CN108066650B - Traditional Chinese medicine compound composition with effect of treating metabolic syndrome and preparation method and application thereof - Google Patents
Traditional Chinese medicine compound composition with effect of treating metabolic syndrome and preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a Chinese medicinal compound composition for treating metabolic syndrome, and a preparation method and application thereof, wherein the Chinese medicinal compound composition is prepared from 15-45 parts of radix pseudostellariae, 15-45 parts of radix ophiopogonis, 10-30 parts of salvia miltiorrhiza, 10-30 parts of sophora flower bud, 10-30 parts of chrysanthemum, 10-30 parts of honeysuckle, 10-30 parts of lalang grass rhizome and 10-30 parts of radish seed. The traditional Chinese medicine compound composition provided by the invention is prepared according to a formula by adopting a syndrome differentiation treatment theory, and clinical experiment results show that the traditional Chinese medicine compound composition has a comprehensive effect of multiple links and multiple targets, can correct glycolipid metabolic disorders of patients with metabolic syndrome, has the effects of reducing blood sugar, blood fat and blood pressure and improving insulin resistance, can be used for preventing and treating metabolic syndrome, and the clinical experiment results show that the traditional Chinese medicine compound provided by the invention has no adverse reaction after long-term use and is safer to use.
Description
Technical Field
The invention relates to a traditional Chinese medicine compound, in particular to a traditional Chinese medicine compound composition with a function of treating metabolic syndrome, and a preparation method and application thereof.
Background
Metabolic Syndrome (MS) is a group of clinical syndromes which take various metabolic abnormality clusters such as central obesity, hypertension, dyslipidemia, abnormal carbohydrate metabolism and the like as connotations and take insulin resistance as a common pathophysiological basis. In recent years, the incidence of clinical MS is higher and higher, the risk of cardiovascular and cerebrovascular diseases of the population is increased by 3 times, and the physical and psychological health of patients is seriously affected.
At present, most of the medicines for treating the metabolic syndrome are used, although western medicines used clinically have a certain curative effect, most of the western medicines have large adverse reactions, such as rebound after stopping taking the medicines, liver and kidney damage of patients, rhabdomyolysis and other side effects, and the symptoms are treated but not the root causes, while the traditional Chinese medicine has unique advantages in the aspect of treating the metabolic syndrome.
Disclosure of Invention
The purpose of the invention is as follows: the invention aims to solve the defects of the prior art and provides the traditional Chinese medicine compound which is scientific and reasonable in proportion, can obviously improve insulin resistance, blood sugar, blood fat and blood pressure of patients with metabolic syndrome and can improve clinical symptoms of the patients; the invention also aims to provide a preparation method and application of the traditional Chinese medicine compound composition.
The technical scheme is as follows: in order to achieve the above purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine compound composition with a function of treating metabolic syndrome is prepared from the following raw material medicines in parts by weight: 15-45 parts of radix pseudostellariae, 15-45 parts of radix ophiopogonis, 10-30 parts of salvia miltiorrhiza, 10-30 parts of sophora flower bud, 10-30 parts of chrysanthemum, 10-30 parts of honeysuckle, 10-30 parts of cogongrass rhizome and 10-30 parts of radish seed.
As a preferred scheme, the traditional Chinese medicine compound composition with the effect of treating metabolic syndrome is prepared from the following raw material medicines in parts by weight: 15-30 parts of radix pseudostellariae, 15-30 parts of radix ophiopogonis, 10-20 parts of salvia miltiorrhiza, 10-20 parts of sophora flower bud, 10-20 parts of chrysanthemum, 10-20 parts of honeysuckle, 10-20 parts of cogongrass rhizome and 10-20 parts of radish seed.
As a preferred scheme, the traditional Chinese medicine compound composition with the effect of treating metabolic syndrome is prepared from the following raw material medicines in parts by weight: 15 parts of radix pseudostellariae, 15 parts of radix ophiopogonis, 10 parts of salvia miltiorrhiza, 10 parts of sophora flower bud, 10 parts of chrysanthemum, 10 parts of honeysuckle, 10 parts of lalang grass rhizome and 10 parts of radish seed.
According to the traditional Chinese medicine theory and the clinical manifestations of metabolic syndrome, the project groups are summarized into the syndrome of qi-yin deficiency and blood stasis heat inclusion (the syndrome of yin deficiency with blood stasis) according to the symptoms. Adopts the method of supplementing qi, nourishing yin, removing blood stasis and relieving fever to treat. Through a large number of experimental screens, the Chinese herbal compound preferentially obtained by the invention is radix pseudostellariae, radix ophiopogonis, salvia miltiorrhiza, sophora japonica, chrysanthemum, honeysuckle, lalang grass rhizome and radish seed. Radix pseudostellariae is sweet in taste, slightly bitter and neutral in nature, and has the effects of tonifying qi and spleen, promoting the production of body fluid and moistening lung. Radix ophiopogonis is sweet and cold in flavor, and has the effects of nourishing yin, promoting the secretion of saliva or body fluid, moistening lung and clearing away heart-fire. The pseudostellaria root and the ophiopogon root are used as monarch drugs together, so that qi and yin are supplemented. Salvia miltiorrhiza, bitter in taste and slightly pungent in flavor, slightly cold in nature, activates blood and removes stasis, nourishes blood and tranquilizes mind, cools blood and reduces swelling. Flos Sophorae Immaturus is cold in nature, sweet and mild in taste, and has effects of clearing liver-fire, cooling blood and stopping bleeding. Chrysanthemum, sweet and bland in taste, cold in nature, clear heat, calm liver and improve eyesight. Honeysuckle flower, flos Lonicerae, sweet and cold in nature, has the effects of clearing away heat and toxic material, and dredging the channels and collaterals. Lalang grass rhizome, sweet and cold, cools blood to stop bleeding, clears heat and induces diuresis. The salvia miltiorrhiza, the sophora flower bud, the chrysanthemum, the honeysuckle and the lalang grass rhizome are combined as ministerial drugs for removing blood stasis and clearing heat. Radish seed, pungent, sweet and mild, has the functions of promoting digestion, relieving flatulence, descending qi, reducing phlegm, improving abdominal fullness symptoms of patients and promoting drug absorption, and is an adjuvant drug.
A medicine for treating metabolic syndrome is prepared from extract of Chinese medicinal compound composition and pharmaceutically acceptable vehicle by making into oral liquid, granule, capsule, tablet, powder for injection, dripping pill, soft capsule or injection.
Or the extract of the Chinese medicinal compound composition and a food acceptable carrier are prepared into effervescent tablets, tea bags or functional beverages according to a conventional method.
When the extracts of the raw materials of the traditional Chinese medicine compound provided by the invention are prepared into oral liquid, the extracts of the raw materials are dissolved in distilled water, filtered, and the pH value is adjusted to prepare the oral liquid.
When the extracts of the raw materials of the traditional Chinese medicine compound provided by the invention are prepared into tablets, the raw materials, lactose or corn starch and lubricant magnesium stearate are added if necessary, mixed uniformly, granulated and then tabletted to prepare the tablets.
When the extract of the traditional Chinese medicine compound provided by the invention is prepared into capsules, the extract of each raw material and carrier lactose or corn starch are uniformly mixed, granulated and then encapsulated to prepare the capsules.
When the extracts of the raw materials of the traditional Chinese medicine compound provided by the invention are prepared into granules, the extracts of the raw materials and diluent lactose or corn starch are uniformly mixed, granulated, dried and prepared into the granules.
When the extracts of the raw materials of the traditional Chinese medicine compound provided by the invention are prepared into powder injection, the extracts of the raw materials are frozen, dried and sterilized to prepare the powder injection.
When the extracts of the raw materials of the traditional Chinese medicine compound provided by the invention are prepared into injection, the extracts of the raw materials are taken and added with normal saline to be dissolved, then activated carbon is added, the mixture is uniformly stirred, heated at 80 ℃ for 30 minutes, filtered, adjusted in pH value, filtered by a sintered glass funnel or other filters until the mixture is clear, filled and sterilized at 100-115 ℃ for 30 minutes to prepare the injection.
The preparation method of the medicine with the effect of treating the metabolic syndrome nephropathy comprises the following steps:
(1) taking radix pseudostellariae, radix ophiopogonis, salvia miltiorrhiza, sophora japonica, chrysanthemum, honeysuckle and lalang grass rhizome according to the weight parts of any one of claims 1 to 3, adding water with the weight being 8-10 times of that of the medicinal materials, decocting or reflux-extracting for 2-3 times, 1-2 hours each time, combining the extracting solutions, and concentrating to obtain an extract for later use;
(2) taking radish seeds according to any one of claims 1 to 3, carrying out reflux extraction for 2-3 times by using ethanol with the weight of 8-10 times of that of medicinal materials, carrying out 1-2 hours each time, combining extracting solutions, recovering ethanol, and concentrating to obtain an extract for later use;
(3) and (3) mixing the extract obtained in the step (1) and the extract obtained in the step (2) with a pharmaceutically acceptable carrier, and preparing the mixture into the medicaments in the dosage forms of oral liquid, granules, capsules, tablets, powder injection, dropping pills, soft capsules or injection.
Or preparing the extract obtained in the step (1), the extract obtained in the step (2) and a food acceptable carrier into effervescent tablets, tea bags or functional beverages.
The invention relates to application of a traditional Chinese medicine compound composition with the effect of treating metabolic syndrome in preparation of a medicine for treating metabolic syndrome.
The invention relates to application of a traditional Chinese medicine compound composition with the effect of treating metabolic syndrome in preparation of a medicine for treating metabolic syndrome nephropathy.
The invention relates to application of a traditional Chinese medicine compound composition with the effect of treating metabolic syndrome in preparing a medicine for preventing and treating metabolic syndrome combined hyperlipidemia.
The invention relates to application of a traditional Chinese medicine compound composition with the effect of treating metabolic syndrome in preparing a medicine for preventing and treating the metabolic syndrome combined with peripheral neuritis.
Has the advantages that: according to the traditional Chinese medicine theory of treatment based on syndrome differentiation, the traditional Chinese medicine formula is screened according to the pathogenesis of metabolic syndrome and complications thereof, the provided traditional Chinese medicine compound is scientific and reasonable in proportion and rigorous in medication, and experimental results show that the traditional Chinese medicine compound composition provided by the invention has good effects of reducing blood pressure, blood sugar and blood fat. The traditional Chinese medicine compound composition provided by the invention has small toxic and side effects after long-term use and is safe and reliable to use.
Detailed Description
The present invention is further illustrated by the following examples, which are intended to be purely exemplary and are not intended to limit the scope of the invention, as various equivalent modifications of the invention will occur to those skilled in the art upon reading the present disclosure and fall within the scope of the appended claims.
Example 1
1. A traditional Chinese medicine compound composition with a function of treating metabolic syndrome is prepared from the following raw material medicines in parts by weight: 15g of radix pseudostellariae, 15g of radix ophiopogonis, 10g of salvia miltiorrhiza, 10g of sophora flower bud, 10g of chrysanthemum, 10g of honeysuckle, 10g of rhizoma imperatae and 10g of radish seed.
2. The preparation method of the traditional Chinese medicine compound composition with the effect of treating metabolic syndrome, which is disclosed by the invention, comprises the following steps of:
(1) taking 15g of radix pseudostellariae, 15g of radix ophiopogonis, 10g of salvia miltiorrhiza, 10g of sophora flower bud, 10g of chrysanthemum, 10g of honeysuckle and 10g of lalang grass rhizome according to the weight parts, adding water with the weight being 10 times of the weight of the medicinal materials, decocting and extracting for 3 times, each time for 1 hour, combining extracting solutions, and concentrating to obtain an extract for later use;
(2) taking 10g of radish seeds according to the weight part, carrying out reflux extraction for 2 times by using ethanol with the weight of 8 times of the weight of the medicinal materials, carrying out 2 hours each time, combining extracting solutions, recovering ethanol, and concentrating to obtain an extract for later use;
(3) and (3) uniformly mixing the extract obtained in the step (1) and the extract obtained in the step (2) with carrier lactose or corn starch, granulating, and encapsulating to prepare capsules. (batch number: 001)
Example 2
1. A traditional Chinese medicine compound composition with a function of treating metabolic syndrome is prepared from the following raw material medicines in parts by weight: 45g of radix pseudostellariae, 45g of radix ophiopogonis, 30g of salvia miltiorrhiza, 30g of sophora flower bud, 30g of chrysanthemum, 30g of honeysuckle, 30g of rhizoma imperatae and 30g of radish seed.
2. The preparation method of the traditional Chinese medicine compound composition with the effect of treating metabolic syndrome, which is disclosed by the invention, comprises the following steps of:
(1) taking 45g of radix pseudostellariae, 45g of radix ophiopogonis, 30g of salvia miltiorrhiza, 30g of sophora flower bud, 30g of chrysanthemum, 30g of honeysuckle and 30g of lalang grass rhizome according to the weight parts, adding water with the weight being 8 times of the weight of the medicinal materials, carrying out reflux extraction for 2 times, 2 hours each time, combining extracting solutions, and concentrating to obtain an extract for later use;
(2) taking 30g of radish seeds according to the weight part, carrying out reflux extraction for 3 times by using ethanol with the weight of 10 times of the weight of the medicinal materials, carrying out 1 hour each time, combining extracting solutions, recovering ethanol, and concentrating to obtain an extract for later use;
(3) dissolving the extract obtained in step (1) and the extract obtained in step (2) with distilled water, filtering, adjusting pH, and making into oral liquid. (batch No. 002)
Example 3
1. A traditional Chinese medicine compound composition with a function of treating metabolic syndrome is prepared from the following raw material medicines in parts by weight: 30g of radix pseudostellariae, 30g of radix ophiopogonis, 20g of salvia miltiorrhiza, 20g of sophora flower bud, 20g of chrysanthemum, 20g of honeysuckle, 20g of rhizoma imperatae and 20g of radish seed.
2. The preparation method of the traditional Chinese medicine compound composition with the effect of treating metabolic syndrome, which is disclosed by the invention, comprises the following steps of:
(1) taking 30g of radix pseudostellariae, 30g of radix ophiopogonis, 20g of salvia miltiorrhiza, 20g of sophora flower bud, 20g of chrysanthemum, 20g of honeysuckle and 20g of lalang grass rhizome according to the weight parts, adding water with the weight being 12 times of the weight of the medicinal materials, carrying out reflux extraction for 2 times, and carrying out 1 hour each time, combining extracting solutions, and concentrating to obtain an extract for later use;
(2) taking 20g of radish seeds according to the weight part, carrying out reflux extraction for 2 times by using ethanol with the weight of 8 times of the weight of the medicinal materials, carrying out 2 hours each time, combining extracting solutions, recovering ethanol, and concentrating to obtain an extract for later use;
(3) and (3) taking the extract obtained in the step (1) and the extract obtained in the step (2), adding a diluent cyclodextrin or corn starch, uniformly mixing, granulating, drying, and preparing into granules. (batch No. 003)
Example 4
And (3) freeze-drying the extract obtained in the step (1) in the embodiment 1 and the dry extract obtained in the step (2), sterilizing and preparing the powder injection. (batch number: 004)
EXAMPLE 5 clinical study
1 clinical data
1.1 diagnostic criteria:
the Western medicine diagnosis standard adopts the diagnosis standard in 'Chinese adult dyslipidemia prevention and treatment guideline' 2007, namely ① abdominal obesity, more than 90cm waist circumference of male, more than 85cm waist circumference of female, more than or equal to 1.7 mmol/L waist circumference of ② TG, less than 1.04 mmol/L blood HD L-C, more than or equal to 130/85mmHg blood pressure of ③, more than or equal to 6.1 mmol/L fasting blood sugar of ④ or more than or equal to 7.8 mmol/L blood sugar 2h after sugar load or has a history of diabetes, and people with the above 3 can be diagnosed as MS.
The traditional Chinese medicine diagnosis standard is as follows: according to the guideline of clinical research on new Chinese medicine, the syndrome of deficiency of both qi and yin and obstruction of collaterals by stagnant heat: the main symptoms are: shortness of breath, fatigue, dry mouth and throat, and obesity. The secondary symptoms are as follows: dysphoria with feverish sensation in the chest, palms and soles, tidal fever, night sweat, constipation, dizziness, tinnitus, palpitation, insomnia, thirst, polydipsia, soreness and weakness of waist and knees. Tongue pulse: a pale and dark tongue with ecchymosis or a red tongue with little body fluid, a thin or peeled coating, a thready, rapid and weak pulse, or a thready and wiry pulse. The above main symptoms are 3 items, and the secondary symptoms are 2 items, and the diagnosis can be confirmed by referring to the tongue pulse. Symptom grading and quantifying standard: the score criteria for the chief complaints were: no-0 min, light-2 min, medium-4 min and heavy-6 min. The secondary symptoms scoring standard is as follows: no-0 min, light-1 min, medium-2 min and heavy-3 min.
1.2 inclusion criteria: voluntarily attending, understanding and signing an informed consent; 45-70 years old with unlimited nature; it meets the diagnosis standard of Western medicine and Chinese medicine syndrome differentiation standard.
Exclusion criteria: pregnant or lactating women; patients with severe center of gravity, cerebrovascular diseases, primary kidney diseases, liver diseases, and blood system diseases; severe center of gravity, liver and renal insufficiency.
1.3 general data: and collecting qualified patients in the subsidiary hospital of the traditional Chinese medicine university from 8 months to 2016 months and 8 months of Nanjing in 2014 according to the above standards. The treatment groups were divided into 66 cases and 62 cases according to the random number table method. 31 male and 35 female in the treatment group, wherein the age range is 42-70 years, the average age is 56.24 +/-9.07, the disease course range is 11 months-10 years, and the average disease course is 5.78 +/-3.11; 30 male and 32 female control groups with age range of 41-67 years, mean age of 55.65 + -9.22, disease course range of 10 months-12 years and mean disease course of 5.82 + -2.98. The study was approved by the ethical committee of my hospital and informed consent was obtained from each patient. The difference between the two groups of patients in terms of sex, age, course of disease, fasting blood sugar, blood pressure, blood fat and the like has no statistical significance (P is more than 0.05), and the two groups of patients have comparability.
2 method
2.1 methods of treatment: and (4) health education: two groups of patients were asked to control diet and appropriate exercise. The basic western medicine treatment before the patients are treated is maintained in both groups, and for patients with abnormal blood sugar, pioglitazone hydrochloride capsules (15 mg/capsule, produced by Guangdong Rott pharmacy Co., Ltd.) are orally taken, 15mg each time; for the dyslipidemic patients, atorvastatin calcium tablets (20 mg/tablet, pfeiffe pharmaceutical limited) were taken 10 mg/time; for blood pressure disorder, valsartan capsule (80 mg/tablet, manufactured by Beijing Nowa pharmaceutical Co., Ltd.) was orally administered at 80mg each time 1 time per day. In addition, the treatment groups took: the capsule prepared in the embodiment 1 of the invention is taken 2 times a day; the control group received placebo capsules 2 times daily. The treatment period was observed to be 8 weeks.
2.2 Observation indexes of waistline, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Triglyceride (TG), cholesterol (TC), low density lipoprotein (L D L-C), high density lipoprotein (HD L-C), fasting plasma glucose, glycosylated hemoglobin, fasting insulin, insulin resistance index, cytokines including plasma tumor necrosis factor a (TNFa) and interleukin-6 (I L-6), and hematuria routine and liver and kidney function indexes.
2.3 statistical methods: all data were analyzed using SPSS12.0 software. Data are all represented as X + -S. Observation indicators for pre-and post-treatment comparisons within groups paired sample t-tests were used, for inter-group comparisons independent sample t-tests were used, and for count data X2 was used. The difference is statistically significant when P is less than 0.05.
3. Results of the experiment
3.1 the Effect of the Chinese medicinal composition of the invention on the blood pressure and waist circumference of patients
Table 1: the influence of the traditional Chinese medicine composition on blood pressure and waistline
| Group of | Number of examples | SBP(mmHg) | DBP(mmHg) | Waist circumference (cm) | |
| Control group | Before treatment | 62 | 145.72±8.53 | 89.38±7.02 | 93.61±5.36 |
| After treatment | 62 | 130.11±3.57# | 82.81±4.37# | 93.22±5.43 | |
| Treatment group | Before treatment | 66 | 146.02±9.51 | 88.87±8.84 | 93.87±5.72 |
| After treatment | 66 | 124.32±4.13#* | 77.16±3.52#* | 91.13±5.84#* |
# p < 0.05, compared to the group before treatment, # p < 0.05, compared to the control group at the same time
The SBP, DBP and waist circumference of the two groups before treatment have no significant difference (P is more than 0.05); after treatment, SBP and DBP in the two groups are obviously reduced; SBP and DBP of the traditional Chinese medicine composition after treatment are lower than those of a control group; the waistline of the traditional Chinese medicine composition is reduced to a certain extent after treatment, and the value of the traditional Chinese medicine composition has statistical significance after treatment with a control group. The result shows that the traditional Chinese medicine composition has good effect on blood pressure and waist circumference.
3.2 the Effect of the Chinese medicinal composition of the invention on the blood fat of patients
Table 2: the influence of the traditional Chinese medicine composition on blood fat
| Group of | Number of examples | TC(mmol/L) | TG(mmol/L) | LDL-C(mmol/L) | HDL-C(mmol/L) | |
| Control group | Before treatment | 62 | 5.72±0.64 | 2.78±0.43 | 4.05±0.37 | 1.17±0.27 |
| After treatment | 62 | 4.84±0.55 | 1.85±0.57# | 2.86±0.46# | 1.22±0.25 | |
| Treatment group | Before treatment | 66 | 5.61±0.73 | 2.67±0.42 | 4.13±0.56 | 1.16±0.25 |
| After treatment | 66 | 3.45±0.52#* | 1.71±0.35#* | 2.41±0.35#* | 1.23±0.24 |
# p < 0.05, compared to the group before treatment, # p < 0.05, compared to the control group at the same time
The TC, TG and L D L-C, HD L-C in the two groups before treatment have no significant difference (P is more than 0.05), and the TC, TG and L D L-C in the two groups after treatment are obviously reduced, wherein the TC, TG and L D L-C in the Chinese medicinal composition after treatment are lower than those in the control group, and the numerical value change of HD L-C in the two groups is not obvious.
3.3 Effect of the Chinese medicinal composition of the present invention on blood glucose of patients
Table 3: the influence of the traditional Chinese medicine composition on blood sugar
# p < 0.05, compared to the group before treatment, # p < 0.05, compared to the control group at the same time
As can be seen from Table 3 above, there was no significant difference (P > 0.05) between fasting plasma glucose, fasting insulin, insulin resistance index, and glycated hemoglobin in the first two groups; after treatment, the fasting blood sugar, the fasting insulin, the insulin resistance index and the glycosylated hemoglobin of the two groups are all obviously reduced; wherein the fasting blood sugar, the fasting insulin, the insulin resistance index and the glycosylated hemoglobin after the treatment of the traditional Chinese medicine composition are lower than the numerical values after the treatment of a control group. The results show that the traditional Chinese medicine composition has good effects of reducing blood sugar and inhibiting insulin resistance.
3.4 Effect of the Chinese medicinal composition of the present invention on the patient's cytokines TNFa and I L-6
Table 4: effect of the Chinese medicinal composition of the present invention on cytokines
| Group of | Number of examples | TNFa(ng/L) | IL-6(ng/L) | |
| Control group | Before treatment | 62 | 26.25±2.23 | 70.87±4.58 |
| After treatment | 62 | 17.34±1.67# | 43.75±2.24# | |
| Treatment group | Before treatment | 66 | 25.53±2.85 | 68.32±5.42 |
| After treatment | 66 | 13.31±1.26#* | 28.76±3.14#* |
# p < 0.05, compared to the group before treatment, # p < 0.05, compared to the control group at the same time
The TNFa and I L-6 of the two groups before treatment have no significant difference (P is more than 0.05), the TNFa and I L-6 of the two groups after treatment are obviously reduced, and the TNFa and I L-6 of the traditional Chinese medicine composition after treatment are lower than the values after treatment of a control group.
3.5 safety assay
The examinations of hematuria routine, liver and kidney functions and the like are carried out before and after the treatment of two groups of patients, and no adverse effect of taking test medicines on the hematuria routine, the liver and kidney functions is seen.
The invention is summarized into the syndrome of qi and yin deficiency and blood stasis and heat inclusion (yin deficiency with blood stasis) according to the traditional Chinese medicine theory and the clinical manifestations of metabolic syndrome. Adopts the method of supplementing qi, nourishing yin, removing blood stasis and relieving fever to treat. Through a large number of experimental screens, the Chinese herbal compound preferentially obtained by the invention is radix pseudostellariae, radix ophiopogonis, salvia miltiorrhiza, sophora japonica, chrysanthemum, honeysuckle, lalang grass rhizome and radish seed. Radix pseudostellariae is sweet in taste, slightly bitter and neutral in nature, and has the effects of tonifying qi and spleen, promoting the production of body fluid and moistening lung. Radix ophiopogonis is sweet and cold in flavor, and has the effects of nourishing yin, promoting the secretion of saliva or body fluid, moistening lung and clearing away heart-fire. The pseudostellaria root and the ophiopogon root are used as monarch drugs together, so that qi and yin are supplemented. Salvia miltiorrhiza, bitter in taste and slightly pungent in flavor, slightly cold in nature, activates blood and removes stasis, nourishes blood and tranquilizes mind, cools blood and reduces swelling. Flos Sophorae Immaturus is cold in nature, sweet and mild in taste, and has effects of clearing liver-fire, cooling blood and stopping bleeding. Chrysanthemum, sweet and bland in taste, cold in nature, clear heat, calm liver and improve eyesight. Honeysuckle flower, flos Lonicerae, sweet and cold in nature, has the effects of clearing away heat and toxic material, and dredging the channels and collaterals. Lalang grass rhizome, sweet and cold, cools blood to stop bleeding, clears heat and induces diuresis. The salvia miltiorrhiza, the sophora flower bud, the chrysanthemum, the honeysuckle and the lalang grass rhizome are combined as ministerial drugs for removing blood stasis and clearing heat. Radish seed, pungent, sweet and mild, has the functions of promoting digestion, relieving flatulence, descending qi, reducing phlegm, improving abdominal fullness symptoms of patients and promoting drug absorption, and is an adjuvant drug.
The traditional Chinese medicine compound provided by the invention is prepared according to the traditional Chinese medicine theory and by adopting the theory of treatment based on syndrome differentiation, and the experimental results show that the traditional Chinese medicine compound provided by the invention has the comprehensive effects of multiple links and multiple targets, can correct MS comprehensive symptoms and improve insulin resistance, and the clinical experimental results show that the traditional Chinese medicine compound provided by the invention has no adverse reaction after long-term use and is safer to take medicine.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (9)
1. A traditional Chinese medicine compound composition with a function of treating metabolic syndrome is characterized by being prepared from the following raw material medicines in parts by weight: 15-45 parts of radix pseudostellariae, 15-45 parts of radix ophiopogonis, 10-30 parts of salvia miltiorrhiza, 10-30 parts of sophora flower bud, 10-30 parts of chrysanthemum, 10-30 parts of honeysuckle, 10-30 parts of cogongrass rhizome and 10-30 parts of radish seed.
2. The compound traditional Chinese medicine composition with the effect of treating metabolic syndrome according to claim 1, is characterized by being prepared from the following raw material medicines in parts by weight: 15-30 parts of radix pseudostellariae, 15-30 parts of radix ophiopogonis, 10-20 parts of salvia miltiorrhiza, 10-20 parts of sophora flower bud, 10-20 parts of chrysanthemum, 10-20 parts of honeysuckle, 10-20 parts of cogongrass rhizome and 10-20 parts of radish seed.
3. The compound traditional Chinese medicine composition with the effect of treating metabolic syndrome according to claim 2, is characterized by being prepared from the following raw material medicines in parts by weight: 15 parts of radix pseudostellariae, 15 parts of radix ophiopogonis, 10 parts of salvia miltiorrhiza, 10 parts of sophora flower bud, 10 parts of chrysanthemum, 10 parts of honeysuckle, 10 parts of lalang grass rhizome and 10 parts of radish seed.
4. A medicine with the effect of treating metabolic syndrome is characterized in that the extract of the traditional Chinese medicine compound composition of any one of claims 1 to 3 and a pharmaceutically acceptable carrier are prepared into the medicines of oral liquid, granules, capsules, tablets, powder injection, dropping pills or injection formulations.
5. The process for producing a pharmaceutical composition for treating metabolic syndrome according to claim 4, comprising the steps of:
(1) taking radix pseudostellariae, radix ophiopogonis, salvia miltiorrhiza, sophora japonica, chrysanthemum, honeysuckle and lalang grass rhizome according to the weight parts of any one of claims 1 to 3, adding water with the weight being 8-10 times of that of the medicinal materials, decocting or reflux-extracting for 2-3 times, 1-2 hours each time, combining the extracting solutions, and concentrating to obtain an extract for later use;
(2) taking radish seeds according to any one of claims 1 to 3, carrying out reflux extraction for 2-3 times by using ethanol with the weight of 8-10 times of that of medicinal materials, carrying out 1-2 hours each time, combining extracting solutions, recovering ethanol, and concentrating to obtain an extract for later use;
(3) and (3) mixing the extract obtained in the step (1) and the extract obtained in the step (2) with a pharmaceutically acceptable carrier, and preparing the mixture into the medicaments in the dosage forms of oral liquid, granules, capsules, tablets, powder injection, dropping pills or injection.
6. Use of the compound Chinese medicinal composition for treating metabolic syndrome according to any one of claims 1 to 3 in the preparation of a medicament for treating metabolic syndrome.
7. The use of the compound Chinese medicinal composition for treating metabolic syndrome according to any one of claims 1 to 3 in the preparation of a medicament for treating metabolic syndrome complicated with diabetes.
8. Use of the compound Chinese medicinal composition for treating metabolic syndrome according to any one of claims 1 to 3 in the preparation of a medicament for preventing and treating metabolic syndrome complicated with hyperlipidemia.
9. The use of the Chinese herbal compound composition with the effect of treating metabolic syndrome according to any one of claims 1 to 3 in the preparation of a medicament for preventing and treating metabolic syndrome complicated with hypertension.
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| CN104940730A (en) * | 2015-07-16 | 2015-09-30 | 张善超 | Traditional Chinese medicine composition for treating metabolic syndrome |
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