CN100523179C - 烯酮还原酶 - Google Patents

烯酮还原酶 Download PDF

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Publication number
CN100523179C
CN100523179C CNB03804272XA CN03804272A CN100523179C CN 100523179 C CN100523179 C CN 100523179C CN B03804272X A CNB03804272X A CN B03804272XA CN 03804272 A CN03804272 A CN 03804272A CN 100523179 C CN100523179 C CN 100523179C
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CN
China
Prior art keywords
enone reductase
microorganism
molecular weight
enzyme
cell
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB03804272XA
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English (en)
Chinese (zh)
Other versions
CN1636057A (zh
Inventor
片冈道彦
清水昌
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DSM IP Assets BV
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DSM IP Assets BV
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Publication date
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Publication of CN1636057A publication Critical patent/CN1636057A/zh
Application granted granted Critical
Publication of CN100523179C publication Critical patent/CN100523179C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
    • C12P7/26—Ketones

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
CNB03804272XA 2002-02-22 2003-02-14 烯酮还原酶 Expired - Fee Related CN100523179C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP02003967.3 2002-02-22
EP02003967 2002-02-22

Publications (2)

Publication Number Publication Date
CN1636057A CN1636057A (zh) 2005-07-06
CN100523179C true CN100523179C (zh) 2009-08-05

Family

ID=27741105

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB03804272XA Expired - Fee Related CN100523179C (zh) 2002-02-22 2003-02-14 烯酮还原酶

Country Status (10)

Country Link
US (1) US7202068B2 (enExample)
EP (1) EP1476544B1 (enExample)
JP (1) JP2005517442A (enExample)
KR (1) KR20040088511A (enExample)
CN (1) CN100523179C (enExample)
AT (1) ATE382081T1 (enExample)
AU (1) AU2003210271A1 (enExample)
CA (1) CA2474780A1 (enExample)
DE (1) DE60318297T2 (enExample)
WO (1) WO2003070924A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004027065A2 (en) * 2002-09-23 2004-04-01 Dsm Ip Assets B.V. Enone reductase gene and microbial production of levodione
SG172783A1 (en) 2008-12-25 2011-08-29 Codexis Inc Enone reductases
CN102559553B (zh) * 2012-01-08 2013-06-05 中国科学院成都生物研究所 一株无色杆菌及其不对称催化还原碳碳双键的方法
CN112143764B (zh) * 2020-09-24 2022-04-19 奥锐特药业股份有限公司 一种生物酶催化制备布瓦西坦中间体化合物的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156100A (en) * 1974-08-21 1979-05-22 Hoffmann-La Roche Inc. Optically active cyclohexane derivatives
CN1285410A (zh) * 1999-08-02 2001-02-28 霍夫曼-拉罗奇有限公司 左旋二酮的微生物生产方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1074630B1 (en) 1999-08-02 2012-01-18 DSM IP Assets B.V. Microbial production of levodione
JP4688313B2 (ja) * 2001-02-23 2011-05-25 ダイセル化学工業株式会社 新規なエノン還元酵素、その製造方法、およびこれを利用したα，β−不飽和ケトンの炭素−炭素２重結合を選択的に還元する方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4156100A (en) * 1974-08-21 1979-05-22 Hoffmann-La Roche Inc. Optically active cyclohexane derivatives
CN1285410A (zh) * 1999-08-02 2001-02-28 霍夫曼-拉罗奇有限公司 左旋二酮的微生物生产方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
OLD YELLOW ENZYME FROM CANDIDAMACEDONIENSIS CATALYZES THE STEREOSPECIFICREDUCTION OF THE C=C BOND OF KETOISOPHORONE. KATAOKA MICHIHIKO ETAL.BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY,Vol.66 No.12. 2002 *
PURIFICATION AND CHARACTERIZATION OF TWOENONE REDUCTASES FROM SACCHAROMYCESCEREVISIAE. WANNER PETER ETAL.EUROPEAN JOURNAL OF BIOCHEMISTRY,Vol.255 No.1. 1998 *

Also Published As

Publication number Publication date
AU2003210271A1 (en) 2003-09-09
ATE382081T1 (de) 2008-01-15
KR20040088511A (ko) 2004-10-16
EP1476544A1 (en) 2004-11-17
EP1476544B1 (en) 2007-12-26
DE60318297D1 (de) 2008-02-07
CA2474780A1 (en) 2003-08-28
US7202068B2 (en) 2007-04-10
CN1636057A (zh) 2005-07-06
WO2003070924A1 (en) 2003-08-28
DE60318297T2 (de) 2008-05-08
JP2005517442A (ja) 2005-06-16
US20050106696A1 (en) 2005-05-19

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Granted publication date: 20090805

Termination date: 20180214