CN1958019A - Method for preparing gel of treating wean cough - Google Patents
Method for preparing gel of treating wean cough Download PDFInfo
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- CN1958019A CN1958019A CN 200510003260 CN200510003260A CN1958019A CN 1958019 A CN1958019 A CN 1958019A CN 200510003260 CN200510003260 CN 200510003260 CN 200510003260 A CN200510003260 A CN 200510003260A CN 1958019 A CN1958019 A CN 1958019A
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Abstract
A medicinal gel for treating infantile cough is prepared from 9 Chinese-medicinal materials including ephedra, loquat leaf, liquorice root, stemona root, etc through respectively extracting their active components to obtain liquid, adding fruit jelly powder, immersing at 40 deg.C, stirring, adding the aqueous solution of sweetening agent, potassium sorbate and citric acid, adding water, boiling and filling it in containers.
Description
Technical field
The invention belongs to medical technical field, relate in particular to a kind of preparation method of gel for the treatment of wean cough.
Background technology
Cough is the common respiratory tract disease of child, this type of medicine mainly contains dosage forms such as granule, syrup, mixture, tablet, capsule in the market, all there is certain defective, mainly contain: syrup, mixture etc. mostly is bottled, can't once take after the uncork, easily there is the possibility of polluting in grow mold; Need use boiled water when granule is taken, tablet need pulverize to be taken, and occurs dysphagia etc. when capsule is taken and takes inconvenient phenomenon; Though the syrup mouthfeel is sweeter, also have the bitterness of medicine after all, though some medicine has sugar-coat, still there is bitterness the inside.Most of children is all mismatched when taking medicine, and therefore, the head of a family generally believes that taking medicine to the child is the comparatively thing of difficulty of part.
Summary of the invention
A kind of determined curative effect that the objective of the invention is to overcome above-mentioned shortcoming and provide, steady quality, the simple easy operating of production method carries and taking convenience, can not cause secondary pollution, the preparation method of the gel for the treatment of wean cough that the child takes like a shot.
The preparation method of gel for the treatment of wean cough of the present invention comprises the steps:
(1) take by weighing the following weight proportion raw material:
Radix Asteris 130-170 part, Radix Stemonae 130-170 part, Folium Eriobotryae 130-170 part, Radix Peucedani 130-170 part, Radix Glycyrrhizae 45-55 part, Semen Armeniacae Amarum 90-110 part, Radix Platycodonis 45-55 part, Herba Ephedrae 22-28 part, Folium Polygoni Tinctorii 130-170 part;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, and relative density 1.13～1.16 when being concentrated into 50 ℃, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Relative density 1.13～1.16 when filtrate was concentrated into 50 ℃, added ethanol and made and contain alcohol amount and reach 60%, left standstill 24 hours, drew supernatant, reclaimed ethanol to there being the ethanol flavor, added 0.3% beta-schardinger dextrin-, stirred evenly, and obtained medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, added 8～12 parts of 40 ℃ of warm macerating of jelly powder 2 hours, heated and stirred is to dissolving, other gets 2 parts of aspartames, 1 part of potassium sorbate, citric acid and adds an amount of water heating for dissolving for 0.2 part, merges with above-mentioned solution, adds water to 900～1100 parts, abundant mixing, boiling sterilization is packed, promptly while hot.
The preparation method of gel for the treatment of wean cough comprises the steps: preferably
(1) take by weighing the following weight proportion raw material:
150 parts of Radix Asteriss, 150 parts of the Radixs Stemonae, 150 parts of Folium Eriobotryaes, 150 parts of Radix Peucedanis, 50 parts in Radix Glycyrrhizae, 100 parts of Semen Armeniacae Amarums, 50 parts of Radix Platycodoniss, 25 parts in Herba Ephedrae, 150 parts of Folium Polygoni Tinctoriis;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, is concentrated into relative density 1.13～1.16 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Filtrate is concentrated into relative density 1.13～1.16 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, adds 0.3% beta-schardinger dextrin-, stirs evenly, and obtains medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time,, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, added 8～12 parts of warm macerating of jelly powder (40 ℃) 2 hours, heated and stirred is to dissolving, other gets 2 parts of aspartames, 1 part of potassium sorbate, citric acid and adds an amount of water heating for dissolving for 0.2 part, merges with above-mentioned solution, adds water to 900～1100 parts, abundant mixing, boiling sterilization is packed, promptly while hot.
Above-mentioned jelly powder is that weight ratio is a carrageenan: the mixture of Konjac glucomannan=1: 2.
The present invention compared with prior art, be through repetition test, optimize the preferable prescription of effect that is used to prepare treatment infantile cough medicine, at this prescription active ingredient curative effect of medication, bioavailability, technical specifications such as stability, optimizing the adjuvant gel-type vehicle is jelly powder, in conjunction with adopting scientific and reasonable technological design, medicine of the present invention is made food (fruit jelly) form that liked by the child, curative effect of medication not only, technical specifications such as bioavailability can not change, and the gel of making (fruit jelly) steady quality, be not prone to the easy elutriation that occurs of common fruit jelly and go out phenomenon, and the simple easy operating of production method, also can be deployed into various tastes as required.Carry and taking convenience, can not cause secondary pollution, thereby the child takes like a shot and can reach conscious effect of taking medicine, thoroughly solved child's problem of difficult of taking medicine, and Chinese medicine manufacturer is had extensive applicability.
The specific embodiment
Embodiment 1:
(1) take by weighing the following weight proportion raw material:
Radix Asteris 130g, Radix Stemonae 130g, Folium Eriobotryae 130g, Radix Peucedani 130g, Radix Glycyrrhizae 45g, Semen Armeniacae Amarum 90g, Radix Platycodonis 45g, Herba Ephedrae 22g, Folium Polygoni Tinctorii 130g;
Carrageenan 2.67g, Konjac glucomannan 5.33g;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, is concentrated into relative density 1.16 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Filtrate is concentrated into relative density 1.16 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, adds 0.3% beta-schardinger dextrin-, stirs evenly, and obtains medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time,, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, adding mixed the jelly powder 8g warm macerating (40 ℃) that is made into 2 hours by carrageenan and Konjac glucomannan, heated and stirred is to dissolving, and other gets aspartame 2g, potassium sorbate 1g, citric acid 0.2g, adds an amount of water heating for dissolving, merge with above-mentioned solution, add water to 900～1100g, abundant mixing, boiling sterilization, pack while hot, promptly.
Embodiment 2:
(1) take by weighing the following weight proportion raw material:
Radix Asteris 150g, Radix Stemonae 150g, Folium Eriobotryae 150g, Radix Peucedani 150g, Radix Glycyrrhizae 50g, Semen Armeniacae Amarum 100g, Radix Platycodonis 50g, Herba Ephedrae 25g, Folium Polygoni Tinctorii 150g;
Carrageenan 3g, Konjac glucomannan 6g;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, is concentrated into relative density 1.15 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Filtrate is concentrated into relative density 1.15 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, adds 0.3% beta-schardinger dextrin-, stirs evenly, and obtains medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time,, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, adding mixed the jelly powder 9g warm macerating (40 ℃) that is made into 2 hours by carrageenan and Konjac glucomannan, heated and stirred is to dissolving, and other gets aspartame 2g, potassium sorbate 1g, citric acid 0.2g, adds an amount of water heating for dissolving, merge with above-mentioned solution, add water to 900～1100g, abundant mixing, boiling sterilization, pack while hot, promptly.
Embodiment 3:
(1) take by weighing the following weight proportion raw material:
Radix Asteris 170g, Radix Stemonae 170g, Folium Eriobotryae 170g, Radix Peucedani 170g, Radix Glycyrrhizae 55g, Semen Armeniacae Amarum 110g, Radix Platycodonis 55g, Herba Ephedrae 28g, Folium Polygoni Tinctorii 170g;
Carrageenan 4g, Konjac glucomannan 8g;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, is concentrated into relative density 1.13 (50 ℃), adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Filtrate is concentrated into relative density 1.13 (50 ℃), adds ethanol and makes and contain alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, adds 0.3% beta-schardinger dextrin-, stirs evenly, and obtains medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time,, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, adding mixed the jelly powder 12g warm macerating (40 ℃) that is made into 2 hours by carrageenan and Konjac glucomannan, heated and stirred is to dissolving, and other gets aspartame 2g, potassium sorbate 1g, citric acid 0.2g, adds an amount of water heating for dissolving, merge with above-mentioned solution, add water to 900～1100g, abundant mixing, boiling sterilization, pack while hot, promptly.
Claims (3)
1, a kind of preparation method of gel for the treatment of wean cough comprises the steps:
(1) take by weighing the following weight proportion raw material:
Radix Asteris 130-170 part, Radix Stemonae 130-170 part, Folium Eriobotryae 130-170 part, Radix Peucedani 130-170 part, Radix Glycyrrhizae 45-55 part, Semen Armeniacae Amarum 90-110 part, Radix Platycodonis 45-55 part, Herba Ephedrae 22-28 part, Folium Polygoni Tinctorii 130-170 part;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, and relative density 1.13～1.16 when being concentrated into 50 ℃, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Relative density 1.13～1.16 when filtrate was concentrated into 50 ℃, added ethanol and made and contain alcohol amount and reach 60%, left standstill 24 hours, drew supernatant, reclaimed ethanol to there being the ethanol flavor, added 0.3% beta-schardinger dextrin-, stirred evenly, and obtained medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, added 8～12 parts of 40 ℃ of warm macerating of jelly powder 2 hours, heated and stirred is to dissolving, other gets 2 parts of aspartames, 1 part of potassium sorbate, citric acid and adds an amount of water heating for dissolving for 0.2 part, merges with above-mentioned solution, adds water to 900～1100 parts, abundant mixing, boiling sterilization is packed, promptly while hot.
2, the preparation method of gel for the treatment of wean cough as claimed in claim 1 comprises the steps:
(1) take by weighing the following weight proportion raw material:
150 parts of Radix Asteriss, 150 parts of the Radixs Stemonae, 150 parts of Folium Eriobotryaes, 150 parts of Radix Peucedanis, 50 parts in Radix Glycyrrhizae, 100 parts of Semen Armeniacae Amarums, 50 parts of Radix Platycodoniss, 25 parts in Herba Ephedrae, 150 parts of Folium Polygoni Tinctoriis;
(2) Herba Ephedrae, Folium Polygoni Tinctorii are added water boil after, in 80 ℃ of warm macerating secondaries, 2 hours for the first time, 1 hour for the second time, filter, merging filtrate obtains filtrate one;
(3) Radix Asteris, Folium Eriobotryae, Radix Glycyrrhizae, Radix Platycodonis are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered, and obtains filtrate two;
(4) filtrate one merges with filtrate two, and relative density 1.13～1.16 when being concentrated into 50 ℃, adds ethanol and makes and contain the alcohol amount and reach 60%, leaves standstill 24 hours, draws supernatant, reclaims ethanol to there being the ethanol flavor, obtains medicinal liquid one;
(5) Radix Stemonae, Radix Peucedani are decocted with water twice, 3 hours for the first time, 2 hours for the second time, collecting decoction filtered.Relative density 1.13～1.16 when filtrate was concentrated into 50 ℃, added ethanol and made and contain alcohol amount and reach 60%, left standstill 24 hours, drew supernatant, reclaimed ethanol to there being the ethanol flavor, added 0.3% beta-schardinger dextrin-, stirred evenly, and obtained medicinal liquid two;
(6) with Semen Armeniacae Amarum with 80% alcohol reflux secondary, 3 hours for the first time, 2 hours for the second time, filter, merging filtrate, and reclaim ethanol obtains medicinal liquid three;
(7) medicinal liquid one, medicinal liquid two and medicinal liquid three are merged, added 8～12 parts of 40 ℃ of warm macerating of jelly powder 2 hours, heated and stirred is to dissolving, other gets 2 parts of aspartames, 1 part of potassium sorbate, citric acid and adds an amount of water heating for dissolving for 0.2 part, merges with above-mentioned solution, adds water to 900～1100 parts, abundant mixing, boiling sterilization is packed, promptly while hot.
3, the preparation method of gel for the treatment of wean cough as claimed in claim 1 or 2, wherein jelly powder is that weight ratio is a carrageenan: the mixture of Konjac glucomannan=1: 2.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 200510003260 CN1958019A (en) | 2005-11-03 | 2005-11-03 | Method for preparing gel of treating wean cough |
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| Application Number | Priority Date | Filing Date | Title |
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| CN 200510003260 CN1958019A (en) | 2005-11-03 | 2005-11-03 | Method for preparing gel of treating wean cough |
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| CN1958019A true CN1958019A (en) | 2007-05-09 |
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| CN 200510003260 Pending CN1958019A (en) | 2005-11-03 | 2005-11-03 | Method for preparing gel of treating wean cough |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139068A (en) * | 2011-03-13 | 2011-08-03 | 李义军 | Traditional Chinese medicine for treating cough in children |
| CN103027228A (en) * | 2012-12-29 | 2013-04-10 | 罗永祺 | Radix stemonae-konjak soup and making method thereof |
| CN103330114A (en) * | 2013-06-27 | 2013-10-02 | 叶建斌 | Cough-preventing jelly and preparation method thereof |
| CN103599440A (en) * | 2013-10-31 | 2014-02-26 | 广西健丰药业有限公司 | Traditional Chinese medicine combination containing mango leaf |
-
2005
- 2005-11-03 CN CN 200510003260 patent/CN1958019A/en active Pending
Cited By (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102139068A (en) * | 2011-03-13 | 2011-08-03 | 李义军 | Traditional Chinese medicine for treating cough in children |
| CN102139068B (en) * | 2011-03-13 | 2012-10-31 | 李义军 | Traditional Chinese medicine for treating cough in children |
| CN103027228A (en) * | 2012-12-29 | 2013-04-10 | 罗永祺 | Radix stemonae-konjak soup and making method thereof |
| CN103330114A (en) * | 2013-06-27 | 2013-10-02 | 叶建斌 | Cough-preventing jelly and preparation method thereof |
| CN103599440A (en) * | 2013-10-31 | 2014-02-26 | 广西健丰药业有限公司 | Traditional Chinese medicine combination containing mango leaf |
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