CN100540523C - L-2-（α-羟基戊基）苯甲酸盐及其制法和用途 - Google Patents
L-2-（α-羟基戊基）苯甲酸盐及其制法和用途 Download PDFInfo
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- CN100540523C CN100540523C CNB2004100482689A CN200410048268A CN100540523C CN 100540523 C CN100540523 C CN 100540523C CN B2004100482689 A CNB2004100482689 A CN B2004100482689A CN 200410048268 A CN200410048268 A CN 200410048268A CN 100540523 C CN100540523 C CN 100540523C
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- China
- Prior art keywords
- alpha
- amyl group
- hydroxy amyl
- benzoate
- hydroxy
- Prior art date
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- Expired - Lifetime
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- PJJZFXPJNUVBMR-UHFFFAOYSA-L magnesium benzoate Chemical class [Mg+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 PJJZFXPJNUVBMR-UHFFFAOYSA-L 0.000 description 1
- 159000000003 magnesium salts Chemical class 0.000 description 1
- 208000010125 myocardial infarction Diseases 0.000 description 1
- ACTNHJDHMQSOGL-UHFFFAOYSA-N n',n'-dibenzylethane-1,2-diamine Chemical class C=1C=CC=CC=1CN(CCN)CC1=CC=CC=C1 ACTNHJDHMQSOGL-UHFFFAOYSA-N 0.000 description 1
- SCZVXVGZMZRGRU-UHFFFAOYSA-N n'-ethylethane-1,2-diamine Chemical compound CCNCCN SCZVXVGZMZRGRU-UHFFFAOYSA-N 0.000 description 1
- RIWRFSMVIUAEBX-UHFFFAOYSA-N n-methyl-1-phenylmethanamine Chemical compound CNCC1=CC=CC=C1 RIWRFSMVIUAEBX-UHFFFAOYSA-N 0.000 description 1
- 230000002981 neuropathic effect Effects 0.000 description 1
- 210000000956 olfactory bulb Anatomy 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 230000008520 organization Effects 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 238000012856 packing Methods 0.000 description 1
- 231100000915 pathological change Toxicity 0.000 description 1
- 230000036285 pathological change Effects 0.000 description 1
- SBNFWQZLDJGRLK-UHFFFAOYSA-N phenothrin Chemical compound CC1(C)C(C=C(C)C)C1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-UHFFFAOYSA-N 0.000 description 1
- 235000013809 polyvinylpolypyrrolidone Nutrition 0.000 description 1
- 229920000523 polyvinylpolypyrrolidone Polymers 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 229940079832 sodium starch glycolate Drugs 0.000 description 1
- 239000008109 sodium starch glycolate Substances 0.000 description 1
- 229920003109 sodium starch glycolate Polymers 0.000 description 1
- 238000013112 stability test Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000010189 synthetic method Methods 0.000 description 1
- 210000003582 temporal bone Anatomy 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 210000000707 wrist Anatomy 0.000 description 1
- JDLYKQWJXAQNNS-UHFFFAOYSA-L zinc;dibenzoate Chemical compound [Zn+2].[O-]C(=O)C1=CC=CC=C1.[O-]C(=O)C1=CC=CC=C1 JDLYKQWJXAQNNS-UHFFFAOYSA-L 0.000 description 1
- 210000000216 zygoma Anatomy 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/09—Preparation of carboxylic acids or their salts, halides or anhydrides from carboxylic acid esters or lactones
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
- C07C51/41—Preparation of salts of carboxylic acids
- C07C51/412—Preparation of salts of carboxylic acids by conversion of the acids, their salts, esters or anhydrides with the same carboxylic acid part
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100482689A CN100540523C (zh) | 2004-06-17 | 2004-06-17 | L-2-（α-羟基戊基）苯甲酸盐及其制法和用途 |
| PCT/CN2005/000102 WO2005123651A1 (fr) | 2004-06-17 | 2005-01-24 | L-2-(a-hydroxypentyle)benzoates, leur elaboration et leur utilisation |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2004100482689A CN100540523C (zh) | 2004-06-17 | 2004-06-17 | L-2-（α-羟基戊基）苯甲酸盐及其制法和用途 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1594270A CN1594270A (zh) | 2005-03-16 |
| CN100540523C true CN100540523C (zh) | 2009-09-16 |
Family
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB2004100482689A Expired - Lifetime CN100540523C (zh) | 2004-06-17 | 2004-06-17 | L-2-（α-羟基戊基）苯甲酸盐及其制法和用途 |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN100540523C (fr) |
| WO (1) | WO2005123651A1 (fr) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2011527290A (ja) * | 2008-07-08 | 2011-10-27 | インスティトゥート オブ マタリア メディカ，チャイニーズ アカデミー オブ メディカル サイエンシズ | ２−（α−ヒドロキシ−ペンチル）安息香酸カリウムを用いたアルツハイマー病の予防と／またおよび／または治療においての役割への適用 |
| CN101402565B (zh) * | 2008-11-14 | 2012-07-04 | 郑州大学 | 卤代2－（a－羟基戊基）苯甲酸盐及其制法和用途 |
| CN103113210A (zh) * | 2013-02-19 | 2013-05-22 | 石药集团中奇制药技术（石家庄）有限公司 | 羟戊基苯甲酸钾晶体及其制备方法 |
| CN105616375B (zh) * | 2013-03-06 | 2018-08-28 | 贵州贵安新区协生元医药科技有限公司 | 消旋2-(α-羟基戊基)苯甲酸盐片及其制备方法 |
| CN105343014B (zh) * | 2013-03-25 | 2018-08-24 | 贵州贵安新区协生元医药科技有限公司 | 注射用消旋2-(α-羟基戊基)苯甲酸盐冻干粉针及其制备方法 |
| CN104086399B (zh) * | 2013-07-17 | 2016-08-24 | 浙江奥翔药业股份有限公司 | 5-溴-2-（α-羟基戊基）苯甲酸钠盐的不同晶型及其制备方法 |
| CN109776466B (zh) * | 2018-03-19 | 2023-01-31 | 河南真实生物科技有限公司 | 苯甲酸类化合物及其制备方法和应用 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1136209C (zh) * | 1999-07-05 | 2004-01-28 | 中国医学科学院药物研究所 | 制备光学活性3-正丁苯酞的方法 |
| CN1243541C (zh) * | 2002-05-09 | 2006-03-01 | 中国医学科学院药物研究所 | 2－(α－羟基戊基)苯甲酸盐及其制法和用途 |
-
2004
- 2004-06-17 CN CNB2004100482689A patent/CN100540523C/zh not_active Expired - Lifetime
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2005
- 2005-01-24 WO PCT/CN2005/000102 patent/WO2005123651A1/fr active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| WO2005123651A8 (fr) | 2006-04-13 |
| WO2005123651A1 (fr) | 2005-12-29 |
| CN1594270A (zh) | 2005-03-16 |
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