HK1079426A1 - Use of ikappab kinase inhibitors for the treatment of pain - Google Patents

Use of ikappab kinase inhibitors for the treatment of pain

Info

Publication number
HK1079426A1
HK1079426A1 HK05111381.9A HK05111381A HK1079426A1 HK 1079426 A1 HK1079426 A1 HK 1079426A1 HK 05111381 A HK05111381 A HK 05111381A HK 1079426 A1 HK1079426 A1 HK 1079426A1
Authority
HK
Hong Kong
Prior art keywords
pain
treatment
kinase inhibitors
ikappab kinase
ikappab
Prior art date
Application number
HK05111381.9A
Inventor
Martin Michaelis
Olaf Ritzeler
Gerhard Jaehne
Karl Rudolphi
Gerd Geisslinger
Hans-Georg Schaible
Original Assignee
Sanofi Aventis Deutschland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Aventis Deutschland filed Critical Sanofi Aventis Deutschland
Publication of HK1079426A1 publication Critical patent/HK1079426A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
HK05111381.9A 2002-08-17 2005-12-12 Use of ikappab kinase inhibitors for the treatment of pain HK1079426A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10237723A DE10237723A1 (en) 2002-08-17 2002-08-17 Use of IKappaB kinase inhibitors in pain therapy
PCT/EP2003/008628 WO2004022057A1 (en) 2002-08-17 2003-08-05 USE OF IκB KINASE INHIBITORS FOR THE TREATMENT OF PAIN

Publications (1)

Publication Number Publication Date
HK1079426A1 true HK1079426A1 (en) 2006-04-07

Family

ID=31968975

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05111381.9A HK1079426A1 (en) 2002-08-17 2005-12-12 Use of ikappab kinase inhibitors for the treatment of pain

Country Status (34)

Country Link
EP (1) EP1531819B1 (en)
JP (1) JP4504811B2 (en)
KR (2) KR20110135428A (en)
CN (1) CN100398107C (en)
AR (1) AR043045A1 (en)
AT (1) ATE418336T1 (en)
AU (1) AU2003271555B2 (en)
BR (1) BR0313555A (en)
CA (1) CA2495455C (en)
CO (1) CO5690585A2 (en)
CR (1) CR7716A (en)
CY (1) CY1108874T1 (en)
DE (2) DE10237723A1 (en)
DK (1) DK1531819T3 (en)
EC (1) ECSP055609A (en)
ES (1) ES2320118T3 (en)
HK (1) HK1079426A1 (en)
HR (1) HRP20050041B1 (en)
IL (1) IL166780A (en)
MA (1) MA27334A1 (en)
MX (1) MXPA05001218A (en)
MY (1) MY138059A (en)
NO (1) NO334309B1 (en)
OA (1) OA12907A (en)
PL (1) PL212356B1 (en)
PT (1) PT1531819E (en)
RS (1) RS51878B (en)
RU (1) RU2320338C2 (en)
SI (1) SI1531819T1 (en)
TN (1) TNSN05044A1 (en)
TW (1) TWI325782B (en)
UA (1) UA80837C2 (en)
WO (1) WO2004022057A1 (en)
ZA (1) ZA200500323B (en)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7879840B2 (en) 2005-08-25 2011-02-01 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
US7718644B2 (en) 2004-01-22 2010-05-18 The Trustees Of Columbia University In The City Of New York Anti-arrhythmic and heart failure drugs that target the leak in the ryanodine receptor (RyR2) and uses thereof
US8022058B2 (en) 2000-05-10 2011-09-20 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
DE10237722A1 (en) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indole or benzimidazole derivatives for the modulation of IKappaB kinase
US8710045B2 (en) 2004-01-22 2014-04-29 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the ryanodine receptors
KR20070083484A (en) 2004-07-14 2007-08-24 피티씨 테라퓨틱스, 인크. Methods for treating hepatitis c
US7868037B2 (en) 2004-07-14 2011-01-11 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7772271B2 (en) 2004-07-14 2010-08-10 Ptc Therapeutics, Inc. Methods for treating hepatitis C
US7781478B2 (en) 2004-07-14 2010-08-24 Ptc Therapeutics, Inc. Methods for treating hepatitis C
AU2005275182A1 (en) 2004-07-22 2006-02-23 Ptc Therapeutics, Inc. Thienopyridines for treating Hepatitis C
DE102005025225A1 (en) * 2005-06-01 2006-12-07 Sanofi-Aventis Deutschland Gmbh Process for the preparation of 2- (2-amino-pyrimidin-4-yl) -1H-indole-5-carboxylic acid derivatives
US7704990B2 (en) 2005-08-25 2010-04-27 The Trustees Of Columbia University In The City Of New York Agents for preventing and treating disorders involving modulation of the RyR receptors
EP2025674A1 (en) 2007-08-15 2009-02-18 sanofi-aventis Substituted tetra hydro naphthalines, method for their manufacture and their use as drugs
AR072297A1 (en) 2008-06-27 2010-08-18 Novartis Ag DERIVATIVES OF INDOL-2-IL-PIRIDIN-3-ILO, PHARMACEUTICAL COMPOSITION THAT INCLUDES THEM AND ITS USE IN MEDICINES FOR THE TREATMENT OF DISEASES MEDIATED BY THE SYNTHESIS ALDOSTERONE.
WO2011107494A1 (en) 2010-03-03 2011-09-09 Sanofi Novel aromatic glycoside derivatives, medicaments containing said compounds, and the use thereof
WO2011157827A1 (en) 2010-06-18 2011-12-22 Sanofi Azolopyridin-3-one derivatives as inhibitors of lipases and phospholipases
TW201215387A (en) 2010-07-05 2012-04-16 Sanofi Aventis Spirocyclically substituted 1,3-propane dioxide derivatives, processes for preparation thereof and use thereof as a medicament
TW201221505A (en) 2010-07-05 2012-06-01 Sanofi Sa Aryloxyalkylene-substituted hydroxyphenylhexynoic acids, process for preparation thereof and use thereof as a medicament
TW201215388A (en) 2010-07-05 2012-04-16 Sanofi Sa (2-aryloxyacetylamino)phenylpropionic acid derivatives, processes for preparation thereof and use thereof as medicaments
TW201242962A (en) 2010-12-01 2012-11-01 Sumitomo Chemical Co Pyrimidine compound and use for pest control thereof
WO2012120055A1 (en) 2011-03-08 2012-09-13 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2683700B1 (en) 2011-03-08 2015-02-18 Sanofi Tetra-substituted oxathiazine derivatives, method for their preparation, their usage as medicament and medicament containing same and its use
WO2012120052A1 (en) 2011-03-08 2012-09-13 Sanofi Oxathiazine derivatives substituted with carbocycles or heterocycles, method for producing same, drugs containing said compounds, and use thereof
EP2683705B1 (en) 2011-03-08 2015-04-22 Sanofi Di- and tri-substituted oxathiazine derivates, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
US8828995B2 (en) 2011-03-08 2014-09-09 Sanofi Branched oxathiazine derivatives, method for the production thereof, use thereof as medicine and drug containing said derivatives and use thereof
EP2532755A1 (en) * 2011-06-10 2012-12-12 Sanofi-Aventis Methods and uses based on Slfn2 expression and relating to the identification and profiling of compounds for use in the treatment or prevention of pain
WO2013045413A1 (en) 2011-09-27 2013-04-04 Sanofi 6-(4-hydroxy-phenyl)-3-alkyl-1h-pyrazolo[3,4-b]pyridine-4-carboxylic acid amide derivatives as kinase inhibitors
AU2012347393B2 (en) * 2011-12-06 2017-06-08 Sanofi Crystalline forms of 2-(2-methylamino-pyrimidin-4-yl)-1H-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
EP3184095A1 (en) 2013-05-23 2017-06-28 IP Gesellschaft für Management mbH Administration units comprising polymorph 1 of 2-(2-methylamino-pyrimidin-4-yl]-1h-indole-5-carboxylic acid [(s)-1-carbamoyl-2-(phenyl-pyrimidin-2-yl-amino)-ethyl]-amide
JO3425B1 (en) 2013-07-15 2019-10-20 Novartis Ag Piperidinyl indole derivatives and their use as complement factor b inhibitors
JP6553179B2 (en) * 2014-07-03 2019-07-31 サノフイＳａｎｏｆｉ 2- (2-Methylamino-pyrimidin-4-yl) -1H-indole-5-carboxylic acid [(S) -1-carbamoyl-2- (phenyl-) for use in the treatment of pain associated with osteoarthritis Pyrimidin-2-yl-amino) -ethyl] -amide
AU2019304216B2 (en) 2018-07-16 2022-06-02 Novartis Ag Chemical process for preparing phenylpiperidinyl indole derivatives

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1194425B1 (en) * 1999-06-23 2005-08-10 Aventis Pharma Deutschland GmbH Substituted benzimidazole
DE19951360A1 (en) * 1999-10-26 2001-05-03 Aventis Pharma Gmbh Substituted indoles
DE10237722A1 (en) * 2002-08-17 2004-08-19 Aventis Pharma Deutschland Gmbh Indole or benzimidazole derivatives for the modulation of IKappaB kinase

Also Published As

Publication number Publication date
KR101119845B1 (en) 2012-02-28
CO5690585A2 (en) 2006-10-31
RU2005107419A (en) 2005-08-10
IL166780A (en) 2011-11-30
ATE418336T1 (en) 2009-01-15
AU2003271555A1 (en) 2004-03-29
NO20051339L (en) 2005-05-03
CN1674899A (en) 2005-09-28
TWI325782B (en) 2010-06-11
SI1531819T1 (en) 2009-06-30
UA80837C2 (en) 2007-11-12
JP2005539053A (en) 2005-12-22
EP1531819B1 (en) 2008-12-24
CY1108874T1 (en) 2014-07-02
EP1531819A1 (en) 2005-05-25
ECSP055609A (en) 2005-04-18
RS20050070A (en) 2007-06-04
NO334309B1 (en) 2014-02-03
KR20110135428A (en) 2011-12-16
IL166780A0 (en) 2006-01-15
BR0313555A (en) 2005-07-12
JP4504811B2 (en) 2010-07-14
CN100398107C (en) 2008-07-02
MXPA05001218A (en) 2005-05-16
RU2320338C2 (en) 2008-03-27
OA12907A (en) 2006-10-13
MY138059A (en) 2009-04-30
TW200417370A (en) 2004-09-16
RS51878B (en) 2012-02-29
DE50310980D1 (en) 2009-02-05
AU2003271555B2 (en) 2009-03-26
CA2495455C (en) 2011-01-11
HRP20050041B1 (en) 2013-07-31
DK1531819T3 (en) 2009-04-20
PL373568A1 (en) 2005-09-05
CA2495455A1 (en) 2004-03-18
HRP20050041A2 (en) 2006-04-30
AR043045A1 (en) 2005-07-13
TNSN05044A1 (en) 2007-05-14
DE10237723A1 (en) 2004-07-08
CR7716A (en) 2008-11-25
WO2004022057A1 (en) 2004-03-18
KR20050058339A (en) 2005-06-16
PL212356B1 (en) 2012-09-28
ZA200500323B (en) 2006-02-22
MA27334A1 (en) 2005-05-02
PT1531819E (en) 2009-02-18
ES2320118T3 (en) 2009-05-19

Similar Documents

Publication Publication Date Title
HK1079426A1 (en) Use of ikappab kinase inhibitors for the treatment of pain
HRP20041029A2 (en) Therapeutic use of selcetive pde10 inhibitors
PL374700A1 (en) Use of cytokine synthesis inhibitors for the treatment of dry eye disorders
IL209352A0 (en) 4-tetrazolyl-4phenylpiperidine derivatives for treating pain
SI1627639T1 (en) Use of COX-2 inhibitors for the treatment of affective disorders
AU2003268424A8 (en) Treatment of pain by inhibition of p38 map kinase
HK1083732A1 (en) Compounds for the treatment of tobacco dependence and withdrawal
IL157593A0 (en) Carbamate compounds for use in the treatment of pain
GB0213869D0 (en) The treatment of pain
AU2003210983A8 (en) Kinase inhibitors and methods of use thereof
HUP0303306A3 (en) Use of il-18 inhibitors for the treatment and/or prevention of heart disease
GB0211295D0 (en) Treatment of pain
IL162818A0 (en) Combination therapy for the treatment of bacterialinfections
AU2003259074A8 (en) Gal3 antagonists for the treatment of neuropathic pain
GB2410744B (en) Kinase inhibitors for the treatment of disease
AU2003264297A1 (en) Use of vanilloid receptor antagonists for the treatment of pain
IL172101A0 (en) Use of indazole derivatives for the treatment of neuropathic pain
HK1062806A1 (en) Novel methods for the treatment and prevention of pain using stress- activated protein kinase inhibitors
HUP0402664A3 (en) 2-indanylamino derivatives for the therapy of chronic pain
AU2003294697A8 (en) Combinations of benzodithiazoles and cox-2 inhibitors for the treatment of pain
IL174968A0 (en) The use of ifenprodil in the treatment of pain
GB0211297D0 (en) Pain treatment
GB0325957D0 (en) The treatment of pain
GB0213870D0 (en) The treatment of pain conditions
SI1487829T1 (en) Thiadiazolylpiperazine derivatives useful for treating or preventing pain

Legal Events

Date Code Title Description
CORR Corrigendum

Free format text: CORRECTED DATA OF SECTION 20 TO JOURNAL OF 20060407: ¢71! SANOFI-AVENTIS DEUTSCHLAND GMBH - D-65929 FRANKFURT AM MAIN - GERMANY

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20160805