MA27334A1 - Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleur - Google Patents
Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleurInfo
- Publication number
- MA27334A1 MA27334A1 MA28107A MA28107A MA27334A1 MA 27334 A1 MA27334 A1 MA 27334A1 MA 28107 A MA28107 A MA 28107A MA 28107 A MA28107 A MA 28107A MA 27334 A1 MA27334 A1 MA 27334A1
- Authority
- MA
- Morocco
- Prior art keywords
- pain
- treatment
- kinase inhibitors
- ikb kinase
- ikb
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4245—Oxadiazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
Abstract
L'invention concerne l'utilisation d'inhibiteurs de l'IkB kinase pour produire des médicaments servant au traitement des douleurs. Les inhibiteurs appropriés proviennent des composés de formules (I) et (Ia).
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10237723A DE10237723A1 (de) | 2002-08-17 | 2002-08-17 | Verwendung von IKappaB-Kinase Inhibitoren in der Schmerztherapie |
Publications (1)
Publication Number | Publication Date |
---|---|
MA27334A1 true MA27334A1 (fr) | 2005-05-02 |
Family
ID=31968975
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA28107A MA27334A1 (fr) | 2002-08-17 | 2005-02-15 | Utilisation d'inhibiteurs de l'ikb kinase dans le traitement de la douleur |
Country Status (34)
Country | Link |
---|---|
EP (1) | EP1531819B1 (fr) |
JP (1) | JP4504811B2 (fr) |
KR (2) | KR20110135428A (fr) |
CN (1) | CN100398107C (fr) |
AR (1) | AR043045A1 (fr) |
AT (1) | ATE418336T1 (fr) |
AU (1) | AU2003271555B2 (fr) |
BR (1) | BR0313555A (fr) |
CA (1) | CA2495455C (fr) |
CO (1) | CO5690585A2 (fr) |
CR (1) | CR7716A (fr) |
CY (1) | CY1108874T1 (fr) |
DE (2) | DE10237723A1 (fr) |
DK (1) | DK1531819T3 (fr) |
EC (1) | ECSP055609A (fr) |
ES (1) | ES2320118T3 (fr) |
HK (1) | HK1079426A1 (fr) |
HR (1) | HRP20050041B1 (fr) |
IL (1) | IL166780A (fr) |
MA (1) | MA27334A1 (fr) |
MX (1) | MXPA05001218A (fr) |
MY (1) | MY138059A (fr) |
NO (1) | NO334309B1 (fr) |
OA (1) | OA12907A (fr) |
PL (1) | PL212356B1 (fr) |
PT (1) | PT1531819E (fr) |
RS (1) | RS51878B (fr) |
RU (1) | RU2320338C2 (fr) |
SI (1) | SI1531819T1 (fr) |
TN (1) | TNSN05044A1 (fr) |
TW (1) | TWI325782B (fr) |
UA (1) | UA80837C2 (fr) |
WO (1) | WO2004022057A1 (fr) |
ZA (1) | ZA200500323B (fr) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8022058B2 (en) | 2000-05-10 | 2011-09-20 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7879840B2 (en) | 2005-08-25 | 2011-02-01 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
US7718644B2 (en) | 2004-01-22 | 2010-05-18 | The Trustees Of Columbia University In The City Of New York | Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof |
DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
US8710045B2 (en) | 2004-01-22 | 2014-04-29 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the ryanodine receptors |
WO2006019831A1 (fr) | 2004-07-14 | 2006-02-23 | Ptc Therapeutics, Inc. | Procedes pour le traitement de l'hepatite c |
US7772271B2 (en) | 2004-07-14 | 2010-08-10 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7781478B2 (en) | 2004-07-14 | 2010-08-24 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
US7868037B2 (en) | 2004-07-14 | 2011-01-11 | Ptc Therapeutics, Inc. | Methods for treating hepatitis C |
JP2008507518A (ja) | 2004-07-22 | 2008-03-13 | ピーティーシー セラピューティクス,インコーポレーテッド | C型肝炎を治療するためのチエノピリジン |
DE102005025225A1 (de) * | 2005-06-01 | 2006-12-07 | Sanofi-Aventis Deutschland Gmbh | Verfahren zur Herstellung von 2-(2-Amino-pyrimidin-4-yl)-1H-indol-5-carbonsäure-derivaten |
US7704990B2 (en) | 2005-08-25 | 2010-04-27 | The Trustees Of Columbia University In The City Of New York | Agents for preventing and treating disorders involving modulation of the RyR receptors |
EP2025674A1 (fr) | 2007-08-15 | 2009-02-18 | sanofi-aventis | Tetrahydronaphthaline substituée, son procédé de fabrication et son utilisation en tant que médicament |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
WO2011107494A1 (fr) | 2010-03-03 | 2011-09-09 | Sanofi | Nouveaux dérivés aromatiques de glycoside, médicaments contenants ces composés, et leur utilisation |
EP2582709B1 (fr) | 2010-06-18 | 2018-01-24 | Sanofi | Dérivés d'azolopyridin-3-one en tant qu'inhibiteurs de lipases et de phospholipases |
TW201215387A (en) | 2010-07-05 | 2012-04-16 | Sanofi Aventis | Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament |
TW201215388A (en) | 2010-07-05 | 2012-04-16 | Sanofi Sa | (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments |
TW201221505A (en) | 2010-07-05 | 2012-06-01 | Sanofi Sa | Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament |
TW201242962A (en) | 2010-12-01 | 2012-11-01 | Sumitomo Chemical Co | Pyrimidine compound and use for pest control thereof |
EP2683699B1 (fr) | 2011-03-08 | 2015-06-24 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
EP2683704B1 (fr) | 2011-03-08 | 2014-12-17 | Sanofi | Dérivés oxathiazine ramifiés, procédé pour leur préparation, utilisation en tant que médicament, agents pharmaceutiques contenant ces dérivés et leur utilisation |
WO2012120054A1 (fr) | 2011-03-08 | 2012-09-13 | Sanofi | Dérivés oxathiazine di- et tri-substitués, procédé pour leur préparation, utilisation en tant que médicament, agent pharmaceutique contenant ces dérivés et utilisation |
US8901114B2 (en) | 2011-03-08 | 2014-12-02 | Sanofi | Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof |
US8871758B2 (en) | 2011-03-08 | 2014-10-28 | Sanofi | Tetrasubstituted oxathiazine derivatives, method for producing them, their use as medicine and drug containing said derivatives and the use thereof |
EP2532755A1 (fr) * | 2011-06-10 | 2012-12-12 | Sanofi-Aventis | Procédés et utilisations basés sur l'expression de Slfn2 et liés à l'identification et au profilage de composés pour une utilisation dans le traitement ou la prévention de la douleur |
WO2013045413A1 (fr) | 2011-09-27 | 2013-04-04 | Sanofi | Dérivés d'amide d'acide 6-(4-hydroxyphényl)-3-alkyl-1h-pyrazolo[3,4-b] pyridine-4-carboxylique utilisés comme inhibiteurs de kinase |
KR20140103968A (ko) * | 2011-12-06 | 2014-08-27 | 사노피 | 2-(2-메틸아미노-피리미딘-4-일)-1h-인돌-5-카복실산 [(s)-1-카바모일-2-(페닐-피리미딘-2일-아미노)-에틸]-아미드의 결정 형태 |
EP3184095A1 (fr) | 2013-05-23 | 2017-06-28 | IP Gesellschaft für Management mbH | Unitées d'administration comprennante une polymorphe 1 de 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide |
JO3425B1 (ar) | 2013-07-15 | 2019-10-20 | Novartis Ag | مشتقات البابيريدينيل-اندول واستخدامها كعامل متمم لمثبطات b |
MX2017000165A (es) * | 2014-07-03 | 2017-04-25 | Sanofi Sa | [(s)-1-carbamoil-2-(fenil-pirimidin-2-il-amino)-etil]-amida de acido 2-(2-metilamino-pirimidin-4-il)-1h-indol-5-carboxilico para su uso en el tratamiento del dolor asociado a la osteoartritis. |
US11208398B2 (en) | 2018-07-16 | 2021-12-28 | Novartis Ag | Chemical process for preparing phenylpiperidinyl indole derivatives |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR100718830B1 (ko) * | 1999-06-23 | 2007-05-17 | 사노피-아벤티스 도이칠란트 게엠베하 | 치환된 벤즈이미다졸 및 이의 제조방법 |
DE19951360A1 (de) * | 1999-10-26 | 2001-05-03 | Aventis Pharma Gmbh | Substituierte Indole |
DE10237722A1 (de) * | 2002-08-17 | 2004-08-19 | Aventis Pharma Deutschland Gmbh | Indol- oder Benzimidazolderivate zur Modulation der IKappaB-Kinase |
-
2002
- 2002-08-17 DE DE10237723A patent/DE10237723A1/de not_active Withdrawn
-
2003
- 2003-05-08 UA UAA200502388A patent/UA80837C2/uk unknown
- 2003-08-05 SI SI200331531T patent/SI1531819T1/sl unknown
- 2003-08-05 OA OA1200500046A patent/OA12907A/en unknown
- 2003-08-05 PT PT03753349T patent/PT1531819E/pt unknown
- 2003-08-05 CN CNB038195429A patent/CN100398107C/zh not_active Expired - Fee Related
- 2003-08-05 PL PL373568A patent/PL212356B1/pl unknown
- 2003-08-05 KR KR1020117028345A patent/KR20110135428A/ko not_active Application Discontinuation
- 2003-08-05 BR BR0313555-1A patent/BR0313555A/pt not_active Application Discontinuation
- 2003-08-05 CA CA2495455A patent/CA2495455C/fr not_active Expired - Fee Related
- 2003-08-05 MX MXPA05001218A patent/MXPA05001218A/es active IP Right Grant
- 2003-08-05 AU AU2003271555A patent/AU2003271555B2/en not_active Ceased
- 2003-08-05 RU RU2005107419/15A patent/RU2320338C2/ru not_active IP Right Cessation
- 2003-08-05 EP EP03753349A patent/EP1531819B1/fr not_active Expired - Lifetime
- 2003-08-05 ES ES03753349T patent/ES2320118T3/es not_active Expired - Lifetime
- 2003-08-05 AT AT03753349T patent/ATE418336T1/de active
- 2003-08-05 KR KR1020057002712A patent/KR101119845B1/ko not_active IP Right Cessation
- 2003-08-05 RS YU20050070A patent/RS51878B/sr unknown
- 2003-08-05 JP JP2004533318A patent/JP4504811B2/ja not_active Expired - Fee Related
- 2003-08-05 DE DE50310980T patent/DE50310980D1/de not_active Expired - Lifetime
- 2003-08-05 WO PCT/EP2003/008628 patent/WO2004022057A1/fr active Application Filing
- 2003-08-05 DK DK03753349T patent/DK1531819T3/da active
- 2003-08-14 AR ARP030102944A patent/AR043045A1/es not_active Application Discontinuation
- 2003-08-14 TW TW092122310A patent/TWI325782B/zh not_active IP Right Cessation
- 2003-08-15 MY MYPI20033112A patent/MY138059A/en unknown
-
2005
- 2005-01-13 ZA ZA200500323A patent/ZA200500323B/xx unknown
- 2005-01-14 HR HRP20050041AA patent/HRP20050041B1/hr not_active IP Right Cessation
- 2005-02-09 IL IL166780A patent/IL166780A/en not_active IP Right Cessation
- 2005-02-15 MA MA28107A patent/MA27334A1/fr unknown
- 2005-02-15 CO CO05013333A patent/CO5690585A2/es not_active Application Discontinuation
- 2005-02-16 TN TNP2005000044A patent/TNSN05044A1/en unknown
- 2005-02-17 EC EC2005005609A patent/ECSP055609A/es unknown
- 2005-03-07 CR CR7716A patent/CR7716A/es unknown
- 2005-03-15 NO NO20051339A patent/NO334309B1/no not_active IP Right Cessation
- 2005-12-12 HK HK05111381.9A patent/HK1079426A1/xx not_active IP Right Cessation
-
2009
- 2009-03-17 CY CY20091100291T patent/CY1108874T1/el unknown
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