KR100587434B1 - 신규 화합물 - Google Patents

신규 화합물 Download PDF

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Publication number
KR100587434B1
KR100587434B1 KR1020007006078A KR20007006078A KR100587434B1 KR 100587434 B1 KR100587434 B1 KR 100587434B1 KR 1020007006078 A KR1020007006078 A KR 1020007006078A KR 20007006078 A KR20007006078 A KR 20007006078A KR 100587434 B1 KR100587434 B1 KR 100587434B1
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KR
South Korea
Prior art keywords
formula
compound
compounds
alkyl
thrombin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020007006078A
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English (en)
Korean (ko)
Other versions
KR20010024676A (ko
Inventor
올레 칼손
마르셀 린쇼텐
얀-에릭 니슈트룀
Original Assignee
아스트라제네카 아베
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Publication of KR20010024676A publication Critical patent/KR20010024676A/ko
Application granted granted Critical
Publication of KR100587434B1 publication Critical patent/KR100587434B1/ko
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Use Of Switch Circuits For Exchanges And Methods Of Control Of Multiplex Exchanges (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
KR1020007006078A 1997-12-05 1998-12-01 신규 화합물 Expired - Fee Related KR100587434B1 (ko)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
SE9704543-9 1997-12-05
SE9704543A SE9704543D0 (sv) 1997-12-05 1997-12-05 New compounds

Publications (2)

Publication Number Publication Date
KR20010024676A KR20010024676A (ko) 2001-03-26
KR100587434B1 true KR100587434B1 (ko) 2006-06-08

Family

ID=20409280

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020007006078A Expired - Fee Related KR100587434B1 (ko) 1997-12-05 1998-12-01 신규 화합물

Country Status (22)

Country Link
US (1) US6337394B2 (enExample)
EP (1) EP1036061B1 (enExample)
JP (1) JP2001525394A (enExample)
KR (1) KR100587434B1 (enExample)
CN (1) CN100379722C (enExample)
AT (1) ATE250574T1 (enExample)
AU (1) AU748834B2 (enExample)
BR (1) BR9813410A (enExample)
CA (1) CA2312431C (enExample)
DE (1) DE69818510T2 (enExample)
EE (1) EE200000322A (enExample)
HU (1) HUP0102681A3 (enExample)
ID (1) ID28008A (enExample)
IL (1) IL136295A (enExample)
IS (1) IS5511A (enExample)
NO (1) NO317096B1 (enExample)
NZ (1) NZ504528A (enExample)
PL (1) PL341047A1 (enExample)
SE (1) SE9704543D0 (enExample)
SK (1) SK6992000A3 (enExample)
TR (1) TR200001554T2 (enExample)
WO (1) WO1999029664A1 (enExample)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9602263D0 (sv) * 1996-06-07 1996-06-07 Astra Ab New amino acid derivatives
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
AR023510A1 (es) 1999-04-21 2002-09-04 Astrazeneca Ab Un equipo de partes, formulacion farmaceutica y uso de un inhibidor de trombina.
SE0001803D0 (sv) 2000-05-16 2000-05-16 Astrazeneca Ab New compounds i
US6433186B1 (en) 2000-08-16 2002-08-13 Astrazeneca Ab Amidino derivatives and their use as thormbin inhibitors
AR035216A1 (es) * 2000-12-01 2004-05-05 Astrazeneca Ab Derivados de acido mandelico ,derivados farmaceuticamente aceptables, uso de estos derivados para la fabricacion de medicamentos, metodos de tratamiento ,procesos para la preparacion de estos derivados, y compuestos intermediarios
RU2300521C2 (ru) * 2000-12-01 2007-06-10 Астразенека Аб Новые производные миндальной кислоты и их применение в качестве ингибиторов тромбина
US7129233B2 (en) * 2000-12-01 2006-10-31 Astrazeneca Ab Mandelic acid derivatives and their use as thrombin inhibitors
CA2431588A1 (en) * 2000-12-18 2002-06-27 Merck & Co., Inc. Benzylamine derivatives and their use as thrombin inhibitors
US7144899B2 (en) 2001-02-09 2006-12-05 Merck & Co., Inc. Thrombin inhibitors
SE0101762D0 (sv) * 2001-05-18 2001-05-18 Astrazeneca Ab New use
AR034517A1 (es) 2001-06-21 2004-02-25 Astrazeneca Ab Formulacion farmaceutica
SE0201661D0 (sv) * 2002-05-31 2002-05-31 Astrazeneca Ab New salts
SE0201659D0 (sv) 2002-05-31 2002-05-31 Astrazeneca Ab Modified release pharmaceutical formulation
AU2004240704B9 (en) * 2003-05-21 2009-10-22 Boehringer Ingelheim International Gmbh Hepatitis C inhibitor compounds
US7781424B2 (en) * 2003-05-27 2010-08-24 Astrazeneca Ab Modified release pharmaceutical formulation
UY29016A1 (es) * 2004-07-20 2006-02-24 Boehringer Ingelheim Int Analogos de dipeptidos inhibidores de la hepatitis c
JP4914355B2 (ja) * 2004-07-20 2012-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｃ型肝炎インヒビターペプチド類似体
TW200827336A (en) * 2006-12-06 2008-07-01 Astrazeneca Ab New crystalline forms
US20090061000A1 (en) * 2007-08-31 2009-03-05 Astrazeneca Ab Pharmaceutical formulation use 030

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002284A1 (en) * 1995-07-06 1997-01-23 Astra Aktiebolag New thrombin inhibitors, their preparation and use
WO1997046577A1 (en) * 1996-06-07 1997-12-11 Astra Aktiebolag New amino acid derivatives and their use as thrombin inhibitors

Family Cites Families (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU178398B (en) 1979-06-12 1982-04-28 Gyogyszerkutato Intezet Process for producing new agmatine derivatives of activity against haemagglutination
HU192646B (en) 1984-12-21 1987-06-29 Gyogyszerkutato Intezet Process for preparing new n-alkyl-peptide aldehydes
AU600226B2 (en) 1985-02-04 1990-08-09 Merrell Pharmaceuticals Inc. Novel peptidase inhibitors
US5187157A (en) 1987-06-05 1993-02-16 Du Pont Merck Pharmaceutical Company Peptide boronic acid inhibitors of trypsin-like proteases
EP0362002B1 (en) 1988-09-01 1995-07-26 Merrell Dow Pharmaceuticals Inc. HIV protease inhibitors
ZA897515B (en) 1988-10-07 1990-06-27 Merrell Dow Pharma Novel peptidase inhibitors
TW201303B (enExample) 1990-07-05 1993-03-01 Hoffmann La Roche
CA2075154A1 (en) 1991-08-06 1993-02-07 Neelakantan Balasubramanian Peptide aldehydes as antithrombotic agents
SE9102462D0 (sv) 1991-08-28 1991-08-28 Astra Ab New isosteric peptides
CZ333492A3 (en) 1991-11-12 1993-09-15 Lilly Co Eli Dipeptide of l-azetidine-2-carboxylic acids and l-argininaldehyde, process of its preparation and pharmaceutical preparation in which said dipeptide is comprised
SE9103612D0 (sv) 1991-12-04 1991-12-04 Astra Ab New peptide derivatives
DE69314478T2 (de) 1992-03-04 1999-02-11 Gyogyszerkutato Intezet Kft., Budapest Neuartige antikoagulierende peptidderivate und arzneimittel die solche enthalten so wie entsprechendes herstellungsverfahren
TW223629B (enExample) 1992-03-06 1994-05-11 Hoffmann La Roche
AU675981B2 (en) 1992-12-02 1997-02-27 Bristol-Myers Squibb Company Guanidinyl-substituted heterocyclic thrombin inhibitors
US5583146A (en) 1992-12-02 1996-12-10 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
JPH06340619A (ja) 1993-05-03 1994-12-13 Bristol Myers Squibb Co グアニジニルまたはアミジニル置換メチルアミノ複素環トロンビン抑制剤
US5780631A (en) 1993-06-03 1998-07-14 Astra Aktiebolag Starting materials in the synthesis of thrombin and kininogenase inhibitors
SE9301916D0 (sv) 1993-06-03 1993-06-03 Ab Astra New peptides derivatives
EP0648780A1 (en) 1993-08-26 1995-04-19 Bristol-Myers Squibb Company Heterocyclic thrombin inhibitors
TW394760B (en) 1993-09-07 2000-06-21 Hoffmann La Roche Novel Carboxamides, process for their preparation and pharmaceutical composition containing the same
AU1025795A (en) 1994-01-27 1995-08-03 Mitsubishi Chemical Corporation Prolineamide derivatives
US5705487A (en) 1994-03-04 1998-01-06 Eli Lilly And Company Antithrombotic agents
IL112795A (en) 1994-03-04 2001-01-28 Astrazeneca Ab Peptide derivatives as antithrombic agents their preparation and pharmaceutical compositions containing them
US5726159A (en) 1994-03-04 1998-03-10 Eli Lilly And Company Antithrombotic agents
US5707966A (en) 1994-03-04 1998-01-13 Eli Lilly And Company Antithrombotic agents
US5561146A (en) 1994-06-10 1996-10-01 Bristol-Myers Squibb Company Modified guanidino and amidino thrombin inhibitors
DE4421052A1 (de) 1994-06-17 1995-12-21 Basf Ag Neue Thrombininhibitoren, ihre Herstellung und Verwendung
US5510369A (en) 1994-07-22 1996-04-23 Merck & Co., Inc. Pyrrolidine thrombin inhibitors
DE4443390A1 (de) 1994-12-06 1996-06-13 Basf Ag Neue dipeptidische p-Amidinobenzylamide mit N-terminalen Sulfonyl- bzw. Aminosulfonylresten
US5932567A (en) 1995-02-10 1999-08-03 Basf Aktiengesellschaft Thrombin inhibitors
CA2211109A1 (en) 1995-02-17 1996-08-22 Basf Aktiengesellschaft Novel thrombin inhibitors
US5710130A (en) 1995-02-27 1998-01-20 Eli Lilly And Company Antithrombotic agents
US5914319A (en) 1995-02-27 1999-06-22 Eli Lilly And Company Antithrombotic agents
AU698911B2 (en) 1995-04-04 1998-11-12 Merck & Co., Inc. Thrombin inhibitors
US5629324A (en) 1995-04-10 1997-05-13 Merck & Co., Inc. Thrombin inhibitors
TWI238827B (en) 1995-12-21 2005-09-01 Astrazeneca Ab Prodrugs of thrombin inhibitors
JPH1095898A (ja) 1996-09-25 1998-04-14 Sumitomo Bakelite Co Ltd 難燃性樹脂組成物およびこれを用いた積層板
SE9602646D0 (sv) 1996-07-04 1996-07-04 Astra Ab Pharmaceutically-useful compounds
DE19632773A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Thrombininhibitoren
DE19632772A1 (de) 1996-08-14 1998-02-19 Basf Ag Neue Benzamidine
AR013084A1 (es) 1997-06-19 2000-12-13 Astrazeneca Ab Derivados de amidino utiles como inhibidores de la trombina, composicion farmaceutica, utilizacion de dichos compuestos para la preparacion demedicamentos y proceso para la preparacion de los compuestos mencionados

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997002284A1 (en) * 1995-07-06 1997-01-23 Astra Aktiebolag New thrombin inhibitors, their preparation and use
WO1997046577A1 (en) * 1996-06-07 1997-12-11 Astra Aktiebolag New amino acid derivatives and their use as thrombin inhibitors

Also Published As

Publication number Publication date
CN100379722C (zh) 2008-04-09
CN1284063A (zh) 2001-02-14
CA2312431A1 (en) 1999-06-17
HUP0102681A3 (en) 2002-01-28
EP1036061A1 (en) 2000-09-20
IL136295A (en) 2009-02-11
NO20002848D0 (no) 2000-06-02
KR20010024676A (ko) 2001-03-26
DE69818510T2 (de) 2004-06-24
TR200001554T2 (tr) 2001-01-22
US20010046981A1 (en) 2001-11-29
WO1999029664A1 (en) 1999-06-17
EP1036061B1 (en) 2003-09-24
HUP0102681A2 (hu) 2001-12-28
US6337394B2 (en) 2002-01-08
JP2001525394A (ja) 2001-12-11
PL341047A1 (en) 2001-03-26
IS5511A (is) 2000-05-26
ATE250574T1 (de) 2003-10-15
SK6992000A3 (en) 2001-02-12
AU1791299A (en) 1999-06-28
NO20002848L (no) 2000-08-07
ID28008A (id) 2001-05-03
CA2312431C (en) 2008-01-22
NZ504528A (en) 2002-03-01
BR9813410A (pt) 2000-10-10
AU748834B2 (en) 2002-06-13
EE200000322A (et) 2001-08-15
SE9704543D0 (sv) 1997-12-05
DE69818510D1 (de) 2003-10-30
NO317096B1 (no) 2004-08-09

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