CN100406010C - 抗癌剂及其制备方法 - Google Patents

抗癌剂及其制备方法 Download PDF

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Publication number
CN100406010C
CN100406010C CNB028171373A CN02817137A CN100406010C CN 100406010 C CN100406010 C CN 100406010C CN B028171373 A CNB028171373 A CN B028171373A CN 02817137 A CN02817137 A CN 02817137A CN 100406010 C CN100406010 C CN 100406010C
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CN
China
Prior art keywords
znpp
peg
protoporphyrin
polyethylene glycol
tumor
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Expired - Fee Related
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CNB028171373A
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English (en)
Chinese (zh)
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CN1549712A (zh
Inventor
前田浩
泽智裕
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB028171373A 2001-08-31 2002-08-29 抗癌剂及其制备方法 Expired - Fee Related CN100406010C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001264918A JP5000050B2 (ja) 2001-08-31 2001-08-31 抗腫瘍剤及びその製造方法
JP264918/2001 2001-08-31

Publications (2)

Publication Number Publication Date
CN1549712A CN1549712A (zh) 2004-11-24
CN100406010C true CN100406010C (zh) 2008-07-30

Family

ID=19091449

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB028171373A Expired - Fee Related CN100406010C (zh) 2001-08-31 2002-08-29 抗癌剂及其制备方法

Country Status (11)

Country Link
US (1) US7026488B2 (enExample)
EP (1) EP1421938B1 (enExample)
JP (1) JP5000050B2 (enExample)
KR (1) KR100876343B1 (enExample)
CN (1) CN100406010C (enExample)
AT (1) ATE456951T1 (enExample)
CA (1) CA2458744C (enExample)
DE (1) DE60235279D1 (enExample)
DK (1) DK1421938T3 (enExample)
ES (1) ES2339430T3 (enExample)
WO (1) WO2003018007A1 (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004196770A (ja) * 2002-10-24 2004-07-15 Effector Cell Institute Inc 樹状細胞前駆体の血中レベル上昇剤
GB2397067B (en) 2002-12-23 2005-05-11 Destiny Pharma Ltd Porphin & azaporphin derivatives with at least one cationic-nitrogen-containing meso-substituent for use in photodynamic therapy & in vitro sterilisation
GB2408265A (en) * 2003-11-21 2005-05-25 Univ Sheffield Water-soluble hyperbranched polymer porphyrins
GB2415372A (en) 2004-06-23 2005-12-28 Destiny Pharma Ltd Non photodynamical or sonodynamical antimicrobial use of porphyrins and azaporphyrins containing at least one cationic-nitrogen-containing substituent
EP1873204B1 (en) * 2005-04-18 2011-09-21 Hiroshi Maeda Polymeric pharmaceutical agent for treatment of cancer and process for production of the same
WO2008014266A2 (en) * 2006-07-24 2008-01-31 University Of Maryland, Baltimore Heme oxygenase inhibitors and methods of therapeutic use
WO2009015274A2 (en) * 2007-07-24 2009-01-29 University Of Florida Research Foundation, Inc. Polyethylene based bioactive agents
JP2010024170A (ja) * 2008-07-17 2010-02-04 Hiroshi Maeda 抗悪性腫瘍剤の腫瘍組織への局所送達増強剤
CN102000070B (zh) * 2009-07-08 2012-05-23 山东弘立医学动物实验研究有限公司 用于治疗肿瘤的锰卟啉-氯尼达明联合用药物
KR101164138B1 (ko) 2009-12-24 2012-07-11 재단법인대구경북과학기술원 광역학 치료용 수용성 나노구조체
CN101948566B (zh) * 2010-06-23 2012-09-19 中国科学院化学研究所 一种用于抗真菌、抗癌及细胞成像的多功能聚合物及其制备方法
HUE032791T2 (en) * 2011-09-05 2017-11-28 Hiroshi Maeda Polymer-type fluorescent molecule probe
CN104069492B (zh) * 2014-01-24 2019-05-28 中国科学院福建物质结构研究所 靶向表达尿激酶受体的肿瘤的光敏剂及其制备方法和用途
CN108610346B (zh) * 2018-04-02 2020-06-02 杭州至重医药科技有限公司 一种光敏酞菁固体材料及其制备方法与应用
CN114262442B (zh) * 2021-12-24 2023-05-02 厦门金达威生物科技有限公司 一种两亲聚合物和脂溶性营养素纳米颗粒及其制备方法
CN119456038A (zh) * 2025-01-14 2025-02-18 浙江工业大学 一种金属卟啉基柔性共轭有机聚合物-卤氧铋复合材料及制备方法和光催化co2还原应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2645079A1 (de) * 1976-10-06 1978-04-13 Bayer Ernst Polymere sauerstofftraeger und verfahren zu ihrer herstellung
WO1991018006A1 (en) * 1990-05-15 1991-11-28 Diatron Corporation Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
US5849259A (en) * 1992-09-28 1998-12-15 Institut Fur Diagnostikforschung Gmbh 3-,8-substituted deuteroporphyrin derivatives, pharmaceutical agents containing the latter and process for their production

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS584061B2 (ja) * 1979-04-27 1983-01-24 森六株式会社 ブロック共重合体金属錯体
US5622685A (en) * 1990-05-30 1997-04-22 Deutches Krebsforchunszentrum Stiftung Des Offentlichen Rechts Polyether-substituted porphyrin anti-tumor agents
EP0502723B1 (en) 1991-03-05 1996-10-09 Hitachi Chemical Co., Ltd. Water-soluble tetraazaporphins and fluorochrome for labeling
US6362175B1 (en) * 1991-09-20 2002-03-26 The Trustees Of The University Of Pennsylvania Porphyrin compounds for imaging tissue oxygen
DE69129150T2 (de) * 1991-10-14 1998-10-08 The Procter & Gamble Co., Cincinnati, Ohio Waschmittelzusammensetzungen mit Zusätzen zur Verhinderung der Farbstoffübertragung
GB9408746D0 (en) * 1994-05-03 1994-06-22 Scotia Holdings Plc Tumour locallising photosensitising compounds
US5591422A (en) * 1995-06-02 1997-01-07 Pharmacyclics, Inc. Texaphyrin complexes having improved functionalization
US20020155999A1 (en) * 1998-04-30 2002-10-24 Han In Suk Method of using a porphyrin-like molecule conjugated with an anti-cancer drug for the treatment of cancer
GB0001455D0 (en) * 2000-01-21 2000-03-15 Scotia Holdings Plc Porphyrins and related compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2645079A1 (de) * 1976-10-06 1978-04-13 Bayer Ernst Polymere sauerstofftraeger und verfahren zu ihrer herstellung
WO1991018006A1 (en) * 1990-05-15 1991-11-28 Diatron Corporation Fluorescent porphyrin, and fluorescent phthalocyanine - polyethylene glycol, polyol, and saccharide derivatives as fluorescent probes
US5849259A (en) * 1992-09-28 1998-12-15 Institut Fur Diagnostikforschung Gmbh 3-,8-substituted deuteroporphyrin derivatives, pharmaceutical agents containing the latter and process for their production

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
水溶性金属卟啉衍生物的合成及其对癌细胞生长的抑制活性. 孙炳银，李淑蓉，长尾则男，宇田泰三.中国药学杂志，第30卷第12期. 1995 *

Also Published As

Publication number Publication date
EP1421938A1 (en) 2004-05-26
KR100876343B1 (ko) 2008-12-29
CA2458744C (en) 2010-09-14
CA2458744A1 (en) 2003-03-06
JP2003073273A (ja) 2003-03-12
DE60235279D1 (de) 2010-03-25
EP1421938B1 (en) 2010-02-03
JP5000050B2 (ja) 2012-08-15
EP1421938A4 (en) 2005-11-23
ES2339430T3 (es) 2010-05-20
US7026488B2 (en) 2006-04-11
CN1549712A (zh) 2004-11-24
WO2003018007A1 (en) 2003-03-06
KR20040030951A (ko) 2004-04-09
US20040234495A1 (en) 2004-11-25
DK1421938T3 (da) 2010-05-17
ATE456951T1 (de) 2010-02-15

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Granted publication date: 20080730

Termination date: 20120829