CN1616385A - 富含对映体的2-丁醇 - Google Patents
富含对映体的2-丁醇 Download PDFInfo
- Publication number
- CN1616385A CN1616385A CN200410079129.2A CN200410079129A CN1616385A CN 1616385 A CN1616385 A CN 1616385A CN 200410079129 A CN200410079129 A CN 200410079129A CN 1616385 A CN1616385 A CN 1616385A
- Authority
- CN
- China
- Prior art keywords
- palladium
- described method
- compound
- butanols
- enantiomorph
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/132—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Catalysts (AREA)
Abstract
Description
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 20.4 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 19.6 |
3.35(46.5) | 0.335 | - | - | 10 | 25 | 24 | 100∶0 | 100 | 33.4 |
45.0(624) | 4.50 | - | - | 50 | 25 | 24 | 99∶1 | 100 | 99.2 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 3.7 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 14.1 |
3.35(46.5) | 0.335 | - | - | 10 | 25 | 24 | 100∶0 | 100 | 13.3 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 13.4 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 13.0 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 99∶1 | 100 | 42.0 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 99∶1 | 100 | 72.1 |
3.35(46.5) | 0.335 | - | - | 10 | 25 | 24 | 99∶1 | 100 | 85.7 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 100∶0 | 100 | 6.6 |
3.35(46.5) | 0.335 | - | - | 5 | 25 | 24 | 100∶0 | 100 | 1.7 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 溶剂 | ml | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
0.29(4.0) | 0.029 | 甲醇 | 8 | 5 | 25 | 24 | 88∶12 | 100 | 92.9 |
(R)-1,2-环氧丁烷[g]/[mmol] | 催化剂[g] | 1,2-二氨基乙烷 | P[巴] | T[℃] | t[h] | 比例 | ee(S)[%] | 转化率[%] |
3.35(46.5) | 0.335 | - | 5 | 25 | 24 | 89∶11 | 100 | 100.0 |
3.35(46.5) | 0.335 | 0.020 | 10 | 25 | 24 | 99∶1 | 100 | 95.8 |
3.35(46.5) | 0.335 | 0.020 | 10 | 50 | 24 | 98∶2 | 100 | 99.2 |
3.35(46.5) | 0.335 | 0.040 | 10 | 50 | 24 | 98∶2 | 100 | 98.4 |
3.35(46.5) | 0.335 | 0.010 | 10 | 25 | 24 | 98∶2 | 100 | 97.8 |
3.35(46.5) | 0.335 | 0.010 | 10 | 50 | 24 | 97∶3 | 100 | 98.6 |
3.35(46.5) | 0.335 | 0.005 | 10 | 25 | 24 | 98∶2 | 100 | 96.9 |
Claims (9)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10341270.0 | 2003-09-08 | ||
DE10341270A DE10341270A1 (de) | 2003-09-08 | 2003-09-08 | Enantiomerenangereichertes 2-Butanol |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1616385A true CN1616385A (zh) | 2005-05-18 |
CN100424059C CN100424059C (zh) | 2008-10-08 |
Family
ID=34177753
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2004100791292A Expired - Fee Related CN100424059C (zh) | 2003-09-08 | 2004-09-08 | 富含对映体的2-丁醇 |
Country Status (7)
Country | Link |
---|---|
US (1) | US7396964B2 (zh) |
EP (1) | EP1518850B1 (zh) |
CN (1) | CN100424059C (zh) |
AT (1) | ATE365151T1 (zh) |
DE (2) | DE10341270A1 (zh) |
ES (1) | ES2288655T3 (zh) |
HK (1) | HK1074832A1 (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7628920B2 (en) * | 2004-04-07 | 2009-12-08 | Waters Technologies Corporation | Compositions and methods for separating enantiomers |
BRPI0717691B1 (pt) * | 2006-12-01 | 2017-07-18 | E.I. Dupont De Nemours And Company | Method of manufacture of 2-butanol |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4870208A (en) * | 1988-06-03 | 1989-09-26 | Monsanto Company | Asymmetric hydrogenolysis of epoxides |
JPH02242700A (ja) * | 1989-03-16 | 1990-09-27 | Bio-Le Kk | 光学活性2―メチル―1―ブタノールの製造法 |
-
2003
- 2003-09-08 DE DE10341270A patent/DE10341270A1/de not_active Withdrawn
-
2004
- 2004-08-27 DE DE502004004125T patent/DE502004004125D1/de active Active
- 2004-08-27 EP EP04020370A patent/EP1518850B1/de not_active Not-in-force
- 2004-08-27 ES ES04020370T patent/ES2288655T3/es active Active
- 2004-08-27 AT AT04020370T patent/ATE365151T1/de not_active IP Right Cessation
- 2004-09-02 US US10/932,423 patent/US7396964B2/en not_active Expired - Fee Related
- 2004-09-08 CN CNB2004100791292A patent/CN100424059C/zh not_active Expired - Fee Related
-
2005
- 2005-08-18 HK HK05107169.5A patent/HK1074832A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ES2288655T3 (es) | 2008-01-16 |
ATE365151T1 (de) | 2007-07-15 |
HK1074832A1 (en) | 2005-11-25 |
EP1518850A1 (de) | 2005-03-30 |
DE502004004125D1 (de) | 2007-08-02 |
US7396964B2 (en) | 2008-07-08 |
EP1518850B1 (de) | 2007-06-20 |
DE10341270A1 (de) | 2005-03-31 |
US20050054736A1 (en) | 2005-03-10 |
CN100424059C (zh) | 2008-10-08 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN1289515C (zh) | 不对称(转移)氢化催化剂 | |
CN101035799A (zh) | 提纯含磷鳌合配体的方法 | |
CN1809527A (zh) | 取代4-二甲基氨基-2-芳基-丁-2-醇化合物脱水的方法和通过多相催化制备取代二甲基-( 3-芳基-丁基)-胺化合物的方法 | |
CN1705664A (zh) | (s,s)-顺式-2-二苯甲基-3-苄基氨基奎宁环的制备方法 | |
CN1414937A (zh) | 制备醇/酮混合物的方法 | |
CN1579627A (zh) | 一种手性配体金属络合物催化体系及制法和应用 | |
CN1194969C (zh) | 对映选择性铱催化氢化取代芳香吡啶环和吡嗪环的方法 | |
CN1616385A (zh) | 富含对映体的2-丁醇 | |
CN101074207A (zh) | 一类水溶性的手性二胺衍生物及其应用和制备 | |
CN1860105A (zh) | 制备6,7-二(2-甲氧基乙氧基)喹唑啉-4-酮的方法 | |
CN1408703A (zh) | 具有β2-受体兴奋作用的新型苯乙醇胺类化合物及其制法 | |
CN1008095B (zh) | 手性铑二膦络合物的制备 | |
CN1142130C (zh) | 生产反式-(r,r)-放线菌醇的方法 | |
CN1163499C (zh) | 旋转对映异构双(氧化膦)化合物的外消旋化方法 | |
CN1832918A (zh) | 生产旋光活性1-烷基-取代的2,2,2-三氟乙基胺的方法 | |
CN1169811C (zh) | 合成(3aS)-5,5-二氧代-2,3,3a,4-四氢-1H-吡咯并[2,1-c][1,2,4]苯并噻二嗪的新方法 | |
CN1272310C (zh) | 旋光2-氨基-、2-氯-、2-羟基-或2-烷氧基-1-醇的制备方法 | |
CN1186125C (zh) | 用于氧化偶联萘酚的手性催化剂 | |
CN1051765C (zh) | 一种立体选择性合成对映体纯3-氨基-1,2-二取代吡咯烷的方法 | |
CN1051764C (zh) | 对映体纯3-氨基-1,2-二取代吡咯烷的立体选择性合成方法 | |
CN1115335C (zh) | 甲酰咪唑的制备方法 | |
CN1656056A (zh) | 含氨甲基的苯甲酰胺化合物的制造方法 | |
CN1281582C (zh) | 高光学纯度手性β—氨基醇类化合物、制备方法及其用途 | |
CN1385409A (zh) | 外消旋的联二酚的光学拆分方法 | |
CN1243722C (zh) | 氨基二苯乙烯衍生物的制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
REG | Reference to a national code |
Ref country code: HK Ref legal event code: DE Ref document number: 1074832 Country of ref document: HK |
|
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
ASS | Succession or assignment of patent right |
Owner name: LANXESS GERMAN LIMITED LIABILITY COMPANY Free format text: FORMER OWNER: BAYER CHEMICAL PRODUCT AG. Effective date: 20080111 |
|
C41 | Transfer of patent application or patent right or utility model | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20080111 Address after: Germany Leverkusen Applicant after: Lanxess Deutschland GmbH Address before: The Federal Republic of Germany Leverkusen Applicant before: Bayer Chem Ltd. |
|
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C41 | Transfer of patent application or patent right or utility model | ||
TR01 | Transfer of patent right |
Effective date of registration: 20081205 Address after: Germany Langenfeld Patentee after: Saltigo GmbH Address before: Germany Leverkusen Patentee before: Lanxess Deutschland GmbH |
|
ASS | Succession or assignment of patent right |
Owner name: TOP CO.,LTD. Free format text: FORMER OWNER: LANXESS GERMAN LIMITED LIABILITY COMPANY Effective date: 20081205 |
|
REG | Reference to a national code |
Ref country code: HK Ref legal event code: GR Ref document number: 1074832 Country of ref document: HK |
|
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20081008 Termination date: 20150908 |
|
EXPY | Termination of patent right or utility model |