CN106038720A - Type-II diabetes preparation and preparation method thereof - Google Patents
Type-II diabetes preparation and preparation method thereof Download PDFInfo
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- CN106038720A CN106038720A CN201610463267.3A CN201610463267A CN106038720A CN 106038720 A CN106038720 A CN 106038720A CN 201610463267 A CN201610463267 A CN 201610463267A CN 106038720 A CN106038720 A CN 106038720A
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/062—Ascomycota
- A61K36/064—Saccharomycetales, e.g. baker's yeast
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- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/074—Ganoderma
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
- C07H1/08—Separation; Purification from natural products
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H3/00—Compounds containing only hydrogen atoms and saccharide radicals having only carbon, hydrogen, and oxygen atoms
- C07H3/06—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
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- A61K2236/30—Extraction of the material
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- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/35—Extraction with lipophilic solvents, e.g. Hexane or petrol ether
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Abstract
The invention relates to a type-II diabetics preparation. The type-II diabetes preparation is prepared from the following components in parts by weight: 15 to 30 parts of black tartary buckwheat, 20 to 50 parts of dietary fiber, 10 to 25 parts of ganoderma lucidum spore powder, 1 to 8 parts of extract of mulberry fruit, and 1 to 5 parts of stachyose. The type-II diabetes preparation has the advantages that 1, by repairing and enhancing the normal metabolism function of organs on blood glucose, the effect of further preventing and treating type-II diabetes is realized; 2, cordyceps militaris which can excrete chitinase is used as micrococcus lysoleikticus, the wall of ganoderma lucidum spore can be effectively and safely broken, the active matter of ganoderma lucidum spore powder is furthest reserved and protected, and the human body can favorably absorb and utilize same; 3, a yeast cell is cultured in a trivalent chromium-containing culture medium, and the inorganic chromium is biologically converted into organic chromium, so that the absorbing and utilization rate of chromium in the human body is improved, the toxic or side effect is decreased, and the function of regulating blood glucose, lipid and cholesterol is well realized; 4, the components are simple, the production technology is simple, the production cost is low, and the type-II diabetes preparation can be widely popularized and applied.
Description
Technical field
The present invention relates to a kind of diabetic agent, particularly a kind of type Ⅱdiabetes mellitus preparation and preparation method thereof.
Background technology
Diabetes are one group of metabolic diseases being characterized with hyperglycemia.Hyperglycemia be then due to defect of insulin secretion or
Its biological agent is impaired, or both have concurrently and cause.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye,
Kidney, heart, blood vessel, neural chronic lesion, dysfunction.
Diabetes are divided into I type and type Ⅱdiabetes mellitus:
Type Ⅰ diabetes mellitus:
Age of onset is light, and < 30 years old, onset was unexpected, and polydipsia polyuria polyphagia symptom of becoming thin is obvious, and blood sugar level is high, no mostly
Few patient is with ketoacidosis as onset symptoms, and serum insulin and C peptide low SI, ICA, IAA or GAD antibody can be in sun
Property.Alone oral medicine is invalid, need to treat with insulin.
Type Ⅱdiabetes mellitus:
Original name, Adult Onset's patients with type Ⅰ DM, how 35～the sequela of 40 years old, accounts for diabetics more than 90%, fat
Person's sickness rate is high, often can be with hypertension, the disease such as dyslipidemia, arteriosclerosis.Insidious onset, in early days without any symptom, or
Only having the most weak, the most thirsty, blood glucose increases inconspicuous person need to be done carbohydrate tolerance test and just can make a definite diagnosis.Serum insulin levels is the most just
Often or increase, late period is low.
The morbidity course of disease of diabetes be as the naturally-aged of viscera function and cause abnormal carbohydrate metabolism, endocrine
Imbalance is caused.From viscera hypofunction to the course forming diabetes 10-30 to be had.So, diabetes should be old
The sick kind that year talent has.Regrettably minimum only 9 years old of diabetic age of having now been found that, 20 to three ten years old
Diabetes patient also gets more and more, and therefore, diabetes early prevention and treatment receive much concern.
The ability producing insulin in patients with NIDDM body not completely loses, and the insulin in the patient having is even
Producing too much, but the action effect of insulin is poor, insulin the most in the patient is a kind of shortage relatively, can pass through certain
A little oral drugs stimulate the secretion of internal insulin.But some client need use of exogenous insulins are still had to the later stage.
In type Ⅱdiabetes mellitus natural history is studied, having many evidences to show, insulin resistant is to start resistance to sugar amount extremely
The initiating agent of course of disease physiological process, in the diabetes natural history pattern that a comparison is generally acknowledged, the generation of diabetes
Journey many decades to be gone through, the course of disease is divided into three phases.
First stage: feature is insulin resistant but blood glucose is normal, at this stage beta Cell of islet because passing through increasing
Add the secretion of insulin to overcome the target organ opposing to insulin of insulin, therefore can be protected with the stable state of internal blood glucose
Hold.
Second stage: feature is that insulin resistant post-prandial glycemia raises, this is because the insulin that goes out of β emiocytosis with
Insulin resistant does not matches that or the change of β emiocytosis pattern makes insulin that post-prandial glycemia can not effectively be controlled institute
Cause.
Three phases: what diabetes natural history developed the last stage is diabetic phase, and this stage, β was thin
The insulin that intracrine goes out has been unable to maintain that fasting glucose is within normal range.
Diabetes are one of big difficult and complicated illness in the world three, and in decades, countries in the world have carried out long-term and unremitting grinding one after another
Study carefully and exploitation.Treatment diabetes history had twice important breakthrough: being the 1950's for the first time, first Chinese is artificial
Insulin synthesis, makes a stir all over the world；Second time is biguanides and the appearance of sulphanylureas oral antidiabetic drug, makes the blood glucose of diabetics
Temporarily controlled, be currently used for Chinese medicine and western medicine used by clinical treatment and reached tens of kinds.Wherein, patient's long-term taking Western medicine, can be right
The internal organs such as kidney, liver, the heart, spleen, stomach bring side effect.Domestic its drug effect of various pure Chinese medicinal preparations out newly developed is also in control
Blood glucose processed, glucose in urine increase the stage.Authorization Notice No. is that the Chinese invention patent of CN 101700354B provides one and treats glycosuria
Sick Chinese medicine, its formula is: Radix Panacis Quinquefolii 1-5 part, Rhizoma Anemarrhenae 2-6 part, Gypsum Fibrosum 1-5 part, Fructus Momordicae charantiae 3-8 part, Bombyx bombycis 2-6 part, Radix Astragali 1-5
Part, Rhizoma Dioscoreae 1-5 part, Radix Rehmanniae 1-5 part, Radix Scrophulariae 1-5 part, Radix Glehniae 1-5 part, 1-5 part Radix Ophiopogonis, Rhizoma Polygonati Odorati 1-5 part, Rhizoma Polygonati 1-5 part, sky
Pollen 1-5 part, Endothelium Corneum Gigeriae Galli 1-5 part, Rhizoma Coptidis 1-5 part, Fructus Corni 1-5 part, Fructus Lycii 2-7 part, Fructus Ligustri Lucidi 2-7 part, Herba Epimedii 1-5
Part.This patent can effectively treat diabetes, nurses one's health metabolism disorder comprehensively, and pancreatic tissue damage is had certain repair, with
It is main for recovering islet function, promotes insulin releasing, balance blood sugar level, prevents and treat the pure Chinese medicinal preparation of diabetes.
But also having Radix Panacis Quinquefolii in the formula in this patent, if choosing wild Radix Panacis Quinquefolii, resource is the most rare, and price is held high
Expensive, supply falls short of demand in market；And living environment is required high by it, survival rate is low, and growth of seedling is slow, long ripening period, seedling
At least take could gather in the crops for more than 3 years and be used as medicine；Even general Radix Panacis Quinquefolii also takes within about 6 years, could gather in the crops, the most above-mentioned patent
Not only complicated component and cost are high.
At present, the research to diabetes is more and more focused on, by conditioning patient's own metabolism, improving autoimmunity,
And then prevent and treatment diabetes.
Trivalent chromium is mainly worked in coordination with by GTF and strengthens the effect of insulin, thus affects saccharide, lipid, protein and core
The metabolism of acid etc., affects the growth of animal, breeding, product quality and anti-stress, resistance against diseases.
GTF is with nicotinic acid-trivalent chromium-nicotinic acid as axle center, and glutamic acid, glycine and cysteine are the thing of part
Matter.The biological chemistry action of chromium is primarily as the reinforcing agent of insulin, by insulin impact sugar, protein, fat and core
The metabolism of acid.
Therefore, trivalent chromium (Cr3+) ion is as one of the essential trace element of humans and animals, it is glucose tolerance factor
(GTF) important composition part, has regulating lipid metabolism, improves the effect of carbohydrate tolerance.
Yeast chromium (Rich chromium yeast) is that the chromium nutrition that State Food and Drug Administration specifies supplements one of source.Yeast
Be human use the earliest, widest pure natural nutritional type microorganism, be also natural nutrition precious deposits and preferable bio-carrier.
At present, Drug therapy to diabetes there is problems in that biguanides side effect is big both at home and abroad；Sulfonamides
Drugs damage liver, kidney, and easy and sulfa drugs generation cross allergy.Therefore the research to diabetes is more and more noted
Heavily by conditioning patient's own metabolism, improve autoimmunity, and then prevent and treatment diabetes.
Summary of the invention
In view of the above-mentioned problems in the prior art, present invention is primarily targeted at the defect solving prior art,
The present invention provides a kind of type Ⅱdiabetes mellitus preparation, by strengthening patient's metabolism to saccharide after said preparation is oral, has curative effect
The features such as significantly, composition is simple, have no side effect, applied widely, production cost is low.
The present invention provides a kind of type Ⅱdiabetes mellitus preparation, calculates in parts by weight, including: Black Radix Et Rhizoma Fagopyri Tatarici 15-30 part, meals
Fiber 20-50 part, Ganoderma spore powder 10-25 part, Fructus Mori extract 1-8 part and stachyose 1-5 part.
Optionally, calculate in parts by weight, including: Black Radix Et Rhizoma Fagopyri Tatarici 21.8 parts, dietary fiber 32 parts, Ganoderma spore powder 18
Part, Fructus Mori extract 3 parts and 3 parts of stachyose.
Optionally, 0.5-3 part Rich chromium yeast is also included.
Optionally, described Rich chromium yeast is 2 parts.
Optionally, 0.5-3 part yeast rich in selenium is also included.
Optionally, described yeast rich in selenium is 1 part.
Optionally, described Ganoderma spore powder is Ganoderma spore powder with cellular wall broken.
Optionally, described dietary fiber is composite dietary.
The preparation method of a kind of type Ⅱdiabetes mellitus preparation, comprises the following steps:
(1) ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici:
Using ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici, Black Radix Et Rhizoma Fagopyri Tatarici cell produces a large amount of hot-fluids, beneficially extraction and effectively becomes
Divide flavone, rutin, Quercetin.
(2) prepared by Ganoderma spore powder with cellular wall broken:
1. in aseptic Ganoderma spore powder, add Cordyceps militaris (L.) Link. carry out solid fermentation, obtain Ganoderma spore powder with cellular wall broken；
Or 2. utilize low-temperature airflow breaking cellular wall, obtain Ganoderma spore powder with cellular wall broken；
(3) extracting method for stachyose:
After being cleaned by hair leaf Rhizoma Lycopi Lucidi, pulverizing, soak, vegetable protein is made to solidify through pasteurize, add ten thousand after sterilizing/
The pectin compound enzyme preparation of one carries out degumming, and after degumming, solution carries out ultrafiltration through the ultrafilter membrane of 10000D, then decolours, vacuum
Concentrate, be dried to Herba Stachydis Japonicae Icing Sugar.
(4) preparation of Fructus Mori extract
The rinsing of S1: fresh Fructus Mori is squeezed the juice after going the removal of impurity, collects JUICE CONCENTRATION；
S2: adding the extraction of organic solvent supersonic according to the mass volume ratio 1:10 1:40 of feed liquid, ultrasonic time is 1-
10min, supersound extraction number of times 1-5 time, obtain mixture A；
S3: mixture A filter cleaner, collects filtrate；
S4: collect solids after filtrate rotary evaporation and i.e. obtain Fructus Mori extract.
(5) mixing
S1: composite dietary is crossed 50-500 mesh sieve；
S2: weigh in proportion Black Radix Et Rhizoma Fagopyri Tatarici, composite dietary, yeast rich in selenium, Ganoderma spore powder with cellular wall broken, Fructus Mori extract,
Stachyose, Rich chromium yeast and yeast rich in selenium, be sufficiently mixed and obtain described preparation；
(6) packaging
With the preparation obtained in composite membrane nitrogen gas packing step (five).
Optionally, the ultrasound condition in described step () is: frequency is 2450MHz, and wavelength is 12.2cm；Described step
(2) low temperature in is 0 DEG C ± 5 DEG C；In described S2, solid-liquid ratio is 1:25；In described S2, organic solvent is dehydrated alcohol, acetic acid second
One or more in fat, petroleum ether and methanol.
The present invention has the following advantages and beneficial effect:
1. the type Ⅱdiabetes mellitus preparation that the present invention provides enters blood circulation after oral, dirty by recovering, strengthening
The device homergy function to blood glucose, and then reach prevention and the effect for the treatment of type Ⅱdiabetes mellitus.
2. carry out solid fermentation with addition Cordyceps militaris (L.) Link. in aseptic Ganoderma spore powder, make ganoderma lucidium spore powder wall breaking.Utilization can
The Cordyceps militaris (L.) Link. of secretion chitinase, as molten wall bacterium, can carry out effective, safe breaking cellular wall to Ganoderma spore, make Ganoderma spore powder
Active substance obtains the lowest preserving and protecting, beneficially absorption of human body and utilizes.
3. the Rich chromium yeast in the present invention is to cultivate yeast cells containing in chromic culture medium, passes through bioconversion
Inorganic chromium is walked around and becomes organic chromium, thus improve chromium absorption rate in body, reduce its toxic and side effects, preferably play
Its regulation blood glucose, blood fat reducing and the effect of cholesterol reducing.
4. the composition in the present invention is simple, and production technology is simple, and production cost is low, it is possible to popularization and application widely.
Detailed description of the invention
Below the technical scheme in the embodiment of the present invention is clearly and completely described, it is clear that described embodiment
It is a part of embodiment of the present invention rather than whole embodiments.The detailed description of embodiments of the invention presented below is also
It is not intended to be limiting the scope of claimed invention, but is merely representative of the selected embodiment of the present invention.Based in the present invention
Embodiment, the every other embodiment that those of ordinary skill in the art are obtained under not making creative work premise,
Broadly fall into the scope of protection of the invention.
It is desirable to provide a kind of conditioning type Ⅱdiabetes mellitus preparation, can effectively treat diabetes, conditioning metabolism is disorderly comprehensively
Disorderly, by patient body conditioning is repaired, strengthen the immunity of patient, to recover islet function, promote the secretion of insulin, from
And balance blood sugar.
Technical scheme is as follows:
A kind of type Ⅱdiabetes mellitus preparation, calculates in parts by weight, including: Black Radix Et Rhizoma Fagopyri Tatarici 15-30 part, dietary fiber 20-50
Part, Ganoderma spore powder 10-25 part, Fructus Mori extract 1-8 part and stachyose 1-5 part.
As preferred embodiment, calculate in parts by weight, including: Black Radix Et Rhizoma Fagopyri Tatarici 21.8 parts, dietary fiber 32 parts, spirit
18 parts of Ganoderma lucidum spore powder, Fructus Mori extract 3 parts and 3 parts of stachyose.
As preferred embodiment, also include 0.5-3 part Rich chromium yeast.
As preferred embodiment, Rich chromium yeast is 2 parts.
As preferred embodiment, also include 0.5-3 part yeast rich in selenium.
As preferred embodiment, yeast rich in selenium is 1 part.
As preferred embodiment, Ganoderma spore powder is Ganoderma spore powder with cellular wall broken.
As preferred embodiment, dietary fiber is composite dietary.
The preparation method of type Ⅱdiabetes mellitus preparation, comprises the following steps:
(1) ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici:
Using ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici, Black Radix Et Rhizoma Fagopyri Tatarici cell produces a large amount of hot-fluids, beneficially extraction and effectively becomes
Divide flavone, rutin, Quercetin.
(2) prepared by Ganoderma spore powder with cellular wall broken:
1. in aseptic Ganoderma spore powder, add Cordyceps militaris (L.) Link. carry out solid fermentation, obtain Ganoderma spore powder with cellular wall broken；
Or 2. utilize low-temperature airflow breaking cellular wall, obtain Ganoderma spore powder with cellular wall broken；
(3) extracting method for stachyose:
After being cleaned by hair leaf Rhizoma Lycopi Lucidi, pulverizing, soak, vegetable protein is made to solidify through pasteurize, add ten thousand after sterilizing/
The pectin compound enzyme preparation of one carries out degumming, and after degumming, solution carries out ultrafiltration through the ultrafilter membrane of 10000D, then decolours, vacuum
Concentrate, be dried to Herba Stachydis Japonicae Icing Sugar.
(4) preparation of Fructus Mori extract
The rinsing of S1: fresh Fructus Mori is squeezed the juice after going the removal of impurity, collects JUICE CONCENTRATION；
S2: adding the extraction of organic solvent supersonic according to solid-liquid ratio (g/mL) 1:10 1:40, ultrasonic time is 1-10min,
Supersound extraction number of times 1-5 time, obtains mixture A；
S3: mixture A filter cleaner, collects filtrate；
S4: collect solids after filtrate rotary evaporation and i.e. obtain Fructus Mori extract.
(5) mixing
S1: composite dietary is crossed 50-500 mesh sieve；
S2: weigh in proportion Black Radix Et Rhizoma Fagopyri Tatarici, composite dietary, yeast rich in selenium, Ganoderma spore powder with cellular wall broken, Fructus Mori extract,
Stachyose, Rich chromium yeast and yeast rich in selenium, be sufficiently mixed and obtain described preparation；
(6) packaging
With the preparation obtained in composite membrane nitrogen gas packing step (five).
As preferred embodiment, the ultrasound condition in step () is: frequency is 2450MHz, and wavelength is 12.2cm；
Low temperature in step (two) is 0 DEG C ± 5 DEG C；In S2, solid-liquid ratio is 1:25；In S2 organic solvent be dehydrated alcohol, ethyl acetate,
One or more in petroleum ether and methanol.
The using method of type Ⅱdiabetes mellitus preparation, comprises the following steps:
Open the packaging bag of type Ⅱdiabetes mellitus preparation, add a certain amount of 40-80 DEG C of water, after mix homogeneously forms homogeneous liquid
Oral.
As preferred embodiment, the temperature of above-mentioned water is 60 DEG C；The amount adding water is 150-300 milliliter.
The each material being previously mentioned in the present invention is described below:
Radix Et Rhizoma Fagopyri Tatarici formal name used at school hull buckwheat (F.tataricum), is divided into common Radix Et Rhizoma Fagopyri Tatarici and Black Radix Et Rhizoma Fagopyri Tatarici.Common Radix Et Rhizoma Fagopyri Tatarici shell is HUANGBAI(sic)
Color；Black Radix Et Rhizoma Fagopyri Tatarici i.e. Peal blackberry Radix Et Rhizoma Fagopyri Tatarici, has the title of " black pearl ", and shell is atrous, high nutritive value.
Composite dietary: purchased from Shanghai Jin Song Industrial Co., Ltd., containing the food-grade water-soluble dietary fiber of 99%, outward
Sight state is milky white granules.
Yeast rich in selenium, Rich chromium yeast: purchased from the product of Angel Yeast Co., Ltd.
The content such as table 1 below of each composition of type Ⅱdiabetes mellitus preparation in specific embodiment 1-5:
Each composition of table 1 type Ⅱdiabetes mellitus preparation and content thereof
The preparation method of the conditioning type Ⅱdiabetes mellitus preparation in embodiment 1-5 is as follows:
(1) ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici:
Using ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici, ultrasound condition is: frequency is 2450MHz, and wavelength is 12.2cm.The method
Inside and outside heat simultaneously, Black Radix Et Rhizoma Fagopyri Tatarici cell produce a large amount of hot-fluids, beneficially extraction effective ingredient flavone, rutin, Quercetin.
(2) prepared by Ganoderma spore powder with cellular wall broken:
Carry out solid fermentation with addition Cordyceps militaris (L.) Link. in aseptic Ganoderma spore powder, make ganoderma lucidium spore powder wall breaking.Utilization can divide
Secrete the Cordyceps militaris (L.) Link. of chitinase as molten wall bacterium, Ganoderma spore can be carried out effective, safe breaking cellular wall, make the work of Ganoderma spore powder
Property material obtain the lowest preserving and protecting, beneficially absorption of human body utilize.
(3) extracting method for stachyose:
After hair leaf Rhizoma Lycopi Lucidi is cleaned, pulverizing, soak, through pasteurize and make vegetable protein solidify, toward the extraction after sterilizing
In thing add ten thousand/ pectin compound enzyme preparation carry out degumming, after degumming, solution carries out ultrafiltration through the ultrafilter membrane of 10000D,
Decolour again, be concentrated in vacuo, be dried to Herba Stachydis Japonicae Icing Sugar.
(4) preparation of Fructus Mori extract
The rinsing of S1: fresh Fructus Mori is squeezed the juice after going the removal of impurity, collects JUICE CONCENTRATION；
S2: adding ethyl acetate ultrasonic extraction according to solid-liquid ratio (g/mL) 1:25, ultrasonic time is 5min, supersound extraction time
Several 2 times, obtain mixture A；
S3: mixture A filter cleaner, collects filtrate；
S4: collect solids after filtrate rotary evaporation and i.e. obtain Fructus Mori extract.
(5) mixing
S1: sieved by composite dietary, sieve is 80 mesh；
S2: weigh Black Radix Et Rhizoma Fagopyri Tatarici according to parts by weight, composite dietary, yeast rich in selenium, Ganoderma spore powder with cellular wall broken, Fructus Mori carry
Take thing, stachyose, Rich chromium yeast and yeast rich in selenium, be sufficiently mixed and obtain described preparation；
(6) packaging
With the preparation obtained in composite membrane nitrogen gas packing step (five).
The application process of the application process of type Ⅱdiabetes mellitus preparation:
Opening the packaging bag of type Ⅱdiabetes mellitus preparation, add the water 200ml of 60 DEG C, mix homogeneously forms homogeneous liquid deutostoma
Clothes.
Experimental program
Tested crowd: meet type Ⅱdiabetes mellitus and diagnose 900 examples, is randomly divided into six groups, often organizes 150 people, and one of which is right
According to group, other five groups correspond respectively to embodiment 1-5 as test group.
Therapeutic scheme:
Test group: the formula in embodiment 1-5 in the present invention, 1 day 3 times, a course for the treatment of is surrounding, and three courses for the treatment of are one
The individual cycle.
Matched group: be not added with the water of formula, 1 day 3 times, the course for the treatment of surrounding, three courses for the treatment of are a cycle.
The result of the test that type Ⅱdiabetes mellitus is treated by the formula in embodiment 1-5 in the present invention such as table 2.
Table 2 embodiment 1-5 is nursed one's health the obvious effective rate of type Ⅱdiabetes mellitus
From table 2 it can be seen that the present invention improves significantly to before and after cholesterol, low density lipoprotein, LDL treatment.
After test group treatment, Postprandial insulin is increased significantly, and has significant difference.To insulin before and after treatment of control group
Change there was no significant difference.
Before and after test group treatment, the improvement of glycolated hemoglobin has significant difference, HbAle egg before and after treatment of control group
White improvement no difference of science of statistics
Conclusion: it is safe and effective that the present invention treats type Ⅱdiabetes mellitus, after test group treatment, glycated serum protein is decreased obviously,
There is significant difference.
The above, the only present invention preferably detailed description of the invention, but protection scope of the present invention is not limited thereto,
Any those familiar with the art in the technical scope that the invention discloses, the change that can readily occur in or replacement,
All should contain within protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Enclose and be as the criterion.
Claims (10)
1. a type Ⅱdiabetes mellitus preparation, it is characterised in that calculate in parts by weight, including Black Radix Et Rhizoma Fagopyri Tatarici 15-30 part, meals fibre
Dimension 20-50 part, Ganoderma spore powder 10-25 part, Fructus Mori extract 1-8 part and stachyose 1-5 part.
Type Ⅱdiabetes mellitus preparation the most according to claim 1, it is characterised in that calculate in parts by weight, including: black hardship
Buckwheat 21.8 parts, dietary fiber 32 parts, Ganoderma spore powder 18 parts, Fructus Mori extract 3 parts and 3 parts of stachyose.
Type Ⅱdiabetes mellitus preparation the most according to claim 1 and 2, it is characterised in that also include 0.5-3 part Rich chromium yeast.
Type Ⅱdiabetes mellitus preparation the most according to claim 1, it is characterised in that described Rich chromium yeast is 2 parts.
Type Ⅱdiabetes mellitus preparation the most according to claim 3, it is characterised in that also include 0.5-3 part yeast rich in selenium.
Type Ⅱdiabetes mellitus preparation the most according to claim 5, it is characterised in that described yeast rich in selenium is 1 part.
Type Ⅱdiabetes mellitus preparation the most according to claim 1, it is characterised in that described Ganoderma spore powder is wall-breaking lucidum spore
Sub-powder.
Type Ⅱdiabetes mellitus preparation the most according to claim 1, it is characterised in that described dietary fiber is fine for compound meals
Dimension.
9. the preparation method of a type Ⅱdiabetes mellitus preparation, it is characterised in that comprise the following steps:
(1) ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici:
Using ultrasonic circumfluence distillation Black Radix Et Rhizoma Fagopyri Tatarici, it is yellow that Black Radix Et Rhizoma Fagopyri Tatarici cell produces a large amount of hot-fluids, beneficially extraction effective ingredient
Ketone, rutin, Quercetin.
(2) prepared by Ganoderma spore powder with cellular wall broken:
1. in aseptic Ganoderma spore powder, add Cordyceps militaris (L.) Link. carry out solid fermentation, obtain Ganoderma spore powder with cellular wall broken；
Or 2. utilize low-temperature airflow breaking cellular wall, obtain Ganoderma spore powder with cellular wall broken；
(3) extracting method for stachyose:
After being cleaned by hair leaf Rhizoma Lycopi Lucidi, pulverizing, soak, vegetable protein is made to solidify through pasteurize, add ten thousand after sterilizing/
Pectin compound enzyme preparation carries out degumming, and after degumming, solution carries out ultrafiltration through the ultrafilter membrane of 10000D, then decolours, and vacuum is dense
Contracting, is dried to Herba Stachydis Japonicae Icing Sugar.
(4) preparation of Fructus Mori extract
The rinsing of S1: fresh Fructus Mori is squeezed the juice after going the removal of impurity, collects JUICE CONCENTRATION；
S2: adding the extraction of organic solvent supersonic according to the mass volume ratio 1:10 1:40 of feed liquid, ultrasonic time is 1-10min,
Supersound extraction number of times 1-5 time, obtains mixture A；
S3: mixture A filter cleaner, collects filtrate；
S4: collect solids after filtrate rotary evaporation and i.e. obtain Fructus Mori extract.
(5) mixing
S1: composite dietary is crossed 50-500 mesh sieve；
S2: weigh Black Radix Et Rhizoma Fagopyri Tatarici, composite dietary, yeast rich in selenium, Ganoderma spore powder with cellular wall broken, Fructus Mori extract, Herba Stachydis Japonicae in proportion
Sugar, Rich chromium yeast and yeast rich in selenium, be sufficiently mixed and obtain described preparation；
(6) packaging
With the preparation obtained in composite membrane nitrogen gas packing step (five).
The preparation method of type Ⅱdiabetes mellitus preparation the most according to claim 7, it is characterised in that in described step ()
Ultrasound condition be: frequency is 2450MHz, and wavelength is 12.2cm；Low temperature in described step (two) is 0 DEG C ± 5 DEG C；Described S2
Middle solid-liquid ratio is 1:25；One or many during organic solvent is dehydrated alcohol, ethyl acetate, petroleum ether and methanol in described S2
Kind.
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| CN201610463267.3A CN106038720A (en) | 2016-06-23 | 2016-06-23 | Type-II diabetes preparation and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112079658A (en) * | 2020-09-02 | 2020-12-15 | 王雪薇 | Preparation and application of plant nutrient solution rich in glucose tolerance factor |
| CN112089828A (en) * | 2019-06-16 | 2020-12-18 | 王虎 | Preparation method of biological fermentation type compound trivalent chromium hypoglycemic combination drug |
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|---|---|---|---|---|
| CN1561798A (en) * | 2004-04-13 | 2005-01-12 | 毛奇远 | Method for processing duck wheat coarse grain food |
| CN102608895A (en) * | 2008-08-15 | 2012-07-25 | 珠海赛纳打印科技股份有限公司 | Powder box, drum component and developing device |
| CN104126787A (en) * | 2013-04-30 | 2014-11-05 | 四川好医生攀西药业有限责任公司 | Health-caring product for preventing and treating hyperglycemia and hyperlipidemia and preparation method thereof |
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2016
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1561798A (en) * | 2004-04-13 | 2005-01-12 | 毛奇远 | Method for processing duck wheat coarse grain food |
| CN102608895A (en) * | 2008-08-15 | 2012-07-25 | 珠海赛纳打印科技股份有限公司 | Powder box, drum component and developing device |
| CN104126787A (en) * | 2013-04-30 | 2014-11-05 | 四川好医生攀西药业有限责任公司 | Health-caring product for preventing and treating hyperglycemia and hyperlipidemia and preparation method thereof |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112089828A (en) * | 2019-06-16 | 2020-12-18 | 王虎 | Preparation method of biological fermentation type compound trivalent chromium hypoglycemic combination drug |
| CN112079658A (en) * | 2020-09-02 | 2020-12-15 | 王雪薇 | Preparation and application of plant nutrient solution rich in glucose tolerance factor |
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Application publication date: 20161026 |