compounds

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WO2006045505A1 (en) 2006-05-04
MX2007004738A (es) 2007-06-18
US7378416B2 (en) 2008-05-27
BRPI0516981A (pt) 2008-09-30
DE602005020666D1 (en) 2010-05-27
EP1805170B1 (en) 2010-04-14
US20070219189A1 (en) 2007-09-20
ES2344655T3 (es) 2010-09-02
JP2008517020A (ja) 2008-05-22
EP1805170A1 (en) 2007-07-11
PT1805170E (pt) 2010-07-12
PL1805170T3 (pl) 2010-09-30
GB0423405D0 (en) 2004-11-24
KR20070054253A (ko) 2007-05-28
AU2005298923A1 (en) 2006-05-04
CA2581981A1 (en) 2006-05-04
RU2007118727A (ru) 2008-11-27
AU2005298923B2 (en) 2009-12-17
ATE464307T1 (de) 2010-04-15
RU2383541C2 (ru) 2010-03-10
KR100875767B1 (ko) 2008-12-26

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