CN100453553C - 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 - Google Patents

丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 Download PDF

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Publication number
CN100453553C
CN100453553C CNB2004800140478A CN200480014047A CN100453553C CN 100453553 C CN100453553 C CN 100453553C CN B2004800140478 A CNB2004800140478 A CN B2004800140478A CN 200480014047 A CN200480014047 A CN 200480014047A CN 100453553 C CN100453553 C CN 100453553C
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aliphatic
aliphatic group
cycloalkyl
aryl
compound according
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Expired - Fee Related
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CNB2004800140478A
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English (en)
Chinese (zh)
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CN1795188A (zh
Inventor
L·J·法默
R·P·珀尼
G·R·比瑟蒂
K·P·威尔逊
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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Priority claimed from US10/412,600 external-priority patent/US7273885B2/en
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Publication of CN1795188A publication Critical patent/CN1795188A/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
CNB2004800140478A 2003-04-11 2004-04-09 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂 Expired - Fee Related CN100453553C (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US10/412,600 US7273885B2 (en) 2002-04-11 2003-04-11 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US10/412,600 2003-04-11
US51376503P 2003-10-23 2003-10-23
US60/513,765 2003-10-23

Publications (2)

Publication Number Publication Date
CN1795188A CN1795188A (zh) 2006-06-28
CN100453553C true CN100453553C (zh) 2009-01-21

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CNB2004800140478A Expired - Fee Related CN100453553C (zh) 2003-04-11 2004-04-09 丝氨酸蛋白酶、特别是hcv ns3-ns4a蛋白酶的抑制剂

Country Status (10)

Country Link
US (3) US20050090450A1 (enExample)
EP (2) EP2332935A1 (enExample)
JP (2) JP2006526011A (enExample)
CN (1) CN100453553C (enExample)
AR (1) AR044513A1 (enExample)
AT (1) ATE547412T1 (enExample)
AU (1) AU2004230946A1 (enExample)
CA (1) CA2521678A1 (enExample)
ES (1) ES2381548T3 (enExample)
WO (1) WO2004092162A1 (enExample)

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ATE547412T1 (de) 2012-03-15
AU2004230946A1 (en) 2004-10-28
US20050090450A1 (en) 2005-04-28
EP1636208A1 (en) 2006-03-22
CN1795188A (zh) 2006-06-28
AR044513A1 (es) 2005-09-14
EP1636208B1 (en) 2012-02-29
EP2332935A1 (en) 2011-06-15
US20120014914A1 (en) 2012-01-19
CA2521678A1 (en) 2004-10-28
JP2006526011A (ja) 2006-11-16
ES2381548T3 (es) 2012-05-29
HK1090644A1 (zh) 2006-12-29
US8618152B2 (en) 2013-12-31

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