CN110638921A - Oral liquid with kidney tonifying function and preparation method thereof - Google Patents
Oral liquid with kidney tonifying function and preparation method thereof Download PDFInfo
- Publication number
- CN110638921A CN110638921A CN201911052363.9A CN201911052363A CN110638921A CN 110638921 A CN110638921 A CN 110638921A CN 201911052363 A CN201911052363 A CN 201911052363A CN 110638921 A CN110638921 A CN 110638921A
- Authority
- CN
- China
- Prior art keywords
- parts
- filtrate
- oral liquid
- kidney tonifying
- placing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000007788 liquid Substances 0.000 title claims abstract description 34
- 210000003734 kidney Anatomy 0.000 title claims abstract description 32
- 238000002360 preparation method Methods 0.000 title claims abstract description 22
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 235000008708 Morus alba Nutrition 0.000 claims abstract description 19
- 240000002853 Nelumbo nucifera Species 0.000 claims abstract description 19
- 235000006508 Nelumbo nucifera Nutrition 0.000 claims abstract description 19
- 235000006510 Nelumbo pentapetala Nutrition 0.000 claims abstract description 19
- 239000008213 purified water Substances 0.000 claims abstract description 18
- 239000000843 powder Substances 0.000 claims abstract description 14
- 241001107116 Castanospermum australe Species 0.000 claims abstract description 9
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 9
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 9
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 9
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 9
- 244000241838 Lycium barbarum Species 0.000 claims abstract description 9
- 235000015459 Lycium barbarum Nutrition 0.000 claims abstract description 9
- 235000015468 Lycium chinense Nutrition 0.000 claims abstract description 9
- 240000000249 Morus alba Species 0.000 claims abstract description 9
- 235000009754 Vitis X bourquina Nutrition 0.000 claims abstract description 9
- 235000012333 Vitis X labruscana Nutrition 0.000 claims abstract description 9
- 235000014787 Vitis vinifera Nutrition 0.000 claims abstract description 9
- 235000021279 black bean Nutrition 0.000 claims abstract description 9
- 235000007215 black sesame Nutrition 0.000 claims abstract description 9
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 9
- 240000006365 Vitis vinifera Species 0.000 claims abstract 3
- 239000000706 filtrate Substances 0.000 claims description 35
- 238000007873 sieving Methods 0.000 claims description 20
- 238000011049 filling Methods 0.000 claims description 16
- 241000219095 Vitis Species 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 241000218231 Moraceae Species 0.000 claims description 10
- 238000001914 filtration Methods 0.000 claims description 10
- 239000011259 mixed solution Substances 0.000 claims description 10
- 210000000582 semen Anatomy 0.000 claims description 10
- 239000002994 raw material Substances 0.000 claims description 6
- 241000221377 Auricularia Species 0.000 claims description 5
- 235000009392 Vitis Nutrition 0.000 claims description 5
- 238000009835 boiling Methods 0.000 claims description 5
- 238000004140 cleaning Methods 0.000 claims description 5
- 238000001035 drying Methods 0.000 claims description 5
- 239000011521 glass Substances 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 238000004806 packaging method and process Methods 0.000 claims description 5
- 238000010298 pulverizing process Methods 0.000 claims description 5
- 229910001220 stainless steel Inorganic materials 0.000 claims description 5
- 239000010935 stainless steel Substances 0.000 claims description 5
- 230000001954 sterilising effect Effects 0.000 claims description 5
- 238000003756 stirring Methods 0.000 claims description 5
- 238000005406 washing Methods 0.000 claims description 5
- 235000013305 food Nutrition 0.000 abstract description 4
- 238000012360 testing method Methods 0.000 description 10
- 241000699666 Mus <mouse, genus> Species 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 7
- 239000000243 solution Substances 0.000 description 7
- 210000001624 hip Anatomy 0.000 description 6
- 239000012153 distilled water Substances 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 230000036541 health Effects 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 241000700159 Rattus Species 0.000 description 3
- 210000003127 knee Anatomy 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 201000004384 Alopecia Diseases 0.000 description 2
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 description 2
- 206010012735 Diarrhoea Diseases 0.000 description 2
- 238000012449 Kunming mouse Methods 0.000 description 2
- 208000002193 Pain Diseases 0.000 description 2
- 206010037660 Pyrexia Diseases 0.000 description 2
- 208000009205 Tinnitus Diseases 0.000 description 2
- 208000031975 Yang Deficiency Diseases 0.000 description 2
- 208000031971 Yin Deficiency Diseases 0.000 description 2
- 231100000360 alopecia Toxicity 0.000 description 2
- 229960004397 cyclophosphamide Drugs 0.000 description 2
- 230000006378 damage Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 208000002173 dizziness Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 201000001881 impotence Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000013642 negative control Substances 0.000 description 2
- 206010029410 night sweats Diseases 0.000 description 2
- 230000036565 night sweats Effects 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 206010036596 premature ejaculation Diseases 0.000 description 2
- 235000021251 pulses Nutrition 0.000 description 2
- 231100000886 tinnitus Toxicity 0.000 description 2
- 230000002110 toxicologic effect Effects 0.000 description 2
- 231100000027 toxicology Toxicity 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 208000004998 Abdominal Pain Diseases 0.000 description 1
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 201000000736 Amenorrhea Diseases 0.000 description 1
- 206010001928 Amenorrhoea Diseases 0.000 description 1
- 238000010953 Ames test Methods 0.000 description 1
- 231100000039 Ames test Toxicity 0.000 description 1
- 206010063659 Aversion Diseases 0.000 description 1
- 206010011224 Cough Diseases 0.000 description 1
- 206010013789 Dry throat Diseases 0.000 description 1
- 208000010228 Erectile Dysfunction Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 206010024642 Listless Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010027514 Metrorrhagia Diseases 0.000 description 1
- 206010030113 Oedema Diseases 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000003286 Protein-Energy Malnutrition Diseases 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 206010041497 Spermatorrhoea Diseases 0.000 description 1
- 206010050208 Teratospermia Diseases 0.000 description 1
- 208000002312 Teratozoospermia Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 231100000460 acute oral toxicity Toxicity 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 231100000540 amenorrhea Toxicity 0.000 description 1
- 238000010171 animal model Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 210000003855 cell nucleus Anatomy 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 238000003745 diagnosis Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 206010013781 dry mouth Diseases 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 230000007674 genetic toxicity Effects 0.000 description 1
- 231100000025 genetic toxicology Toxicity 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 208000021267 infertility disease Diseases 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 210000002414 leg Anatomy 0.000 description 1
- 208000017971 listlessness Diseases 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 206010026820 marasmus Diseases 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 108700039855 mouse a Proteins 0.000 description 1
- 239000003471 mutagenic agent Substances 0.000 description 1
- 231100000707 mutagenic chemical Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 238000003305 oral gavage Methods 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 230000003860 sleep quality Effects 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
- A61K36/815—Lycium (desert-thorn)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/87—Vitaceae or Ampelidaceae (Vine or Grape family), e.g. wine grapes, muscadine or peppervine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Botany (AREA)
- Epidemiology (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Anesthesiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Urology & Nephrology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of health-care food, in particular to an oral liquid with a kidney tonifying function and a preparation method thereof, wherein the oral liquid comprises, by weight, 15 ~ 45 parts of Chinese yam, 8 ~ 30 parts of wolfberry fruit, 5 ~ 20 parts of agaric, 5 ~ 18 parts of lotus seed, 4 ~ 12 parts of grape, 4 ~ 12 parts of mulberry, 2 ~ 5 parts of black bean, 2 ~ 5 parts of black sesame, 2 ~ 5 parts of orange powder and 9000 ~ 12000mL of purified water.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to an oral liquid with a kidney tonifying function and a preparation method thereof.
Background
Kidneys are the innate root and the yin essence in kidneys are the general source of the yin fluid of the whole body. Deficiency of yin essence can cause various diseases, such as dizziness, tinnitus, soreness and weakness of waist and knees, bone steaming, tidal fever, diabetes, alopecia, etc.
The traditional Chinese medicine considers that kidney deficiency is divided into kidney yin deficiency and kidney yang deficiency, and different diagnosis and treatment are carried out according to different symptoms. Symptoms of yang deficiency: soreness and pain of the waist and knees, cold pain of the waist and back, aversion to cold, especially in the lower limbs; dizziness, listlessness, white or black complexion; pale, swollen and white coating, deep and weak pulse; male is easy to impotence and premature ejaculation, and female is easy to be infertile by cold womb; or diarrhea before dawn, diarrhea before dawn; or edema, even in the area below the waist, but not in the area below the waist, or even in the case of abdominal distension and pain, palpitation and cough. Symptoms of yin deficiency: soreness and weakness of waist and knees, weakness of legs, vertigo, tinnitus, alopecia, loose teeth, night sweat, insomnia, somntalking, dry mouth, yellow urine, dry stool, male sexual impotence, premature ejaculation, spermatorrhea, female amenorrhea, metrorrhagia, marasmus, hectic fever, night sweat, vexation, dry throat, red cheeks, yellow urine, dry stool, red tongue, little saliva, and thready and rapid pulse.
At present, with the progress of society and the improvement of living standard of people, more and more people begin to pay attention to daily health care. Most of products for tonifying the kidney in the market are medicines or health-care products, the situation is single, the damage to the health is caused, the medicine effect is poor, the side effect is more, and the harm to the health is caused. Therefore, the health care product with the kidney tonifying function has great market potential.
Disclosure of Invention
Based on the above problems, the present invention aims to provide an oral liquid with kidney tonifying function and a preparation method thereof.
An oral liquid with a kidney tonifying function comprises, by weight, 15 ~ 45 parts of Chinese yam, 8 ~ 30 parts of wolfberry fruit, 5 ~ 20 parts of agaric, 5 ~ 18 parts of lotus seed, 4 ~ 12 parts of grape, 4 ~ 12 parts of mulberry, 2 ~ 5 parts of black bean, 2 ~ 5 parts of black sesame, 2 ~ 5 parts of orange powder and 9000 ~ 12000mL of purified water.
Preferably, the oral liquid comprises the following raw materials in parts by weight: 30 parts of Chinese yam, 8 parts of wolfberry fruit, 20 parts of agaric, 12 parts of lotus seed, 11 parts of grape, 11 parts of mulberry, 3 parts of black bean, 2 parts of black sesame, 3 parts of orange powder and 10000mL of purified water.
The preparation method of the oral liquid with the kidney tonifying function comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: cleaning rhizoma Dioscoreae, fructus Lycii, Auricularia and fructus Vitis Viniferae with water, placing in a jacketed pan, decocting for 1.5 hr with ten times of water, hot sieving with 200 mesh sieve, and placing the filtrate in a preparation tank;
step two: washing lotus seeds and mulberries, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the lotus seeds and the mulberries are hot, wherein the filtrate is reserved;
step three: drying semen Sojae Atricolor and semen Sesami Niger in the shade, pulverizing with pulverizer, sieving with 100 mesh sieve, placing in a preparation tank, heating and boiling for 40 min, stirring for dissolving, hot sieving with 200 mesh sieve, and filtering to obtain filtrate;
step four: uniformly mixing the filtrate obtained in the three steps and orange powder in proportion, and fixing the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting.
Further, the steps two to six are all carried out in a hundred thousand grade clean space.
Compared with the prior art, the invention has the following beneficial effects:
the oral liquid with the kidney tonifying function provided by the invention is prepared from the following main raw materials of common high-quality food materials and traditional Chinese medicines: the Chinese yam, the wolfberry fruit, the edible fungus, the lotus seed, the grape, the mulberry, the black bean and the black sesame have the function of comprehensively improving the sleep quality. In consideration of the taste, the orange powder is added into the product to adjust the taste, so that the taste is better. The preparation method of the oral liquid with the kidney tonifying function is simple and convenient to operate; cost and labor are saved; the process equipment is safe and sanitary.
Detailed Description
The technical solutions in the embodiments of the present invention will be described clearly and completely with reference to the following embodiments, and it should be understood that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
An oral liquid with a kidney tonifying function comprises the following raw materials in parts by weight: 450g of Chinese yam, 300g of wolfberry fruit, 50g of agaric, 50g of lotus seed, 40g of grape, 40g of mulberry, 20g of black bean, 30g of black sesame, 20g of orange powder and 9000mL of purified water.
The preparation method of the oral liquid with the kidney tonifying function comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: cleaning rhizoma Dioscoreae, fructus Lycii, Auricularia and fructus Vitis Viniferae with water, placing in a jacketed pan, decocting for 1.5 hr with ten times of water, hot sieving with 200 mesh sieve, and placing the filtrate in a preparation tank;
step two: washing lotus seeds and mulberries, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the lotus seeds and the mulberries are hot, wherein the filtrate is reserved;
step three: drying semen Sojae Atricolor and semen Sesami Niger in the shade, pulverizing with pulverizer, sieving with 100 mesh sieve, placing in a preparation tank, heating and boiling for 40 min, stirring for dissolving, hot sieving with 200 mesh sieve, and filtering to obtain filtrate;
step four: uniformly mixing the filtrate obtained in the three steps and orange powder in proportion, and fixing the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting. Wherein, the steps two to six are all carried out in a hundred thousand grade clean space.
Example 2
An oral liquid with a kidney tonifying function comprises the following raw materials in parts by weight: 300g of Chinese yam, 80g of wolfberry fruit, 200g of agaric, 120g of lotus seed, 110g of grape, 110g of mulberry, 30g of black bean, 20g of black sesame, 30g of orange powder and 10000mL of purified water.
The preparation method of the oral liquid with the kidney tonifying function comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: cleaning rhizoma Dioscoreae, fructus Lycii, Auricularia and fructus Vitis Viniferae with water, placing in a jacketed pan, decocting for 1.5 hr with ten times of water, hot sieving with 200 mesh sieve, and placing the filtrate in a preparation tank;
step two: washing lotus seeds and mulberries, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the lotus seeds and the mulberries are hot, wherein the filtrate is reserved;
step three: drying semen Sojae Atricolor and semen Sesami Niger in the shade, pulverizing with pulverizer, sieving with 100 mesh sieve, placing in a preparation tank, heating and boiling for 40 min, stirring for dissolving, hot sieving with 200 mesh sieve, and filtering to obtain filtrate;
step four: uniformly mixing the filtrate obtained in the three steps and orange powder in proportion, and fixing the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting. Wherein, the steps two to six are all carried out in a hundred thousand grade clean space.
Example 3
An oral liquid with a kidney tonifying function comprises the following raw materials in parts by weight: 150g of Chinese yam, 130g of wolfberry fruit, 150g of agaric, 180g of lotus seed, 120g of grape, 120g of mulberry, 50g of black bean, 50g of black sesame, 50g of orange powder and 12000mL of purified water.
The preparation method of the oral liquid with the kidney tonifying function comprises the following steps: the method specifically comprises the following steps:
the method comprises the following steps: cleaning rhizoma Dioscoreae, fructus Lycii, Auricularia and fructus Vitis Viniferae with water, placing in a jacketed pan, decocting for 1.5 hr with ten times of water, hot sieving with 200 mesh sieve, and placing the filtrate in a preparation tank;
step two: washing lotus seeds and mulberries, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the lotus seeds and the mulberries are hot, wherein the filtrate is reserved;
step three: drying semen Sojae Atricolor and semen Sesami Niger in the shade, pulverizing with pulverizer, sieving with 100 mesh sieve, placing in a preparation tank, heating and boiling for 40 min, stirring for dissolving, hot sieving with 200 mesh sieve, and filtering to obtain filtrate;
step four: uniformly mixing the filtrate obtained in the three steps and orange powder in proportion, and fixing the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting. Wherein, the steps two to six are all carried out in a hundred thousand grade clean space.
Example 4
And (3) toxicological experiments:
1. the purpose of the test is as follows: the oral liquid with the kidney tonifying function is toxic or not.
Experimental materials: (1) sample preparation: the recommended dosage of the oral liquid for human bodies is 20mL per day, the weight of adults is calculated according to 60kg, the dosage is 0.333 mL/kg/day, and 5 times of concentrated solution is taken for experiments.
2. Experimental animals: clean-grade Kunming mouse, SD rat and feed.
3. The experimental environmental conditions comprise the temperature of 22 ~ 24 ℃ and the humidity of 52 ~ 58%.
4. The experimental method comprises the following steps:
through mouse acute toxicity experiment (taking 5 times of concentrated solution of oral liquid with kidney tonifying function to a mouse and giving the mouse a one-time oral gavage according to the gavage volume of 0.2mL/10 g.bw), Ames experiment (five doses are set in the experiment, namely 5000 mug/dish, 1000 mug/dish, 200 mug/dish, 40 mug/dish and 8 mug/dish, and self-reversion, solvent control and positive mutagen control are set at the same time), mouse marrow pleochromophilia cell nucleus experiment (taking cyclophosphamide with the dose of 40mg/kg.bw as positive control and distilled water as negative control, 3 doses in an experimental group are respectively 10.0mL/kg.bw, 5.0mL/kg.bw and 2.5mL/kg.bw, taking 50.0mL, 25mL and 12.5mL of concentrated solution of oral liquid with kidney tonifying function to 100mL to prepare a test solution with corresponding dose to a mouse, and taking 40mg/kg of cyclophosphamide as control, the test group is prepared by taking 10.0mL/kg.bw, 5.0mL/kg.bw and 2.5mL/kg.bw as negative control, taking 50.0mL, 25.0mL and 12.5mL of oral liquid 5-fold concentrated solution with kidney tonifying function and adding distilled water to 50mL respectively to prepare test liquid with corresponding dose to be filled into a mouse for stomach filling, and carrying out 30-day feeding test (taking 17mL, 33mL and 67mL of oral liquid 5-fold concentrated solution with kidney tonifying function and adding distilled water to fix the volume to 100mL, and taking the control group to be filled with distilled water with the same volume once a day for continuous 30 days) to carry out toxicological test evaluation.
5. And (3) test results:
(1) acute oral toxicity test: the maximum tolerance dose to female and male Kunming mice is more than 20.0mL/kg.bw, and the drug belongs to a nontoxic grade.
(2) And (3) genetic toxicity test: the Ames test, mouse marrow pleochromocyte micronucleus test and mouse teratospermia test results are all negative.
(3) And feeding the rats for 30 days by using 1.7mL/kg.bw, 3.3mL/kg.bw and 6.7mL/kg.bw of oral liquid 5-time concentrated solution with the kidney tonifying function, wherein the rats are gavaged for 30 days, animals grow and develop well in the experimental period, and the weight, the weight gain, the food utilization rate, the blood conventional index, the organ weight and the organ/weight ratio of each dose group are compared with those of a control group, so that no significant difference exists.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (4)
1. An oral liquid with a kidney tonifying function is characterized by comprising, by weight, 15 ~ 45 parts of Chinese yam, 8 ~ 30 parts of wolfberry fruit, 5 ~ 20 parts of agaric, 5 ~ 18 parts of lotus seed, 4 ~ 12 parts of grape, 4 ~ 12 parts of mulberry, 2 ~ 5 parts of black bean, 2 ~ 5 parts of black sesame, 2 ~ 5 parts of orange powder and 9000 ~ 12000mL of purified water.
2. The oral liquid with the kidney tonifying function according to claim 1, which is optimally prepared from the following raw materials in parts by weight: 30 parts of Chinese yam, 8 parts of wolfberry fruit, 20 parts of agaric, 12 parts of lotus seed, 11 parts of grape, 11 parts of mulberry, 3 parts of black bean, 2 parts of black sesame, 3 parts of orange powder and 10000mL of purified water.
3. The preparation method of the oral liquid with the kidney tonifying function, which is disclosed by claim 1, is characterized by comprising the following steps of:
the method comprises the following steps: cleaning rhizoma Dioscoreae, fructus Lycii, Auricularia and fructus Vitis Viniferae with water, placing in a jacketed pan, decocting for 1.5 hr with ten times of water, hot sieving with 200 mesh sieve, and placing the filtrate in a preparation tank;
step two: washing lotus seeds and mulberries, adding 3 times of purified water, decocting for 1.5 hours, and sieving with a 200-mesh sieve while the lotus seeds and the mulberries are hot, wherein the filtrate is reserved;
step three: drying semen Sojae Atricolor and semen Sesami Niger in the shade, pulverizing with pulverizer, sieving with 100 mesh sieve, placing in a preparation tank, heating and boiling for 40 min, stirring for dissolving, hot sieving with 200 mesh sieve, and filtering to obtain filtrate;
step four: uniformly mixing the filtrate obtained in the three steps and orange powder in proportion, and fixing the volume of purified water to be sufficient;
step five: refrigerating and standing the mixed solution obtained in the step four for 48 hours, and filtering the mixed solution through a plate and frame filter to obtain filtrate;
step six: placing the filtrate obtained in the fifth step into a clean stainless steel liquid storage tank, filling the filtrate into brown glass bottles meeting the sanitary requirements by using a filling machine, and adjusting the filling amount to be 10 mL/bottle;
step seven: sterilizing at 115 deg.C for 25 min, packaging, and inspecting.
4. The method for preparing an oral liquid with a kidney tonifying function according to claim 3, wherein the steps two to six are performed in a hundred thousand clean space.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911052363.9A CN110638921A (en) | 2019-10-31 | 2019-10-31 | Oral liquid with kidney tonifying function and preparation method thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201911052363.9A CN110638921A (en) | 2019-10-31 | 2019-10-31 | Oral liquid with kidney tonifying function and preparation method thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
CN110638921A true CN110638921A (en) | 2020-01-03 |
Family
ID=68995279
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201911052363.9A Pending CN110638921A (en) | 2019-10-31 | 2019-10-31 | Oral liquid with kidney tonifying function and preparation method thereof |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN110638921A (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114532511A (en) * | 2022-02-17 | 2022-05-27 | 西安元识鼎基因信息技术有限公司 | A Chinese medicinal pill for male and its preparation method |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1236009A (en) * | 1999-05-06 | 1999-11-24 | 兰国铨 | Preparing method for Chinese yam grape wine |
CN102048076A (en) * | 2009-10-27 | 2011-05-11 | 郝敬方 | Pure-natural plant-synthesized yam beverage |
CN104547555A (en) * | 2015-02-06 | 2015-04-29 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicinal composition having functions of enriching yin and nourishing kidney as well as preparation method and application of traditional Chinese medicinal composition |
-
2019
- 2019-10-31 CN CN201911052363.9A patent/CN110638921A/en active Pending
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1236009A (en) * | 1999-05-06 | 1999-11-24 | 兰国铨 | Preparing method for Chinese yam grape wine |
CN102048076A (en) * | 2009-10-27 | 2011-05-11 | 郝敬方 | Pure-natural plant-synthesized yam beverage |
CN104547555A (en) * | 2015-02-06 | 2015-04-29 | 广州白云山潘高寿药业股份有限公司 | Traditional Chinese medicinal composition having functions of enriching yin and nourishing kidney as well as preparation method and application of traditional Chinese medicinal composition |
Non-Patent Citations (3)
Title |
---|
宋世琴: "肾虚食疗三则", 《陕西中医》 * |
张德记: "《饮食五味调养防治》", 28 February 2018 * |
诺康养生: "哪方面不行感觉腰疼到底是不是肾虚", 《百度》 * |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114532511A (en) * | 2022-02-17 | 2022-05-27 | 西安元识鼎基因信息技术有限公司 | A Chinese medicinal pill for male and its preparation method |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103725573B (en) | A kind of imperial osmanthus wine and preparation method thereof | |
CN101253903B (en) | Health food with fat-reducing function and its preparation | |
CN101579120A (en) | Nutritional food with weight-losing function and preparation method thereof | |
CN109329680A (en) | A kind of composition containing ginseng extract and functional beverage as made from it | |
CN103815373B (en) | A kind of cooking wine containing iron sheet Herba Dendrobii extract and preparation method | |
CN105707598A (en) | Plant drink for dispelling alcohol effects and preparation method thereof | |
CN103330021B (en) | Health-preserving tea | |
CN106729188A (en) | It is a kind of with composition relieved inflammation or internal heat with antialcoholism function and preparation method thereof | |
CN101711840B (en) | Medicine-food dual-purpose composition suitable for cancerous patients and preparation method thereof | |
CN112755138A (en) | Qi-tonifying and spleen-tonifying lollipop and preparation method thereof | |
CN102266052A (en) | Health care food with function of improving sleeping | |
CN110638921A (en) | Oral liquid with kidney tonifying function and preparation method thereof | |
CN104206595A (en) | Blood lipid and blood glucose reducing Chinese wolfberry root-bark health care tea and preparation method thereof | |
CN108186966A (en) | A kind of composition for preventing or improving senile dementia and its application | |
CN104256821B (en) | A kind of agate coffee compound oral liquid and preparation method thereof | |
CN103463456A (en) | Traditional Chinese medicine composition and preparation method thereof | |
CN113521221A (en) | Sealwort ointment traditional Chinese medicine prescription with monarch, minister, assistant and guide compatibility | |
CN103181557A (en) | Nutritious food with slimming function and preparation method thereof | |
CN102242032B (en) | Health-care nutrient beer | |
CN105878517A (en) | Ointment capable of improving sleeping and preparation method of ointment | |
CN101934046B (en) | Semifluid extract of deer foetus and preparation method thereof | |
CN112089792A (en) | Beauty-cleaning cream and preparation method thereof | |
CN105368672A (en) | Health-care wine containing phellinus | |
CN105011309A (en) | Abalone and sea cucumber health-care drink | |
CN109157643A (en) | A kind of postpartum Chinese medicine lactagogue soluble granules and preparation method |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200103 |
|
RJ01 | Rejection of invention patent application after publication |