CN100424059C - 富含对映体的2-丁醇 - Google Patents
富含对映体的2-丁醇 Download PDFInfo
- Publication number
- CN100424059C CN100424059C CNB2004100791292A CN200410079129A CN100424059C CN 100424059 C CN100424059 C CN 100424059C CN B2004100791292 A CNB2004100791292 A CN B2004100791292A CN 200410079129 A CN200410079129 A CN 200410079129A CN 100424059 C CN100424059 C CN 100424059C
- Authority
- CN
- China
- Prior art keywords
- palladium
- described method
- compound
- reaction
- butylene oxide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Catalysts (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Description
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 20.4 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 19.6 |
3.35(46.5) | 0.335 | - | - | 10 | 25 | 24 | 100∶0 | 100 | 33.4 |
45.0(624) | 4.50 | - | - | 50 | 25 | 24 | 99∶1 | 100 | 99.2 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 3.7 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 14.1 |
3.35(46.5) | 0.335 | - | - | 10 | 25 | 24 | 100.0 | 100 | 13.3 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 13.4 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 13.0 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 99∶1 | 100 | 42.0 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 99∶1 | 100 | 72.1 |
3.35(46.5) | 0.335 | - | - | 10 | 25 | 24 | 99∶1 | 100 | 85.7 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 6.6 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 1.7 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 88∶12 | 100 | 92.9 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 1,2-二氨基乙烷 | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
3.35(46.5) | 0.335 | - | 5 | 25 | 24 | 89∶11 | 100 | 100.0 |
3.35(46.5) | 0.335 | 0.020 | 10 | 25 | 24 | 99∶1 | 100 | 95.8 |
3.35(46.5) | 0.335 | 0.020 | 10 | 50 | 24 | 98∶2 | 100 | 99.2 |
3.35(46.5) | 0.335 | 0.040 | 10 | 50 | 24 | 98∶2 | 100 | 98.4 |
3.35(46.5) | 0.335 | 0.010 | 10 | 25 | 24 | 98∶2 | 100 | 97.8 |
3.35(46.5) | 0.335 | 0.010 | 10 | 50 | 24 | 97∶3 | 100 | 98.6 |
3.35(46.5) | 0.335 | 0.005 | 10 | 25 | 24 | 98∶2 | 100 | 96.9 |
Claims (8)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10341270A DE10341270A1 (de) | 2003-09-08 | 2003-09-08 | Enantiomerenangereichertes 2-Butanol |
DE10341270.0 | 2003-09-08 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1616385A CN1616385A (zh) | 2005-05-18 |
CN100424059C true CN100424059C (zh) | 2008-10-08 |
Family
ID=34177753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100791292A Expired - Fee Related CN100424059C (zh) | 2003-09-08 | 2004-09-08 | 富含对映体的2-丁醇 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7396964B2 (zh) |
EP (1) | EP1518850B1 (zh) |
CN (1) | CN100424059C (zh) |
AT (1) | ATE365151T1 (zh) |
DE (2) | DE10341270A1 (zh) |
ES (1) | ES2288655T3 (zh) |
HK (1) | HK1074832A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7628920B2 (en) * | 2004-04-07 | 2009-12-08 | Waters Technologies Corporation | Compositions and methods for separating enantiomers |
CA2667912C (en) * | 2006-12-01 | 2014-01-21 | E. I. Du Pont De Nemours And Company | Method for making 2-butanol |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02242700A (ja) * | 1989-03-16 | 1990-09-27 | Bio-Le Kk | 光学活性2―メチル―1―ブタノールの製造法 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870208A (en) * | 1988-06-03 | 1989-09-26 | Monsanto Company | Asymmetric hydrogenolysis of epoxides |
-
2003
- 2003-09-08 DE DE10341270A patent/DE10341270A1/de not_active Withdrawn
-
2004
- 2004-08-27 AT AT04020370T patent/ATE365151T1/de not_active IP Right Cessation
- 2004-08-27 EP EP04020370A patent/EP1518850B1/de not_active Not-in-force
- 2004-08-27 DE DE502004004125T patent/DE502004004125D1/de active Active
- 2004-08-27 ES ES04020370T patent/ES2288655T3/es active Active
- 2004-09-02 US US10/932,423 patent/US7396964B2/en not_active Expired - Fee Related
- 2004-09-08 CN CNB2004100791292A patent/CN100424059C/zh not_active Expired - Fee Related
-
2005
- 2005-08-18 HK HK05107169.5A patent/HK1074832A1/xx not_active IP Right Cessation
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH02242700A (ja) * | 1989-03-16 | 1990-09-27 | Bio-Le Kk | 光学活性2―メチル―1―ブタノールの製造法 |
Non-Patent Citations (2)
Title |
---|
. H.Sajiki,K.Hattori,K.Hirota.Chemistry Communication. 1999 |
. H.Sajiki,K.Hattori,K.Hirota.Chemistry Communication. 1999 * |
Also Published As
Publication number | Publication date |
---|---|
EP1518850B1 (de) | 2007-06-20 |
EP1518850A1 (de) | 2005-03-30 |
DE10341270A1 (de) | 2005-03-31 |
DE502004004125D1 (de) | 2007-08-02 |
ATE365151T1 (de) | 2007-07-15 |
US20050054736A1 (en) | 2005-03-10 |
US7396964B2 (en) | 2008-07-08 |
HK1074832A1 (en) | 2005-11-25 |
CN1616385A (zh) | 2005-05-18 |
ES2288655T3 (es) | 2008-01-16 |
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