CN102302617B - Traditional Chinese medicinal preparation for invigorating stomach, relaxing bowel and reducing blood fat and preparation method thereof - Google Patents
Traditional Chinese medicinal preparation for invigorating stomach, relaxing bowel and reducing blood fat and preparation method thereof Download PDFInfo
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- CN102302617B CN102302617B CN201110263403A CN201110263403A CN102302617B CN 102302617 B CN102302617 B CN 102302617B CN 201110263403 A CN201110263403 A CN 201110263403A CN 201110263403 A CN201110263403 A CN 201110263403A CN 102302617 B CN102302617 B CN 102302617B
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Abstract
The invention relates to a medicine or healthcare product composition for invigorating stomach, relaxing bowel and/or reducing blood fat. The medicine or healthcare product composition is characterized by being prepared from lyonia ovalifolia, caryopteris forrestii, Chinese mosla herb and barbed skullcap herb. In addition, the invention further relates to a preparation of the medicine or healthcare product composition, a preparation method and application thereof and the like.
Description
Technical field
The invention belongs to traditional medicine and field of health care products, particularly, the present invention relates to the medicine or the Halth-care composition of stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing, it is characterized in that, it comprises with lyonia ovalifolia (W.) drude, Bai Bazi, little Herba Moslae and toothbrush grass and being prepared from.In addition, the invention still further relates to preparation, method for preparing and the application etc. of this medicine or Halth-care composition.
Background technology
China southwest (comprising Yunnan Province, Guizhou Province, Guangxi province and Sichuan Province) is owing to the complexity of geographical conditions, and wherein plant resources demonstrates rich diversity.Yet many plants have potential medicinal value also with health care and are not developed well.In the plant classification of vastness, the inventor puts into practice according to long term studies, has selected following plant and has been used as medicine:
Vaccinium bracteatum Thunb. (Latin systematic name: Lyonia ovalifolia); It is an Ericaceae Lyonia plant; Usually be used as medicine with its stem, leaf and fruit; But contain Jiao Duo andromedotoxin in its leaf, be prone to cause poisoning, cause vomiting, polyuria, nerve centre and symptoms such as motor nerve ending paralysis and muscle spasm;
(the Latin systematic name: Caryopteris forrestii), also claim white hair Herba caryopteridis nepetaefoliae, it is the Verenaceae plant to Caryopteris forrestii, and its nature and flavor are hot, bitter, puckery, and flat, existing report is used to treat heart disease;
(the Latin systematic name: Origanum vulgare), it is the Labiatae origanum to Adeps Bovis seu Bubali, and its acrid in the mouth, cool in nature, nontoxic is used for flu-prevention clinically, treats yellow cellulitis, heatstroke and heating etc.;
(the Latin systematic name: Elsholtzia bodinieri Van.), it is a Labiatae Herba Moslae platymiscium to East Perillae, its diseases such as wind and cold, toothache caused by fire of deficiency type of can curing cold of being used as medicine.
The inventor finds that unexpectedly these plants are used as medicine, can stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing, and also curative effect is obvious, takes effect than comparatively fast, does not have tangible untoward reaction and takes place, and can take for a long time, thereby avoid the recurrence after the drug withdrawal.
Summary of the invention
The technical problem that the present invention will solve is to provide a kind of new compositions, is that it comprises with lyonia ovalifolia (W.) drude, Bai Bazi, little Herba Moslae and toothbrush grass and being prepared from.In addition, the present invention also provides medicine or health-care preparation, method for preparing and the application etc. of said composition.
Particularly,, the invention provides the medicine or the Halth-care composition of stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing, it is characterized in that it comprises that the plant material with following parts by weight is prepared from first aspect:
Lyonia ovalifolia (W.) drude 30-50 part, Bai Bazi 8-16 part, Fructus Foeniculi Ru 15-25 part and toothbrush grass 15-25 part.
In this article, opposite indication, above plant material all comes from existing known plant, can buy in China southwest (like Yunnan Province).Particularly, in this article, lyonia ovalifolia (W.) drude refers to Ericaceae Lyonia plant Vaccinium bracteatum Thunb. (Latin systematic name: Lyonia ovalifolia) dry branch and leaf; Bai Bazi refers to Verenaceae plant Caryopteris forrestii (Latin systematic name: the plant part that ground Caryopteris forrestii) is above; Little Herba Moslae refers to Labiatae origanum Adeps Bovis seu Bubali (Latin systematic name: the plant part that ground Origanum vulgare) is above; The toothbrush grass refers to Labiatae Herba Moslae platymiscium East Perillae (Latin systematic name: the plant part that ground Elsholtzia bodinieri Van.) is above.
Because no obvious boundary line between Chinese medicine medicine and the health product in the practice, therefore in this article, medicine or Halth-care composition are general designations, refer to the compositions that can be used as medicine or health product, have contained composite medicine or Halth-care composition.Usually, composite medicine can with acceptable medicine carrier combinations, be mixed with medicine preparation; Halth-care composition can with acceptable health product carrier combinations, be mixed with health-care preparation.Certainly, in the practice, acceptable medicine carrier mostly overlaps with acceptable health product carrier.
In the preferred first aspect present invention, plant material and parts by weight thereof are lyonia ovalifolia (W.) drude 35-45 part, Bai Bazi 10-14 part, Fructus Foeniculi Ru 17-23 part; With toothbrush grass 17-23 part, more preferably plant material and parts by weight thereof are lyonia ovalifolia (W.) drude 38-42 part, Bai Bazi 11-13 part; Fructus Foeniculi Ru 18-22 part and toothbrush grass 18-22 part, most preferably plant material and parts by weight thereof are 40 parts of lyonia ovalifolia (W.) drude; 12 parts of Bai Bazi, 20 parts of 20 parts of Fructus Foeniculi Ru and toothbrush grass.The medicine or the Halth-care composition of preferred first aspect present invention are formed by above four kind of plant feedstock production.
The medicine or the Halth-care composition of preferred first aspect present invention, it is prepared from following method:
(1) get lyonia ovalifolia (W.) drude, Bai Bazi, little Herba Moslae and toothbrush grass, decocte with water is also filtered, and collects volatile oil during decoction; With
(2) filtrate of concentration step (1) acquisition, the volatile oil that obtains with filtrating step (1) mixes.
In the medicine of further preferred first aspect present invention or the preparation process of Halth-care composition, decocting boils and filtering number of times is 1-5 time, is preferably 3 times; Be decocte with water and filtration; Get filtering residue decocte with water and filtration, get the filtering residue decocte with water again and filter merging filtrate.
Further in the preparation process of the medicine of preferred first aspect present invention or Halth-care composition, the weight that at every turn adds water respectively for the 5-20 of the weight of plant material doubly, be preferably 8-13 doubly, as 12 times, 10 times or 9 times.
In the medicine of further preferred first aspect present invention or the preparation process of Halth-care composition, the temperature of each decocte with water is 80-100 ℃ respectively, is preferably 90-100 ℃, most preferably is boiling temperature.
In the medicine of further preferred first aspect present invention or the preparation process of Halth-care composition, the time of each decocte with water is 0.5-7 hour respectively, is preferably 1-4 hour.
In the preparation process of the specific embodiment of the present invention, add 12 times of weight decoctings for the first time and boiled 4 hours and filtered, add 9 times of amounts of water for the second time and decocted 2 hours and filtered, add 9 times of water gagings for the third time and decocted 1 hour and filtered, collect volatile oil during decoction.
In the medicine of further preferred first aspect present invention or the preparation process of Halth-care composition, the relative density that is concentrated into 50 ℃ is 1.1-1.35, is preferably 1.2-1.3, most preferably is 1.25.
Also in the preparation process of the medicine of further preferred first aspect present invention or Halth-care composition, be concentrated into dried cream, promptly convection drying becomes solid content.
In second aspect, the invention provides the method for preparing of the medicine or the Halth-care composition of first aspect present invention.
The method for preparing of preferred second aspect present invention comprises:
(1) get lyonia ovalifolia (W.) drude, Bai Bazi, little Herba Moslae and toothbrush grass, decocte with water is also filtered, and collects volatile oil during decoction; With
(2) filtrate of concentration step (1) acquisition, the volatile oil that obtains with filtrating step (1) mixes.
In the method for preparing of further preferred second aspect present invention, decocting boils and filtering number of times is 1 ~ 5 time, is preferably 3 times, i.e. decocte with water is also filtered, and gets the filtering residue decocte with water and also filters, and gets the filtering residue decocte with water again and filters merging filtrate.
Further in the method for preparing of preferred second aspect present invention, the weight that at every turn adds water respectively for the 5-20 of the weight of plant material doubly, be preferably 8-13 doubly, as 12 times, 10 times or 9 times.
In the method for preparing of further preferred second aspect present invention, the temperature of each decocte with water is 80-100 ℃ respectively, is preferably 90-100 ℃, most preferably is boiling temperature.
In the method for preparing of further preferred second aspect present invention, the time of each decocte with water is 0.5-7 hour respectively, is preferably 1-4 hour.
In the method for preparing of the specific embodiment of the present invention, add 12 times of weight decoctings for the first time and boiled 4 hours and filtered, add 9 times of amounts of water for the second time and decocted 2 hours and filtered, add 9 times of water gagings for the third time and decocted 1 hour and filtered, collect volatile oil during decoction.
In the method for preparing of further preferred second aspect present invention, the relative density that is concentrated into 50 ℃ is 1.1-1.35, is preferably 1.2-1.3, most preferably is 1.25.
Also in the method for preparing of further preferred second aspect present invention, be concentrated into dried cream, promptly convection drying becomes solid content.
In the third aspect, the invention provides the medicine or the health-care preparation of stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing, it comprises medicine or Halth-care composition and the acceptable medicine or the health product carrier of first aspect present invention.In this article, " acceptable medicine or health product carrier " refers to nontoxic solid-state, semisolid or liquid filler, diluent, buffer agent, protective agent, antiseptic, lapping or other pharmaceutical adjuncts that in medicine or health product, uses.The medicine or the health-care preparation by oral route of preferred third aspect present invention are come administration, and the medicine or the health-care preparation of therefore preferred third aspect present invention are oral formulations, as, oral liquid, granule, electuary, powder, capsule or tablet.Those skilled in the art know conventional acceptable medicine or health product carrier, and preferably in the medicine or health-care preparation of third aspect present invention, carrier is ethanol, starch and/or smart the paste.
Aspect other one, the medicine or the Halth-care composition that the invention provides first aspect present invention are in the medicine of preparation stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing or the application of health product.Available administering mode comprises that injection, oral, rectum, Sublingual, pulmonary, transdermal, ion penetrate, vagina and intranasal administration, the preferred oral administration.Dosage changes according to the situation of action time of dosage form and expectation and treatment target to some extent; The required amount of actual therapeutic can by clinician or health care family according to experimenter's practical situation (as, patient's the state of an illness, body weight, age, sex etc.) and confirm easily.
Beneficial effect of the present invention is: new medicine or the Halth-care composition and the preparation thereof that can supply the patient to select are provided; This medicine or Halth-care composition and preparation curative effect thereof are obvious, take effect than comparatively fast, do not have tangible untoward reaction and take place, and can take for a long time, thereby avoid the recurrence after the drug withdrawal.
For the ease of understanding, below will the present invention be described in detail through concrete embodiment.What need particularly point out is that instantiation only is in order to explain, not constitute limitation of the scope of the invention.Obviously those of ordinary skill in the art can explain according to this paper, within the scope of the invention the present invention is made various corrections and change, and these corrections and change are also included in the scope of the present invention.
The specific embodiment
Following this paper will describe invention through concrete embodiment.As do not specialize part, can implement according to national drug that those skilled in the art were familiar with and health product standard and relevant laws and regulations, regulation.In addition, employed raw material and reagent all can be bought from market through commercial sources except that special instruction is arranged among the embodiment.
The preparation 1 of embodiment 1 compositions of the present invention and preparation thereof
Get the lyonia ovalifolia (W.) drude 400g that sells on the market, Bai Bazi 120g, Fructus Foeniculi Ru 200g and toothbrush grass 200g; Be ground into the coarse powder that can sieve 80 mesh sieves after the mixing, place in the decoction pot (its sealing on be stamped inverted U-shaped sealing volatilised liq gathering-device), add the 11.04kg water boil and kept 4 hours; Filter then, filtering residue adds 8.28kg water and in this container, boils and kept 2 hours, filters then; Filtering residue adds 8.28kg water and in this container, boils and kept 1 hour, and merging filtrate is used to concentrate, and each in addition the decoction collected volatilised liq; Get oil phase, promptly volatile oil is subsequent use.
Above-mentioned filtrating is condensed into the thick paste that relative density is 1.25 (50 ℃) in 80 ℃ of normal pressures; The volatile oil that adds above-mentioned collection in room temperature (25 ℃); Compositions of the present invention, and add respectively with the soluble starch of weight such as thick paste and stick with paste, with the moistening back granulation of 70% ethanol with smart; Promptly process granule, every bag of packing 10g.
The preparation 2 of embodiment 2 compositionss of the present invention and preparation thereof
Get the lyonia ovalifolia (W.) drude 400g that sells on the market, Bai Bazi 120g, Fructus Foeniculi Ru 200g and toothbrush grass 200g; Be ground into the coarse powder that can sieve 80 mesh sieves after the mixing, place decoction pot (its sealing on be stamped inverted U-shaped sealing volatilised liq gathering-device), add the 11.04kg water boil and and kept 4 hours; Filter then, filtering residue add that 8.28kg water boils in this container and and kept 2 hours, filter then; Filtering residue add that 8.28kg water boils in this container and and kept 1 hour, merging filtrate is used to concentrate, each in addition the decoction collected volatilised liq; Get oil phase, promptly volatile oil is subsequent use.
Above-mentioned filtrating is condensed into the thick paste that relative density is 1.25 (50 ℃) in 80 ℃ of normal pressures; And continue at 80 ℃ of constant pressure and dries and become dried cream, the volatile oil that adds above-mentioned collection in room temperature (25 ℃) is in harmonious proportion, compositions of the present invention; And the soluble starch of weight such as adding and dried cream and 1.5 times of essences to dried cream weight are stuck with paste respectively; Mixing is promptly processed powder, every bag of packing 10g.
The curative effect check of embodiment 3 compositionss of the present invention
Under the situation of informed consent, the patient that diagnosis suffers from associated conditions takes preparation of the present invention:
(1) blood fat reducing
According to Ministry of Public Health " health food check and assessment technique standard (2003) "; With 58 adult hyperlipidemia blood patients; Be divided into matched group and experimental group at random; Experimental group oral twice granule 10g according to the embodiment of the invention 1 preparation every day, the oral equivalent of matched group is by starch and the smart placebo of forming of sticking with paste.Test after 60 days, experimental group significantly reduces by 7.3% (P < 0.05) with respect to the serum total cholesterol level of matched group, and serum triglyceride level significantly reduces by 20.7% (P < 0.01).None routine untoward reaction of experimental group, physiochemical indice and liver and renal function index are all in normal range, with no significant change before the experiment.This shows that preparation of the present invention can be taken for a long time, and determined curative effect.
(2) loosening bowel to relieve constipation
Owing to there is not the correlation technique standard, therefore organize Yunnan Province to have the patient of prolonged constipation experience to try out January, add up to 22 patients, every day is oral once according to the powder 10g of the embodiment of the invention 2 preparations, writes down its stool and subjective feeling.All patients all begin defecation after taking medicine 2 hours, lighter with respect to defecation before the experiment; First behind the defecation, 18 patients are light defecation once in per 24 hours in experimental session thereafter; Twice infrequent defecation of 4 patients occurs there is not to surpass 12 hours situation in addition, and period in a medicine has no adverse reaction after reaching and stopping using.This shows, preparation instant effect of the present invention, determined curative effect.
(3) stomach function regulating
To the granule of the rat model administration embodiment of the invention of ethanol property gastric mucosa injury 1 preparation, test is to the therapeutical effect of gastric injury.Choose rat and be divided into two groups at random; All continuous two day every day intragastric infusion 0.5ml 60% ethanol; Cause ethanol property gastric mucosa injury, the granule of gastric infusion embodiment of the invention every day of administration group then 1 preparation, dosage is 0.5g/kg rat/sky; Matched group administration equivalent starch is stuck with paste successive administration 5 days with smart.Put to death rat, get gastric tissue, measure ulcer inhibition rate by following formula, recording ulcer inhibition rate is 23.2%:
Ulcer inhibition rate (%)=100% * (matched group ulcer length summation-administration group ulcer length summation)/matched group ulcer length summation
This shows, preparation instant effect of the present invention, determined curative effect.
Claims (36)
1. the medicine of stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing or Halth-care composition is characterized in that, it is that plant material with following parts by weight is prepared from:
Lyonia ovalifolia (W.) drude 30-50 part, Bai Bazi 8-16 part, Fructus Foeniculi Ru 15-25 part and toothbrush grass 15-25 part.
2. medicine according to claim 1 or Halth-care composition is characterized in that, it is that plant material with following parts by weight is prepared from:
40 parts of lyonia ovalifolia (W.) drude, 12 parts of Bai Bazi, 20 parts of 20 parts of Fructus Foeniculi Ru and toothbrush grass.
3. medicine according to claim 1 and 2 or Halth-care composition, it is prepared from following method:
(1) get lyonia ovalifolia (W.) drude, Bai Bazi, little Herba Moslae and toothbrush grass, decocte with water is also filtered, and collects volatile oil during decoction; With
(2) filtrate of concentration step (1) acquisition, the volatile oil that obtains with step (1) mixes.
4. medicine according to claim 3 or Halth-care composition, wherein decocte with water and filtering number of times are 1-5 time.
5. medicine according to claim 4 or Halth-care composition, wherein decocte with water and filtering number of times are 3 times.
6. medicine according to claim 4 or Halth-care composition, wherein,
The weight that at every turn adds water respectively for the 5-20 of the weight of plant material doubly;
The temperature of each decocte with water respectively is 80-100 ℃;
The time of each decocte with water respectively is 0.5-7 hour.
7. medicine according to claim 6 or Halth-care composition, wherein, the weight that at every turn adds water respectively for the 8-13 of the weight of plant material doubly.
8. medicine according to claim 7 or Halth-care composition, wherein, the weight that at every turn adds water respectively is 12 times, 10 times or 9 times of the weight of plant material.
9. medicine according to claim 6 or Halth-care composition, wherein, the temperature of each decocte with water respectively is 90-100 ℃.
10. medicine according to claim 9 or Halth-care composition, wherein, the temperature of each decocte with water respectively is a boiling temperature.
11. medicine according to claim 6 or Halth-care composition, wherein, the time of each decocte with water respectively is 1-4 hour.
12. medicine according to claim 5 or Halth-care composition wherein add for the first time 12 times of weight decoctings and boiled 4 hours and filtered, and add 9 times of amounts of water for the second time and decoct 2 hours and filtered, and add 9 times of water gagings for the third time and decoct 1 hour and filtered, and collect volatile oil during decoction.
13. medicine according to claim 3 or Halth-care composition, the relative density that wherein is concentrated into 50 ℃ is 1.1-1.35.
14. medicine according to claim 13 or Halth-care composition, the relative density that wherein is concentrated into 50 ℃ is 1.2-1.3.
15. medicine according to claim 14 or Halth-care composition, the relative density that wherein is concentrated into 50 ℃ is 1.25.
16. medicine according to claim 3 or Halth-care composition wherein are concentrated into dried cream.
17. according to the arbitrary described medicine of claim 1-16 or the method for preparing of Halth-care composition, it comprises:
(1) get lyonia ovalifolia (W.) drude, Bai Bazi, little Herba Moslae and toothbrush grass, decocte with water is also filtered, and collects volatile oil during decoction; With
(2) filtrate of concentration step (1) acquisition, the volatile oil that obtains with step (1) mixes.
18. method for preparing according to claim 17, wherein decocte with water and filtering number of times are 1-5 time.
19. method for preparing according to claim 18, wherein decocte with water and filtering number of times are 3 times.
20. method for preparing according to claim 18, wherein,
The weight that at every turn adds water respectively for the 5-20 of the weight of plant material doubly;
The temperature of each decocte with water respectively is 80-100 ℃;
The time of each decocte with water respectively is 0.5-7 hour.
21. method for preparing according to claim 20, wherein, the weight that at every turn adds water respectively for the 8-13 of the weight of plant material doubly.
22. method for preparing according to claim 21, wherein, the weight that at every turn adds water respectively is 12 times, 10 times or 9 times of the weight of plant material.
23. method for preparing according to claim 20, wherein, the temperature of each decocte with water respectively is 90-100 ℃.
24. method for preparing according to claim 23, wherein, the temperature of each decocte with water respectively is a boiling temperature.
25. method for preparing according to claim 20, wherein, the time of each decocte with water respectively is 1-4 hour.
26. method for preparing according to claim 19 wherein adds for the first time 12 times of weight decoctings and boiled 4 hours and filtered, and adds 9 times of amounts of water for the second time and decocts 2 hours and filtered, and adds 9 times of water gagings for the third time and decocts 1 hour and filtered, and collects volatile oil during decoction.
27. method for preparing according to claim 17, the relative density that wherein is concentrated into 50 ℃ is 1.1-1.35.
28. method for preparing according to claim 27, the relative density that wherein is concentrated into 50 ℃ is 1.2-1.3.
29. method for preparing according to claim 28, the relative density that wherein is concentrated into 50 ℃ is 1.25.
30. method for preparing according to claim 17 wherein is concentrated into dried cream.
31. the medicine of stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing or health-care preparation, it comprises arbitrary described medicine or Halth-care composition and acceptable medicine or the health product carrier of claim 1-16.
32. medicine according to claim 31 or health-care preparation, it is an oral formulations.
33. medicine according to claim 32 or health-care preparation, it is oral liquid, granule, powder, capsule or tablet.
34. medicine according to claim 32 or health-care preparation, it is an electuary.
35. medicine according to claim 31 or health-care preparation, wherein carrier is ethanol, starch and/or dextrin.
36. according to the arbitrary described medicine of claim 1-16 or Halth-care composition in the medicine of preparation stomach function regulating, loosening bowel to relieve constipation and/or blood fat reducing or the application of health product.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110263403A CN102302617B (en) | 2011-09-07 | 2011-09-07 | Traditional Chinese medicinal preparation for invigorating stomach, relaxing bowel and reducing blood fat and preparation method thereof |
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| CN201110263403A CN102302617B (en) | 2011-09-07 | 2011-09-07 | Traditional Chinese medicinal preparation for invigorating stomach, relaxing bowel and reducing blood fat and preparation method thereof |
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| CN102302617B true CN102302617B (en) | 2012-10-03 |
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| CN103947811A (en) * | 2014-05-20 | 2014-07-30 | 西南林业大学 | Lyonia ovalifolia(W.)Drude drink and preparation method thereof |
| CN104171211A (en) * | 2014-09-11 | 2014-12-03 | 勐海茶业有限责任公司 | Herbal tea and preparation method thereof |
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