CN100379722C - 新化合物 - Google Patents
新化合物 Download PDFInfo
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- CN100379722C CN100379722C CNB988134756A CN98813475A CN100379722C CN 100379722 C CN100379722 C CN 100379722C CN B988134756 A CNB988134756 A CN B988134756A CN 98813475 A CN98813475 A CN 98813475A CN 100379722 C CN100379722 C CN 100379722C
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE97045439 | 1997-12-05 | ||
| SE9704543A SE9704543D0 (sv) | 1997-12-05 | 1997-12-05 | New compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1284063A CN1284063A (zh) | 2001-02-14 |
| CN100379722C true CN100379722C (zh) | 2008-04-09 |
Family
ID=20409280
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB988134756A Expired - Fee Related CN100379722C (zh) | 1997-12-05 | 1998-12-01 | 新化合物 |
Country Status (22)
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| US (1) | US6337394B2 (enExample) |
| EP (1) | EP1036061B1 (enExample) |
| JP (1) | JP2001525394A (enExample) |
| KR (1) | KR100587434B1 (enExample) |
| CN (1) | CN100379722C (enExample) |
| AT (1) | ATE250574T1 (enExample) |
| AU (1) | AU748834B2 (enExample) |
| BR (1) | BR9813410A (enExample) |
| CA (1) | CA2312431C (enExample) |
| DE (1) | DE69818510T2 (enExample) |
| EE (1) | EE200000322A (enExample) |
| HU (1) | HUP0102681A3 (enExample) |
| ID (1) | ID28008A (enExample) |
| IL (1) | IL136295A (enExample) |
| IS (1) | IS5511A (enExample) |
| NO (1) | NO317096B1 (enExample) |
| NZ (1) | NZ504528A (enExample) |
| PL (1) | PL341047A1 (enExample) |
| SE (1) | SE9704543D0 (enExample) |
| SK (1) | SK6992000A3 (enExample) |
| TR (1) | TR200001554T2 (enExample) |
| WO (1) | WO1999029664A1 (enExample) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| US6323180B1 (en) * | 1998-08-10 | 2001-11-27 | Boehringer Ingelheim (Canada) Ltd | Hepatitis C inhibitor tri-peptides |
| AR023510A1 (es) | 1999-04-21 | 2002-09-04 | Astrazeneca Ab | Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina. |
| SE0001803D0 (sv) | 2000-05-16 | 2000-05-16 | Astrazeneca Ab | New compounds i |
| US6433186B1 (en) | 2000-08-16 | 2002-08-13 | Astrazeneca Ab | Amidino derivatives and their use as thormbin inhibitors |
| AR035216A1 (es) * | 2000-12-01 | 2004-05-05 | Astrazeneca Ab | Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios |
| RU2300521C2 (ru) * | 2000-12-01 | 2007-06-10 | Астразенека Аб | Новые производные миндальной кислоты и их применение в качестве ингибиторов тромбина |
| US7129233B2 (en) * | 2000-12-01 | 2006-10-31 | Astrazeneca Ab | Mandelic acid derivatives and their use as thrombin inhibitors |
| CA2431588A1 (en) * | 2000-12-18 | 2002-06-27 | Merck & Co., Inc. | Benzylamine derivatives and their use as thrombin inhibitors |
| US7144899B2 (en) | 2001-02-09 | 2006-12-05 | Merck & Co., Inc. | Thrombin inhibitors |
| SE0101762D0 (sv) * | 2001-05-18 | 2001-05-18 | Astrazeneca Ab | New use |
| AR034517A1 (es) | 2001-06-21 | 2004-02-25 | Astrazeneca Ab | Formulacion farmaceutica |
| SE0201661D0 (sv) * | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | New salts |
| SE0201659D0 (sv) | 2002-05-31 | 2002-05-31 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| AU2004240704B9 (en) * | 2003-05-21 | 2009-10-22 | Boehringer Ingelheim International Gmbh | Hepatitis C inhibitor compounds |
| US7781424B2 (en) * | 2003-05-27 | 2010-08-24 | Astrazeneca Ab | Modified release pharmaceutical formulation |
| UY29016A1 (es) * | 2004-07-20 | 2006-02-24 | Boehringer Ingelheim Int | Analogos de dipeptidos inhibidores de la hepatitis c |
| JP4914355B2 (ja) * | 2004-07-20 | 2012-04-11 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Ｃ型肝炎インヒビターペプチド類似体 |
| TW200827336A (en) * | 2006-12-06 | 2008-07-01 | Astrazeneca Ab | New crystalline forms |
| US20090061000A1 (en) * | 2007-08-31 | 2009-03-05 | Astrazeneca Ab | Pharmaceutical formulation use 030 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0669317A1 (en) * | 1994-01-27 | 1995-08-30 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| WO1997002284A1 (en) * | 1995-07-06 | 1997-01-23 | Astra Aktiebolag | New thrombin inhibitors, their preparation and use |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HU178398B (en) | 1979-06-12 | 1982-04-28 | Gyogyszerkutato Intezet | Process for producing new agmatine derivatives of activity against haemagglutination |
| HU192646B (en) | 1984-12-21 | 1987-06-29 | Gyogyszerkutato Intezet | Process for preparing new n-alkyl-peptide aldehydes |
| AU600226B2 (en) | 1985-02-04 | 1990-08-09 | Merrell Pharmaceuticals Inc. | Novel peptidase inhibitors |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0362002B1 (en) | 1988-09-01 | 1995-07-26 | Merrell Dow Pharmaceuticals Inc. | HIV protease inhibitors |
| ZA897515B (en) | 1988-10-07 | 1990-06-27 | Merrell Dow Pharma | Novel peptidase inhibitors |
| TW201303B (enExample) | 1990-07-05 | 1993-03-01 | Hoffmann La Roche | |
| CA2075154A1 (en) | 1991-08-06 | 1993-02-07 | Neelakantan Balasubramanian | Peptide aldehydes as antithrombotic agents |
| SE9102462D0 (sv) | 1991-08-28 | 1991-08-28 | Astra Ab | New isosteric peptides |
| CZ333492A3 (en) | 1991-11-12 | 1993-09-15 | Lilly Co Eli | Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised |
| SE9103612D0 (sv) | 1991-12-04 | 1991-12-04 | Astra Ab | New peptide derivatives |
| DE69314478T2 (de) | 1992-03-04 | 1999-02-11 | Gyogyszerkutato Intezet Kft., Budapest | Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren |
| TW223629B (enExample) | 1992-03-06 | 1994-05-11 | Hoffmann La Roche | |
| AU675981B2 (en) | 1992-12-02 | 1997-02-27 | Bristol-Myers Squibb Company | Guanidinyl-substituted heterocyclic thrombin inhibitors |
| US5583146A (en) | 1992-12-02 | 1996-12-10 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| JPH06340619A (ja) | 1993-05-03 | 1994-12-13 | Bristol Myers Squibb Co | グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤 |
| US5780631A (en) | 1993-06-03 | 1998-07-14 | Astra Aktiebolag | Starting materials in the synthesis of thrombin and kininogenase inhibitors |
| SE9301916D0 (sv) | 1993-06-03 | 1993-06-03 | Ab Astra | New peptides derivatives |
| EP0648780A1 (en) | 1993-08-26 | 1995-04-19 | Bristol-Myers Squibb Company | Heterocyclic thrombin inhibitors |
| TW394760B (en) | 1993-09-07 | 2000-06-21 | Hoffmann La Roche | Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same |
| US5705487A (en) | 1994-03-04 | 1998-01-06 | Eli Lilly And Company | Antithrombotic agents |
| IL112795A (en) | 1994-03-04 | 2001-01-28 | Astrazeneca Ab | Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them |
| US5726159A (en) | 1994-03-04 | 1998-03-10 | Eli Lilly And Company | Antithrombotic agents |
| US5707966A (en) | 1994-03-04 | 1998-01-13 | Eli Lilly And Company | Antithrombotic agents |
| US5561146A (en) | 1994-06-10 | 1996-10-01 | Bristol-Myers Squibb Company | Modified guanidino and amidino thrombin inhibitors |
| DE4421052A1 (de) | 1994-06-17 | 1995-12-21 | Basf Ag | Neue Thrombininhibitoren, ihre Herstellung und Verwendung |
| US5510369A (en) | 1994-07-22 | 1996-04-23 | Merck & Co., Inc. | Pyrrolidine thrombin inhibitors |
| DE4443390A1 (de) | 1994-12-06 | 1996-06-13 | Basf Ag | Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten |
| US5932567A (en) | 1995-02-10 | 1999-08-03 | Basf Aktiengesellschaft | Thrombin inhibitors |
| CA2211109A1 (en) | 1995-02-17 | 1996-08-22 | Basf Aktiengesellschaft | Novel thrombin inhibitors |
| US5710130A (en) | 1995-02-27 | 1998-01-20 | Eli Lilly And Company | Antithrombotic agents |
| US5914319A (en) | 1995-02-27 | 1999-06-22 | Eli Lilly And Company | Antithrombotic agents |
| AU698911B2 (en) | 1995-04-04 | 1998-11-12 | Merck & Co., Inc. | Thrombin inhibitors |
| US5629324A (en) | 1995-04-10 | 1997-05-13 | Merck & Co., Inc. | Thrombin inhibitors |
| TWI238827B (en) | 1995-12-21 | 2005-09-01 | Astrazeneca Ab | Prodrugs of thrombin inhibitors |
| JPH1095898A (ja) | 1996-09-25 | 1998-04-14 | Sumitomo Bakelite Co Ltd | 難燃性樹脂組成物およびこれを用いた積層板 |
| SE9602263D0 (sv) * | 1996-06-07 | 1996-06-07 | Astra Ab | New amino acid derivatives |
| SE9602646D0 (sv) | 1996-07-04 | 1996-07-04 | Astra Ab | Pharmaceutically-useful compounds |
| DE19632773A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Thrombininhibitoren |
| DE19632772A1 (de) | 1996-08-14 | 1998-02-19 | Basf Ag | Neue Benzamidine |
| AR013084A1 (es) | 1997-06-19 | 2000-12-13 | Astrazeneca Ab | Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados |
-
1997
- 1997-12-05 SE SE9704543A patent/SE9704543D0/xx unknown
-
1998
- 1998-12-01 NZ NZ504528A patent/NZ504528A/en unknown
- 1998-12-01 PL PL98341047A patent/PL341047A1/xx not_active Application Discontinuation
- 1998-12-01 DE DE69818510T patent/DE69818510T2/de not_active Expired - Lifetime
- 1998-12-01 EP EP98962750A patent/EP1036061B1/en not_active Expired - Lifetime
- 1998-12-01 ID IDW20001009A patent/ID28008A/id unknown
- 1998-12-01 KR KR1020007006078A patent/KR100587434B1/ko not_active Expired - Fee Related
- 1998-12-01 CA CA002312431A patent/CA2312431C/en not_active Expired - Fee Related
- 1998-12-01 WO PCT/SE1998/002187 patent/WO1999029664A1/en not_active Ceased
- 1998-12-01 AT AT98962750T patent/ATE250574T1/de not_active IP Right Cessation
- 1998-12-01 SK SK699-2000A patent/SK6992000A3/sk unknown
- 1998-12-01 HU HU0102681A patent/HUP0102681A3/hu unknown
- 1998-12-01 JP JP2000524261A patent/JP2001525394A/ja active Pending
- 1998-12-01 EE EEP200000322A patent/EE200000322A/xx unknown
- 1998-12-01 CN CNB988134756A patent/CN100379722C/zh not_active Expired - Fee Related
- 1998-12-01 AU AU17912/99A patent/AU748834B2/en not_active Ceased
- 1998-12-01 BR BR9813410-8A patent/BR9813410A/pt not_active Application Discontinuation
- 1998-12-01 TR TR2000/01554T patent/TR200001554T2/xx unknown
- 1998-12-01 US US09/214,143 patent/US6337394B2/en not_active Expired - Fee Related
-
2000
- 2000-05-22 IL IL136295A patent/IL136295A/en not_active IP Right Cessation
- 2000-05-26 IS IS5511A patent/IS5511A/is unknown
- 2000-06-02 NO NO20002848A patent/NO317096B1/no not_active IP Right Cessation
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0669317A1 (en) * | 1994-01-27 | 1995-08-30 | Mitsubishi Chemical Corporation | Prolineamide derivatives |
| WO1997002284A1 (en) * | 1995-07-06 | 1997-01-23 | Astra Aktiebolag | New thrombin inhibitors, their preparation and use |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1284063A (zh) | 2001-02-14 |
| CA2312431A1 (en) | 1999-06-17 |
| HUP0102681A3 (en) | 2002-01-28 |
| EP1036061A1 (en) | 2000-09-20 |
| IL136295A (en) | 2009-02-11 |
| NO20002848D0 (no) | 2000-06-02 |
| KR20010024676A (ko) | 2001-03-26 |
| DE69818510T2 (de) | 2004-06-24 |
| KR100587434B1 (ko) | 2006-06-08 |
| TR200001554T2 (tr) | 2001-01-22 |
| US20010046981A1 (en) | 2001-11-29 |
| WO1999029664A1 (en) | 1999-06-17 |
| EP1036061B1 (en) | 2003-09-24 |
| HUP0102681A2 (hu) | 2001-12-28 |
| US6337394B2 (en) | 2002-01-08 |
| JP2001525394A (ja) | 2001-12-11 |
| PL341047A1 (en) | 2001-03-26 |
| IS5511A (is) | 2000-05-26 |
| ATE250574T1 (de) | 2003-10-15 |
| SK6992000A3 (en) | 2001-02-12 |
| AU1791299A (en) | 1999-06-28 |
| NO20002848L (no) | 2000-08-07 |
| ID28008A (id) | 2001-05-03 |
| CA2312431C (en) | 2008-01-22 |
| NZ504528A (en) | 2002-03-01 |
| BR9813410A (pt) | 2000-10-10 |
| AU748834B2 (en) | 2002-06-13 |
| EE200000322A (et) | 2001-08-15 |
| SE9704543D0 (sv) | 1997-12-05 |
| DE69818510D1 (de) | 2003-10-30 |
| NO317096B1 (no) | 2004-08-09 |
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