CN100435785C - 抑制iapp的化合物或其可药用酯或其可药用盐的制药应用 - Google Patents
抑制iapp的化合物或其可药用酯或其可药用盐的制药应用 Download PDFInfo
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- CN100435785C CN100435785C CNB008107203A CN00810720A CN100435785C CN 100435785 C CN100435785 C CN 100435785C CN B008107203 A CNB008107203 A CN B008107203A CN 00810720 A CN00810720 A CN 00810720A CN 100435785 C CN100435785 C CN 100435785C
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- Prior art keywords
- tetrahydroisoquinoline
- iapp
- group
- tetrahydro isoquinolyl
- sulfonic acid
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- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/192—Carboxylic acids, e.g. valproic acid having aromatic groups, e.g. sulindac, 2-aryl-propionic acids, ethacrynic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
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Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US13554599P | 1999-05-24 | 1999-05-24 | |
US60/135,545 | 1999-05-24 | ||
US14312399P | 1999-07-09 | 1999-07-09 | |
US60/143,123 | 1999-07-09 | ||
US09/576,677 US6562836B1 (en) | 1999-05-24 | 2000-05-23 | Methods and compounds for inhibiting amyloid deposits |
US09/576,677 | 2000-05-23 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNA2008101498521A Division CN101396352A (zh) | 1999-05-24 | 2000-05-24 | 抑制淀粉样蛋白沉积的方法和化合物 |
Publications (2)
Publication Number | Publication Date |
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CN1377260A CN1377260A (zh) | 2002-10-30 |
CN100435785C true CN100435785C (zh) | 2008-11-26 |
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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CNB008107203A Expired - Fee Related CN100435785C (zh) | 1999-05-24 | 2000-05-24 | 抑制iapp的化合物或其可药用酯或其可药用盐的制药应用 |
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Families Citing this family (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20040208875A1 (en) * | 1995-03-15 | 2004-10-21 | Queen's University At Kingston | Method for treating amyloidosis |
CN100482233C (zh) * | 1999-04-28 | 2009-04-29 | 贝卢斯健康(国际)有限公司 | 用于治疗淀粉样变性的组合物和方法 |
US6562836B1 (en) * | 1999-05-24 | 2003-05-13 | Queen's University Of Kingston | Methods and compounds for inhibiting amyloid deposits |
AU5994900A (en) * | 1999-07-09 | 2001-01-30 | Isis Innovation Limited | Compounds for inhibiting diseases and preparing cells for transplantation |
EP1432674A2 (en) | 2001-10-04 | 2004-06-30 | Elan Pharmaceuticals, Inc. | Hydroxypropylamines |
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WO2000071101A2 (en) | 2000-11-30 |
CA2373093A1 (en) | 2000-11-30 |
WO2000071101A3 (en) | 2001-12-06 |
IL146681A0 (en) | 2002-07-25 |
CA2373093C (en) | 2010-01-19 |
US20040248876A1 (en) | 2004-12-09 |
NZ541238A (en) | 2007-02-23 |
US6562836B1 (en) | 2003-05-13 |
EP1227803A2 (en) | 2002-08-07 |
AU4905000A (en) | 2000-12-12 |
MXPA01011989A (es) | 2002-05-06 |
HK1050133A1 (zh) | 2003-06-13 |
CA2684016A1 (en) | 2000-11-30 |
EP1227803B1 (en) | 2010-05-05 |
ATE466571T1 (de) | 2010-05-15 |
NZ552354A (en) | 2008-04-30 |
US20080227767A1 (en) | 2008-09-18 |
JP2003500350A (ja) | 2003-01-07 |
US7786174B2 (en) | 2010-08-31 |
IL180523A0 (en) | 2009-02-11 |
US7393875B2 (en) | 2008-07-01 |
IL146681A (en) | 2007-12-03 |
DE60044365D1 (de) | 2010-06-17 |
NZ566739A (en) | 2009-10-30 |
CN1377260A (zh) | 2002-10-30 |
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