CN100526300C - 生产4-硝基咪唑化合物的方法 - Google Patents

生产4-硝基咪唑化合物的方法 Download PDF

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Publication number
CN100526300C
CN100526300C CNB2005800053101A CN200580005310A CN100526300C CN 100526300 C CN100526300 C CN 100526300C CN B2005800053101 A CNB2005800053101 A CN B2005800053101A CN 200580005310 A CN200580005310 A CN 200580005310A CN 100526300 C CN100526300 C CN 100526300C
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China
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alkyl
halogen
unsubstituted
group
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB2005800053101A
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English (en)
Chinese (zh)
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CN1922154A (zh
Inventor
新滨光一
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Otsuka Pharmaceutical Co Ltd
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Otsuka Pharmaceutical Co Ltd
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Publication of CN1922154A publication Critical patent/CN1922154A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/91—Nitro radicals
    • C07D233/92—Nitro radicals attached in position 4 or 5
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
    • A01N43/50—1,3-Diazoles; Hydrogenated 1,3-diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pest Control & Pesticides (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Agronomy & Crop Science (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Dentistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Catalysts (AREA)
CNB2005800053101A 2004-02-18 2005-02-15 生产4-硝基咪唑化合物的方法 Expired - Fee Related CN100526300C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2004041381 2004-02-18
JP041381/2004 2004-02-18
JP2004278999 2004-09-27
JP278999/2004 2004-09-27

Publications (2)

Publication Number Publication Date
CN1922154A CN1922154A (zh) 2007-02-28
CN100526300C true CN100526300C (zh) 2009-08-12

Family

ID=34863488

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB2005800053101A Expired - Fee Related CN100526300C (zh) 2004-02-18 2005-02-15 生产4-硝基咪唑化合物的方法

Country Status (19)

Country Link
US (1) US7569702B2 (enExample)
EP (1) EP1720838B1 (enExample)
JP (1) JP4789483B2 (enExample)
KR (1) KR100830386B1 (enExample)
CN (1) CN100526300C (enExample)
AR (1) AR047672A1 (enExample)
AT (1) ATE366241T1 (enExample)
AU (1) AU2005212093B2 (enExample)
BR (1) BRPI0507777A (enExample)
CA (1) CA2555372A1 (enExample)
DE (1) DE602005001553T2 (enExample)
EG (1) EG24393A (enExample)
ES (1) ES2289695T3 (enExample)
MY (1) MY141776A (enExample)
RU (1) RU2345071C2 (enExample)
TW (1) TWI300409B (enExample)
UA (1) UA82773C2 (enExample)
WO (1) WO2005077913A1 (enExample)
ZA (1) ZA200606332B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW200838855A (en) * 2002-10-15 2008-10-01 Otsuka Pharma Co Ltd Method for preparing 1-substituted-4-nitroimidazole compound
TW200624422A (en) * 2004-09-27 2006-07-16 Otsuka Pharma Co Ltd Process for production of 2-chloro-4-nitroimidazole
JP5072675B2 (ja) 2007-04-03 2012-11-14 四国化成工業株式会社 ２−ハロイミダゾール化合物の製造方法
JP5525515B2 (ja) * 2008-08-21 2014-06-18 デイナミート ノーベル ゲゼルシャフト ミット ベシュレンクテル ハフツング エクスプロジーフシュトッフ− ウント ジステームテヒニク ２−ハロ−４−ニトロイミダゾール及びその中間体の製造方法
RU2542988C2 (ru) * 2009-07-31 2015-02-27 Глоубал Элаенс Фор Тб Драг Дивелопмент Нитроимидазооксазины и их применения при противотуберкулезной терапии
CN103265494A (zh) * 2013-05-28 2013-08-28 南京理工大学 一种硝基咪唑含能化合物及其制备方法
CN105439957B (zh) * 2015-11-24 2018-05-08 浙江省诸暨合力化学对外贸易有限公司 一种合成2-溴-4-硝基咪唑的方法
CN111655670A (zh) * 2018-01-29 2020-09-11 大塚制药株式会社 制备2-氯-4-硝基咪唑衍生物的方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341548A (en) * 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
US4021442A (en) * 1974-03-25 1977-05-03 Basf Aktiengesellschaft Production of 1-alkyl-5-nitroimidazoles
US4925949A (en) * 1988-01-15 1990-05-15 Rhone-Poulenc Sante Process for preparing 1-alkyl-5-nitroimidazoles

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2049780C1 (ru) * 1992-12-04 1995-12-10 Государственный научно-исследовательский институт "Кристалл" Способ получения производных 2-r-4(5)-нитроимидазолов
US5668127A (en) 1995-06-26 1997-09-16 Pathogenesis Corporation Nitroimidazole antibacterial compounds and methods of use thereof
AR041198A1 (es) 2002-10-11 2005-05-04 Otsuka Pharma Co Ltd Compuesto 2,3-dihidro-6-nitroimidazo[2,1-b] oxaxol, y composiciones farmaceuticas que lo contienen
TW200838855A (en) 2002-10-15 2008-10-01 Otsuka Pharma Co Ltd Method for preparing 1-substituted-4-nitroimidazole compound

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3341548A (en) * 1964-04-29 1967-09-12 Hoffmann La Roche Nitroimidazoles and their preparation
US4021442A (en) * 1974-03-25 1977-05-03 Basf Aktiengesellschaft Production of 1-alkyl-5-nitroimidazoles
US4925949A (en) * 1988-01-15 1990-05-15 Rhone-Poulenc Sante Process for preparing 1-alkyl-5-nitroimidazoles

Also Published As

Publication number Publication date
UA82773C2 (uk) 2008-05-12
KR20060116857A (ko) 2006-11-15
WO2005077913A1 (en) 2005-08-25
BRPI0507777A (pt) 2007-07-17
RU2345071C2 (ru) 2009-01-27
HK1097846A1 (zh) 2007-07-06
DE602005001553D1 (de) 2007-08-16
ZA200606332B (en) 2008-01-30
CA2555372A1 (en) 2005-08-25
MY141776A (en) 2010-06-30
KR100830386B1 (ko) 2008-05-19
EG24393A (en) 2009-04-19
DE602005001553T2 (de) 2008-03-13
RU2006133312A (ru) 2008-03-27
EP1720838A1 (en) 2006-11-15
US7569702B2 (en) 2009-08-04
AR047672A1 (es) 2006-02-01
US20070161802A1 (en) 2007-07-12
ATE366241T1 (de) 2007-07-15
AU2005212093A1 (en) 2005-08-25
JP4789483B2 (ja) 2011-10-12
AU2005212093B2 (en) 2008-04-03
CN1922154A (zh) 2007-02-28
TWI300409B (en) 2008-09-01
EP1720838B1 (en) 2007-07-04
TW200530194A (en) 2005-09-16
ES2289695T3 (es) 2008-02-01
JP2006117628A (ja) 2006-05-11

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