CL2023002737A1 - Moduladores de sting (estimulador de genes de interferón) - Google Patents

Moduladores de sting (estimulador de genes de interferón)

Info

Publication number
CL2023002737A1
CL2023002737A1 CL2023002737A CL2023002737A CL2023002737A1 CL 2023002737 A1 CL2023002737 A1 CL 2023002737A1 CL 2023002737 A CL2023002737 A CL 2023002737A CL 2023002737 A CL2023002737 A CL 2023002737A CL 2023002737 A1 CL2023002737 A1 CL 2023002737A1
Authority
CL
Chile
Prior art keywords
interferon gene
gene stimulator
sting modulators
compounds
sting
Prior art date
Application number
CL2023002737A
Other languages
English (en)
Inventor
Jalaie Mehran
Satish Gajiwala Ketan
Woo Huh Chan
Lloyd Patman Ryan
Yuanjin Rui Eugene
Sun Jianmin
James Wythes Martin
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of CL2023002737A1 publication Critical patent/CL2023002737A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Saccharide Compounds (AREA)

Abstract

En la presente se proporcionan compuestos de la Fórmula general (I): y sales aceptables desde el punto de vista farmacéutico de estos, procesos para la preparación de estos compuestos, composiciones que contienen estos compuestos y los usos de estos compuestos.
CL2023002737A 2021-03-18 2023-09-14 Moduladores de sting (estimulador de genes de interferón) CL2023002737A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US202163162640P 2021-03-18 2021-03-18
US202163165459P 2021-03-24 2021-03-24

Publications (1)

Publication Number Publication Date
CL2023002737A1 true CL2023002737A1 (es) 2024-04-01

Family

ID=80819922

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2023002737A CL2023002737A1 (es) 2021-03-18 2023-09-14 Moduladores de sting (estimulador de genes de interferón)

Country Status (17)

Country Link
US (1) US11964978B2 (es)
EP (1) EP4308563A1 (es)
JP (1) JP7554410B2 (es)
KR (1) KR20230146606A (es)
AU (1) AU2022238001A1 (es)
BR (1) BR112023017731A2 (es)
CA (1) CA3213427A1 (es)
CL (1) CL2023002737A1 (es)
CO (1) CO2023012198A2 (es)
CR (1) CR20230413A (es)
DO (1) DOP2023000194A (es)
EC (1) ECSP23070418A (es)
IL (1) IL306034A (es)
MX (1) MX2023010942A (es)
TW (1) TWI829112B (es)
UY (1) UY39676A (es)
WO (1) WO2022195462A1 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023222644A1 (en) 2022-05-18 2023-11-23 F. Hoffmann-La Roche Ag Pyrazole derivatives as sting agonists

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035296A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Improved release of medicament active agents from a chewing gum coating
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
AR076601A1 (es) 2009-05-21 2011-06-22 Chlorion Pharma Inc Pirimidinas como agentes terapeuticos
NZ714128A (en) 2010-09-09 2017-10-27 Pfizer 4-1bb binding molecules
TWI595006B (zh) 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
RU2748949C2 (ru) 2016-01-25 2021-06-02 Пфайзер Инк. Комбинация моноклональных антител агониста ох40 и агониста 4-1вв для лечения рака
AU2017247806B2 (en) * 2016-04-07 2019-11-14 Glaxosmithkline Intellectual Property Development Limited Heterocyclic amides useful as protein modulators
WO2017198341A1 (en) 2016-05-19 2017-11-23 Bayer Aktiengesellschaft Macrocyclic indole derivatives
MX2019015468A (es) * 2017-06-22 2020-08-03 Curadev Pharma Ltd Moduladores de moleculas pequeñas de sting humana.
CN110016025B (zh) 2018-01-08 2021-08-06 成都先导药物开发股份有限公司 一种免疫调节剂
IL276844B1 (en) 2018-02-21 2024-09-01 Scripps Research Inst Preparations containing substances of the type 1H-IMIDAZOL-1-YL)-3-PYRIDAZINECARBOXAMIDE) for the treatment of tumors
TWI741268B (zh) * 2018-03-15 2021-10-01 美商輝瑞股份有限公司 干擾素基因刺激劑（ｓｔｉｎｇ）的環戊烷為主體之調節劑
TWI793294B (zh) 2018-04-03 2023-02-21 美商默沙東有限責任公司 Sting促效劑化合物
TW202014408A (zh) 2018-07-03 2020-04-16 美商Ｉｆｍ Ｄｕｅ有限公司 用於治療與sting活性相關之病症的化合物及組合物
WO2020028565A1 (en) * 2018-07-31 2020-02-06 Incyte Corporation Tricyclic heteraryl compounds as sting activators
WO2020075790A1 (ja) 2018-10-11 2020-04-16 小野薬品工業株式会社 Ｓｔｉｎｇ作動化合物
MA55214A (fr) * 2019-03-05 2022-01-12 F Star Therapeutics Inc Composés, compositions et procédés pour le traitement d'une maladie
CN114302875A (zh) * 2019-05-16 2022-04-08 斯汀塞拉股份有限公司 氧代吖啶基乙酸衍生物及使用方法
BR112022005463A2 (pt) 2019-09-25 2022-06-14 Pfizer Moduladores poli-heterocíclicos de sting (estimulador de genes de interferon)

Also Published As

Publication number Publication date
CR20230413A (es) 2023-10-13
IL306034A (en) 2023-11-01
ECSP23070418A (es) 2023-10-31
CA3213427A1 (en) 2022-09-22
TWI829112B (zh) 2024-01-11
UY39676A (es) 2022-10-31
KR20230146606A (ko) 2023-10-19
DOP2023000194A (es) 2023-11-30
WO2022195462A1 (en) 2022-09-22
BR112023017731A2 (pt) 2023-10-03
US11964978B2 (en) 2024-04-23
MX2023010942A (es) 2023-09-28
JP2024509982A (ja) 2024-03-05
JP7554410B2 (ja) 2024-09-20
TW202246262A (zh) 2022-12-01
EP4308563A1 (en) 2024-01-24
AU2022238001A1 (en) 2023-09-14
US20220306641A1 (en) 2022-09-29
CO2023012198A2 (es) 2023-11-30

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