CN100354297C - 辅助的脑膜炎球菌组合物 - Google Patents
辅助的脑膜炎球菌组合物 Download PDFInfo
- Publication number
- CN100354297C CN100354297C CNB028241282A CN02824128A CN100354297C CN 100354297 C CN100354297 C CN 100354297C CN B028241282 A CNB028241282 A CN B028241282A CN 02824128 A CN02824128 A CN 02824128A CN 100354297 C CN100354297 C CN 100354297C
- Authority
- CN
- China
- Prior art keywords
- antigen
- plg
- cpg
- particulate
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6093—Synthetic polymers, e.g. polyethyleneglycol [PEG], Polymers or copolymers of (D) glutamate and (D) lysine
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Virology (AREA)
- Molecular Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Biological Depolymerization Polymers (AREA)
- Compositions Of Macromolecular Compounds (AREA)
Applications Claiming Priority (14)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US32692901P | 2001-10-03 | 2001-10-03 | |
US60/326,929 | 2001-10-03 | ||
USPCT/US02/10869 | 2002-04-05 | ||
PCT/US2002/010869 WO2002080648A2 (en) | 2001-04-05 | 2002-04-05 | Mucosal boosting following parenteral priming |
US37354702P | 2002-04-17 | 2002-04-17 | |
US60/373,547 | 2002-04-17 | ||
US38067702P | 2002-05-13 | 2002-05-13 | |
US60/380,677 | 2002-05-13 | ||
US25443802A | 2002-09-24 | 2002-09-24 | |
US10/254,438 | 2002-09-24 | ||
US0230423 | 2002-09-24 | ||
USPCT/US02/30423 | 2002-09-24 | ||
US10/265,083 | 2002-10-03 | ||
USPCT/US02/31486 | 2002-10-03 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1599746A CN1599746A (zh) | 2005-03-23 |
CN100354297C true CN100354297C (zh) | 2007-12-12 |
Family
ID=32601151
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB028241282A Expired - Fee Related CN100354297C (zh) | 2001-10-03 | 2002-10-03 | 辅助的脑膜炎球菌组合物 |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP1438323A4 (pt) |
JP (1) | JP4522699B2 (pt) |
CN (1) | CN100354297C (pt) |
AU (1) | AU2002334844B2 (pt) |
BR (1) | BR0213119A (pt) |
CA (1) | CA2462646C (pt) |
NZ (1) | NZ532274A (pt) |
WO (1) | WO2003028661A2 (pt) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101559225B (zh) * | 2008-04-18 | 2012-07-11 | 北京生物制品研究所 | 脑膜炎球菌疫苗 |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0115176D0 (en) | 2001-06-20 | 2001-08-15 | Chiron Spa | Capular polysaccharide solubilisation and combination vaccines |
MXPA04011249A (es) * | 2002-05-14 | 2005-06-06 | Chiron Srl | Vacunas mucosales con adyuvante de quitosano y antigenos meningococicos. |
GB0302218D0 (en) | 2003-01-30 | 2003-03-05 | Chiron Sri | Vaccine formulation & Mucosal delivery |
SI2255826T1 (sl) * | 2002-08-02 | 2016-07-29 | Glaxosmithkline Biologicals S.A. | Neisserijski vakcinski sestavki, ki obsegajo kombinacijo antigenov |
US8034378B2 (en) | 2002-12-27 | 2011-10-11 | Novartis Vaccines And Diagnostics, Inc | Immunogenic compositions containing phospholipid |
ATE426412T1 (de) * | 2003-01-30 | 2009-04-15 | Novartis Vaccines & Diagnostic | Adjuvante influenza-vakzine |
ES2411080T3 (es) | 2003-01-30 | 2013-07-04 | Novartis Ag | Vacunas inyectables contra múltiples serogrupos de meningococos |
US7731967B2 (en) | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
JP5557415B2 (ja) | 2003-06-02 | 2014-07-23 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 吸着させたトキソイドおよび多糖類含有抗原を含む微粒子に基づく免疫原性組成物 |
JP2007523173A (ja) * | 2004-02-20 | 2007-08-16 | イデラ ファーマシューティカルズ インコーポレイテッド | 修飾免疫調節オリゴヌクレオチドにより誘導された強力な粘膜免疫応答 |
CA2588089C (en) * | 2004-11-15 | 2015-06-23 | Novartis Vaccines And Diagnostics Inc. | Immunogenic compositions containing anthrax antigen, biodegradable polymer microparticles, and polynucleotide-containing immunological adjuvant |
WO2006081576A2 (en) | 2005-01-28 | 2006-08-03 | Galenbio, Inc. | Immunologically active compositions |
ATE438385T1 (de) * | 2005-03-02 | 2009-08-15 | Secr Defence | Pharmazeutische zusammensetzung |
EP3067048B1 (en) | 2007-12-07 | 2018-02-14 | GlaxoSmithKline Biologicals SA | Compositions for inducing immune responses |
PL2863942T3 (pl) * | 2012-06-21 | 2019-12-31 | Northwestern University | Cząstki sprzężone z peptydem |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999057280A2 (en) * | 1998-05-01 | 1999-11-11 | Chiron Corporation | Neisseria meningitidis antigens and compositions |
WO2000022430A2 (en) * | 1998-10-09 | 2000-04-20 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
WO2000050006A2 (en) * | 1999-02-26 | 2000-08-31 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
WO2000050075A2 (en) * | 1999-02-26 | 2000-08-31 | Chiron S.P.A. | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
CN1286727A (zh) * | 1997-11-06 | 2001-03-07 | 启龙股份公司 | 奈瑟球菌抗原 |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR9906927A (pt) * | 1998-01-14 | 2001-11-20 | Chiron Spa | Proteìnas de neisseria meningitidis |
JP4601168B2 (ja) * | 1998-07-29 | 2010-12-22 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | 吸着表面を有する微小粒子、それを作製する方法、およびその使用 |
MXPA01010924A (es) * | 1999-04-30 | 2002-05-06 | Chiron Spa | Antigenos de neisseria conservados. |
BR0108711A (pt) * | 2000-02-28 | 2004-06-22 | Chiron Spa | Expressão heteróloga de proteìnas de neisseria |
-
2002
- 2002-10-03 WO PCT/US2002/031726 patent/WO2003028661A2/en active IP Right Grant
- 2002-10-03 CA CA2462646A patent/CA2462646C/en not_active Expired - Fee Related
- 2002-10-03 BR BR0213119-6A patent/BR0213119A/pt not_active IP Right Cessation
- 2002-10-03 NZ NZ532274A patent/NZ532274A/en not_active IP Right Cessation
- 2002-10-03 CN CNB028241282A patent/CN100354297C/zh not_active Expired - Fee Related
- 2002-10-03 AU AU2002334844A patent/AU2002334844B2/en not_active Ceased
- 2002-10-03 JP JP2003531997A patent/JP4522699B2/ja not_active Expired - Fee Related
- 2002-10-03 EP EP02800481A patent/EP1438323A4/en not_active Withdrawn
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
CN1286727A (zh) * | 1997-11-06 | 2001-03-07 | 启龙股份公司 | 奈瑟球菌抗原 |
WO1999057280A2 (en) * | 1998-05-01 | 1999-11-11 | Chiron Corporation | Neisseria meningitidis antigens and compositions |
WO2000022430A2 (en) * | 1998-10-09 | 2000-04-20 | Chiron Corporation | Neisseria genomic sequences and methods of their use |
WO2000050006A2 (en) * | 1999-02-26 | 2000-08-31 | Chiron Corporation | Microemulsions with adsorbed macromoelecules and microparticles |
WO2000050075A2 (en) * | 1999-02-26 | 2000-08-31 | Chiron S.P.A. | Enhancement of bactericidal activity of neisseria antigens with oligonucleotides containing cg motifs |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101559225B (zh) * | 2008-04-18 | 2012-07-11 | 北京生物制品研究所 | 脑膜炎球菌疫苗 |
Also Published As
Publication number | Publication date |
---|---|
CA2462646A1 (en) | 2003-04-10 |
JP4522699B2 (ja) | 2010-08-11 |
BR0213119A (pt) | 2004-12-28 |
EP1438323A2 (en) | 2004-07-21 |
CA2462646C (en) | 2013-02-12 |
JP2005526697A (ja) | 2005-09-08 |
AU2002334844B8 (en) | 2003-04-14 |
WO2003028661A3 (en) | 2003-10-09 |
AU2002334844B2 (en) | 2007-08-02 |
CN1599746A (zh) | 2005-03-23 |
WO2003028661A2 (en) | 2003-04-10 |
NZ532274A (en) | 2006-02-24 |
EP1438323A4 (en) | 2007-08-01 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
C14 | Grant of patent or utility model | ||
GR01 | Patent grant | ||
C56 | Change in the name or address of the patentee |
Owner name: NOVARTIS VACCINES & DIAGNOSTIC Free format text: FORMER NAME OR ADDRESS: CHIRON CORP. |
|
CP03 | Change of name, title or address |
Address after: Delaware Patentee after: Novartis Vaccines & Diagnostic Inc. Address before: American California Patentee before: Chiron Corporation |
|
C17 | Cessation of patent right | ||
CF01 | Termination of patent right due to non-payment of annual fee |
Granted publication date: 20071212 Termination date: 20131003 |