CN100357275C - N-吡嗪基-苯磺酰胺及其在治疗趋化因子介导疾病中的用途 - Google Patents

N-吡嗪基-苯磺酰胺及其在治疗趋化因子介导疾病中的用途 Download PDF

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CN100357275C
CN100357275C CNB038044811A CN03804481A CN100357275C CN 100357275 C CN100357275 C CN 100357275C CN B038044811 A CNB038044811 A CN B038044811A CN 03804481 A CN03804481 A CN 03804481A CN 100357275 C CN100357275 C CN 100357275C
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chloro
pyrazinyl
methoxyl group
benzsulfamide
group
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Expired - Fee Related
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Chinese (zh)
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CN1639132A (zh
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安德鲁·巴克斯特
蒂莫西·约翰逊
尼古拉斯·金顿
布赖恩·罗伯茨
迈克尔·斯托克斯
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AstraZeneca AB
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Priority claimed from SE0201857A external-priority patent/SE0201857D0/xx
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Publication of CN1639132A publication Critical patent/CN1639132A/zh
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CNB038044811A 2002-01-16 2003-01-14 N-吡嗪基-苯磺酰胺及其在治疗趋化因子介导疾病中的用途 Expired - Fee Related CN100357275C (zh)

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Application Number Priority Date Filing Date Title
SE02001196 2002-01-16
SE0200119A SE0200119D0 (sv) 2002-01-16 2002-01-16 Novel compounds
SE0201857A SE0201857D0 (sv) 2002-06-17 2002-06-17 Novel compounds
SE02018570 2002-06-17

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CN1639132A CN1639132A (zh) 2005-07-13
CN100357275C true CN100357275C (zh) 2007-12-26

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008418A (zh) * 2016-05-20 2016-10-12 厦门大学 一种5-氨甲基-2-呋喃甲醇的合成方法

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1541563A4 (en) * 2002-07-10 2007-11-07 Ono Pharmaceutical Co ANTAGONIST OF CCR4 AND CORRESPONDING MEDICINAL USE
GB0217431D0 (en) 2002-07-27 2002-09-04 Astrazeneca Ab Novel compounds
DE60318219T2 (de) 2002-08-24 2009-01-15 Astrazeneca Ab PYRIMIDINDERIVATE ALS MODULATOREN DER AKTIVITuT VON CHEMOKINREZEPTOREN
SE0301653D0 (sv) * 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0302304D0 (sv) * 2003-08-27 2003-08-27 Astrazeneca Ab Novel compounds
US7732442B2 (en) 2003-09-05 2010-06-08 Ono Pharmaceutical Co., Ltd. Chemokine receptor antagonist and medical use thereof
GB0401269D0 (en) * 2004-01-21 2004-02-25 Astrazeneca Ab Compounds
DE602005020313D1 (de) 2004-08-12 2010-05-12 Amgen Inc Bisaryl-sulfonamide
BRPI0514735B8 (pt) 2004-08-28 2021-05-25 Astrazeneca Ab derivados de pirimidino sulfonamida como moduladores do receptor de quimiocina.
TW200800921A (en) * 2005-09-19 2008-01-01 Astrazeneca Ab Novel compounds
EP1970373A1 (en) * 2005-12-02 2008-09-17 Mitsubishi Tanabe Pharma Corporation Alicyclic heterocyclic compound
WO2007063935A1 (ja) * 2005-12-02 2007-06-07 Mitsubishi Tanabe Pharma Corporation 芳香族化合物
TW200730512A (en) * 2005-12-12 2007-08-16 Astrazeneca Ab Novel compounds
GB0526255D0 (en) 2005-12-22 2006-02-01 Novartis Ag Organic compounds
JP5140154B2 (ja) 2007-06-27 2013-02-06 アストラゼネカ・アクチエボラーグ ピラジノン誘導体および肺疾患の処置におけるそれらの使用
WO2009126675A1 (en) * 2008-04-09 2009-10-15 Boehringer Ingelheim International Gmbh 2-sulfonylamino-4-heteroaryl butyramide antagonists of ccr10
PT2374802E (pt) 2008-11-10 2014-07-10 Kyowa Hakko Kirin Co Ltd Inibidor de produção de quinurenina
MX2011011139A (es) * 2009-04-22 2012-01-27 Axikin Pharmaceuticals Inc Antagonistas ccr3 arisulfonamida 2, 5-disustituidos.
TWI535442B (zh) 2010-05-10 2016-06-01 Kyowa Hakko Kirin Co Ltd A nitrogen-containing heterocyclic compound having an action of inhibiting the production of canine erythritine
EP2955173B1 (en) * 2010-12-16 2017-10-04 Allergan, Inc. 1,2-bis-sulfonamide derivatives as chemokine receptor modulators
ES2903205T3 (es) 2011-11-09 2022-03-31 Kyowa Kirin Co Ltd Compuestos heterocíclicos que contienen nitrógeno
JP6327803B2 (ja) * 2013-07-09 2018-05-23 久慶 ▲ふく▼楊 大出力高効率単相多極発電機
HUE069276T2 (hu) * 2018-01-26 2025-02-28 Rapt Therapeutics Inc Kemokin receptor modulátorok és azok felhasználása
CN113069446B (zh) * 2021-03-01 2022-12-02 中山亿维迪科技有限公司 El102在制备治疗新型冠状病毒所致疾病的药物中的应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295616A (en) * 1994-12-01 1996-06-05 Zeneca Ltd N-Diazine-benzenesulphonamide derivatives as endothelin receptor antagonists

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US143024A (en) * 1873-09-23 Improvement in clothes-pins
US5962490A (en) 1987-09-25 1999-10-05 Texas Biotechnology Corporation Thienyl-, furyl- and pyrrolyl-sulfonamides and derivatives thereof that modulate the activity of endothelin
GB9504854D0 (en) * 1994-03-31 1995-04-26 Zeneca Ltd Nitrogen derivatives
CA2162630C (en) 1994-11-25 2007-05-01 Volker Breu Sulfonamides
GB9512697D0 (en) * 1995-06-22 1995-08-23 Zeneca Ltd Heterocyclic compounds
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
KR20010083092A (ko) * 1998-07-06 2001-08-31 스티븐 비. 데이비스 이중 안지오텐신 엔도텔린 수용체 길항제로서의 비페닐술폰아미드
EP1237888B1 (en) 1999-12-15 2006-09-13 Bristol-Myers Squibb Company Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
EP1458715B1 (en) 2001-12-18 2005-12-07 AstraZeneca AB Novel compounds
EP1541563A4 (en) 2002-07-10 2007-11-07 Ono Pharmaceutical Co ANTAGONIST OF CCR4 AND CORRESPONDING MEDICINAL USE
SE0301650D0 (sv) 2003-06-04 2003-06-04 Astrazeneca Ab Novel compounds
SE0301654D0 (sv) 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0301653D0 (sv) 2003-06-05 2003-06-05 Astrazeneca Ab Novel compounds
SE0302304D0 (sv) 2003-08-27 2003-08-27 Astrazeneca Ab Novel compounds
TW200800921A (en) 2005-09-19 2008-01-01 Astrazeneca Ab Novel compounds
TW200730512A (en) 2005-12-12 2007-08-16 Astrazeneca Ab Novel compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2295616A (en) * 1994-12-01 1996-06-05 Zeneca Ltd N-Diazine-benzenesulphonamide derivatives as endothelin receptor antagonists

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Penetration of sulfanilamides into inflammatory foci. Kivman,G. Ya. et al.Khim..Farm.Zh.,Vol.16 No.6. 1982 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106008418A (zh) * 2016-05-20 2016-10-12 厦门大学 一种5-氨甲基-2-呋喃甲醇的合成方法

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