CN100480389C - 聚酮化合物的制备 - Google Patents

聚酮化合物的制备 Download PDF

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Publication number
CN100480389C
CN100480389C CNB018087116A CN01808711A CN100480389C CN 100480389 C CN100480389 C CN 100480389C CN B018087116 A CNB018087116 A CN B018087116A CN 01808711 A CN01808711 A CN 01808711A CN 100480389 C CN100480389 C CN 100480389C
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pks
esperamicin
gene
assembly
epothilone
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Expired - Fee Related
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CNB018087116A
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English (en)
Chinese (zh)
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CN1511192A (zh
Inventor
R·L·阿尔斯拉尼安
G·阿什利
S·弗吕克曼
B·朱利恩
L·卡茨
C·科斯拉
J·劳
P·J·利卡里
R·雷根廷
D·桑蒂
L·唐
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Kosan Biosciences Inc
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Kosan Biosciences Inc
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Priority claimed from US09/560,367 external-priority patent/US6410301B1/en
Priority claimed from US09/825,856 external-priority patent/US6489314B1/en
Priority claimed from US09/825,876 external-priority patent/US6589968B2/en
Application filed by Kosan Biosciences Inc filed Critical Kosan Biosciences Inc
Publication of CN1511192A publication Critical patent/CN1511192A/zh
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/181—Heterocyclic compounds containing oxygen atoms as the only ring heteroatoms in the condensed system, e.g. Salinomycin, Septamycin
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D313/00—Heterocyclic compounds containing rings of more than six members having one oxygen atom as the only ring hetero atom
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    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
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    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/16—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing two or more hetero rings
    • C—CHEMISTRY; METALLURGY
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Cell Biology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Polyesters Or Polycarbonates (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CNB018087116A 2000-04-28 2001-04-26 聚酮化合物的制备 Expired - Fee Related CN100480389C (zh)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US09/560,367 2000-04-28
US09/560,367 US6410301B1 (en) 1998-11-20 2000-04-28 Myxococcus host cells for the production of epothilones
US23269600P 2000-09-14 2000-09-14
US60/232,696 2000-09-14
US25751700P 2000-12-21 2000-12-21
US60/257,517 2000-12-21
US26902001P 2001-02-13 2001-02-13
US09/825,856 US6489314B1 (en) 2001-04-03 2001-04-03 Epothilone derivatives and methods for making and using the same
US09/825,876 2001-04-03
US09/825,856 2001-04-03
US09/825,876 US6589968B2 (en) 2001-02-13 2001-04-03 Epothilone compounds and methods for making and using the same
US60/269,020 2001-04-13

Publications (2)

Publication Number Publication Date
CN1511192A CN1511192A (zh) 2004-07-07
CN100480389C true CN100480389C (zh) 2009-04-22

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CNB018087116A Expired - Fee Related CN100480389C (zh) 2000-04-28 2001-04-26 聚酮化合物的制备

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EP (2) EP1320611B1 (de)
KR (2) KR20070092334A (de)
CN (1) CN100480389C (de)
AT (2) ATE444368T1 (de)
AU (2) AU9519501A (de)
CA (1) CA2404938C (de)
CY (1) CY1109698T1 (de)
DE (2) DE60114865T2 (de)
DK (1) DK1652926T3 (de)
ES (2) ES2254493T3 (de)
IL (1) IL151960A0 (de)
MX (1) MXPA02010565A (de)
NZ (2) NZ521788A (de)
PT (1) PT1652926E (de)
WO (1) WO2001083800A2 (de)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69734362T2 (de) 1996-12-03 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, zwischenprodukte dazu, analoga und verwendungen davon
FR2775187B1 (fr) 1998-02-25 2003-02-21 Novartis Ag Utilisation de l'epothilone b pour la fabrication d'une preparation pharmaceutique antiproliferative et d'une composition comprenant l'epothilone b comme agent antiproliferatif in vivo
US6410301B1 (en) 1998-11-20 2002-06-25 Kosan Biosciences, Inc. Myxococcus host cells for the production of epothilones
JP4662635B2 (ja) 1998-11-20 2011-03-30 コーサン バイオサイエンシーズ， インコーポレイテッド エポチロンおよびエポチロン誘導体を生成するための組換え方法および材料
US6998256B2 (en) 2000-04-28 2006-02-14 Kosan Biosciences, Inc. Methods of obtaining epothilone D using crystallization and /or by the culture of cells in the presence of methyl oleate
GB0029895D0 (en) * 2000-12-07 2001-01-24 Novartis Ag Organic compounds
US6893859B2 (en) 2001-02-13 2005-05-17 Kosan Biosciences, Inc. Epothilone derivatives and methods for making and using the same
WO2003022844A2 (en) * 2001-09-06 2003-03-20 Sloan-Kettering Institute For Cancer Research Synthesis of epothilones intermediates thereto and analogues thereof
WO2003042217A2 (en) * 2001-11-15 2003-05-22 Kosan Biosciences, Inc. Method for making epothilone compounds by bioconversion with microorganisms
US20030134883A1 (en) * 2001-11-26 2003-07-17 David Myles 14-Methyl-epothilones
US7220560B2 (en) * 2002-02-25 2007-05-22 Kosan Biosciences Incorporated Secondary metabolite congener distribution modulation
AU2003212457A1 (en) * 2002-03-01 2003-09-16 University Of Notre Dame Derivatives of epothilone b and d and synthesis thereof
AU2003296878A1 (en) * 2002-05-20 2004-12-13 Kosan Biosciences, Inc. Methods to administer epothilone d
EP2860241A1 (de) * 2002-07-29 2015-04-15 Optimer Pharmaceuticals, Inc. Tiacumicinherstellung
EP1524979A2 (de) * 2002-07-31 2005-04-27 Schering AG Neue effektor-konjugate, verfahren zu ihrer herstellung und ihre pharmazeutische verwendung
AR040956A1 (es) 2002-07-31 2005-04-27 Schering Ag Nuevos conjugados de efectores, procedimientos para su preparacion y su uso farmaceutico
AU2003291337B2 (en) 2002-11-07 2010-09-09 Kosan Biosciences Incorporated Trans-9,10-dehydroepothilone C and D, analogs thereof and methos of making the same
CN1723018A (zh) * 2002-12-09 2006-01-18 诺瓦提斯公司 用于治疗支架狭窄的微管稳定剂
US7378508B2 (en) 2007-01-22 2008-05-27 Optimer Pharmaceuticals, Inc. Polymorphic crystalline forms of tiacumicin B
GB0805363D0 (en) * 2008-03-20 2008-04-30 Sinvent As Novel NRPS-PKS gene cluster and its manipulation and utility
EP2141242A1 (de) * 2008-07-04 2010-01-06 Universität des Saarlandes Synthetische Wegenzyme zur Herstellung von Argyrinen
JO3464B1 (ar) 2013-01-15 2020-07-05 Astellas Pharma Europe Ltd التركيبات الخاصة بمركبات التياكوميسين
WO2015003816A2 (en) * 2013-07-12 2015-01-15 Helmholtz-Zentrum für Infektionsforschung GmbH Cystobactamides
KR101575295B1 (ko) 2014-01-21 2015-12-09 선문대학교 산학협력단 신규한 에포틸론 글리코시드 및 이의 제조방법
US20200231562A1 (en) * 2014-07-07 2020-07-23 Helmholtz-Zentrum für Infektionsforschung GmbH Novel macrolide antibiotics
CN107041886A (zh) * 2016-02-06 2017-08-15 北京华昊中天生物技术有限公司 脱环氧埃坡霉素衍生物制剂、制备及其治疗肿瘤的应用
CN108456703B (zh) * 2017-02-20 2022-01-14 复旦大学 一种异源表达埃博霉素的方法
CN107629994B (zh) * 2017-10-25 2021-11-02 中国科学院上海有机化学研究所 一种构建fk520高产工程菌株的方法和吸水链霉菌高产菌株
CN113969255A (zh) * 2020-07-24 2022-01-25 北京华昊中天生物医药股份有限公司 生产脱环氧埃坡霉素b的重组菌及其用途

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237970C (zh) 2000-10-31 2006-01-25 贝林格尔英格海姆法玛两合公司 含提欧川平盐的溶液的可吸入制剂

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE267197T1 (de) * 1996-11-18 2004-06-15 Biotechnolog Forschung Gmbh Epothilon d, dessen herstellung und dessen verwendung als cytostatisches mittel bzw. als pflanzenschutzmittel
US6194181B1 (en) * 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
NZ508326A (en) * 1998-06-18 2003-10-31 Novartis Ag A polyketide synthase and non ribosomal peptide synthase genes, isolated from a myxobacterium, necessary for synthesis of epothiones A and B
DE19846493A1 (de) * 1998-10-09 2000-04-13 Biotechnolog Forschung Gmbh DNA-Sequenzen für die enzymatische Synthese von Polyketid- oder Heteropolyketidverbindungen
JP4662635B2 (ja) * 1998-11-20 2011-03-30 コーサン バイオサイエンシーズ， インコーポレイテッド エポチロンおよびエポチロン誘導体を生成するための組換え方法および材料

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1237970C (zh) 2000-10-31 2006-01-25 贝林格尔英格海姆法玛两合公司 含提欧川平盐的溶液的可吸入制剂

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
cloning and heteroloogous ecpression of the epothionegeneeluster. tang l shah s et al.cloning and heterologous expression of the epothilone gene cluster,Vol.287 No.5453. 2000
The biosynthetic gene cluster for the microtubule-stabilizingagents epothilones A and B from Sorangium cellulosum Soce90.. Molnar I, Schupp T et al.Chem Biol.,Vol.7 No.2. 2000
the biosynthetie gene clustert for themicrotubule stabilizingagents epothiones a and b fromstorangium cellulosum soce90. Molnar I, Schupp T et al.Chem Biol.,Vol.7 No.2. 2000
天然抗癌药物EPLTHLONES研究进展. 蒋稼欢.天然产物研究与开发，第11卷第3期. 1999
天然抗癌药物Epothilones研究进展. 蒋稼欢.天然产物研究与发展，第11卷第3期. 1999

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AU2001295195B2 (en) 2007-02-01
NZ546497A (en) 2008-04-30
CA2404938A1 (en) 2001-11-08
EP1320611B1 (de) 2005-11-09
ATE309369T1 (de) 2005-11-15
ES2332727T3 (es) 2010-02-11
WO2001083800A3 (en) 2003-04-10
AU9519501A (en) 2001-11-12
KR20070092334A (ko) 2007-09-12
PT1652926E (pt) 2009-12-03
CN1511192A (zh) 2004-07-07
WO2001083800A9 (en) 2003-09-12
DE60140087D1 (de) 2009-11-12
ES2254493T3 (es) 2006-06-16
CA2404938C (en) 2011-11-01
DE60114865D1 (de) 2005-12-15
EP1652926A3 (de) 2006-08-09
NZ521788A (en) 2007-04-27
KR20030032942A (ko) 2003-04-26
EP1652926A2 (de) 2006-05-03
EP1320611A2 (de) 2003-06-25
IL151960A0 (en) 2003-04-10
WO2001083800A8 (en) 2003-01-03
EP1652926B1 (de) 2009-09-30
DE60114865T2 (de) 2006-07-27
ATE444368T1 (de) 2009-10-15
CY1109698T1 (el) 2014-08-13
KR100832145B1 (ko) 2008-05-27
DK1652926T3 (da) 2010-02-15
WO2001083800A2 (en) 2001-11-08
MXPA02010565A (es) 2004-05-17

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