CN1954879A - Granule of zhamusa-four-does and its preparation method - Google Patents
Granule of zhamusa-four-does and its preparation method Download PDFInfo
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- CN1954879A CN1954879A CN 200510116623 CN200510116623A CN1954879A CN 1954879 A CN1954879 A CN 1954879A CN 200510116623 CN200510116623 CN 200510116623 CN 200510116623 A CN200510116623 A CN 200510116623A CN 1954879 A CN1954879 A CN 1954879A
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- lixiviating solution
- zhamusa
- granule
- fructus
- rhizoma zingiberis
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Abstract
A 4-element Zhamusha, a Mongolian medicine, in the form of particles is prepared from salit, myrobalan, dried ginger and long pepper through pulverizing salit, extracting active components from others in solvent, mixing, adding excipient, drying and granulating.
Description
Technical field
The present invention relates to treat the medicine of indigestion disease, relate in particular to dosage form of zhamusa-four-does and preparation method thereof.
Background technology
Zhamusa-four-does comes from " the paramount side that wants ", it is a kind of medicine for the treatment of the indigestion disease, form by natural salt, Rhizoma Zingiberis, Fructus Piperis Longi and Fructus Chebulae, also claim " four flavors wait branch soup " or natural salt-4 flavor soup, be very important a kind of in the mongolian medicine, be used for removing " Ba Dagan " sympotoms caused by cold factors such as the vomiting and diarrhoea that medicine and food indigestion, Ba Dagan bag cause as disease and Ba Dagan, belch, flatulence.According to traditional Mongolian medicine record, so-called Ba Da does disease and is meant that Ba Dagan increases that all diseases are inappetence due to the Sheng, dyspepsia, and n or V, flatulence is vexed, and belch is done frequently, and the sense of taste is unwise, and the body sense is heavy etc.Ba Dagan bag as disease show as that health is heavy, xerostomia, anorexia, stomach pain, urinate arteries and veins and all are thermal image.
Among its side, bright saline taste one-tenth, warm in nature, sharp can remove Ba Dagan, help digestion; The Fructus Chebulae and in, coordinate voxel, and have Detoxication; Rhizoma Zingiberis and Fructus Piperis Longi, acrid in the mouth, warm in nature, sharp is mended stomach-fire, removes dried hertz of Ba Da and complies with (Ba Da does the conspicuous symptom that disease is meant that the disease merging of Ba Dagan and He Yi occurs of complying with).Use each crude drug combination back of distinguishing the flavor of, and the stomach-fire that the improper fiery bad habit of daily life is caused is failed and disease such as dyspepsia has better curative effect.
Over the past thousands of years, this medicine is taken with the conventional dosage forms-zhamusa-four-does soup of mongolian medicine always, with etc. natural salt, Rhizoma Zingiberis, Fructus Piperis Longi and the Fructus Chebulae of weight be milled to powder and be zhamusa-four-does soup, when taking flour put in patient's mouth and uses mixing in water for oral taking.Though it is called zhamusa-four-does soup, all take after mixing it with water with above-mentioned powder type always.Because this dosage form and take mode causes this drug administration inconvenience, and onset time is long, drug effect is not remarkable, has limited the effect of this medicine.
Summary of the invention
According to the deficiencies in the prior art, technical problem to be solved by this invention is to propose a kind of being suitable for to take, and rapid-action, the significant zhamusa-four-does granule of drug effect and preparation method thereof.
The objective of the invention is to be achieved through the following technical solutions.
The invention provides a kind of granule of zhamusa-four-does, it comprises the lixiviating solution of natural salt, Fructus Chebulae's lixiviating solution, Rhizoma Zingiberis and Fructus Piperis Longi.
The present invention also provides a kind of method for preparing the zhamusa-four-does granule, and this method may further comprise the steps:
A. the weight proportion by former zhamusa-four-does soup formula takes by weighing natural salt, Fructus Chebulae, Rhizoma Zingiberis and Fructus Piperis Longi;
B. natural salt is ground into powder or ultra-micro powder, standby;
C. use solvent, for example alcohol or water extraction Fructus Chebulae, Fructus Chebulae's lixiviating solution;
D. use solvent, for example water and/or alcohol extraction Fructus Piperis Longi and Rhizoma Zingiberis, the lixiviating solution of Fructus Piperis Longi and Rhizoma Zingiberis;
E. powder that above-mentioned steps b, c and d are obtained and lixiviating solution mix, or add an amount of excipient in addition, and drying is granulated.
Wherein, among the step b, preferably natural salt is ground into ultra-micro powder, for example;
Among the step c, preferably use the second alcohol and water, more preferably water extracts as solvent, and the gained lixiviating solution preferably re-uses after making fluid extract through concentrating;
In the steps d, preferably extract as solvent with 70% ethanol, the gained lixiviating solution re-uses after preferably being condensed into thick paste;
Among the step e, excipient preferably uses beta-schardinger dextrin-or medical starch, and the drying and granulating process is preferably by using about 60 ℃ flowing steam to carry out.
Among the present invention, natural salt, Rhizoma Zingiberis, Fructus Piperis Longi and Fructus Chebulae can buy from pharmacy, and its specification should meet national medical standard.
The inventor finds by big quantity research and test, and natural salt is ground into powder, especially is ground into ultra-micro powder, can make cell wall breaking, can better bring into play its effect; The Fructus Chebulae is because contain tannin class material, thus use solution, particularly alcohol or water, more especially water extraction can lixiviate go out main effective ingredient; Fructus Piperis Longi and Rhizoma Zingiberis because of it contains volatility oils and alkaloids composition, are used solvent, and particularly alcohol and/or water use after more especially 70% alcoholic solution extracts, and have good effect.
The instructions of taking of zhamusa-four-does granule of the present invention is: be converted into the weight agent of raw materials used medicine, each 3-5 gram, every day 2-3 time.
The granule of the zhamusa-four-does made from the inventive method concentrates the raw material the effective elements of the medicine and cooperates, and can better bring into play efficacy of drugs, and taking convenience, does not have uncomfortable sensations such as pungent when taking.
Further specify the effect of granule of the present invention below in conjunction with clinical trial.
One, material source
Medicine for treatment is made the zhamusa-four-does granule by the Drug Manufacturing Room of west of Inner Mongolia crow flag Mongolian medicine hospital according to the inventive method, and specification is every bag 1 gram, is equivalent to crude drug 2 grams; The contrast medication is made the powder of zhamusa-four-does decoction by this hospital preparation chamber, includes crude drug 2 grams.
Two, patient source
100 routine patients from the outpatient service and the inpatient of west of Inner Mongolia crow flag Mongolian medicine hospital, are divided into two groups at random.Wherein 60 examples are organized in treatment, male 35 examples, 58.33%; Woman's 25 examples, 41.67%; Matched group 40 examples, male 28 examples, 70%; Woman's 12 examples, 30%.In 60 examples, suffer from medicine or sick 48 examples of food indigestion that sympotoms caused by cold factors cause, belch, flatulence 12 examples in the treatment group.In matched group 40 examples, suffer from medicine or sick 26 examples of food indigestion that sympotoms caused by cold factors cause, belch, flatulence 14 examples.Do not have significant difference (P＞0.5) between two groups, have comparability.
Three, Therapeutic Method
The treatment group gives the zhamusa-four-does granule, and every day 3 times, each 1 gram corresponding to crude drug 2 grams, is taken after mixing it with water with boiled water.Matched group gives zhamusa-four-does soup, and every day 3 times, each 2 grams are put in powder in patient's mouth, use mixing in water for oral taking.7-14 day is a course of treatment.During taking this medicine, withdraw other related drugs.
Four, therapeutic outcome
1, efficacy assessment standard:
Recovery from illness: symptom complete obiteration in the whirlwind 7 days; Take a turn for the better: the body symptom is clearly better in the 7-14 day of taking medicine; Invalid: the body symptom does not have change in the 7-14 day of taking medicine.
2, result: treatment is organized among the 60 routine patients, and cured person 38 examples account for 63.33%; Improvement person's 19 examples account for 31.67%; Nonresponder's 3 examples account for 5%; Total effective rate 95%.Among the matched group 40 routine patients, cured person 28 examples account for 70%; Improvement person's 6 examples account for 15%; Nonresponder's 6 examples account for 15%; Total effective rate 85%.Two groups of curative effects have been compared significant difference (P＜0.5).The curative effect of granule that zhamusa-four-does is described is apparently higher than traditional decoction.
The specific embodiment
Below in conjunction with embodiment embodiments of the present invention are described, but these embodiment and unrestricted embodiments of the present invention.The present invention has multiple different embodiment, has more than to be limited to content described in this description.Those skilled in the art is under the present application mental condition, and the scheme of being finished should be within the scope of the invention.
Embodiment 1
Take by weighing 1 kilogram natural salt, Rhizoma Zingiberis, Fructus Piperis Longi and Fructus Chebulae respectively; Natural salt is ground into micropowders; The Fructus Chebulae was extracted respectively 2 hours, 1 hour and 1 hour at 60 ℃ with pure water 5000ml, 3000ml and 2000ml, three extracting solution are mixed, concentrate and make fluid extract; Under 60 ℃ temperature, Rhizoma Zingiberis and Fructus Piperis Longi were extracted respectively 3 hours, 1.5 hours and 1 hour with 70% ethanol 6500ml, 4600ml and 3000ml, filter, filtrate is merged, reclaim ethanol, obtain aqueous stiff paste; Above-mentioned micropowders, fluid extract and moisture stiff paste are mixed, add 1 kilogram of beta-schardinger dextrin-, mixing through 60 ℃ flowing steam drying and granulating, is distributed into the fractional pack of 1.0 gram/bags.
Claims (9)
1. the granule of a zhamusa-four-does comprises the lixiviating solution of natural salt, Fructus Chebulae's lixiviating solution, Rhizoma Zingiberis and Fructus Piperis Longi.
2. granule as claimed in claim 1 is characterized in that, described Fructus Chebulae's lixiviating solution is the lixiviating solution of alcohol or water.
3. granule as claimed in claim 1 is characterized in that, the lixiviating solution of the lixiviating solution of described Rhizoma Zingiberis and Fructus Piperis Longi for using 70% ethanol to extract.
4. method for preparing the zhamusa-four-does granule, this method may further comprise the steps:
A. take by weighing natural salt, Fructus Chebulae, Rhizoma Zingiberis and Fructus Piperis Longi by former zhamusa-four-does soup formula weight proportion;
B. natural salt is ground into powder or ultra-micro powder, standby;
C. use the solvent extraction Fructus Chebulae, get Fructus Chebulae's lixiviating solution;
D. use solvent extraction Fructus Piperis Longi and Rhizoma Zingiberis, get the lixiviating solution of Fructus Piperis Longi and Rhizoma Zingiberis;
E. powder that above-mentioned steps b, c and d are obtained and lixiviating solution mix, or add an amount of excipient again, and drying is granulated.
5. method as claimed in claim 4 is characterized in that, solvent for use is alcohol or water among the step c; The gained lixiviating solution re-uses after making fluid extract through concentrating.
6. method as claimed in claim 5 is characterized in that, solvent for use is a water among the step c.
7. method as claimed in claim 4 is characterized in that, solvent for use is water and/or alcohol in the steps d; The gained lixiviating solution re-uses after being condensed into thick paste.
8. method as claimed in claim 7 is characterized in that, solvent for use is 70% alcoholic solution in the steps d.
9. method as claimed in claim 4 is characterized in that, among the step e, excipient is beta-schardinger dextrin-or medical starch; The drying and granulating process is undertaken by using about 60 ℃ flowing steam.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101166236A CN100571769C (en) | 2005-10-26 | 2005-10-26 | Granule of zhamusa-four-does and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB2005101166236A CN100571769C (en) | 2005-10-26 | 2005-10-26 | Granule of zhamusa-four-does and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1954879A true CN1954879A (en) | 2007-05-02 |
| CN100571769C CN100571769C (en) | 2009-12-23 |
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| Application Number | Title | Priority Date | Filing Date |
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| CNB2005101166236A Expired - Fee Related CN100571769C (en) | 2005-10-26 | 2005-10-26 | Granule of zhamusa-four-does and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700397B (en) * | 2009-11-10 | 2011-06-15 | 尼玛次仁 | Tibetan medicine composite for treating diabetes and preparation method of preparation thereof |
| CN103893733A (en) * | 2014-04-22 | 2014-07-02 | 青海省通天河藏药制药有限责任公司 | Preparation method of traditional Tibetan medicine for treating chronic gastritis |
-
2005
- 2005-10-26 CN CNB2005101166236A patent/CN100571769C/en not_active Expired - Fee Related
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101700397B (en) * | 2009-11-10 | 2011-06-15 | 尼玛次仁 | Tibetan medicine composite for treating diabetes and preparation method of preparation thereof |
| CN103893733A (en) * | 2014-04-22 | 2014-07-02 | 青海省通天河藏药制药有限责任公司 | Preparation method of traditional Tibetan medicine for treating chronic gastritis |
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| Publication number | Publication date |
|---|---|
| CN100571769C (en) | 2009-12-23 |
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