CN1824127A - Spleen fortifying appetite increasing gel preparation for child and its preparation method - Google Patents
Spleen fortifying appetite increasing gel preparation for child and its preparation method Download PDFInfo
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Abstract
A Chinese medicine in the form of gel for baby to promote appetite and invigorate the function of spleen is prepared from 10 Chinese-medicinal materials including astragalus root, haw, jujube, yam, etc and one or more of konjak gum, carragreen gum, xanthan gum and guar gum. Its preparing process is also disclosed.
Description
Technical field: the present invention is a kind of spleen fortifying appetite increasing gel preparation for child and preparation method thereof, belongs to the technical field of medicine.
Technical background: anorexia, calcium deficiency are the common diseases of children's.Apositia is that the long appetite of children's is low, is subjected to the obviously symptom of influence to cause the normal nutritional development of children's.Infantile anorexia mainly is because the digestive functions disorder causes due to loss of appetite or the disappearance.Common cause has improper feeding, and living environment changes, psychentonia, drug influence, sickness influence etc.The anorexia overlong time can cause infant malnutrition, weak, the resistance decline of health, and so just easier generation other diseases causes adverse consequences.Infant lacks calcareous meeting and causes rickets, and it mainly shows is the skeleton hypocalcification, and hardness is relatively poor, thereby occurs that rib turns up, pigeon chest, funnel chest, and thorax and lower limb malformation such as bowlegs, can influence children's's growth promoter.The rickets prevalence is up to 40.7% in the infant, by Ministry of Public Health classify as the department of pediatrics keypoint control four big diseases it.Chinese medicine infantile anorexia, calcium deficiency etc. have one's own knack, and wherein commercially available infant spleen-tonifying appetizing mixture is exactly a Chinese medicine compound product evident in efficacy.But herb mixture occurs mildew, fermentation easily or quality problems such as precipitation occur, be unfavorable for medicine storage, carry, take, and the child is to the dislike emotion of common drug preparation, so infant use existing product has certain difficulty, displeased acceptance.In the real life, child patient quantity is huge, and is poor to the ability to accept of general formulation, and the outward appearance of medicine, mouthfeel directly influence the application and the curative effect of medicine; In view of the develop rapidly of medical science and to these situations that deepen continuously of dosage form research, need exploitation effective medicine preparation that a kind of market prospect is wide, the child takes like a shot, the treatment of pediatric patient is reached a new high, thereby infantile common cold patient's quality of life is further improved.
Summary of the invention: the objective of the invention is to: a kind of spleen fortifying appetite increasing gel preparation for child and preparation method thereof is provided; The present invention utilizes the prescription of existing commercially available infant spleen-tonifying appetizing mixture, be made into the fruit jelly or the soft sweet type gel that liked by the child, children's extremely is ready to take, reduce the adult and advised the trouble of feeding, not only tasty, and therapeutical effect is good, has enriched the dosage form kind, and market prospect is very wide; At the character of medicine, select feasible substrate and technology rationally, make the product appearance, the good mouthfeel that make, for infantile anorexia better therapeutic effect is arranged.
The present invention constitutes like this: calculate according to weight, it is made into fluid or semifluid gel oral formulations by the Radix Astragali 30～60g, the Rhizoma Atractylodis Macrocephalae 10～30g, Rhizoma Dioscoreae 10～30g, Fructus Jujubae 5～15g, Fructus Crataegi 10～30g, Semen Nelumbinis 10～30g, Fructus Lycii 5～15g, Pericarpium Citri Reticulatae 3～8g, Margarita layer powder 5～15g, Radix Glycyrrhizae 15～25g and Mel 50～80g and an amount of substrate, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.Infant spleen-tonifying appetizing preparation of the present invention can also be prepared into: soft capsule, dispersible tablet, drop pill, pellet or slow releasing preparation.Specifically: spleen fortifying appetite increasing gel preparation for child of the present invention is prepared into gel preparation by one or more material matrix prepared in Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g and Konjac glucomannan, carrageenan, xanthan gum, the guar gum, is semifluid or solid gel shape.Among the present invention, optimal host material be by Konjac glucomannan, carrageenan, xanthan gum, guar gum by 5: 3: 1: the preparation of 2 part by weight.
The preparation method of spleen fortifying appetite increasing gel preparation for child of the present invention is: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water 1～3, each 1～3 hour, collecting decoction filters, and filtrate concentrates, add 1～3 times of amount of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol, standby; Margarita layer powder added soaking in rice vinegar 8～15 hours, filtered filtrate for later use; Mel, sucrose add water and dissolve in right amount, merge with said extracted liquid, soak; One or more material matrix prepared in Konjac glucomannan, carrageenan, xanthan gum, the guar gum are dissolved in the hot water, and stirring and being mixed with concentration is 0.5～1.5% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stir, and cooling at low temperatures rapidly, promptly.
Specifically: the preparation method of spleen fortifying appetite increasing gel preparation for child of the present invention is: the gel in the described preparation prepares like this: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add for the first time 8 times of amounts, add for the second time 6 times of amounts, each 2 hours, collecting decoction, filter, the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, add 2 times of amounts of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; With Konjac glucomannan, carrageenan, xanthan gum, guar gum by 5: 3: 1: 2 part by weight is dissolved in the hot water, and stirring and being mixed with concentration is 1.0% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stir, and cooling at low temperatures rapidly, promptly.
Among the we, Radix Astragali tonifying Qi and lifting yang, benefit is defended consolidating superficial resistance, inducing diuresis to remove edema, holder skin ulcer granulation promoting is monarch drug; Rhizoma Atractylodis Macrocephalae air making-up and spleen enlivening, the dampness diuretic, hidroschesis, antiabortive; The Rhizoma Dioscoreae supplementing QI and nourishing YIN, spleen reinforcing lung kidney, treating spontaneous emission and leukorrhagia; The Fructus Jujubae invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind relaxes the property of medicine; The hawthorn digesting eliminate indigestion, the circulation of qi promoting dissipating blood stasis; The Semen Nelumbinis supplementing the kidney to control the nocturnal, spleen reinforcing antidiarrheal, leukorrhagia stopping nourishes heart, and is ministerial drug altogether; The Fructus Lycii invigorating the liver and kidney, make eye bright, Pericarpium Citri Reticulatae regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm, Margarita layer powder suppressing the hyperactive liver and subsiding YANG, liver heat removing item, tranquilizing mind, Mel invigorating middle warmer emergency, moisturizing, detoxifying is adjuvant drug altogether; With the invigorating middle warmer of Radix Glycyrrhizae QI invigorating, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, the mediation property of medicine is messenger drug, the mediation property of medicine.
Compared with prior art, the application makes fluid or the semifluid gel that liked by the child with commercially available infant spleen-tonifying appetizing mixture, children's extremely is ready to take, reduce the adult and advised the trouble of feeding, not only tasty, and better therapeutic effect is arranged for infantile anorexia, and enriched the dosage form kind, market prospect is very wide.The applicant finds in the process of development gel, and one of effective ingredient of Radix Scutellariae baicalin equal facile hydrolysis under alkaline environment and hot environment in the prescription is an optimal stability in 4.8 the water liquid at pH value; The effective ingredient of Fructus Lycii also has thermal instability.Found through experiments, product of the present invention is stable under about 5 the environment at pH value, so the kind of the substrate of oral gel, consumption, pH value are also just very important.Edible Gelatinum oxhide its gel strength, viscosity etc. under sour environment commonly used all can seriously reduce, and have a strong impact on the performance of gel; Acid-catalyzed hydrolysis easily takes place in carrageenan in acid solution, thereby makes gel strength and viscosity degradation, and this hydrolysis degree can be stronger under the heat temperature raising situation, and the stability of carrageenan is poorer.And Konjac glucomannan stability under sour environment better can not be subjected to the influence of pH value.And the main component konjak portuguese gansu polyose of Konjac glucomannan, be a kind of good dietary fiber, can promote enterogastric peristalsis, help absorption and digestion to nutrient substance such as protein.But list only just can be gel state with Konjac glucomannan under alkali condition, and easily takes off the liquid shrinkage phenomenon.For this reason we to Konjac glucomannan and other glue the gel characteristic after composite study.The applicant has carried out a series of experiments, final Konjac glucomannan, carrageenan, xanthan gum, the guar gum of adopting was by 5: 3: 1: 2 part by weight mixes the substrate that obtains, the product of gained is stable effective ingredients under about 5 the environment at pH value, have good gel concertedness can control again and take off the food glue that liquid shrinks, and selects the supplementary product kind of preparation technology, use of pharmaceutical preparation provided by the invention and consumption, ratio etc.; Guarantee its science, reasonable, feasible; The preparation that obtains has effective therapeutic effect for infantile anorexia.
Experimental example 1: Study on Forming
1, the selection of matrix species: under the condition of pH value 5, prepare gel.
Table 1 choice of base
| Substrate | Consumption % | Gel effect |
| Gelatin carragheen konjac glucomannan xanthans | 0.5 1.0 2.0 0.5 1.0 2.0 0.5 1.0 2.0 0.5 1.0 2.0 | Not gel or not gel fragility is not big; Easily syneresis fragility is big; Easily syneresis fragility is big, easily syneresis gel gel or not of gel not or not or not |
The result shows: gelatin its gel strength, viscosity etc. under sour environment all can seriously reduce, and have a strong impact on the performance of gel; Though carrageenan energy gel, but retention ability is poor, easily takes off liquid and shrinks; Konjac glucomannan needs pH value to fall acetyl group greater than hydrolysis under 9 the strong alkaline condition could form gel, and consumption is big; Though xanthan gum is gel separately, under the condition of Acidity of Aikalinity, all have stable and excellent compatibility; So carry out the combine experiment of substrate.
2, substrate combine experiment
By orthogonal table L
9(3
4) experiment arrangement, four brood lacly mix by the proportionings in the orthogonal table, prepare gel under the condition of pH value 5, measure each gel strength of handling number, take off the liquid shrinkage factor.The results are shown in Table 3.
The mensuration of gel strength: the gel strength detector, molding cup size: diameter 4cm, high 2.5cm, formpiston jumper bar diameter is 1cm, gel strength (g/cm
2)=impulse force/active area=reading dial scale/(3.14*0.5
2)=0.785* reading.
Taking off the mensuration of liquid shrinkage factor: the glue for preparing pours in the fruit jelly cup → and sealing → sterilization (30min) → cooling → storage (room temperature, low temperature) → respectively measures and takes off the liquid shrinkage factor.During mensuration the liquid of separating out is poured out, the weight that the weighing gel alleviates was surveyed once in per 5 days, measured one month, averaged then.Take off liquid shrinkage factor (%)=(gross weight of the amount of liquid/gel of separating out) * 100%
Table 2 L
9(3
4) orthogonal table factor level table
| Level | Konjac glucomannan | Carrageenan | Xanthan gum | Guar gum |
| 1 2 3 | 30 50 50 | 30 20 50 | 30 20 10 | 0 20 30 |
Table 3 Orthogonal experiment results
| Konjac glucomannan | Carrageenan | Xanthan gum | Guar gum | Gel strength (g/cm 2) | Take off liquid shrinkage factor (%) |
| 1 1 1 2 2 2 3 3 3 | 1 2 3 1 2 3 1 2 3 | 1 2 3 3 2 1 3 1 2 | 1 2 3 3 1 2 2 3 1 | 1278.5 631.4 1657.1 954.8 432.6 1367.5 1103.7 923.2 1237.3 | 7.138 8.351 6.279 8.317 8.285 6.847 2.538 9.067 9.754 |
If gel strength is too high, mouthfeel is too tough; Gel strength is low excessively, mouthfeel elasticity deficiency, and gel strength is at 1100g/cm
2Left and right sides mouthfeel the best; Take off liquid shrinkage phenomenon (also claiming the bleed phenomenon) and produce when forming gel, the liquid of being discharged not is pure water but has certain density colloidal sol, sometimes also contain the electrolyte that originally just is present in the gel, both influenced outward appearance so take off the liquid contraction, also easily causing the variation at product matter dawn, is good gellant problem demanding prompt solution.Result according to table 3, guar gum is the straight chain macromole, hydroxyl on the chain can interact with linear polysaccharide carrageenan, xanthan gum, similar to the molecular structure of Konjac glucomannan, can produce good potentiation, adopt best compounded combination Konjac glucomannan, carrageenan, xanthan gum, guar gum=5: 3: 1: the 2 product gel strengths that make rationally, to take off the liquid shrinkage factor low.
3, the screening of substrates quantity.
After the selection of gel, also need use amount is studied,, scientifically reduce composition simultaneously as far as possible to obtain high-quality gel.The applicant prepares the infant spleen-tonifying appetite increasing gel of 0.8%, 0.9%, 1.0%, 1.1%, 1.2% 5 concentration glue amount respectively, and measures its rupture strength.Concrete data see Table 4.
Table 4 variable concentrations glue amount is to the influence of gel rupture strength
| The use amount (%) of total gel | Rupture strength (the g/cm of gel 2) |
| 0.8 0.9 1.0 1.1 1.2 | 7.21 7.38 7.45 7.48 7.50 |
The result of table 4 shows, increase along with the gel use amount, the rupture strength of gel is also along with increase, but after concentration reached 1.0%, along with the increase of concentration, the increasing degree of rupture strength diminished, when gel concentration reaches 1.0%, the rupture strength of gel meets the requirements, so consider that from the cost angle gel use amount of gel of the present invention is decided to be 1.0%.
Experimental example 2: pharmacodynamic experiment
1, the therapeutical effect of apositia is studied.
Get 60 of SD rats, 35～40 ages in days, body constitution amount (60 ± 10) g, male and female half and half.With the modeling of special forage feed method (special feedstuff is prepared by a certain percentage with milk powder, egg, dried fish floss, Semen Glycines powder, Semen Maydis powder etc.).Laboratory animal is divided into blank group, model control group, infant spleen-tonifying appetizing mixture group and gel group of the present invention, 15 every group at random.The blank group is fed conventional Mus feedstuff, and all the other each groups are fed special feedstuff.The all single cage of all rats is raised ad lib water.Write down the animal food-intake every day in the experimentation.Modeling began to irritate stomach on the 8th.Blank group and model control group are irritated normal saline, and infant spleen-tonifying appetizing mixture group and gel group of the present invention are irritated infant spleen-tonifying appetizing mixture (15g/kg) and gel of the present invention (20g/kg) with the effect amount respectively.Irritate stomach fasting 4h, then execution after 20 days.The eye socket blood sampling is left standstill 3h under the room temperature, and the centrifuging and taking supernatant is to be measured.10g/L heparin (10Ml/L blood sample) is handled test tube, drying for standby.Every pipe adds aprotinin 20mL/L blood sample before the blood sampling, and eye socket is got to inject in the calparine pipe behind the blood and fully shaken up and put immediately 4 ℃ of refrigerators, 4000r/min low-temperature centrifugation 10min in the 3h, and separated plasma, to be measured in-70 ℃ of preservations.Get behind the blood the rat sacrificed by decapitation, take out full brain stomach function regulating immediately, boil 5min in the normal saline of going into to boil, separate hypothalamus, scrape and get gastric antrum portion mucosa, claim to add 1mol/L NAC 1mL in the rearmounted glass homogenate of the quality pipe with analytical balance, fully pour in the plastic test tube after the homogenate, under room temperature, place 100min, add 1mol/L NaOH 1mL, 4000r/min low-temperature centrifugation 10min, it is to be measured in-70 ℃ of preservations to get supernatant.Each testing result specifically sees Table 5,6.
The influence (g) of table 5 anorexia rat food ration in pair young age
| Group | 7 days | 14 days | 21 days | 28 days |
| Blank group model control group children spleen benefiting and stimulating the appetite mixture group gel group of the present invention | 13.7±1.8 10.2±2.5 11.1±1.7 11.3±2.7 | 16.5±2.0 12.0±1.9 14.1±2.4 15.8±2.6 | 18.3±2.4 13.4±2.3 17.2±1.7 18.1±3.2 | 19.7±2.3 15.1±2.0 19.3±2.8 19.6±3.4 |
The influence of table 6 anorexia rat stomach secretin in pair young age and CCK
| Group | The gastrin ng/g of gastric antrum portion | Serum gastrin ng/L | Hypothalamus CCK-8 nmol/g | Plasma C CK-8 ng/L |
| Blank group model control group children spleen benefiting and stimulating the appetite mixture group gel group of the present invention | 53.4±16.4 25.9±13.4 42.5±15.7 46.7±11.0 | 143.5±20.7 138.4±15.3 125.6±13.8 136.7±18.4 | 87.9±23.7 131.1±25.9 110.4±21.0 89.6±18.6 | 258.0±864.4 453.0±145.8 277±86.7 279.0±59.7 |
Table 5 is the result show, gel of the present invention can obviously increase the food ration of anorexia rat, and effect is not less than infant spleen-tonifying appetizing mixture.And the result of table 6 shows, gel of the present invention can obviously reduce hypothalamus and plasma C CK-8, increases gastric antrum portion gastrin content, and effect is not less than infant spleen-tonifying appetizing mixture.
2, the effect of dyspepsia treatment of conditions is studied
1. to the influence of gastric emptying
Get 30 of purebred white mice, male and female half and half, body weight (18～22) g.Be divided into blank group, infant spleen-tonifying appetizing mixture group and gel group of the present invention at random, 10 every group, irritate respectively stomach award normal saline, with the infant spleen-tonifying appetizing mixture (30ml/kg) and the gel of the present invention (35g/kg) of effect amount.The phenol red standard curve of preparation variable concentrations gradient.Behind the mouse stomach administration 10d, empty stomach 24h, add flour (15: 1) heating with 0.01% phenol red liquid and be modulated into phenol red paste, press the 0.5ml/20g body weight and irritate stomach, put to death mice behind the 15min, cut open the belly immediately, rapid ligation cardia, pylorus, cut off along the greater gastric curvature side, the careful gastric content that takes out is put into scale in vitro, washes stomach repeatedly to total amount 6ml with distilled water.Then each in vitro adds the Ba (OH) of 0.15mol/L respectively
22ml fully leaves standstill 3～5min behind the mixing, respectively adds 2mL5%ZnSO again
4After firmly shaking up, with the centrifugal 10min of 3000r/min, respectively get supernatant 4ml, add 10%NaOH 0.5ml, measure optical density in 560nm wavelength place behind the mixing, contrast phenol red standard curve and check in and respectively organize the phenol red content of mice gastric, with the phenol red residual content of gastric/phenol red retained percentage of the phenol red total amount * 100%=of filling stomach gastric, estimate with this and respectively to organize gastric emptying speed.Concrete data see Table 7.
2. small intestinal charcoal end propulsion trial
Get 30 of purebred white mice, male and female half and half, body weight (18～22) g.Be divided into blank group, infant spleen-tonifying appetizing mixture group and gel group of the present invention at random, 10 every group, irritate respectively stomach give normal saline, with the infant spleen-tonifying appetizing mixture (30ml/kg) and the gel of the present invention (35g/kg) of effect amount.Be mixed with 5% charcoal end suspension with 10% arabic gum.After irritating stomach knot medicine 10d, empty stomach 24h, each is organized mice and irritates stomach with charcoal end suspension 0.2ml/10g body weight, when 25nin, put to death mice subsequently, cut open the belly immediately and take out from pylorus, be tiled on the glass plate, measure pylorus to charcoal not distal-most end distance and small intestinal total length to ileocecus small intestinal total length, with formula: small intestinal charcoal end advance distance/small intestinal total length * 100%, calculate and respectively organize small intestinal charcoal end and advance percentage rate.Concrete data see Table 7.
The influence of table 7 pair experimental mice gastric emptying and small intestinal charcoal end fltting speed
| Group | Gastric emptying % | Enterokinesia % |
| Blank group infant spleen-tonifying appetizing mixture group gel group of the present invention | 62.75±8.15 50.02±9.76 48.34±10.47 | 62.28±4.63 71.58±6.57 74.22±7.35 |
The result of table 7 shows that gel of the present invention can quicken gastric emptying, improve the fltting speed of small intestine contents, and effect is not less than infant spleen-tonifying appetizing mixture.
Concrete embodiment:
Embodiments of the invention 1: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add 8 times of amounts for the first time, add 6 times of amounts for the second time, each 2 hours, collecting decoction filters, and the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, add 2 times of amounts of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; With Konjac glucomannan, carrageenan, xanthan gum, guar gum by 5: 3: 1: 2 part by weight is dissolved in the hot water, and stirring and being mixed with concentration is 1.0% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stirs, and cooling at low temperatures promptly gets gel rapidly, this product oral, three times on the one, each 2 bags, every bag of 25g.
Embodiments of the invention 2: Radix Astragali 60g, Rhizoma Atractylodis Macrocephalae 30g, Rhizoma Dioscoreae 30g, Fructus Jujubae 15g, Fructus Crataegi 30g, Semen Nelumbinis 30g, Fructus Lycii 15g, Pericarpium Citri Reticulatae 8g, Margarita layer powder 15g, Radix Glycyrrhizae 25g, Mel 80g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water 1 hour, and collecting decoction filters, and filtrate concentrates, and adds 1 times of amount ethanol, stirs evenly, and standing over night filters, and filtrate recycling ethanol is standby; Margarita layer powder added soaking in rice vinegar 8 hours, filtered filtrate for later use; Mel, sucrose add water and dissolve in right amount, merge with said extracted liquid, soak; With Konjac glucomannan, carrageenan, xanthan gum, guar gum by 5: 3: 1: 2 part by weight is dissolved in the hot water, and stirring and being mixed with concentration is 0.5% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stirs, and cooling at low temperatures promptly gets gel rapidly.
Embodiments of the invention 3: Radix Astragali 30g, Rhizoma Atractylodis Macrocephalae 10g, Rhizoma Dioscoreae 10g, Fructus Jujubae 5g, Fructus Crataegi 10g, Semen Nelumbinis 10g, Fructus Lycii 5g, Pericarpium Citri Reticulatae 3g, Margarita layer powder 5g, Radix Glycyrrhizae 15g, Mel 50g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water 3, and each 3 hours, collecting decoction filtered, and filtrate concentrates, and added 3 times of amount ethanol, stirred evenly, and standing over night filters, and filtrate recycling ethanol is standby; Margarita layer powder added soaking in rice vinegar 15 hours, filtered filtrate for later use; Mel, sucrose add water and dissolve in right amount, merge with said extracted liquid, soak; The preparation of glue: with gelatin: glycerol: water=1: 0.2: 0.8, get gelatin and add an amount of distilled water and make its imbibition, glycerol and remaining water are put be heated to 70～80 ℃ in the glue pot in addition, mix homogeneously adds expansible gelatin and stirs, and makes it to dissolve into uniform glue, in 70 ℃ of insulations 1～2 hour, leave standstill, remove the come-up foam, filter with cloth bag, in encapsulating machine, be pressed into soft capsule, be pressed into soft capsule, put in the drum drying machine and finalize the design, whole ball, drying promptly gets soft capsule.
Embodiments of the invention 4: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water 3, and each 3 hours, collecting decoction filtered, and filtrate concentrates, and added 3 times of amount ethanol, stirred evenly, and standing over night filters, and filtrate recycling ethanol is standby; Margarita layer powder added soaking in rice vinegar 15 hours, filtered filtrate for later use; Mel, sucrose add water and dissolve in right amount, merge with said extracted liquid, soak, splash into the ratio that adopts PEG6000 and PEG4000 and are in 5: 3 the mixed-matrix, and the water dropper model adopts No. 1 water dropper, and coolant temperature is 20～22 ℃, promptly gets drop pill.
Embodiments of the invention 5: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water 3, and each 3 hours, collecting decoction filtered, and filtrate concentrates, and added 3 times of amount ethanol, stirred evenly, and standing over night filters, and filtrate recycling ethanol is standby; Margarita layer powder added soaking in rice vinegar 15 hours, filtered filtrate for later use; Mel, sucrose add water and dissolve in right amount, merge with said extracted liquid, soak; With Konjac glucomannan, carrageenan, xanthan gum, guar gum in 5: 3: 1: 2 ratio is dissolved in the hot water, and stirring and being mixed with concentration is 1.5% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stirs, and cooling at low temperatures promptly gets gel rapidly.
Embodiments of the invention 6: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add 8 times of amounts for the first time, add 6 times of amounts for the second time, each 2 hours, collecting decoction filters, and the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, add 2 times of amounts of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; 0.8% carrageenan is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, heating, agitation and filtration then, filter the back and under condition of stirring, add the medicine clear paste, mix homogeneously, adding the citric acid adjust pH is 5, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 7: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add 8 times of amounts for the first time, add 6 times of amounts for the second time, each 2 hours, collecting decoction filters, and the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, add 2 times of amounts of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; 0.9% Konjac glucomannan is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, heating, agitation and filtration then, filter the back and add the medicine clear paste under condition of stirring, adding the citric acid adjust pH is 5, mix homogeneously, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 8: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add 8 times of amounts for the first time, add 6 times of amounts for the second time, each 2 hours, collecting decoction filters, and the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, add 2 times of amounts of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; 0.8% xanthan gum is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, heating, agitation and filtration then, filter the back and add the medicine clear paste under condition of stirring, adding the citric acid adjust pH is 5, mix homogeneously, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Embodiments of the invention 9: Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g
The Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add 8 times of amounts for the first time, add 6 times of amounts for the second time, each 2 hours, collecting decoction filters, and the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, add 2 times of amounts of ethanol, stir evenly, standing over night filters, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; 1.3% guar gum is put into cold water, make it to disperse, soak 20～30min, make the abundant water absorption and swelling of substrate, heating, agitation and filtration then, filter the back and add the medicine clear paste under condition of stirring, adding the citric acid adjust pH is 5, mix homogeneously, join rapidly in the disinfecting container, seal, sterilization, be cooled to rapidly about 30 ℃, condensation, drying promptly gets gel.
Claims (6)
1. spleen fortifying appetite increasing gel preparation for child, it is characterized in that: calculate according to weight, it is made into fluid or semifluid gel oral formulations by the Radix Astragali 30～60g, the Rhizoma Atractylodis Macrocephalae 10～30g, Rhizoma Dioscoreae 10～30g, Fructus Jujubae 5～15g, Fructus Crataegi 10～30g, Semen Nelumbinis 10～30g, Fructus Lycii 5～15g, Pericarpium Citri Reticulatae 3～8g, Margarita layer powder 5～15g, Radix Glycyrrhizae 15～25g and Mel 50～80g and an amount of substrate, and wherein: substrate can be animal glue, plant gum, microbiological gum, alginate jelly, chemical modification glue or compound gel.
2. according to the described spleen fortifying appetite increasing gel preparation for child of claim 1, it is characterized in that: it can also be prepared into: soft capsule, drop pill, dispersible tablet, pellet or slow releasing preparation.
3. according to claim 1 or 2 described spleen fortifying appetite increasing gel preparation for child, it is characterized in that: it is prepared into gel preparation by the substrate that a kind of substrate in Radix Astragali 50g, Rhizoma Atractylodis Macrocephalae 20g, Rhizoma Dioscoreae 20g, Fructus Jujubae 10g, Fructus Crataegi 20g, Semen Nelumbinis 20g, Fructus Lycii 10g, Pericarpium Citri Reticulatae 6g, Margarita layer powder 12g, Radix Glycyrrhizae 20g, Mel 60g and Konjac glucomannan, carrageenan, xanthan gum, the guar gum or more than one materials are mixed with, and product is semifluid or solid gel shape.
4. according to the described spleen fortifying appetite increasing gel preparation for child of claim 3, it is characterized in that: substrate be by Konjac glucomannan, carrageenan, xanthan gum, guar gum by 5: 3: 1: the preparation of 2 part by weight.
5. as the preparation method of spleen fortifying appetite increasing gel preparation for child as described in the claim 1～4 any, it is characterized in that: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water 1～3, each 1～3 hour, collecting decoction, filter, filtrate concentrates, and adds 1～3 times of amount of ethanol, stirs evenly, standing over night, filter, filtrate recycling ethanol, standby; Margarita layer powder added soaking in rice vinegar 8～15 hours, filtered filtrate for later use; Mel, sucrose add water and dissolve in right amount, merge with said extracted liquid, soak; The stromatolysis that a kind of substrate in Konjac glucomannan, carrageenan, xanthan gum, the guar gum or more than one materials are mixed with is in hot water, and stirring and being mixed with concentration is 0.5～1.5% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stir, and cooling at low temperatures rapidly, promptly.
6. according to the preparation method of the described spleen fortifying appetite increasing gel preparation for child of claim 5, it is characterized in that: the gel in the described preparation prepares like this: the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae, Fructus Jujubae, Fructus Crataegi, Semen Nelumbinis, Fructus Lycii, Pericarpium Citri Reticulatae, Radix Glycyrrhizae are decocted with water secondary, add for the first time 8 times of amounts, add for the second time 6 times of amounts, each 2 hours, collecting decoction, filter, the relative density of measuring when filtrate is concentrated into 70 ℃ is 1.14 clear paste, adds 2 times of amounts of ethanol, stirs evenly, standing over night, filter, filtrate recycling ethanol to relative density is 1.02, and is standby; Margarita layer powder soaked 12 hours with rice vinegar 252ml, filtered filtrate for later use; Mel, sucrose 80g add water and dissolve in right amount, merge with said extracted liquid, soak; With Konjac glucomannan, carrageenan, xanthan gum, guar gum by 5: 3: 1: 2 part by weight is dissolved in the hot water, and stirring and being mixed with concentration is 1.0% solution; Add above mixed liquor then, adding the citric acid adjust pH is 5, stir, and cooling at low temperatures rapidly, promptly.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103250931A (en) * | 2013-05-02 | 2013-08-21 | 洪圣娟 | Yam healthcare konnyaku |
| CN103316306A (en) * | 2013-07-13 | 2013-09-25 | 朱玉芳 | Traditional Chinese medicine for treating child anorexia |
| CN103656664A (en) * | 2013-12-20 | 2014-03-26 | 大连赛姆生物工程技术有限公司 | Pig self feeding type drug carrier and preparation method thereof |
| CN103656664B (en) * | 2013-12-20 | 2016-08-31 | 大连赛姆生物工程技术有限公司 | A kind of pig self feeding type pharmaceutical carrier and preparation method thereof |
| CN103783509A (en) * | 2013-12-31 | 2014-05-14 | 陈慧婷 | Endothelium corneum gigeriae galli-yam dispersible tablet and preparation method thereof |
| CN103783509B (en) * | 2013-12-31 | 2016-02-17 | 陈慧婷 | A kind of Endothelium Corneum Gigeriae Galli Chinese yam dispersible tablet and preparation method |
| CN105055774A (en) * | 2015-08-12 | 2015-11-18 | 梁海通 | Traditional Chinese medicine composition for treating stomachache |
| CN105994909A (en) * | 2016-06-13 | 2016-10-12 | 王卫华 | Kudzu vine root soft sweets with aglaia odorata flower flavor and making method thereof |
| CN106722750A (en) * | 2017-01-22 | 2017-05-31 | 天津商业大学 | Gel for solidifying tartar sauce |
| CN110558505A (en) * | 2019-08-21 | 2019-12-13 | 合肥师范学院 | Method for making chicken's gizzard-membrane haw jelly |
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