CN101027078B - 用于预防或治疗口腔炎的组合物和方法 - Google Patents

用于预防或治疗口腔炎的组合物和方法 Download PDF

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Publication number
CN101027078B
CN101027078B CN2005800325924A CN200580032592A CN101027078B CN 101027078 B CN101027078 B CN 101027078B CN 2005800325924 A CN2005800325924 A CN 2005800325924A CN 200580032592 A CN200580032592 A CN 200580032592A CN 101027078 B CN101027078 B CN 101027078B
Authority
CN
China
Prior art keywords
pharmaceutically acceptable
glutathione
acceptable salt
compositions
orotic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN2005800325924A
Other languages
English (en)
Chinese (zh)
Other versions
CN101027078A (zh
Inventor
古川令
岛田健次郎
D·琼斯
T·齐格勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Kyowa Hakko Bio Co Ltd
Emory University
Original Assignee
Kyowa Hakko Kogyo Co Ltd
Kyowa Hakko Bio Co Ltd
Emory University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Kyowa Hakko Kogyo Co Ltd, Kyowa Hakko Bio Co Ltd, Emory University filed Critical Kyowa Hakko Kogyo Co Ltd
Publication of CN101027078A publication Critical patent/CN101027078A/zh
Application granted granted Critical
Publication of CN101027078B publication Critical patent/CN101027078B/zh
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
    • A61K38/063—Glutathione
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Confectionery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Jellies, Jams, And Syrups (AREA)
  • Orthopedics, Nursing, And Contraception (AREA)
CN2005800325924A 2004-09-03 2005-09-02 用于预防或治疗口腔炎的组合物和方法 Expired - Lifetime CN101027078B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US60705304P 2004-09-03 2004-09-03
US60/607,053 2004-09-03
PCT/US2005/031364 WO2006028991A2 (en) 2004-09-03 2005-09-02 Composition and method for prevention or treatment of stomatits

Publications (2)

Publication Number Publication Date
CN101027078A CN101027078A (zh) 2007-08-29
CN101027078B true CN101027078B (zh) 2012-07-04

Family

ID=36036881

Family Applications (1)

Application Number Title Priority Date Filing Date
CN2005800325924A Expired - Lifetime CN101027078B (zh) 2004-09-03 2005-09-02 用于预防或治疗口腔炎的组合物和方法

Country Status (7)

Country Link
US (1) US8067537B2 (enExample)
EP (1) EP1789068B1 (enExample)
JP (1) JP5066448B2 (enExample)
CN (1) CN101027078B (enExample)
AT (1) ATE516040T1 (enExample)
CA (1) CA2578748C (enExample)
WO (1) WO2006028991A2 (enExample)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5408882B2 (ja) * 2008-01-23 2014-02-05 ヤマサ醤油株式会社 唾液分泌促進剤
EP2990048B1 (en) * 2013-01-21 2023-03-01 Kyowa Hakko Bio Co., Ltd. Nitric oxide concentration elevating agent
JP6582983B2 (ja) * 2013-07-31 2019-10-02 味の素株式会社 癌化学療法時の副作用軽減剤
DK3006045T3 (en) 2014-10-07 2017-07-17 Cyprumed Gmbh Pharmaceutical formulations for oral administration of peptide or protein drugs
US20160367620A1 (en) 2015-06-19 2016-12-22 Harry B. Demopoulos Glutathione
EP3359181A1 (en) 2015-10-07 2018-08-15 Cyprumed GmbH Pharmaceutical formulations for the oral delivery of peptide drugs
EP3485871B1 (en) 2016-07-14 2025-12-24 Resonac Corporation Non-therapeutic use of an orotic acid derivative for inhibiting melanin production and whitening the skin
EP3622957A4 (en) * 2017-05-12 2021-01-27 Furukawa Research Office Co., Ltd. IMPROVING THE DEGREE OF ARTERIAL SATURATION WITH OXYGEN
JP7874258B2 (ja) * 2020-03-31 2026-06-16 株式会社古川リサーチオフィス 亜鉛化合物配合組成物

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2250553A (en) * 1938-04-18 1941-07-29 Simon L Ruskin Medicinal preparation
DE3011437A1 (de) * 1980-03-25 1981-10-01 Hrvoje Dr. Zagreb Krnjevic Pharmazeutisches mittel zur heilung von entzuendlichen und/oder degenerativen und/oder atrophischen schleimhauterkrankungen
US4508898A (en) * 1980-09-16 1985-04-02 Ogilvie Kelvin K Antiviral triazine compounds
US4975434A (en) * 1986-05-27 1990-12-04 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antiviral and anticancer cyclopentenyl cytosine
US5204114A (en) 1992-03-30 1993-04-20 Health Maintenance Programs, Inc. Methods of manufacturing high dosage glutathione the tablets and capsules produced thereby
US5686436A (en) * 1993-05-13 1997-11-11 Hiv Diagnostics, Inc. Multi-faceted method to repress reproduction of latent viruses in humans and animals
GB9620504D0 (en) * 1996-10-02 1996-11-20 Boehringer Ingelheim Ltd Compositions
WO1998029101A1 (en) 1996-12-31 1998-07-09 Antioxidant Pharmaceuticals Corporation Pharmaceutical preparations of glutathione and methods of administration thereof
US6896899B2 (en) * 1996-12-31 2005-05-24 Antioxidant Pharmaceuticals Corp. Pharmaceutical preparations of glutathione and methods of administration thereof
EP1402892A4 (en) 2001-06-11 2006-11-08 Kyowa Hakko Kogyo Kk Antiinflammatoric and antitussive compositions
JP2005530738A (ja) * 2002-04-16 2005-10-13 アイシス・イノヴェイション・リミテッド 組織障害の予防及び／又は治療のためのクルクミン
JP2003321356A (ja) * 2002-05-01 2003-11-11 Rohto Pharmaceut Co Ltd 催乳作用を有する組成物
US7625928B2 (en) * 2002-10-01 2009-12-01 Mitos Pharmaceuticals, Inc. Nitroxide radioprotector formulations and methods of use
JP4731321B2 (ja) 2003-07-22 2011-07-20 協和発酵バイオ株式会社 ウィルス感染症の予防または治療用組成物

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
王瑜等.外用谷胱甘肽预防放射性口腔粘膜损伤30例疗效观察.山东医药43 23.2003,43(23),59.
王瑜等.外用谷胱甘肽预防放射性口腔粘膜损伤30例疗效观察.山东医药43 23.2003,43(23),59. *
钱明等.古拉定防治放射性口腔反应的临床研究.中国新药杂志9 7.2000,9(7),473-474.
钱明等.古拉定防治放射性口腔反应的临床研究.中国新药杂志9 7.2000,9(7),473-474. *

Also Published As

Publication number Publication date
WO2006028991A3 (en) 2006-04-27
HK1099918A1 (en) 2007-08-31
EP1789068A4 (en) 2007-10-17
JP2008512381A (ja) 2008-04-24
US20070259024A1 (en) 2007-11-08
US8067537B2 (en) 2011-11-29
JP5066448B2 (ja) 2012-11-07
CA2578748C (en) 2014-10-14
EP1789068A2 (en) 2007-05-30
EP1789068B1 (en) 2011-07-13
WO2006028991A2 (en) 2006-03-16
CA2578748A1 (en) 2006-03-16
CN101027078A (zh) 2007-08-29
ATE516040T1 (de) 2011-07-15

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Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: XIEHE FERMENTATION BIOCHEMICAL CO., LTD.

Free format text: FORMER OWNER: KYOWA HAKKO KOGYO CO., LTD.

Effective date: 20090821

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20090821

Address after: Tokyo

Applicant after: KYOWA HAKKO BIO Co.,Ltd.

Co-applicant after: EMORY University

Address before: Tokyo

Applicant before: KYOWA HAKKO KOGYO Co.,Ltd.

Co-applicant before: EMORY University

C14 Grant of patent or utility model
GR01 Patent grant
CX01 Expiry of patent term
CX01 Expiry of patent term

Granted publication date: 20120704