CN100419414C - 发光测定的装置 - Google Patents
发光测定的装置 Download PDFInfo
- Publication number
- CN100419414C CN100419414C CNB021320268A CN21302026A CN100419414C CN 100419414 C CN100419414 C CN 100419414C CN B021320268 A CNB021320268 A CN B021320268A CN 21302026 A CN21302026 A CN 21302026A CN 100419414 C CN100419414 C CN 100419414C
- Authority
- CN
- China
- Prior art keywords
- particle
- magnet
- electrode
- ecl
- electrogenerated chemiluminescence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Images
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
- G01N21/69—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence specially adapted for fluids, e.g. molten metal
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
- G01N33/54326—Magnetic particles
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54366—Apparatus specially adapted for solid-phase testing
- G01N33/54373—Apparatus specially adapted for solid-phase testing involving physiochemical end-point determination, e.g. wave-guides, FETS, gratings
- G01N33/5438—Electrodes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/40—Concentrating samples
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Hematology (AREA)
- Physics & Mathematics (AREA)
- General Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Biotechnology (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Abstract
Description
Claims (8)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US827269 | 1986-02-06 | ||
US65242791A | 1991-02-06 | 1991-02-06 | |
US652427 | 1991-02-06 | ||
US827270 | 1992-02-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN100419414C true CN100419414C (zh) | 2008-09-17 |
Family
ID=24616797
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB021320268A Expired - Lifetime CN100419414C (zh) | 1991-02-06 | 1992-02-07 | 发光测定的装置 |
Country Status (3)
Country | Link |
---|---|
US (1) | US6325973B1 (zh) |
CN (1) | CN100419414C (zh) |
ZA (2) | ZA92803B (zh) |
Families Citing this family (35)
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US7462322B2 (en) * | 1991-02-06 | 2008-12-09 | Bioveris Corporation | Methods and apparatus for improved luminescence assays |
US6413410B1 (en) | 1996-06-19 | 2002-07-02 | Lifescan, Inc. | Electrochemical cell |
AUPN661995A0 (en) | 1995-11-16 | 1995-12-07 | Memtec America Corporation | Electrochemical cell 2 |
AUPO581397A0 (en) * | 1997-03-21 | 1997-04-17 | Memtec America Corporation | Sensor connection means |
RU2278612C2 (ru) | 2000-07-14 | 2006-06-27 | Лайфскен, Инк. | Иммуносенсор |
EP2275819B1 (en) * | 2000-10-19 | 2019-11-27 | Mycartis NV | Method for the manipulation of microcarriers for an identification purpose |
US6862398B2 (en) * | 2001-03-30 | 2005-03-01 | Texas Instruments Incorporated | System for directed molecular interaction in surface plasmon resonance analysis |
US20030059839A1 (en) * | 2001-05-22 | 2003-03-27 | Obiso Richard J. | Method for detecting pathogens using immunoassays |
EP3021106B8 (en) | 2001-07-30 | 2019-03-27 | Meso Scale Technologies, LLC | Methods of using assay electrode having immobilized lipid/protein layers for luminescence test measurements |
JP4768224B2 (ja) | 2001-09-10 | 2011-09-07 | メソ スケイル テクノロジーズ,エルエルシー | 1つの試料について複数の測定を実施する方法及び装置 |
IL156007A0 (en) | 2001-10-10 | 2003-12-23 | Lifescan Inc | Electrochemical cell |
US20030180814A1 (en) * | 2002-03-21 | 2003-09-25 | Alastair Hodges | Direct immunosensor assay |
US20060134713A1 (en) * | 2002-03-21 | 2006-06-22 | Lifescan, Inc. | Biosensor apparatus and methods of use |
US7052694B2 (en) * | 2002-07-16 | 2006-05-30 | Mayo Foundation For Medical Education And Research | Dendritic cell potentiation |
KR100434690B1 (ko) * | 2002-07-19 | 2004-06-04 | 소광섭 | 생명체에 대한 자기장의 영향을 측정하는 장치 및 방법 |
EP1560930A4 (en) * | 2002-11-15 | 2007-05-16 | Applera Corp | NUKLEINSûURESEQUENZNACHWEIS |
KR100480033B1 (ko) * | 2002-11-19 | 2005-03-31 | 엘지전자 주식회사 | 전기화학발광을 이용한 핵산 혼성화 검출장치 및 핵산혼성화 검출방법 |
CN101057145B (zh) * | 2004-06-23 | 2014-10-22 | 得克萨斯系统大学评议会 | 使用双粒子复合体检测生物分子的方法和组合物 |
US9494581B2 (en) * | 2004-08-24 | 2016-11-15 | University Of Wyoming | System and method for Raman spectroscopy assay using paramagnetic particles |
EP1836495A2 (en) * | 2004-11-17 | 2007-09-26 | BioVeris Corporation | Electrochemiluminescent assay |
US20060154372A1 (en) * | 2004-12-21 | 2006-07-13 | Arter Thomas C | Providing additional motion in assays |
EP1893990B1 (en) | 2005-06-03 | 2018-05-02 | Board of Regents of the University of Texas System | Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode |
DK2271938T3 (da) | 2008-04-11 | 2014-05-12 | Univ Texas | Fremgangsmåde og apparat til nanopartikel-elektrogenereret kemiluminescens-amplifikation |
JP5258360B2 (ja) * | 2008-04-14 | 2013-08-07 | 富士フイルム株式会社 | イムノクロマト測定方法およびイムノクロマト測定キット |
AU2009244904B2 (en) | 2008-05-08 | 2014-04-17 | Board Of Regents Of The University Of Texas System | Luminescent nanostructured materials for use in electrogenerated chemiluminescence |
CA2772020A1 (en) | 2009-08-31 | 2011-03-03 | Mbio Diagnostics, Inc. | Integrated sample preparation and analyte detection |
US9233370B2 (en) | 2010-08-05 | 2016-01-12 | Abbott Point Of Care Inc. | Magnetic immunosensor and method of use |
WO2012019109A1 (en) * | 2010-08-05 | 2012-02-09 | Abbott Point Of Care Inc. | Oscillating immunoassay method and device |
US11402375B2 (en) | 2010-08-05 | 2022-08-02 | Abbott Point Of Care Inc. | Magnetic immunosensor with trench configuration and method of use |
CN103118785B (zh) | 2010-08-05 | 2015-11-25 | 雅培医护站股份有限公司 | 使用易感磁微珠捕获的免疫测定方法和装置 |
US9625465B2 (en) | 2012-05-15 | 2017-04-18 | Defined Diagnostics, Llc | Clinical diagnostic systems |
US9075042B2 (en) | 2012-05-15 | 2015-07-07 | Wellstat Diagnostics, Llc | Diagnostic systems and cartridges |
US9213043B2 (en) | 2012-05-15 | 2015-12-15 | Wellstat Diagnostics, Llc | Clinical diagnostic system including instrument and cartridge |
CN105378477B9 (zh) | 2013-03-11 | 2021-08-06 | 梅索磅秤技术有限公司 | 用于进行多路测定法的改进方法 |
US10866192B2 (en) * | 2018-10-19 | 2020-12-15 | Endress+Hauser Conducta Gmbh+Co. Kg | Optochemical sensor unit and a method for the qualitative and/or quantitative determination of an analyte in a measuring medium with the sensor unit |
Citations (2)
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-
1992
- 1992-02-04 ZA ZA92803A patent/ZA92803B/xx unknown
- 1992-02-04 ZA ZA92804A patent/ZA92804B/xx unknown
- 1992-02-07 CN CNB021320268A patent/CN100419414C/zh not_active Expired - Lifetime
-
1999
- 1999-02-19 US US09/253,558 patent/US6325973B1/en not_active Expired - Fee Related
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
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US4280815A (en) * | 1979-06-18 | 1981-07-28 | Technicon Instruments Corporation | Electrochemiluminescent immunoassay and apparatus therefor |
US4978610A (en) * | 1984-07-10 | 1990-12-18 | Forrest Gordon C | Method of assay employing a magnetic electrode |
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ZA92803B (en) | 1992-11-25 |
US6325973B1 (en) | 2001-12-04 |
ZA92804B (en) | 1992-12-30 |
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