CN100335041C - 美味咀嚼片剂 - Google Patents

美味咀嚼片剂 Download PDF

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Publication number
CN100335041C
CN100335041C CNB038070448A CN03807044A CN100335041C CN 100335041 C CN100335041 C CN 100335041C CN B038070448 A CNB038070448 A CN B038070448A CN 03807044 A CN03807044 A CN 03807044A CN 100335041 C CN100335041 C CN 100335041C
Authority
CN
China
Prior art keywords
cetirizine
excipient
sucrose
tablet
cyclodextrin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CNB038070448A
Other languages
English (en)
Chinese (zh)
Other versions
CN1642531A (zh
Inventor
卡斯拉·卡斯雷安
坦亚·哈夫利尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Products Inc
Original Assignee
Pfizer Products Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc filed Critical Pfizer Products Inc
Publication of CN1642531A publication Critical patent/CN1642531A/zh
Application granted granted Critical
Publication of CN100335041C publication Critical patent/CN100335041C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2086—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat
    • A61K9/209—Layered tablets, e.g. bilayer tablets; Tablets of the type inert core-active coat containing drug in at least two layers or in the core and in at least one outer layer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/282—Organic compounds, e.g. fats
    • A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CNB038070448A 2002-04-04 2003-03-26 美味咀嚼片剂 Expired - Fee Related CN100335041C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37008602P 2002-04-04 2002-04-04
US60/370,086 2002-04-04

Publications (2)

Publication Number Publication Date
CN1642531A CN1642531A (zh) 2005-07-20
CN100335041C true CN100335041C (zh) 2007-09-05

Family

ID=28792024

Family Applications (1)

Application Number Title Priority Date Filing Date
CNB038070448A Expired - Fee Related CN100335041C (zh) 2002-04-04 2003-03-26 美味咀嚼片剂

Country Status (23)

Country Link
US (1) US7482022B2 (cg-RX-API-DMAC7.html)
EP (1) EP1494654B1 (cg-RX-API-DMAC7.html)
JP (1) JP2005526104A (cg-RX-API-DMAC7.html)
KR (1) KR20040098036A (cg-RX-API-DMAC7.html)
CN (1) CN100335041C (cg-RX-API-DMAC7.html)
AR (1) AR039242A1 (cg-RX-API-DMAC7.html)
AT (1) ATE388693T1 (cg-RX-API-DMAC7.html)
BR (1) BR0308927A (cg-RX-API-DMAC7.html)
CA (1) CA2481025A1 (cg-RX-API-DMAC7.html)
DE (1) DE60319685T2 (cg-RX-API-DMAC7.html)
ES (1) ES2298540T3 (cg-RX-API-DMAC7.html)
HN (1) HN2003000112A (cg-RX-API-DMAC7.html)
IL (1) IL164106A0 (cg-RX-API-DMAC7.html)
MX (1) MXPA04009617A (cg-RX-API-DMAC7.html)
NO (1) NO20044774L (cg-RX-API-DMAC7.html)
PA (1) PA8570601A1 (cg-RX-API-DMAC7.html)
PE (1) PE20030950A1 (cg-RX-API-DMAC7.html)
PL (1) PL372904A1 (cg-RX-API-DMAC7.html)
RU (1) RU2004129573A (cg-RX-API-DMAC7.html)
TW (1) TW200401651A (cg-RX-API-DMAC7.html)
UY (1) UY27746A1 (cg-RX-API-DMAC7.html)
WO (1) WO2003084511A1 (cg-RX-API-DMAC7.html)
ZA (1) ZA200407537B (cg-RX-API-DMAC7.html)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2354688T3 (es) * 2002-01-15 2011-03-17 Ucb Farchim S.A. Formulaciones para la administración oral de compuestos activos.
US20050232995A1 (en) 2002-07-29 2005-10-20 Yam Nyomi V Methods and dosage forms for controlled delivery of paliperidone and risperidone
EP1758856A2 (en) 2004-05-04 2007-03-07 Novo Nordisk A/S Indole derivatives for the treatment of obesity
CA2574602A1 (en) * 2004-07-22 2006-02-02 Pfizer Products Inc. Taste masking formulation comprising the drug in a dissolution-retarded form and/or cyclodextrin in a dissolution-enhanced form
US8758816B2 (en) 2004-11-24 2014-06-24 Meda Pharmaceuticals Inc. Compositions comprising azelastine and methods of use thereof
US20070020330A1 (en) 2004-11-24 2007-01-25 Medpointe Healthcare Inc. Compositions comprising azelastine and methods of use thereof
PL2486942T3 (pl) 2004-11-24 2019-05-31 Meda Pharmaceuticals Inc Kompozycje zawierające azelastynę oraz sposoby ich stosowania
WO2007144902A1 (en) * 2006-06-12 2007-12-21 Jubliant Organosys Limited Chewable bilayer tablet formulation
EP2178521B1 (en) * 2007-07-11 2014-01-15 Fertin Pharma A/S Stable medicated chewing gum comprising cyclodextrin inclusion complex
WO2009006892A1 (en) * 2007-07-11 2009-01-15 Fertin Pharma A/S Stable medicated chewing gum comprising antioxidant
EP2178522A1 (en) * 2007-07-11 2010-04-28 Fertin Pharma A/S Compressed chewing gum tablet comprising taste-masking agent
CL2008003230A1 (es) * 2007-11-01 2009-11-27 Sanofi Aventis Healthcare Pty Ltd Composicion de recubrimiento de tableta que comprende polimero celulosico, plastificante, edulcorante y composicion de sabor en polvo la que comprende saborizante asociado con portador solido; fluido de recubrimiento de tableta que comprende dicha composicion; tableta farmaceutica; proceso de preparacion de dicha tableta.
CN102711739B (zh) 2009-11-13 2015-12-16 阿斯利康(瑞典)有限公司 双层片剂
WO2011110939A2 (en) 2010-03-11 2011-09-15 Rubicon Research Private Limited Pharmaceutical compositions of substituted benzhydrylpiperazines
WO2013129436A1 (ja) * 2012-02-29 2013-09-06 武田薬品工業株式会社 経口剤
PL2861236T3 (pl) 2012-06-15 2020-03-31 Pharmathen S.A. Kompozycja farmaceutyczna zawierająca polimer wiążący fosforany
CN102716099B (zh) * 2012-07-05 2013-10-09 湖南千金湘江药业股份有限公司 盐酸左西替利嗪咀嚼片及其制备方法
CA2882950A1 (en) 2012-09-28 2014-04-03 Merck Sharp & Dohme Corp. Novel compounds that are erk inhibitors
WO2016033424A1 (en) 2014-08-29 2016-03-03 Genzyme Corporation Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
JP2016094364A (ja) * 2014-11-14 2016-05-26 ニプロ株式会社 安定化および苦味抑制された口腔内崩壊製剤
EP3061501A1 (en) 2015-02-27 2016-08-31 Rottapharm Ltd. Composition for the treatment of acne
EP3117825A1 (en) 2015-07-16 2017-01-18 Rottapharm S.p.A. Oral formulation comprising berberine and morus alba extract
JP2019001730A (ja) * 2017-06-13 2019-01-10 武田テバファーマ株式会社 安定な経口医薬組成物

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1261799A (zh) * 1997-07-03 2000-08-02 Ucb公司 含活性物质和环糊精的口服药物组合物
CN1295464A (zh) * 1998-03-31 2001-05-16 Asta药物股份公司 固体、快速崩解的西替利嗪制剂

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3558600A (en) 1967-07-28 1971-01-26 Abbott Lab Alkyl sulfate salts of 1-(p-chlorobenzhydryl)-4-methylhomopiperazines
NO155805C (no) 1981-02-06 1987-06-10 Ucb Sa Analogifremgangsmaate for fremstilling av terapeutisk virksomme 2-(4-(difenylmethyl)-1-piperazinyl)-eddiksyrer og deres amider og ikke-toksiske salter.
US4650663A (en) 1983-07-20 1987-03-17 Warner-Lambert Company Magnesium trisilicate suitable for preparation of medicament adsorbates of antitussives
US4792448A (en) 1987-06-11 1988-12-20 Pfizer Inc. Generic zero order controlled drug delivery system
IL91398A (en) 1988-08-30 1994-05-30 Pfizer Pharmaceutical delivery device comprising active substance surrounded by asymmetric membrane
DE9190107U1 (de) 1990-08-07 1993-12-16 Pfizer Inc., New York, N.Y. Abgabe-Vorrichtung mit durch Grenzflächen-Polymerisation erhaltenen Membranen
CA2146637C (en) 1992-10-09 2001-02-13 James Grigg Upson Pharmaceutical compositions and methods for treating cold symptoms
BE1011045A3 (fr) * 1997-03-14 1999-04-06 Ucb Sa Compositions pharmaceutiques pour la liberation controlee de substances actives.
US6027746A (en) * 1997-04-23 2000-02-22 Warner-Lambert Company Chewable soft gelatin-encapsulated pharmaceutical adsorbates
US6270790B1 (en) 1998-08-18 2001-08-07 Mxneil-Ppc, Inc. Soft, convex shaped chewable tablets having reduced friability
US7223421B2 (en) * 2000-06-30 2007-05-29 Mcneil-Ppc, Inc. Teste masked pharmaceutical particles
US20030035839A1 (en) * 2001-05-15 2003-02-20 Peirce Management, Llc Pharmaceutical composition for both intraoral and oral administration
ES2354688T3 (es) * 2002-01-15 2011-03-17 Ucb Farchim S.A. Formulaciones para la administración oral de compuestos activos.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1261799A (zh) * 1997-07-03 2000-08-02 Ucb公司 含活性物质和环糊精的口服药物组合物
CN1295464A (zh) * 1998-03-31 2001-05-16 Asta药物股份公司 固体、快速崩解的西替利嗪制剂

Also Published As

Publication number Publication date
ES2298540T3 (es) 2008-05-16
EP1494654B1 (en) 2008-03-12
BR0308927A (pt) 2005-01-04
RU2004129573A (ru) 2005-04-10
ATE388693T1 (de) 2008-03-15
UY27746A1 (es) 2003-10-31
MXPA04009617A (es) 2005-01-11
ZA200407537B (en) 2006-06-28
WO2003084511A1 (en) 2003-10-16
AU2003209953A1 (en) 2003-10-20
DE60319685D1 (de) 2008-04-24
US7482022B2 (en) 2009-01-27
IL164106A0 (en) 2005-12-18
PL372904A1 (en) 2005-08-08
EP1494654A1 (en) 2005-01-12
CN1642531A (zh) 2005-07-20
PA8570601A1 (es) 2003-12-10
NO20044774L (no) 2004-11-03
PE20030950A1 (es) 2003-11-12
US20030215503A1 (en) 2003-11-20
JP2005526104A (ja) 2005-09-02
AR039242A1 (es) 2005-02-16
CA2481025A1 (en) 2003-10-16
TW200401651A (en) 2004-02-01
DE60319685T2 (de) 2009-03-26
HN2003000112A (es) 2004-05-05
KR20040098036A (ko) 2004-11-18

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