CN103157002B - Pure traditional Chinese medicine composition for treating diabetes mellitus and preparation method for same - Google Patents
Pure traditional Chinese medicine composition for treating diabetes mellitus and preparation method for same Download PDFInfo
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- CN103157002B CN103157002B CN201110408891.0A CN201110408891A CN103157002B CN 103157002 B CN103157002 B CN 103157002B CN 201110408891 A CN201110408891 A CN 201110408891A CN 103157002 B CN103157002 B CN 103157002B
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- 239000003814 drug Substances 0.000 title claims abstract description 40
- 206010012601 diabetes mellitus Diseases 0.000 title claims abstract description 18
- 239000000203 mixture Substances 0.000 title claims abstract description 15
- 238000002360 preparation method Methods 0.000 title claims abstract description 15
- 239000002775 capsule Substances 0.000 claims abstract description 9
- 241000222336 Ganoderma Species 0.000 claims abstract description 6
- 229940079593 drug Drugs 0.000 claims description 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 6
- 239000009636 Huang Qi Substances 0.000 claims description 5
- 239000004375 Dextrin Substances 0.000 claims description 3
- 229920001353 Dextrin Polymers 0.000 claims description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 3
- 229930006000 Sucrose Natural products 0.000 claims description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 3
- 238000007605 air drying Methods 0.000 claims description 3
- 239000003153 chemical reaction reagent Substances 0.000 claims description 3
- 235000019425 dextrin Nutrition 0.000 claims description 3
- 238000001914 filtration Methods 0.000 claims description 3
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 238000007689 inspection Methods 0.000 claims description 3
- 238000012856 packing Methods 0.000 claims description 3
- 239000000741 silica gel Substances 0.000 claims description 3
- 229910002027 silica gel Inorganic materials 0.000 claims description 3
- 239000007779 soft material Substances 0.000 claims description 3
- 239000005720 sucrose Substances 0.000 claims description 3
- 235000019640 taste Nutrition 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 abstract description 10
- 239000008280 blood Substances 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 102000004877 Insulin Human genes 0.000 abstract description 5
- 108090001061 Insulin Proteins 0.000 abstract description 5
- 229940125396 insulin Drugs 0.000 abstract description 5
- 230000017531 blood circulation Effects 0.000 abstract description 3
- 210000003734 kidney Anatomy 0.000 abstract description 3
- 230000035922 thirst Effects 0.000 abstract description 3
- 238000004519 manufacturing process Methods 0.000 abstract description 2
- 230000003000 nontoxic effect Effects 0.000 abstract description 2
- 210000000496 pancreas Anatomy 0.000 abstract 2
- 230000001737 promoting effect Effects 0.000 abstract 2
- 241000045403 Astragalus propinquus Species 0.000 abstract 1
- 235000002722 Dioscorea batatas Nutrition 0.000 abstract 1
- 235000006536 Dioscorea esculenta Nutrition 0.000 abstract 1
- 240000001811 Dioscorea oppositifolia Species 0.000 abstract 1
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 abstract 1
- 235000006533 astragalus Nutrition 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 210000003296 saliva Anatomy 0.000 abstract 1
- 230000028327 secretion Effects 0.000 abstract 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 11
- 239000008103 glucose Substances 0.000 description 11
- 210000004153 islets of langerhan Anatomy 0.000 description 4
- 230000000680 avirulence Effects 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 230000007423 decrease Effects 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000006870 function Effects 0.000 description 2
- 230000002218 hypoglycaemic effect Effects 0.000 description 2
- 230000007774 longterm Effects 0.000 description 2
- 235000012054 meals Nutrition 0.000 description 2
- 238000012544 monitoring process Methods 0.000 description 2
- 230000021595 spermatogenesis Effects 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
- 230000001419 dependent effect Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000007410 oral glucose tolerance test Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000002994 raw material Substances 0.000 description 1
- 238000012552 review Methods 0.000 description 1
- 210000002784 stomach Anatomy 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Landscapes
- Medicines Containing Plant Substances (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses a pure traditional Chinese medicine composition for treating diabetes mellitus and a preparation method for the same. The product disclosed by the invention contains the following ingredients in parts by weight: 21 parts of lucid ganoderma, 31.6 parts of Chinese yam, 15.8 parts of astragalus mongholicus, 15.8 parts of rhizoma polygonati, and 15.8 parts of caulis spatholobi. The medicine composition for treating diabetes mellitus disclosed by the invention is a pure traditional Chinese medicine capsule; and the capsule disclosed by the invention has the effects of nourishing yin and the kidney, promoting the secretion of saliva and slaking thirst, clearing heat and relieving fidget, and reducing blood sugar, and is capable of accelerating the blood circulation of the pancreas islet and promoting pancreas islet residual to generate insulin, and then achieving the effect of treating various diabetes mellitus. The traditional Chinese medicine composition disclosed by the invention has the advantages of being safe and reliable, non-toxic, stable and controllable in quality, convenient to take, simple in preparation process, and the like, and production for the traditional Chinese medicine composition can be finished by conventional equipment.
Description
Technical field
The invention belongs to Chinese medicine medicine field, is related to a kind of pure Chinese medicine drug regimen for treating diabetes and its preparation
Method.
Background technology
At present, it is many with regard to treating the product of diabetes currently on the market, but with the safe and nontoxic property of long-term taking, nothing
Dependent product is little.And good few of long-term taking effect.
The content of the invention
The purpose of the present invention aims to provide a kind of pure Chinese medicine drug regimen for treating diabetes and preparation method thereof, this
The capsule being related in invention reaches yin nourishing nourishing kidney to adjust function of human body, and spermatogenesis quenches the thirst, clearing heat and relieving fidgetness, drops hypoglycemic effect.
Islets of langerhans blood circulation can be accelerated, the residual generation insulin of islets of langerhans is improved.And then reach the effect for treating each patients with type Ⅰ DM.The present invention's
Chinese medicine composition have the advantages that safe and reliable, avirulence, it is stable and controllable for quality, conveniently take, preparation process is simple.
The technical scheme is that：A kind of pure Chinese medicine drug regimen and its preparation side for treating diabetes is provided
Method, it is characterised in that the crude drug composition and its weight proportion that it contains be：21 parts of Ganoderma, 31.6 parts of Rhizoma Dioscoreae, the Radix Astragali 15.8
Part, 15.8 parts of Rhizoma Polygonati, 15.8 parts of Caulis Spatholobi.
A kind of preparation method for treating the pure Chinese medicine drug regimen of diabetes, it is characterised in that it includes following
Step：
1）Crude drug is weighed by following weight ratio：21 parts of Ganoderma, 31.6 parts of Rhizoma Dioscoreae, 15.8 parts of the Radix Astragali, 15.8 parts of Rhizoma Polygonati,
15.8 parts of Caulis Spatholobi.
2）The above five tastes, add water to cook it is secondary, 2 hours every time, filtration, collecting decoction, be concentrated into relative density 50-
1.20-1.30 clear paste when 60 DEG C；
3）1 part of qinghuo reagent, 1.7 parts of sucrose, 1.5 parts of dextrin, mix homogeneously, plus ethanol soft material, the granulation of 18 mesh sieves, 55-
60 DEG C of forced air dryings, add micropowder silica gel mix homogeneously；
4）Upper capsule filling machine is filled；
5）Inner packing；
6）Outer package, product inspection, warehouse-in.
This pure Chinese medicine drug regimen for treating diabetes of the present invention and preparation method thereof pure Chinese medicine drug regimen
Capsule realize yin nourishing nourishing kidney to adjust function of human body, spermatogenesis quenches the thirst, clearing heat and relieving fidgetness, drops hypoglycemic effect.Islets of langerhans can be accelerated
Blood circulation, improves the residual generation insulin of islets of langerhans.And then reach the effect for treating each patients with type Ⅰ DM.It is an advantage of the invention that：This
The Chinese medicine composition of invention have the advantages that safe and reliable, avirulence, it is stable and controllable for quality, conveniently take, preparation process is simple.
Specific embodiment
With reference to specific embodiment, the invention will be further described, but not as limitation of the present invention.This reality
The part applied without detailed narration in example is to adopt prior art, and industry standard or known approaches.
Embodiment
Described this pure Chinese medicine drug regimen for treating diabetes and preparation method thereof is made of using following steps
's：
1）Raw material is weighed by following weight ratio：21 parts of Ganoderma, 31.6 parts of Rhizoma Dioscoreae, 15.8 parts of the Radix Astragali, 15.8 parts of Rhizoma Polygonati, chicken
15.8 parts of Caulis seu Radix Schisandrae Henryi.
2）The above five tastes, add water to cook it is secondary, 2 hours every time, filtration, collecting decoction, be concentrated into relative density 1.20-
1.30（50―60℃）Clear paste；
3）1 part of qinghuo reagent, 1.7 parts of sucrose, 1.5 parts of dextrin, mix homogeneously, plus ethanol soft material, the granulation of 18 mesh sieves, 55-
60 DEG C of forced air dryings, add micropowder silica gel mix homogeneously；
4）Upper capsule filling machine is filled；
5）Inner packing；
6）Outer package, product inspection, warehouse-in.
The embodiment of the present invention is this to be seen for treating the clinical of the pure Chinese medicine drug regimen capsule for treating diabetes of diabetes
Examine：
Case selection
161 diabeticss are chosen, treatment group's 8l examples, man 47, female 34 is 51～79 years old age, average 65 years old, sick
Journey 0.5～2.5 year；Matched group 80, man 45, female 35,49～73 years old age, average 61 years old, the course of disease 0.5～2 year.2 groups
The case state of an illness, the course of disease and age difference are little, with comparability.
Therapeutic Method
Treatment group adopts this pure Chinese medicine drug regimen capsule for treating diabetes of the oral inventive embodiments, every night
Sleep first 1 time, daily 7 blood glucose values of monitoring, adjustment dosage is until blood glucose fluctuation.Matched group adopts insulin pump continuous subcutaneous infusion
Insulin, daily 7 blood glucose values of monitoring, adjust basic crack and heavy dose of before the meal to blood glucose fluctuation, and blood glucose fluctuation is on an empty stomach≤6.1
Mmol/L.After 2 h≤7.8mmol/L after the meal, treatment 2 months, review standards：Oral glucose tolerance test.
Curative effect determinate standard
It is effective：Tcm clinical practice symptom, sign are obviously improved, fasting glucose and 2h-plasma glucose, drop to normal range；Have
Effect：Tcm clinical practice symptom, sign take a favorable turn, and fasting glucose and 2h-plasma glucose decrease beyond 20% before treatment；It is invalid：It is empty
Abdomen blood glucose and 2h-plasma glucose decline not substantially, or symptom is without improvement.
As a result
From table 1, from therapeutic outcome it can be seen that treatment group is substantially better than matched group, Jing statistics
Learning processing difference has significance（P<0.05）, it is statistically significant.
It is taken as that this pure Chinese medicine drug regimen for treating diabetes of the present invention and preparation method thereof, with safety
Reliability, avirulence, it is stable and controllable for quality, conveniently take, preparation process is simple the advantages of, conventional equipment can complete production, value
Obtain and further study.
Above-mentioned some operating process and data unit belong to the conventional or well-known operations process of the industry, do not chat one by one here
State.
Claims (1)
1. a kind of pure Chinese medicine drug regimen for treating diabetes, it is characterised in that crude drug composition and its weight that it includes
Proportioning is：21 parts of Ganoderma, 31.6 parts of Rhizoma Dioscoreae, 15.8 parts of the Radix Astragali, 15.8 parts of Rhizoma Polygonati, 15.8 parts of Caulis Spatholobi；
A kind of above-mentioned preparation method for treating the pure Chinese medicine drug regimen of diabetes, comprises the following steps：
1）Crude drug is weighed by following weight ratio：21 parts of Ganoderma, 31.6 parts of Rhizoma Dioscoreae, 15.8 parts of the Radix Astragali, 15.8 parts of Rhizoma Polygonati,
15.8 parts of Caulis Spatholobi；
2）The above five tastes, add water to cook it is secondary, 2 hours every time, filtration, collecting decoction is concentrated into relative density at 50-60 DEG C
When 1.20-1.30 clear paste；
3）1 part of qinghuo reagent, 1.7 parts of sucrose, 1.5 parts of dextrin, mix homogeneously, plus ethanol soft material, the granulation of 18 mesh sieves, 55-
60 DEG C of forced air dryings, add micropowder silica gel mix homogeneously；
4）Upper capsule filling machine is filled；
5）Inner packing；
6）Outer package, product inspection, warehouse-in.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110408891.0A CN103157002B (en) | 2011-12-11 | 2011-12-11 | Pure traditional Chinese medicine composition for treating diabetes mellitus and preparation method for same |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110408891.0A CN103157002B (en) | 2011-12-11 | 2011-12-11 | Pure traditional Chinese medicine composition for treating diabetes mellitus and preparation method for same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103157002A CN103157002A (en) | 2013-06-19 |
| CN103157002B true CN103157002B (en) | 2017-05-03 |
Family
ID=48580867
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201110408891.0A Active CN103157002B (en) | 2011-12-11 | 2011-12-11 | Pure traditional Chinese medicine composition for treating diabetes mellitus and preparation method for same |
Country Status (1)
| Country | Link |
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| CN (1) | CN103157002B (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106072556A (en) * | 2016-06-29 | 2016-11-09 | 马建民 | For health food regulating blood glucose and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520878A (en) * | 2003-02-13 | 2004-08-18 | 萍 陈 | Preparing process for nutrition and health oral liquid |
-
2011
- 2011-12-11 CN CN201110408891.0A patent/CN103157002B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1520878A (en) * | 2003-02-13 | 2004-08-18 | 萍 陈 | Preparing process for nutrition and health oral liquid |
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| Publication number | Publication date |
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| CN103157002A (en) | 2013-06-19 |
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| CB03 | Change of inventor or designer information |
Inventor after: Song Zhe Inventor after: Li Qiufei Inventor after: Song Yuanzhi Inventor after: Tang Yonghong Inventor before: Song Yuanzhi Inventor before: Song Zhe Inventor before: Tang Yonghong |
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Address after: Room 1, No. 710077 B601 gazelle Valley in Shaanxi province high tech Zone of Xi'an Jinye Road No. 69 business development park C District Patentee after: Xi'an Tyco pharmaceuticals Polytron Technologies Inc Address before: 710077, 1-10502B, No. 2, No. 85, No. 3 Road, Xi'an hi tech Zone, Shaanxi Patentee before: Taikomed Consulting Ltd. |
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Denomination of invention: Pure traditional Chinese medicine composition for treating diabetes mellitus and preparation method for same Effective date of registration: 20180208 Granted publication date: 20170503 Pledgee: Shaanxi SME financing Company limited by guarantee Pledgor: Xi'an Tyco pharmaceuticals Polytron Technologies Inc Registration number: 2018610000023 |
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