CN100386116C - 微晶肽混悬剂的持续释放 - Google Patents

微晶肽混悬剂的持续释放 Download PDF

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Publication number
CN100386116C
CN100386116C CNB028173775A CN02817377A CN100386116C CN 100386116 C CN100386116 C CN 100386116C CN B028173775 A CNB028173775 A CN B028173775A CN 02817377 A CN02817377 A CN 02817377A CN 100386116 C CN100386116 C CN 100386116C
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Prior art keywords
suspensoid
counter ion
derived
ion counterionsl
counterionsl gegenions
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Chinese (zh)
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CN1551785A (zh
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R·德亨贾尔
F·布泰格农
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British Medical Research Council Technical Department
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Ardana Bioscience Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08—Peptides having 5 to 11 amino acids
    • A61K38/09—Luteinising hormone-releasing hormone [LHRH], i.e. Gonadotropin-releasing hormone [GnRH]; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/20—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing sulfur, e.g. dimethyl sulfoxide [DMSO], docusate, sodium lauryl sulfate or aminosulfonic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A61P5/04—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin for decreasing, blocking or antagonising the activity of the hypothalamic hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Zoology (AREA)
  • Neurosurgery (AREA)
  • Reproductive Health (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Dispersion Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
CNB028173775A 2001-09-06 2002-08-27 微晶肽混悬剂的持续释放 Expired - Lifetime CN100386116C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US31761601P 2001-09-06 2001-09-06
US60/317,616 2001-09-06

Publications (2)

Publication Number Publication Date
CN1551785A CN1551785A (zh) 2004-12-01
CN100386116C true CN100386116C (zh) 2008-05-07

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CNB028173775A Expired - Lifetime CN100386116C (zh) 2001-09-06 2002-08-27 微晶肽混悬剂的持续释放

Country Status (26)

Country Link
US (5) US7098305B2 (https=)
EP (2) EP1423150B1 (https=)
JP (3) JP2005504787A (https=)
KR (2) KR100818904B1 (https=)
CN (1) CN100386116C (https=)
AR (1) AR042592A1 (https=)
AT (1) ATE463258T1 (https=)
AU (1) AU2002337025B2 (https=)
BR (1) BR0212333A (https=)
CA (1) CA2459309C (https=)
CY (1) CY1118642T1 (https=)
DE (1) DE60235896D1 (https=)
DK (1) DK2198888T3 (https=)
ES (2) ES2362505T3 (https=)
HU (1) HUP0402099A2 (https=)
IL (1) IL160443A0 (https=)
MX (1) MXPA04002185A (https=)
NO (1) NO20040938L (https=)
NZ (1) NZ531734A (https=)
PL (1) PL368056A1 (https=)
PT (1) PT2198888T (https=)
RU (1) RU2311195C2 (https=)
TW (1) TWI249409B (https=)
UA (1) UA79435C2 (https=)
WO (1) WO2003022243A2 (https=)
ZA (1) ZA200401390B (https=)

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WO2000047234A1 (en) * 1999-02-08 2000-08-17 Zentaris Ag Sustained release salts of pharmaceutically active peptides and their production

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DK2198888T3 (en) 2017-02-13
ES2362505T3 (es) 2011-07-06
HUP0402099A2 (hu) 2005-02-28
PT2198888T (pt) 2017-02-10
TWI249409B (en) 2006-02-21
DE60235896D1 (de) 2010-05-20
JP2005504787A (ja) 2005-02-17
UA79435C2 (en) 2007-06-25
JP2013177449A (ja) 2013-09-09
HK1062148A1 (en) 2004-10-21
US20060229238A1 (en) 2006-10-12
WO2003022243A2 (en) 2003-03-20
EP1423150A2 (en) 2004-06-02
ZA200401390B (en) 2004-08-27
US20100239683A1 (en) 2010-09-23
PL368056A1 (en) 2005-03-21
US20060228385A1 (en) 2006-10-12
NZ531734A (en) 2006-02-24
CA2459309C (en) 2012-04-03
US7098305B2 (en) 2006-08-29
RU2311195C2 (ru) 2007-11-27
BR0212333A (pt) 2004-09-21
EP2198888A2 (en) 2010-06-23
AU2002337025B2 (en) 2006-12-07
KR20070107161A (ko) 2007-11-06
CN1551785A (zh) 2004-12-01
AR042592A1 (es) 2005-06-29
ATE463258T1 (de) 2010-04-15
EP2198888A3 (en) 2011-08-31
US8415300B2 (en) 2013-04-09
KR100818904B1 (ko) 2008-04-04
JP2010095533A (ja) 2010-04-30
NO20040938D0 (no) 2004-03-04
US20030044463A1 (en) 2003-03-06
CA2459309A1 (en) 2003-03-20
JP5757686B2 (ja) 2015-07-29
MXPA04002185A (es) 2004-07-23
US20110312889A1 (en) 2011-12-22
WO2003022243A3 (en) 2003-10-30
EP1423150B1 (en) 2010-04-07
IL160443A0 (en) 2004-07-25
EP2198888B1 (en) 2016-11-02
RU2004110615A (ru) 2005-05-10
CY1118642T1 (el) 2017-07-12
NO20040938L (no) 2004-06-04
ES2618777T3 (es) 2017-06-22
KR20040037077A (ko) 2004-05-04

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