CN107596315A - A kind of preparation method of antipyretic gel - Google Patents
A kind of preparation method of antipyretic gel Download PDFInfo
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- CN107596315A CN107596315A CN201710928705.3A CN201710928705A CN107596315A CN 107596315 A CN107596315 A CN 107596315A CN 201710928705 A CN201710928705 A CN 201710928705A CN 107596315 A CN107596315 A CN 107596315A
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Abstract
The invention discloses a kind of preparation method of antipyretic gel, belong to pharmaceutical technology field.The present invention is using potato, green onion, ginger as raw material, their ingredients have the effect of bringing down a fever, and using gelatin as carrier, and it is cross-linked to form bigger network structure with extract solution, make its more preferable adsorption of effective component, gelatin has thickening properties in itself simultaneously, adds sorbierite, makes the sustained drug time longer.In addition, refined jasmine oil plays brain wash of refreshing oneself, the effect of mood placating, safety and comfort of the present invention, refrigerant frank, convenient and swift.The present invention solves clinical at present and pharmacy and sells antipyretic gel often by the use of glycerine as moisturizing and the lubricating substance of absorbing water, but when being air-dried, and glycerine is on the contrary from the direct draws water of human body skin, the problem of causing cooling effect little.
Description
Technical field
The invention belongs to pharmaceutical technology field, and in particular to a kind of preparation method of antipyretic gel.
Background technology
Antipyretic gel, new cold compress physiotherapy and Physical temperature-lowering class medicine equipment, are for mitigating by common cold, popularity
Fever symptoms caused by flu or other reasonses.Especially suitable for the Physical temperature-lowering below 38 DEG C of low fever and high fever treatment process
Emergent physical cools.Simultaneously and summer relieves summer heat and the standing product of high-temperature operation.Heating, also known as has a fever, is due to pyrogen
Effect make body temperature set point move up caused by modulability body temperature rise.Heating is favorably also harmful to human body.Adstante febre human body is exempted from
Epidemic disease function is remarkably reinforced, and this is advantageous to remove pathogen and promotes the recovery from illness of disease.Therefore, can be by more when body temperature is less high
Drink water to reduce the sense of discomfort of heating tape.Warm G/W can play the effect of diuresis cooling, but as body temperature is (small more than 40 DEG C
Youngster is more than 39 DEG C) it may then cause dizzy, convulsions, shock, or even serious sequelae, therefore should see a doctor in time.Cause the original of fever
Because a lot, most commonly infection (including various bacterium infections, virus infect, mycoplasma infection etc.), next to that connective tissue
Sick (i.e. collagen disease), malignant tumour etc..The effect of antipyretic, is obvious, and during excessive heat, general recommendations uses medicine fast cooling.
But children fever is treated and very bothered, because of children's torso physiogeny not fully, side effect of the thing to body is not allowed
Ignore, before the reason for causing fever is not found, it is impossible to being treated using drug for abating fever simply, so easily cover disease
Feelings, influence further treatment.Clinical at present and pharmacy sells antipyretic gel often by the use of glycerine as moisturizing and the lubricating substance of absorbing water,
Glycerine has stronger hygroscopicity, can be absorbed water from air, and the product main function is to be affixed on forehead, the sun
Cave and Dazhui acupoint, the mechanism of heat is taken away during using water vapor, local cooling is brought down a fever to carry out auxiliary, have it is refrigerant it is comfortable,
The characteristics of easy to use, hygienic, safe.But there is also some problems during use：When being air-dried, moisture in air
Sub seldom, glycerine is particularly evident from the direct draws water of human body skin, particularly winter and Arid Area on the contrary.Thus make because
The skin of high temperature fever inherently water shortage is more dried, and influences the moisture retention of glycerine, the lasting fever time of preparation shortens, caused
Heating bounce-back, actual cooling effect are little on the contrary.Therefore, it is extremely urgent to produce a kind of efficient antipyretic gel.
The content of the invention
The technical problems to be solved by the invention：Antipyretic gel, which is sold, for clinical and pharmacy at present is often used as suction by the use of glycerine
Water moisturizing and lubricating substance, but when being air-dried, glycerine from the direct draws water of human body skin, causes cooling effect not on the contrary
A kind of the problem of big, there is provided preparation method of antipyretic gel.
In order to solve the above technical problems, the present invention is using technical scheme as described below：
A kind of preparation method of antipyretic gel, it is characterised in that the preparation method comprises the following steps：
（1）Count in parts by weight, take 10 ~ 15 portions of potatoes, 7 ~ 8 portions of gingers, 3 ~ 4 portions of green onions to be put into pulverizer and crush, obtain crushed material,
In mass ratio 1：2 ~ 3, crushed material, water are put into container, using ultrasonic wave extraction, obtain extract solution；
（2）Count in parts by weight, 30 ~ 40 parts of extract solutions, 10 ~ 15 parts of gelatin, 5 ~ 8 parts of sorbierites, 1 ~ 2 part of Geniposide are put into appearance
In device, 50 ~ 55 DEG C are heated to, stirs 25 ~ 30min, after cooling, collects cooling thing, it is standby；
（3）In mass ratio 1 ~ 2：4 ~ 5, jasmine petal, water are put into distiller and distilled, obtains distillate, is added in distillate
The sodium chloride of jasmine petal quality 1 ~ 2%, 2 ~ 3h is stood, then the activated carbon of distillate quality 20 ~ 30% is added into distillate, it is quiet
20 ~ 30min is put, filters, obtains filtered fluid；
（4）In mass ratio 7 ~ 10：3~4：1 ~ 2, cooling thing, filtered fluid, preservative are put into container and stirred, stirs 1 ~ 2h, is mixed
After closing uniformly, stirring mixture is collected, produces antipyretic gel.
The step（1）The parameter of middle ultrasonic wave extraction is 40 ~ 60 DEG C of temperature, 24 ~ 40min of time.
The step（3）The temperature of middle distillation is 68 ~ 80 DEG C, vacuum 13.3Pa.
The step（4）Middle preservative be calcium propionate, sodium Diacetate, sodium lactate it is therein any one.
Compared with other method, advantageous effects are the present invention：
（1）For the present invention using potato, green onion, ginger as raw material, wherein potato does not only have antibacterial effect effect, while will not cause anti-medicine
Property, green onion contains the multivitamins such as protein, carbohydrate and mineral matter, there is very big benefit to human body, while green onion has thorn
Swash body sweat gland, reach the effect of sweating radiating, can play a part of some antibiotic as ginger, drinking a little gingers in right amount can rise
To the anti-effect to cure cold.
（2）The present invention is cross-linked to form bigger network structure using gelatin as carrier with extract solution, it is preferably adsorbed
Active ingredient, while gelatin has thickening properties in itself, adds sorbierite, makes the sustained drug time longer.In addition, jasmine
Essential oil plays brain wash of refreshing oneself, the effect of mood placating, safety and comfort of the present invention, refrigerant frank, convenient and swift.
Embodiment
Preservative be calcium propionate, sodium Diacetate, sodium lactate it is therein any one.
The preparation method of antipyretic gel of the present invention, comprises the following steps：
（1）Count in parts by weight, take 10 ~ 15 portions of potatoes, 7 ~ 8 portions of gingers, 3 ~ 4 portions of green onions to be put into pulverizer and crush, obtain crushed material,
In mass ratio 1：2 ~ 3, crushed material, water are put into container, at 40 ~ 60 DEG C of temperature, using ultrasonic wave extraction, extraction 24 ~
40min, obtain extract solution；
（2）Count in parts by weight, 30 ~ 40 parts of extract solutions, 10 ~ 15 parts of gelatin, 5 ~ 8 parts of sorbierites, 1 ~ 2 part of Geniposide are put into appearance
In device, 50 ~ 55 DEG C are heated to, stirs 25 ~ 30min, after cooling, collects cooling thing, it is standby；
（3）In mass ratio 1 ~ 2：4 ~ 5, jasmine petal, water are put into distiller, they are 68 ~ 80 DEG C in temperature, vacuum is
Distilled under 13.3Pa, obtain distillate, the sodium chloride of jasmine petal quality 1 ~ 2% is added in distillate, stand 2 ~ 3h, then
The activated carbon of distillate quality 20 ~ 30% is added into distillate, 20 ~ 30min is stood, filtering, obtains filtered fluid；
（4）In mass ratio 7 ~ 10：3~4：1 ~ 2, cooling thing, filtered fluid, preservative are put into container and stirred, stirs 1 ~ 2h, is mixed
After closing uniformly, stirring mixture is collected, produces antipyretic gel.
Example 1
Preservative is calcium propionate.
The preparation method of antipyretic gel of the present invention, comprises the following steps：
（1）Count in parts by weight, take 10 portions of potatoes, 7 portions of gingers, 3 portions of green onions to be put into pulverizer and crush, crushed material is obtained, by quality
Than 1：2, crushed material, water are put into container, at 40 DEG C of temperature, using ultrasonic wave extraction, 24min is extracted, obtains extract solution；
（2）Count in parts by weight, 30 parts of extract solutions, 10 parts of gelatin, 5 parts of sorbierites, 1 part of Geniposide are put into container, heat
To 50 DEG C, 25min is stirred, after cooling, collects cooling thing, it is standby；
（3）In mass ratio 1：4, jasmine petal, water are put into distiller, they are 68 DEG C in temperature, vacuum is to enter under 13.3Pa
Row distillation, obtains distillate, and the sodium chloride of jasmine petal quality 1% is added in distillate, stands 2h, then add into distillate
The activated carbon of distillate quality 20%, 20min is stood, filtering, obtains filtered fluid；
（4）In mass ratio 7：3：1, cooling thing, filtered fluid, preservative are put into container and stirred, stirs 1h, after being well mixed,
Stirring mixture is collected, produces antipyretic gel.
Example 2
Preservative is sodium Diacetate.
The preparation method of antipyretic gel of the present invention, comprises the following steps：
（1）Count in parts by weight, take 15 portions of potatoes, 8 portions of gingers, 4 portions of green onions to be put into pulverizer and crush, crushed material is obtained, by quality
Than 1：3, crushed material, water are put into container, under temperature 60 C, using ultrasonic wave extraction, 40min is extracted, obtains extract solution；
（2）Count in parts by weight, 40 parts of extract solutions, 15 parts of gelatin, 8 parts of sorbierites, 2 parts of Geniposides are put into container, heat
To 55 DEG C, 30min is stirred, after cooling, collects cooling thing, it is standby；
（3）In mass ratio 2：5, jasmine petal, water are put into distiller, they are 80 DEG C in temperature, vacuum is to enter under 13.3Pa
Row distillation, obtains distillate, and the sodium chloride of jasmine petal quality 2% is added in distillate, stands 3h, then add into distillate
The activated carbon of distillate quality 30%, 30min is stood, filtering, obtains filtered fluid；
（4）In mass ratio 5：2：1, cooling thing, filtered fluid, preservative are put into container and stirred, stirs 2h, after being well mixed,
Stirring mixture is collected, produces antipyretic gel.
Example 3
Preservative is sodium lactate.
The preparation method of antipyretic gel of the present invention, comprises the following steps：
（1）Count in parts by weight, take 13 portions of potatoes, 7.5 portions of gingers, 3.5 portions of green onions to be put into pulverizer and crush, obtain crushed material, press
Mass ratio 1：2.5, crushed material, water are put into container, under temperature 50 C, using ultrasonic wave extraction, 32min is extracted, must carry
Take liquid；
（2）Count in parts by weight, 35 parts of extract solutions, 13 parts of gelatin, 6.5 parts of sorbierites, 1.5 parts of Geniposides be put into container,
53 DEG C are heated to, stirs 27min, after cooling, collects cooling thing, it is standby；
（3）In mass ratio 1.5：4.5, jasmine petal, water are put into distiller, they are 74 DEG C in temperature, vacuum 13.3Pa
Under distilled, obtain distillate, the sodium chloride of jasmine petal quality 1.5% added in distillate, stand 2.5h, then to distillation
The activated carbon of distillate quality 25% is added in liquid, 25min is stood, filtering, obtains filtered fluid；
（4）In mass ratio 9：3.5：1.5, cooling thing, filtered fluid, preservative are put into container and stirred, stirs 1.5h, mixing is equal
After even, stirring mixture is collected, produces antipyretic gel.
Reference examples：The antipyretic gel of Shijiazhuang City company production.
The antipyretic gel of antipyretic gel obtained by examples detailed above and reference examples is detected, specific detection is as follows：
Choose 100 low fever children respectively at random, be respectively applied to the antipyretic gel of the antipyretic gel of the present invention and reference examples
The space between the eyebrows, Quchi or Dazhui acupoint, smeared once per 8h, twice daily, record test data after observing 48h, test result is shown in Table 1.
It is effective：Body temperature is in being down to normal and no longer go up in 48h；
Effectively：Body temperature is in 1 ~ 1.5 DEG C of drop in 48h；
It is invalid：Body temperature in 48h in not dropping.
Summary, antipyretic gel cooling-down effect of the invention is more preferable, is worth promoting.
Claims (4)
1. a kind of preparation method of antipyretic gel, it is characterised in that the preparation method comprises the following steps：
（1）Count in parts by weight, take 10 ~ 15 portions of potatoes, 7 ~ 8 portions of gingers, 3 ~ 4 portions of green onions to be put into pulverizer and crush, obtain crushed material,
In mass ratio 1：2 ~ 3, crushed material, water are put into container, using ultrasonic wave extraction, obtain extract solution；
（2）Count in parts by weight, 30 ~ 40 parts of extract solutions, 10 ~ 15 parts of gelatin, 5 ~ 8 parts of sorbierites, 1 ~ 2 part of Geniposide are put into appearance
In device, 50 ~ 55 DEG C are heated to, stirs 25 ~ 30min, after cooling, collects cooling thing, it is standby；
（3）In mass ratio 1 ~ 2：4 ~ 5, jasmine petal, water are put into distiller and distilled, obtains distillate, is added in distillate
The sodium chloride of jasmine petal quality 1 ~ 2%, 2 ~ 3h is stood, then the activated carbon of distillate quality 20 ~ 30% is added into distillate, it is quiet
20 ~ 30min is put, filters, obtains filtered fluid；
（4）In mass ratio 7 ~ 10：3~4：1 ~ 2, cooling thing, filtered fluid, preservative are put into container and stirred, stirs 1 ~ 2h, is mixed
After closing uniformly, stirring mixture is collected, produces antipyretic gel.
2. the preparation method of antipyretic gel according to claim 1, it is characterised in that the step（1）Middle ultrasonic wave extraction
Parameter be 40 ~ 60 DEG C of temperature, 24 ~ 40min of time.
3. the preparation method of antipyretic gel according to claim 1, it is characterised in that the step（3）The temperature of middle distillation
For 68 ~ 80 DEG C, vacuum 13.3Pa.
4. the preparation method of antipyretic gel according to claim 1, it is characterised in that the step（4）Middle preservative is third
Sour calcium, sodium Diacetate, sodium lactate it is therein any one.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710928705.3A CN107596315A (en) | 2017-10-09 | 2017-10-09 | A kind of preparation method of antipyretic gel |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710928705.3A CN107596315A (en) | 2017-10-09 | 2017-10-09 | A kind of preparation method of antipyretic gel |
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| CN107596315A true CN107596315A (en) | 2018-01-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201710928705.3A Pending CN107596315A (en) | 2017-10-09 | 2017-10-09 | A kind of preparation method of antipyretic gel |
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Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958042A (en) * | 2005-11-03 | 2007-05-09 | 贵州中际药业有限公司 | Method for preparing gel for wean to remove heat |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
-
2017
- 2017-10-09 CN CN201710928705.3A patent/CN107596315A/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1958042A (en) * | 2005-11-03 | 2007-05-09 | 贵州中际药业有限公司 | Method for preparing gel for wean to remove heat |
| CN105998251A (en) * | 2016-06-17 | 2016-10-12 | 刘泰 | Preparation method of antipyretic patch |
Non-Patent Citations (2)
| Title |
|---|
| 袁凤鸣: "《药性三字经注解》", 31 January 2016, 中国中医药出版社 * |
| 赵鲲鹏: "《感冒合理用药460问》", 30 September 2013, 中国医药科技出版社 * |
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Application publication date: 20180119 |