CN100363037C - 一种治疗风湿关节炎及跌打损伤疼痛的药物及其制备方法 - Google Patents
一种治疗风湿关节炎及跌打损伤疼痛的药物及其制备方法 Download PDFInfo
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Abstract
Description
组别 | 剂量(g) | n | 致炎后18h足肿胀度 | |
(Δml) | 抑制率(%) | |||
正常组模型组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 1010101010 | 0.13±0.141.11±0.28<sup>b</sup>0.77±0.33<sup>bc</sup>0.70±0.36<sup>bd</sup>0.74±0.37<sup>bc</sup> | 30.636.933.3 |
组 别 | 剂量(g) | n | 致炎后不同时间足肿胀度(Δml) | ||
12d | 19d | 26d | |||
正常组模型组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 1010101010 | 0.08±0.100.63±0.21<sup>b</sup>0.45±0.22<sup>bc</sup>(28.6)0.41±0.23<sup>bd</sup>(34.9)0.44±0.11<sup>bc</sup>(30.2) | 0.11±0.121.02±0.35<sup>b</sup>0.71±0.33<sup>bc</sup>(30.4)0.63±0.28<sup>bd</sup>(38.2)0.70±0.36<sup>bc</sup>(31.4) | 0.07±0.110.88±0.21<sup>b</sup>0.54±0.24<sup>bd</sup>(38.6)0.44±0.25<sup>bd</sup>(50.0)0.52±0.14<sup>bd</sup>(40.9) |
组别 | 剂量(g) | n | 致炎后不同时间关节评分 | ||
12d | 19d | 26d | |||
正常组 | 10 | 0.7±0.7 | 0.7±0.8 | 0.5±0.7 |
模型组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 10101010 | 5.6±2.0<sup>b</sup>3.9±1.2<sup>bc</sup>3.1±1.8<sup>bd</sup>4.1±1.3<sup>bc</sup> | 10.1±2.1<sup>b</sup>7.2±2.1<sup>bd</sup>6.5±2.2<sup>bd</sup>6.7±3.0<sup>bd</sup> | 8.7±2.0<sup>b</sup>5.3±1.6<sup>bd</sup>4.0±1.4<sup>bd</sup>5.0±1.9<sup>bd</sup> |
组 别 | 剂量(g) | n | 体重(g) | 胸腺(mg/100g体重) | 脾脏(mg/100g体重) | |
药前 | 药后 | |||||
正常组模型组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 1010101010 | 194±10197±8195±9195±11197±8 | 295±11294±9295±17293±11290±10 | 197±23198±30202±28201±17200±34 | 225±37230±33219±26235±31228±38 |
组别 | 剂量(g) | n | 致炎后不同时间足肿胀度(Δml) | ||||
6h | 24h | 48h | 72h | 96h | |||
对照组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 10101010 | 0.84±0.140.66±0.10<sup>b</sup>(21.4)0.60±0.17<sup>b</sup>(28.6)0.63±0.14<sup>b</sup>(25.0) | 0.92±0.090.70±0.18<sup>b</sup>(23.9)0.63±0.18<sup>b</sup>(31.5)0.72±0.12<sup>b</sup>(21.7) | 0.85±0.090.62±0.22<sup>b</sup>(27.1)0.58±0.14<sup>b</sup>(31.8)0.65±0.16<sup>b</sup>(23.5) | 0.62±0.120.44±0.18<sup>a</sup>(29.0)0.40±0.16<sup>b</sup>(35.5)0.41±0.19<sup>b</sup>(33.9) | 0.47±0.190.28±0.13<sup>b</sup>(40.4)0.27±0.10<sup>b</sup>(42.6)0.32±0.12<sup>a</sup>(31.9) |
组别 | 剂量(g) | n | 致炎后不同时间足肿胀度(Δml) | ||
1h | 2h | 3h | |||
对照组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组 | 0.51.0 | 101010 | 0.71±0.160.48±0.17<sup>a</sup>(32.4)0.29±0.20<sup>b</sup>(59.2) | 0.59±0.360.26±0.18<sup>b</sup>(55.9)0.19±0.17<sup>b</sup>(67.8) | 0.26±0.190.11±0.12<sup>a</sup>(57.7)0.09±0.12<sup>a</sup>(65.4) |
狗皮膏组 | 1.0 | 10 | 0.38±0.33<sup>b</sup>(46.5) | 0.21±0.13<sup>b</sup>(64.4) | 0.12±0.10<sup>a</sup>(53.8) |
组别 | 剂量(g) | n | 痛阈(kPa) |
对照组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 10101010 | 1.71 ±0.674.09±1.75<sup>h</sup>5.56±2.10<sup>b</sup>5.09±2.42<sup>b</sup> |
组别 | 剂量(g) | n | 药前痛阈(s) | 药后痛阈(s) |
对照组祖师麻风湿膏低剂量组祖师麻风湿膏高剂量组狗皮膏组 | 0.51.01.0 | 10101010 | 22.2±5.924.5±5.121.8±6.923.1±6.1 | 23.3±4.929.9±4.7<sup>af</sup>36.3±8.1<sup>bcf</sup>31.1±7.5<sup>ae</sup> |
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