CN100415216C - 含短效催眠剂或其盐的定时双释剂型 - Google Patents

含短效催眠剂或其盐的定时双释剂型 Download PDF

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Publication number
CN100415216C
CN100415216C CNB00809487XA CN00809487A CN100415216C CN 100415216 C CN100415216 C CN 100415216C CN B00809487X A CNB00809487X A CN B00809487XA CN 00809487 A CN00809487 A CN 00809487A CN 100415216 C CN100415216 C CN 100415216C
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CN
China
Prior art keywords
release
pharmaceutical composition
medicine
acid
coating
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
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CNB00809487XA
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English (en)
Chinese (zh)
Other versions
CN1358087A (zh
Inventor
G·阿劳克斯
F·安德雷
J·杜卡索
G·路易斯
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis France
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Sanofi Synthelabo SA
Sanofi Aventis France
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8242028&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN100415216(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Sanofi Synthelabo SA, Sanofi Aventis France filed Critical Sanofi Synthelabo SA
Publication of CN1358087A publication Critical patent/CN1358087A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Anesthesiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CNB00809487XA 1999-06-28 2000-06-27 含短效催眠剂或其盐的定时双释剂型 Expired - Fee Related CN100415216C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99401605A EP1064937A1 (en) 1999-06-28 1999-06-28 Timed dual release dosage forms comprising a short acting hypnotic or a salt thereof
EP99401605.3 1999-06-28

Publications (2)

Publication Number Publication Date
CN1358087A CN1358087A (zh) 2002-07-10
CN100415216C true CN100415216C (zh) 2008-09-03

Family

ID=8242028

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB00809487XA Expired - Fee Related CN100415216C (zh) 1999-06-28 2000-06-27 含短效催眠剂或其盐的定时双释剂型

Country Status (28)

Country Link
EP (2) EP1064937A1 (https=)
JP (1) JP2003503340A (https=)
KR (1) KR20020015064A (https=)
CN (1) CN100415216C (https=)
AR (1) AR024491A1 (https=)
AT (1) ATE269062T1 (https=)
AU (1) AU782162B2 (https=)
BR (1) BR0011994A (https=)
CA (1) CA2370556C (https=)
CO (1) CO5190680A1 (https=)
CZ (1) CZ20014640A3 (https=)
DE (1) DE60011617T2 (https=)
DK (1) DK1194132T3 (https=)
ES (1) ES2222223T3 (https=)
HK (1) HK1043057B (https=)
HU (1) HU227810B1 (https=)
IL (1) IL146928A0 (https=)
MX (1) MXPA01013212A (https=)
NO (1) NO20016283L (https=)
NZ (1) NZ515997A (https=)
PL (1) PL201777B1 (https=)
PT (1) PT1194132E (https=)
SI (1) SI1194132T1 (https=)
SK (1) SK285347B6 (https=)
TR (1) TR200103594T2 (https=)
TW (1) TWI285118B (https=)
WO (1) WO2001000181A2 (https=)
ZA (1) ZA200110005B (https=)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1064938A1 (en) * 1999-06-28 2001-01-03 Sanofi-Synthelabo Pharmaceutical dosage forms for controlled release producing at least a timed pulse
DE60003194T2 (de) * 1999-08-26 2004-06-17 Neurocrine Biosciences, Inc., San Diego Sedativ hypnotische zusammensetzungen mit gesteuerter freisetzung und diesbezügliche verfahren
US6485746B1 (en) 2000-08-25 2002-11-26 Neurocrine Biosciences, Inc. Controlled-release sedative-hypnotic compositions and methods related thereto
US7811557B1 (en) * 2000-10-27 2010-10-12 Viacell, Inc. Methods for improving central nervous system functioning
EP2311440A1 (en) * 2001-04-05 2011-04-20 Collagenex Pharmaceuticals, Inc. Controlled delivery of tetracycline compounds and tetracycline derivatives
US8329216B2 (en) 2001-07-06 2012-12-11 Endo Pharmaceuticals Inc. Oxymorphone controlled release formulations
KR20030048026A (ko) 2001-07-06 2003-06-18 펜웨스트 파머슈티칼즈 컴파니 옥시모르폰의 서방형 제제
CN1610551A (zh) 2001-07-06 2005-04-27 恩德制药公司 用作止痛剂的6－羟基羟吗啡酮的肠胃外给药
JP4417110B2 (ja) * 2001-12-19 2010-02-17 株式会社三和化学研究所 放出制御型成型品
EP1941878A1 (en) * 2002-01-10 2008-07-09 Biovail Laboratories International Srl Sedative non-benzodiazepine formulations
ES2301797T3 (es) * 2002-01-10 2008-07-01 Biovail Laboratories International Srl Formulaciones sedantes no benzodiazepinicas.
US20030165566A1 (en) * 2002-01-10 2003-09-04 O'toole Edel Sedative non-benzodiazepine formulations
CA2503121A1 (en) * 2002-10-25 2004-05-13 Collegium Pharmaceutical, Inc. Pulsatile release compositions of milnacipran
JP4681843B2 (ja) * 2004-09-30 2011-05-11 日本臓器製薬株式会社 固形医薬製剤
GB0423964D0 (en) * 2004-10-28 2004-12-01 Jagotec Ag Dosage form
FR2887455B1 (fr) * 2005-06-28 2007-08-10 Sanofi Aventis Sa Formulation a liberation prolongee de principes actifs de medicaments
AU2006322314A1 (en) * 2005-11-18 2007-06-14 Synthon B.V. Zolpidem tablets
AR056633A1 (es) * 2005-12-07 2007-10-17 Gador Sa Composiciones farmaceuticas de agentes hipnoticos de accion corta en forma de liberacion modificada y los procedimientos para preparar dichas formulaciones
US8309104B2 (en) * 2006-03-02 2012-11-13 Watson Pharmaceuticals, Inc. Oral controlled release formulation for sedative and hypnotic agents
KR20070091960A (ko) * 2006-03-08 2007-09-12 주식회사종근당 졸피뎀 또는 그의 염을 포함하는 안전한 제어방출형 제제조성물
AU2013202441B2 (en) * 2006-04-26 2016-02-25 Alphapharm Pty Ltd Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix
NZ703464A (en) 2006-04-26 2016-05-27 Alphapharm Pty Ltd Controlled release formulations comprising uncoated discrete unit(s) and an extended release matrix
JP5275560B2 (ja) * 2006-10-24 2013-08-28 小林化工株式会社 酒石酸ゾルピデム含有素錠の製造方法
EP1938805A1 (en) * 2006-12-22 2008-07-02 LEK Pharmaceuticals D.D. Monolithic sustained release zolpidem tablets
EP1970056A1 (en) * 2007-03-15 2008-09-17 Polichem S.A. Time-specific delayed/pulsatile release dosage forms
WO2009021127A2 (en) * 2007-08-07 2009-02-12 Neurogen Corporation Controlled released compositions
KR101601649B1 (ko) 2008-04-18 2016-03-09 인텍 파마 리미티드 카르비도파／레보도파 위체류 약물 전달
US20100068256A1 (en) 2008-09-16 2010-03-18 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Ex vivo modifiable medicament release-substance
JP2012510987A (ja) 2008-12-04 2012-05-17 インテック ファーマ リミテッド ザレプロン胃内滞留性薬剤送達システム
RU2384336C1 (ru) * 2009-04-22 2010-03-20 Маргарита Алексеевна Морозова Фармацевтический состав для коррекции психосоматических проявлений
CN102470108A (zh) * 2009-07-07 2012-05-23 桑诺维恩药品公司 非pH依赖型制剂(6-(5-氯-2-吡啶基)-5-[(4-甲基-1-哌嗪基)羰氧基]-7-氧代-6，7-二氢-5H-吡咯并[3，4-b]吡嗪)
FR2949062B1 (fr) * 2009-08-12 2011-09-02 Debregeas Et Associes Pharma Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
GB201003731D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Immediate/delayed drug delivery
GB201003734D0 (en) 2010-03-05 2010-04-21 Univ Strathclyde Delayed prolonged drug delivery
GB201003766D0 (en) * 2010-03-05 2010-04-21 Univ Strathclyde Pulsatile drug release
FR2968995B1 (fr) * 2010-12-16 2013-03-22 Sanofi Aventis Composition pharmaceutioue pour une administration par voie orale destinee a eviter le mesusage
FR2968992B1 (fr) * 2010-12-16 2013-02-08 Sanofi Aventis Comprime pharmaceutique orodispersible a base de zolpidem
TWI505841B (zh) * 2011-09-29 2015-11-01 Taiwan Biotech Co Ltd 治療睡眠障礙之控釋調配物
MY177906A (en) * 2014-02-06 2020-09-25 Sequential Medicine Ltd Composition and method for aiding sleep
RU2659200C1 (ru) * 2017-07-24 2018-06-28 Общество С Ограниченной Ответственностью "Валента - Интеллект" Фармацевтический состав, содержащий алимемазина тартрат

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0173928A1 (en) * 1984-09-06 1986-03-12 Ab Leo Controlled-release medical preparations
GB2245492A (en) * 1990-07-04 1992-01-08 Zambon Spa Programmed release oral solid pharmaceutical dosage form
EP0361910B1 (en) * 1988-09-30 1994-06-29 Rhone-Poulenc Rorer Limited Granular pharmaceutical formulations
WO1996041617A1 (en) * 1995-06-09 1996-12-27 Apr Applied Pharma Research S.A. Solid pharmaceutical form for oral use
US5650169A (en) * 1993-05-31 1997-07-22 Jagotec Ag Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times
CN1207681A (zh) * 1995-12-22 1999-02-10 埃迪克埃迪法姆药品实验室 含硫氮䓬酮活性成分的缓释微粒
EP0908177A1 (en) * 1997-09-12 1999-04-14 Oscar Gold Procedure to form pharmaceutical compositions in spherical pills or granules of controlled and sustained action that contain as active agent Bromazepam and pharmaceutical compositions obtained by said procedure
WO1999020255A1 (en) * 1997-10-17 1999-04-29 Elan Corporation, Plc Oral morphine multiparticulate formulation

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GB2185887B (en) * 1987-02-18 1989-12-06 Farmitalia Carlo Erba Ltd Temazepam composition
FR2656303B1 (fr) * 1989-12-26 1994-06-10 Parke Davis Solution buvable d'un derive des benzodiazepines et son application pharmacologique.
US5837284A (en) * 1995-12-04 1998-11-17 Mehta; Atul M. Delivery of multiple doses of medications
HRP970493A2 (en) * 1996-09-23 1998-08-31 Wienman E. Phlips Oral delayed immediate release medical formulation and method for preparing the same
FR2772615B1 (fr) * 1997-12-23 2002-06-14 Lipha Comprime multicouche pour la liberation instantanee puis prolongee de substances actives
EP1005863A1 (en) * 1998-12-04 2000-06-07 Synthelabo Controlled-release dosage forms comprising a short acting hypnotic or a salt thereof

Patent Citations (10)

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Publication number Priority date Publication date Assignee Title
EP0173928A1 (en) * 1984-09-06 1986-03-12 Ab Leo Controlled-release medical preparations
US4824678A (en) * 1984-09-06 1989-04-25 Aktiebolaget Leo Controlled-release medical preparations
EP0361910B1 (en) * 1988-09-30 1994-06-29 Rhone-Poulenc Rorer Limited Granular pharmaceutical formulations
GB2245492A (en) * 1990-07-04 1992-01-08 Zambon Spa Programmed release oral solid pharmaceutical dosage form
US5310558A (en) * 1990-07-04 1994-05-10 Zambon Group S.P.A. Programmed release oral solid pharmaceutical dosage form
US5650169A (en) * 1993-05-31 1997-07-22 Jagotec Ag Pharmaceutical tablet capable of releasing the active ingredients contained therein at subsequent times
WO1996041617A1 (en) * 1995-06-09 1996-12-27 Apr Applied Pharma Research S.A. Solid pharmaceutical form for oral use
CN1207681A (zh) * 1995-12-22 1999-02-10 埃迪克埃迪法姆药品实验室 含硫氮䓬酮活性成分的缓释微粒
EP0908177A1 (en) * 1997-09-12 1999-04-14 Oscar Gold Procedure to form pharmaceutical compositions in spherical pills or granules of controlled and sustained action that contain as active agent Bromazepam and pharmaceutical compositions obtained by said procedure
WO1999020255A1 (en) * 1997-10-17 1999-04-29 Elan Corporation, Plc Oral morphine multiparticulate formulation

Also Published As

Publication number Publication date
TR200103594T2 (tr) 2002-06-21
TWI285118B (en) 2007-08-11
SK285347B6 (sk) 2006-11-03
WO2001000181A2 (en) 2001-01-04
CN1358087A (zh) 2002-07-10
HU227810B1 (en) 2012-03-28
AU6694400A (en) 2001-01-31
CZ20014640A3 (cs) 2002-03-13
IL146928A0 (en) 2002-08-14
CA2370556C (en) 2009-09-01
PT1194132E (pt) 2004-10-29
PL201777B1 (pl) 2009-05-29
ZA200110005B (en) 2003-02-26
MXPA01013212A (es) 2002-06-21
AU782162B2 (en) 2005-07-07
EP1194132A2 (en) 2002-04-10
PL357348A1 (en) 2004-07-26
DE60011617T2 (de) 2005-06-09
EP1194132B1 (en) 2004-06-16
AR024491A1 (es) 2002-10-02
DK1194132T3 (da) 2004-10-11
CO5190680A1 (es) 2002-08-29
CA2370556A1 (en) 2001-01-04
ATE269062T1 (de) 2004-07-15
SI1194132T1 (en) 2004-10-31
BR0011994A (pt) 2002-03-05
JP2003503340A (ja) 2003-01-28
HUP0201907A3 (en) 2004-05-28
SK19112001A3 (sk) 2002-05-09
NO20016283D0 (no) 2001-12-20
HUP0201907A2 (hu) 2002-12-28
WO2001000181A3 (en) 2001-03-01
ES2222223T3 (es) 2005-02-01
HK1043057A1 (en) 2002-09-06
EP1064937A1 (en) 2001-01-03
NO20016283L (no) 2002-02-27
NZ515997A (en) 2004-03-26
HK1043057B (en) 2005-02-25
DE60011617D1 (de) 2004-07-22
KR20020015064A (ko) 2002-02-27

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Granted publication date: 20080903

Termination date: 20170627