CN100463689C - Method for preparing gel for wean to remove heat - Google Patents

Method for preparing gel for wean to remove heat Download PDF

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Publication number
CN100463689C
CN100463689C CNB2005100032516A CN200510003251A CN100463689C CN 100463689 C CN100463689 C CN 100463689C CN B2005100032516 A CNB2005100032516 A CN B2005100032516A CN 200510003251 A CN200510003251 A CN 200510003251A CN 100463689 C CN100463689 C CN 100463689C
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parts
radix
fructus
isatidis
concentrated
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CN1958042A (en
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孙挺
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ZHONGJI PHARMACEUTICAL CO Ltd GUIZHOU
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ZHONGJI PHARMACEUTICAL CO Ltd GUIZHOU
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Abstract

A medicinal gel for treating infantile fever is prepared from 12 Chinese-medicinal materials including tree peony bark, honeysuckle flower, capejasmine fruit, scutellaria root, etc through respectively extracting their active components to obtain liquid, adding fruit jelly powder, immersing at 40 deg.C, stirring, adding the aqueous solution of cane sugar, potassium sorbate and citric acid, adding water, boiling and filling it in containers.

Description

A kind of preparation method of gel for wean to remove heat
Technical field
The invention belongs to medical technical field, relate in particular to a kind of preparation method of gel for wean to remove heat.
Background technology
Fever is child's common disease, this type of medicine mainly contains dosage forms such as granule, syrup, mixture, tablet, capsule in the market, all has certain defective, and mainly contain: syrup, mixture etc. mostly is bottled, can't once take after the uncork, easily there is the possibility of polluting in grow mold; Need use boiled water when granule is taken, tablet need pulverize to be taken, and occurs dysphagia etc. when capsule is taken and takes inconvenient phenomenon; Though the syrup mouthfeel is sweeter, also have the bitterness of medicine after all, though some medicine has sugar-coat, still there is bitterness the inside.Most of children is all mismatched when taking medicine, and therefore, the head of a family generally believes that taking medicine to the child is the comparatively thing of difficulty of part.
Summary of the invention
A kind of determined curative effect that the objective of the invention is to overcome above-mentioned shortcoming and provide, steady quality, the simple easy operating of production method carries and taking convenience, can not cause secondary pollution, the preparation method of the gel for wean to remove heat that the child takes like a shot.
The preparation method of gel for wean to remove heat of the present invention comprises the steps:
(1) take by weighing the following weight proportion raw material:
Folium Isatidis 140-160 part, Radix Isatidis 84-96 part, Flos Lonicerae 84-96 part, Fructus Forsythiae 84-96 part, Fructus Gardeniae 84-96 part, Cortex Moutan 84-96 part, Radix Scutellariae 84-96 part, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle 56-64 part, Pheretima 56-64 part, Rhizoma Paridis 42-28 part, Radix Bupleuri 84-96 part, Radix Cynanchi Atrati 56-64 part;
(2) with Cortex Moutan, Radix Bupleuri, Fructus Forsythiae steam distillation, collect distillate, standby;
(3) gained medicinal residues and Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Pheretima, Rhizoma Paridis, Radix Cynanchi Atrati are decocted with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 70%, leave standstill, get supernatant and reclaim ethanol, be concentrated into about 200ml, adding water stirs evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 600ml, obtains medicinal liquid;
(4) the gained medicinal liquid was added 8~12 parts of 40 ℃ of warm macerating of jelly powder 2 hours, heated and stirred is to dissolving, other gets 70 parts of sucrose, 1 part of potassium sorbate, citric acid and adds the suitable quantity of water heating for dissolving for 0.2 part, merge with above-mentioned distillate, add water, fully mixing, boiling sterilization, make 900~1100 parts, packing while hot, promptly.
The preparation method of gel for wean to remove heat comprises the steps: preferably
(1) take by weighing the following weight proportion raw material:
150 parts of Folium Isatidiss, 90 parts of Radix Isatidis, 90 parts of Flos Loniceraes, 90 parts of Fructus Forsythiaes, 90 parts of Fructus Gardeniaes, 90 parts of Cortex Moutans, 90 parts of Radix Scutellariaes, 60 parts of phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendles, 60 parts of Pheretimas, 45 parts of Rhizoma Paridis, 90 parts of Radix Bupleuri, 60 parts of Radix Cynanchi Atratis;
(2) with Cortex Moutan, Radix Bupleuri, Fructus Forsythiae steam distillation, collect distillate, standby;
(3) gained medicinal residues and Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Pheretima, Rhizoma Paridis, Radix Cynanchi Atrati are decocted with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 70%, leave standstill, get supernatant and reclaim ethanol, be concentrated into about 200ml, adding water stirs evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 600ml, obtains medicinal liquid;
(4) the gained medicinal liquid was added 8~12 parts of warm macerating of jelly powder (40 ℃) 2 hours, heated and stirred is to dissolving, other gets 70 parts of sucrose, 1 part of potassium sorbate, citric acid and adds the suitable quantity of water heating for dissolving for 0.2 part, merge with above-mentioned distillate, add water, fully mixing, boiling sterilization, make 900~1100 parts, packing while hot, promptly.
Above-mentioned jelly powder is that weight ratio is the mixture of carrageenan: Konjac glucomannan=1:2.
The present invention compared with prior art, be through repetition test, optimize the preferable prescription of effect that is used to prepare treatment children's antipyretic medicine, at this prescription active ingredient curative effect of medication, bioavailability, technical specifications such as stability, optimizing the adjuvant gel-type vehicle is jelly powder, in conjunction with adopting scientific and reasonable technological design, medicine of the present invention is made food (fruit jelly) form that liked by the child, curative effect of medication not only, technical specifications such as bioavailability can not change, and the gel of making (fruit jelly) steady quality, be not prone to the easy elutriation that occurs of common fruit jelly and go out phenomenon, and the simple easy operating of production method, also can be deployed into various tastes as required.Carry and taking convenience, can not cause secondary pollution, thereby the child takes like a shot and can reach conscious effect of taking medicine, thoroughly solved child's problem of difficult of taking medicine, and Chinese medicine manufacturer is had extensive applicability.
The specific embodiment
Embodiment 1:
(1) take by weighing the following weight proportion raw material:
Folium Isatidis 140g, Radix Isatidis 84g, Flos Lonicerae 84g, Fructus Forsythiae 84g, Fructus Gardeniae 84g, Cortex Moutan 84g, Radix Scutellariae 84g, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle 56g, Pheretima 56g, Rhizoma Paridis 42g, Radix Bupleuri 84g, Radix Cynanchi Atrati 56g;
Carrageenan 2.67g, Konjac glucomannan 5.33g;
(2) with Cortex Moutan, Radix Bupleuri, Fructus Forsythiae steam distillation, collect distillate, standby;
(3) gained medicinal residues and Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Pheretima, Rhizoma Paridis, Radix Cynanchi Atrati are decocted with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 70%, leave standstill, get supernatant and reclaim ethanol, be concentrated into about 200ml, adding water stirs evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 600ml, obtains medicinal liquid;
(4) the gained medicinal liquid is added by carrageenan and mix jelly powder 8~12g warm macerating (40 ℃) of being made into Konjac glucomannan 2 hours, heated and stirred is to dissolving, other gets sucrose 70g, potassium sorbate 1g, citric acid 0.2g adds the suitable quantity of water heating for dissolving, merge with above-mentioned distillate, add water, fully mixing, boiling sterilization, make 900 parts of g, packing while hot, promptly.
Embodiment 2:
(1) take by weighing the following weight proportion raw material:
Folium Isatidis 150g, Radix Isatidis 90g, Flos Lonicerae 90g, Fructus Forsythiae 90g, Fructus Gardeniae 90g, Cortex Moutan 90g, Radix Scutellariae 90g, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle 60g, Pheretima 60g, Rhizoma Paridis 45g, Radix Bupleuri 90g, Radix Cynanchi Atrati 60g;
Carrageenan 3g, Konjac glucomannan 6g;
(2) with Cortex Moutan, Radix Bupleuri, Fructus Forsythiae steam distillation, collect distillate, standby;
(3) gained medicinal residues and Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Pheretima, Rhizoma Paridis, Radix Cynanchi Atrati are decocted with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 70%, leave standstill, get supernatant and reclaim ethanol, be concentrated into about 200ml, adding water stirs evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 600ml, obtains medicinal liquid;
(4) the gained medicinal liquid is added by carrageenan and mix the jelly powder 9g warm macerating (40 ℃) that is made into Konjac glucomannan 2 hours, heated and stirred is to dissolving, other gets sucrose 70g, potassium sorbate 1g, citric acid 0.2g adds the suitable quantity of water heating for dissolving, merge with above-mentioned distillate, add water, fully mixing, boiling sterilization, make 1000g, packing while hot, promptly.
Embodiment 3:
(1) take by weighing the following weight proportion raw material:
Folium Isatidis 160g, Radix Isatidis 96g, Flos Lonicerae 96g, Fructus Forsythiae 96g, Fructus Gardeniae 96g, Cortex Moutan 96g, Radix Scutellariae 96g, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle 64g, Pheretima 64g, Rhizoma Paridis 48g, Radix Bupleuri 96g, Radix Cynanchi Atrati 64g;
Carrageenan 4g, Konjac glucomannan 8g;
(2) with Cortex Moutan, Radix Bupleuri, Fructus Forsythiae steam distillation, collect distillate, standby;
(3) gained medicinal residues and Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Pheretima, Rhizoma Paridis, Radix Cynanchi Atrati are decocted with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 70%, leave standstill, get supernatant and reclaim ethanol, be concentrated into about 200ml, adding water stirs evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 600ml, obtains medicinal liquid;
(4) the gained medicinal liquid is added by carrageenan and mix the jelly powder 12g warm macerating (40 ℃) that is made into Konjac glucomannan 2 hours, heated and stirred is to dissolving, other gets sucrose 70g, potassium sorbate 1g, citric acid 0.2g adds the suitable quantity of water heating for dissolving, merge with above-mentioned distillate, add water, fully mixing, boiling sterilization, make 1100g, packing while hot, promptly.

Claims (2)

1. the preparation method of a gel for wean to remove heat comprises the steps:
(1) take by weighing the following weight proportion raw material:
Folium Isatidis 140-160 part, Radix Isatidis 84-96 part, Flos Lonicerae 84-96 part, Fructus Forsythiae 84-96 part, Fructus Gardeniae 84-96 part, Cortex Moutan 84-96 part, Radix Scutellariae 84-96 part, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle 56-64 part, Pheretima 56-64 part, Rhizoma Paridis 42-28 part, Radix Bupleuri 84-96 part, Radix Cynanchi Atrati 56-64 part;
(2) with Cortex Moutan, Radix Bupleuri, Fructus Forsythiae steam distillation, collect distillate, standby;
(3) gained medicinal residues and Folium Isatidis, Radix Isatidis, Flos Lonicerae, Fructus Gardeniae, Radix Scutellariae, phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendle, Pheretima, Rhizoma Paridis, Radix Cynanchi Atrati are decocted with water secondary, each 1 hour, collecting decoction, filter, filtrate is concentrated in right amount, adds ethanol and makes that to contain that alcohol measures be 70%, leave standstill, get supernatant and reclaim ethanol, be concentrated into about 200ml, adding water stirs evenly, leave standstill, get supernatant, filter, filtrate is concentrated into about 600ml, obtains medicinal liquid;
(4) the gained medicinal liquid was added 8~12 parts of 40 ℃ of warm macerating of jelly powder 2 hours, heated and stirred is to dissolving, other gets 70 parts of sucrose, 1 part of potassium sorbate, citric acid and adds the suitable quantity of water heating for dissolving for 0.2 part, merge with above-mentioned distillate, add water, fully mixing, boiling sterilization, make 900~1100 parts, packing while hot, promptly;
Wherein: jelly powder is that weight ratio is the mixture of carrageenan: Konjac glucomannan=1:2.
2. the preparation method of gel for wean to remove heat as claimed in claim 1, wherein 150 parts of Folium Isatidiss, 90 parts of Radix Isatidis, 90 parts of Flos Loniceraes, 90 parts of Fructus Forsythiaes, 90 parts of Fructus Gardeniaes, 90 parts of Cortex Moutans, 90 parts of Radix Scutellariaes, 60 parts of phyllostachys nigra (lodd.ex lindl.) munro var.henonis (miff.) spapf et rendles, 60 parts of Pheretimas, 45 parts of Rhizoma Paridis, 90 parts of Radix Bupleuri, 60 parts of Radix Cynanchi Atratis.
CNB2005100032516A 2005-11-03 2005-11-03 Method for preparing gel for wean to remove heat Expired - Fee Related CN100463689C (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107596315A (en) * 2017-10-09 2018-01-19 常州美帛纺织品有限公司 A kind of preparation method of antipyretic gel
CN115531492A (en) * 2022-09-21 2022-12-30 青岛权道管理咨询有限公司 Preparation method of heat dissipation gel

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090724A (en) * 1993-02-09 1994-08-17 蒋兴民 A kind of Chinese herbal medicine jelly

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1090724A (en) * 1993-02-09 1994-08-17 蒋兴民 A kind of Chinese herbal medicine jelly

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
中华人民共和国卫生部药品标准 中药成方制剂 第6册. 药典委员会,19. 1992
中华人民共和国卫生部药品标准 中药成方制剂 第6册. 药典委员会,19. 1992 *

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