CN100398107C - IκB激酶抑制剂在制备用于治疗疼痛的药物中的用途 - Google Patents

IκB激酶抑制剂在制备用于治疗疼痛的药物中的用途 Download PDF

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Publication number
CN100398107C
CN100398107C CNB038195429A CN03819542A CN100398107C CN 100398107 C CN100398107 C CN 100398107C CN B038195429 A CNB038195429 A CN B038195429A CN 03819542 A CN03819542 A CN 03819542A CN 100398107 C CN100398107 C CN 100398107C
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alkyl
pain
group
heteroaryl
independently
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Expired - Fee Related
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CNB038195429A
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English (en)
Chinese (zh)
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CN1674899A (zh
Inventor
M·米夏埃利斯
O·里策尔埃
G·耶内
K·鲁道菲
G·盖斯林格
H-·G·沙伊布勒
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Sanofi Aventis Deutschland GmbH
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Sanofi Aventis Deutschland GmbH
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Paper (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CNB038195429A 2002-08-17 2003-08-05 IκB激酶抑制剂在制备用于治疗疼痛的药物中的用途 Expired - Fee Related CN100398107C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10237723A DE10237723A1 (de) 2002-08-17 2002-08-17 Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie
DE10237723.5 2002-08-17

Publications (2)

Publication Number Publication Date
CN1674899A CN1674899A (zh) 2005-09-28
CN100398107C true CN100398107C (zh) 2008-07-02

Family

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CNB038195429A Expired - Fee Related CN100398107C (zh) 2002-08-17 2003-08-05 IκB激酶抑制剂在制备用于治疗疼痛的药物中的用途

Country Status (33)

Country Link
EP (1) EP1531819B1 (https=)
JP (1) JP4504811B2 (https=)
KR (2) KR101119845B1 (https=)
CN (1) CN100398107C (https=)
AR (1) AR043045A1 (https=)
AT (1) ATE418336T1 (https=)
AU (1) AU2003271555B2 (https=)
BR (1) BR0313555A (https=)
CA (1) CA2495455C (https=)
CO (1) CO5690585A2 (https=)
CR (1) CR7716A (https=)
CY (1) CY1108874T1 (https=)
DE (2) DE10237723A1 (https=)
DK (1) DK1531819T3 (https=)
EC (1) ECSP055609A (https=)
ES (1) ES2320118T3 (https=)
HR (1) HRP20050041B1 (https=)
IL (1) IL166780A (https=)
MA (1) MA27334A1 (https=)
MX (1) MXPA05001218A (https=)
MY (1) MY138059A (https=)
NO (1) NO334309B1 (https=)
OA (1) OA12907A (https=)
PL (1) PL212356B1 (https=)
PT (1) PT1531819E (https=)
RS (1) RS51878B (https=)
RU (1) RU2320338C2 (https=)
SI (1) SI1531819T1 (https=)
TN (1) TNSN05044A1 (https=)
TW (1) TWI325782B (https=)
UA (1) UA80837C2 (https=)
WO (1) WO2004022057A1 (https=)
ZA (1) ZA200500323B (https=)

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US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7312044B2 (en) 2003-03-07 2007-12-25 The Trustees Of Columbia University In The City Of New York Type 1 ryanodine receptor-based methods
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US7393652B2 (en) 2000-05-10 2008-07-01 The Trustees Of Columbia University In The City Of New York Methods for identifying a chemical compound that directly enhances binding of FKBP12.6 to PKA-phosphorylated type 2 ryanodine receptor (RyR2)
DE10237722A1 (de) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase
US7544678B2 (en) 2002-11-05 2009-06-09 The Trustees Of Columbia University In The City Of New York Anti-arrythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2)
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019831A1 (en) 2004-07-14 2006-02-23 Ptc Therapeutics, Inc. Methods for treating hepatitis c
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
WO2006019832A1 (en) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating hepatitis c
DE102005025225A1 (de) 2005-06-01 2006-12-07 Sanofi-Aventis Deutschland Gmbh Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP2025674A1 (de) 2007-08-15 2009-02-18 sanofi-aventis Substituierte Tetrahydronaphthaline, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
AR072297A1 (es) 2008-06-27 2010-08-18 Novartis Ag Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona.
WO2011107494A1 (de) 2010-03-03 2011-09-09 Sanofi Neue aromatische glykosidderivate, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2582709B1 (de) 2010-06-18 2018-01-24 Sanofi Azolopyridin-3-on-derivate als inhibitoren von lipasen und phospholipasen
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
JP5790440B2 (ja) 2010-12-01 2015-10-07 住友化学株式会社 ピリミジン化合物およびその有害生物防除用途
EP2766349B1 (de) 2011-03-08 2016-06-01 Sanofi Mit carbozyklen oder heterozyklen substituierte oxathiazinderivate, verfahren zu deren herstellung, diese verbindungen enthaltende arzneimittel und deren verwendung
EP2683704B1 (de) 2011-03-08 2014-12-17 Sanofi Verzweigte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2683699B1 (de) 2011-03-08 2015-06-24 Sanofi Di- und trisubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
US8828994B2 (en) 2011-03-08 2014-09-09 Sanofi Di- and tri-substituted oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
WO2012120056A1 (de) 2011-03-08 2012-09-13 Sanofi Tetrasubstituierte oxathiazinderivate, verfahren zu deren herstellung, ihre verwendung als medikament sowie sie enthaltendes arzneimittel und deren verwendung
EP2532755A1 (en) * 2011-06-10 2012-12-12 Sanofi-Aventis Methods and uses based on Slfn2 expression and relating to the identification and profiling of compounds for use in the treatment or prevention of pain
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
CA2856607C (en) * 2011-12-06 2020-03-10 Sanofi Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
EP3184095A1 (en) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
JO3425B1 (ar) 2013-07-15 2019-10-20 Novartis Ag مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b
WO2016001197A1 (en) * 2014-07-03 2016-01-07 Sanofi 2-(2-methylamino-pyrimidin-4-yl)-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide for use in the treatment of pain associated to osteoarthritis
CN120118068A (zh) 2018-07-16 2025-06-10 诺华股份有限公司 用于制备苯基哌啶基吲哚衍生物的化学方法

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WO2001000610A1 (de) * 1999-06-23 2001-01-04 Aventis Pharma Deutschland Gmbh Substituierte benzimidazole
WO2001030774A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Deutschland Gmbh Substituierte indole zur modulierung von nfkb-aktivität

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Patent Citations (2)

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WO2001000610A1 (de) * 1999-06-23 2001-01-04 Aventis Pharma Deutschland Gmbh Substituierte benzimidazole
WO2001030774A1 (de) * 1999-10-26 2001-05-03 Aventis Pharma Deutschland Gmbh Substituierte indole zur modulierung von nfkb-aktivität

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CR7716A (es) 2008-11-25
KR101119845B1 (ko) 2012-02-28
HK1079426A1 (en) 2006-04-07
RS51878B (sr) 2012-02-29
EP1531819B1 (de) 2008-12-24
MXPA05001218A (es) 2005-05-16
IL166780A0 (en) 2006-01-15
PT1531819E (pt) 2009-02-18
ES2320118T3 (es) 2009-05-19
HRP20050041A2 (hr) 2006-04-30
CO5690585A2 (es) 2006-10-31
RU2005107419A (ru) 2005-08-10
MY138059A (en) 2009-04-30
AU2003271555B2 (en) 2009-03-26
SI1531819T1 (sl) 2009-06-30
ATE418336T1 (de) 2009-01-15
OA12907A (en) 2006-10-13
NO334309B1 (no) 2014-02-03
BR0313555A (pt) 2005-07-12
EP1531819A1 (de) 2005-05-25
ECSP055609A (es) 2005-04-18
AR043045A1 (es) 2005-07-13
JP4504811B2 (ja) 2010-07-14
ZA200500323B (en) 2006-02-22
CY1108874T1 (el) 2014-07-02
RS20050070A (sr) 2007-06-04
AU2003271555A1 (en) 2004-03-29
RU2320338C2 (ru) 2008-03-27
DK1531819T3 (da) 2009-04-20
PL212356B1 (pl) 2012-09-28
CA2495455C (en) 2011-01-11
PL373568A1 (en) 2005-09-05
KR20050058339A (ko) 2005-06-16
UA80837C2 (uk) 2007-11-12
HRP20050041B1 (hr) 2013-07-31
KR20110135428A (ko) 2011-12-16
WO2004022057A1 (de) 2004-03-18
TW200417370A (en) 2004-09-16
CA2495455A1 (en) 2004-03-18
CN1674899A (zh) 2005-09-28
TWI325782B (en) 2010-06-11
NO20051339L (no) 2005-05-03
DE50310980D1 (de) 2009-02-05
MA27334A1 (fr) 2005-05-02
TNSN05044A1 (en) 2007-05-14
JP2005539053A (ja) 2005-12-22
IL166780A (en) 2011-11-30
DE10237723A1 (de) 2004-07-08

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