AR044513A1 - Inhibidores de serina proteasas, particularmente de la proteasa ns3-ns4a del hcv - Google Patents

Inhibidores de serina proteasas, particularmente de la proteasa ns3-ns4a del hcv

Info

Publication number
AR044513A1
AR044513A1 ARP040101227A ARP040101227A AR044513A1 AR 044513 A1 AR044513 A1 AR 044513A1 AR P040101227 A ARP040101227 A AR P040101227A AR P040101227 A ARP040101227 A AR P040101227A AR 044513 A1 AR044513 A1 AR 044513A1
Authority
AR
Argentina
Prior art keywords
aliphatic
optionally
cycloalkyl
heteroaryl
aryl
Prior art date
Application number
ARP040101227A
Other languages
English (en)
Spanish (es)
Inventor
Luc J Farmer
Robert B Perni
Giovinda Rao Bhisetti
Keith P Wilson
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/412,600 external-priority patent/US7273885B2/en
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of AR044513A1 publication Critical patent/AR044513A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0812—Tripeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ARP040101227A 2003-04-11 2004-04-12 Inhibidores de serina proteasas, particularmente de la proteasa ns3-ns4a del hcv AR044513A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/412,600 US7273885B2 (en) 2002-04-11 2003-04-11 Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
US51376503P 2003-10-23 2003-10-23

Publications (1)

Publication Number Publication Date
AR044513A1 true AR044513A1 (es) 2005-09-14

Family

ID=33302781

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP040101227A AR044513A1 (es) 2003-04-11 2004-04-12 Inhibidores de serina proteasas, particularmente de la proteasa ns3-ns4a del hcv

Country Status (10)

Country Link
US (3) US20050090450A1 (enExample)
EP (2) EP1636208B1 (enExample)
JP (2) JP2006526011A (enExample)
CN (1) CN100453553C (enExample)
AR (1) AR044513A1 (enExample)
AT (1) ATE547412T1 (enExample)
AU (1) AU2004230946A1 (enExample)
CA (1) CA2521678A1 (enExample)
ES (1) ES2381548T3 (enExample)
WO (1) WO2004092162A1 (enExample)

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SV2003000617A (es) 2000-08-31 2003-01-13 Lilly Co Eli Inhibidores de la proteasa peptidomimetica ref. x-14912m
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Also Published As

Publication number Publication date
CN1795188A (zh) 2006-06-28
EP1636208A1 (en) 2006-03-22
WO2004092162A1 (en) 2004-10-28
ES2381548T3 (es) 2012-05-29
EP2332935A1 (en) 2011-06-15
AU2004230946A1 (en) 2004-10-28
JP2006526011A (ja) 2006-11-16
CA2521678A1 (en) 2004-10-28
US20050090450A1 (en) 2005-04-28
US8618152B2 (en) 2013-12-31
CN100453553C (zh) 2009-01-21
HK1090644A1 (zh) 2006-12-29
US20090022688A1 (en) 2009-01-22
EP1636208B1 (en) 2012-02-29
ATE547412T1 (de) 2012-03-15
US20120014914A1 (en) 2012-01-19
JP2011068655A (ja) 2011-04-07

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