CL2020002053A1 - Métodos y composiciones para polarización de macrófagos. - Google Patents
Métodos y composiciones para polarización de macrófagos.Info
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- CL2020002053A1 CL2020002053A1 CL2020002053A CL2020002053A CL2020002053A1 CL 2020002053 A1 CL2020002053 A1 CL 2020002053A1 CL 2020002053 A CL2020002053 A CL 2020002053A CL 2020002053 A CL2020002053 A CL 2020002053A CL 2020002053 A1 CL2020002053 A1 CL 2020002053A1
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Abstract
En la presente se describen composiciones y métodos que comprenden vesículas extracelulares que comprenden ácido nucleico que se dirige a genes, lo que conduce a la polarización de macrófagos de macrófagos asociados a tumores. En ciertas modalidades, en la presente se describen métodos y composiciones para aumentar la polarización de macrófagos para el tratamiento del cáncer.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201862629563P | 2018-02-12 | 2018-02-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2020002053A1 true CL2020002053A1 (es) | 2020-12-18 |
Family
ID=65729420
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2020002053A CL2020002053A1 (es) | 2018-02-12 | 2020-08-07 | Métodos y composiciones para polarización de macrófagos. |
Country Status (17)
Country | Link |
---|---|
US (2) | US11512315B2 (es) |
EP (1) | EP3752615A1 (es) |
JP (1) | JP2021512608A (es) |
KR (1) | KR20200120624A (es) |
CN (1) | CN111918967A (es) |
AU (1) | AU2019218991A1 (es) |
BR (1) | BR112020016228A2 (es) |
CA (1) | CA3088009A1 (es) |
CL (1) | CL2020002053A1 (es) |
CO (1) | CO2020009694A2 (es) |
EA (1) | EA202091486A1 (es) |
IL (1) | IL276409A (es) |
MX (1) | MX2020008103A (es) |
PH (1) | PH12020551195A1 (es) |
SG (1) | SG11202006021SA (es) |
TW (1) | TW202003846A (es) |
WO (1) | WO2019157535A1 (es) |
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MX2020008103A (es) | 2018-02-12 | 2020-09-25 | Codiak Biosciences Inc | Metodos y composiciones para polarizacion de macrofagos. |
WO2020106772A1 (en) * | 2018-11-19 | 2020-05-28 | Exosome Therapeutics, Inc. | Exosome loaded therapeutics for the treatment of non-alcoholic steatohepatitis, diabetes mellitus type 1 and type 2, atherosclerotic cardiovascular disease, and alpha 1 antitrypsin deficiency |
JP2022544289A (ja) * | 2019-08-14 | 2022-10-17 | コディアック バイオサイエンシーズ, インコーポレイテッド | Stat6を標的とする細胞外小胞-aso構築物 |
WO2021030769A1 (en) * | 2019-08-14 | 2021-02-18 | Codiak Biosciences, Inc. | Extracellular vesicles with nras antisense oligonucleotides |
CA3145924A1 (en) * | 2019-08-14 | 2021-02-18 | Yi Zhang | Extracellular vesicle linked to molecules and uses thereof |
EP4013878A1 (en) * | 2019-08-14 | 2022-06-22 | Codiak BioSciences, Inc. | Extracellular vesicle-aso constructs targeting cebp/beta |
CN114641570A (zh) * | 2019-08-14 | 2022-06-17 | 科迪亚克生物科学公司 | 具有靶向kras的反义寡核苷酸的细胞外囊泡 |
CN114727947A (zh) * | 2019-09-25 | 2022-07-08 | 科迪亚克生物科学公司 | 细胞外囊泡组合物 |
CA3164248A1 (en) * | 2019-12-05 | 2021-06-10 | Board Of Regents, The University Of Texas System | Exosomes-based therapy for liver fibrosis and other diseases associated with fibrosis |
CN115768877A (zh) | 2020-05-11 | 2023-03-07 | 斯特姆生物公司 | 与巨核细胞来源的细胞外囊泡相关的组合物和方法 |
WO2021237100A1 (en) * | 2020-05-21 | 2021-11-25 | Codiak Biosciences, Inc. | Methods of targeting extracellular vesicles to lung |
CN111748523B (zh) * | 2020-07-17 | 2022-11-22 | 南通大学 | 一种免疫调节小胞外囊泡的制备方法及其用途 |
WO2022076596A1 (en) * | 2020-10-06 | 2022-04-14 | Codiak Biosciences, Inc. | Extracellular vesicle-aso constructs targeting stat6 |
CN113262305B (zh) * | 2021-05-27 | 2022-03-25 | 浙江大学 | Coro1a基因作为靶点在制备抗肿瘤药物中的应用 |
AU2022300794A1 (en) | 2021-07-02 | 2024-01-18 | Spark Biopharma, Inc | Novel benzopyran derivative and use thereof |
CN113521252B (zh) * | 2021-07-29 | 2022-12-20 | 南开大学 | Tnfsf15蛋白作为巨噬细胞免疫增强剂的用途及其活化方法 |
WO2023069628A2 (en) * | 2021-10-21 | 2023-04-27 | Nanothera Biosciences, Inc. | Compositions and methods for silencing kras |
CN114058621B (zh) * | 2021-12-03 | 2023-06-16 | 温州医科大学 | 一种lncRNA基因修饰细胞分泌的外泌体及应用 |
CN114209814B (zh) * | 2021-12-15 | 2024-02-23 | 南开大学 | Tnfsf15蛋白在促进骨髓干细胞分化为巨噬细胞并扩增中的用途 |
CN114561347A (zh) * | 2022-02-25 | 2022-05-31 | 和携科技有限公司 | 一种脂肪间充质干细胞的培养基和培养方法 |
CN115137708B (zh) * | 2022-06-24 | 2023-05-16 | 重庆医科大学 | 装载yap1核酸序列的肝纤维化靶向纳米颗粒及其制备方法和应用 |
WO2024015512A1 (en) * | 2022-07-13 | 2024-01-18 | Navidea Biopharmaceuticals, Inc. | Mannosylated amine dextran drug delivery vehicles with degradable disulfide/carbonate linkers targeting payloads to cd206 expressing cells |
CN115261410A (zh) * | 2022-07-20 | 2022-11-01 | 中山大学 | 一种基因编辑工程化m1型巨噬细胞外泌体的制备方法及其应用 |
WO2024044788A2 (en) * | 2022-08-26 | 2024-02-29 | Georgia State University Research Foundation, Inc. | Treating chronic inflammation and cancer by macrophage polarization |
CN115814108A (zh) * | 2022-12-27 | 2023-03-21 | 华中科技大学 | 一种用于个性化肿瘤治疗的工程化巨噬细胞载药微颗粒制剂及其制备方法 |
KR102635831B1 (ko) * | 2023-11-01 | 2024-02-13 | 강원대학교 산학협력단 | Cxcl11에 의한 m2 대식세포의 재분극 유도를 통한 폐섬유화증 치료 용도 |
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GB2382408B (en) * | 2000-06-19 | 2004-06-02 | Halliburton Energy Systems Inc | Apparatus and methods for applying time lapse VSP to monitor a reservoir |
US20040115634A1 (en) * | 2002-12-11 | 2004-06-17 | Isis Pharmaceuticals, Inc. | Modulation of stat 6 expression |
DE102006050655A1 (de) * | 2006-10-24 | 2008-04-30 | Halmon Beheer B.V. | Pharmazeutische Zusammensetzung zur Behandlung allergischer Erkrankungen |
WO2010115206A2 (en) * | 2009-04-03 | 2010-10-07 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of kras by asymmetric double-stranded rna |
WO2010115202A2 (en) * | 2009-04-03 | 2010-10-07 | Dicerna Pharmaceuticals, Inc. | Methods and compositions for the specific inhibition of kras by blunt ended double-stranded rna |
CN103492590A (zh) * | 2011-02-22 | 2014-01-01 | 卡里斯生命科学卢森堡控股有限责任公司 | 循环生物标志物 |
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KR20170072928A (ko) * | 2014-10-24 | 2017-06-27 | 아스트라제네카 아베 | 조합물 |
EP3307890A1 (en) | 2015-06-10 | 2018-04-18 | Board of Regents, The University of Texas System | Use of exosomes for the treatment of disease |
GB201516801D0 (en) * | 2015-09-22 | 2015-11-04 | Immunovia Ab | Method, array and use thereof |
TW201723176A (zh) * | 2015-09-24 | 2017-07-01 | Ionis製藥公司 | Kras表現之調節劑 |
RU2018136151A (ru) | 2016-03-15 | 2020-04-15 | Кодиак Байосайнсиз, Инк. | Терапевтические мембранные везикулы |
WO2018039119A1 (en) | 2016-08-22 | 2018-03-01 | Codiak Biosciences, Inc. | Methods of suppressing delivery of exosomes to liver and spleen |
SG11202001008RA (en) | 2017-08-25 | 2020-03-30 | Codiak Biosciences Inc | Preparation of therapeutic exosomes using membrane proteins |
MX2020008103A (es) | 2018-02-12 | 2020-09-25 | Codiak Biosciences Inc | Metodos y composiciones para polarizacion de macrofagos. |
CA3145924A1 (en) * | 2019-08-14 | 2021-02-18 | Yi Zhang | Extracellular vesicle linked to molecules and uses thereof |
US20210322405A1 (en) * | 2020-04-15 | 2021-10-21 | Washington University | Compositions and methods for treating cancer |
AU2023228254A1 (en) * | 2022-03-04 | 2024-09-05 | I-Mab Biopharma Co., Ltd. | Combination therapies comprising a kras inhibitor for the treatment of cancer |
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- 2019-02-12 AU AU2019218991A patent/AU2019218991A1/en active Pending
- 2019-02-12 CN CN201980011011.0A patent/CN111918967A/zh active Pending
- 2019-02-12 EP EP19710511.7A patent/EP3752615A1/en active Pending
- 2019-02-12 CA CA3088009A patent/CA3088009A1/en active Pending
- 2019-02-12 EA EA202091486A patent/EA202091486A1/ru unknown
- 2019-02-12 KR KR1020207022341A patent/KR20200120624A/ko unknown
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- 2020-08-07 CL CL2020002053A patent/CL2020002053A1/es unknown
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2022
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Also Published As
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US20200407725A1 (en) | 2020-12-31 |
EP3752615A1 (en) | 2020-12-23 |
CN111918967A (zh) | 2020-11-10 |
IL276409A (en) | 2020-09-30 |
WO2019157535A1 (en) | 2019-08-15 |
JP2021512608A (ja) | 2021-05-20 |
CO2020009694A2 (es) | 2020-10-30 |
TW202003846A (zh) | 2020-01-16 |
BR112020016228A2 (pt) | 2020-12-08 |
CA3088009A1 (en) | 2019-08-15 |
AU2019218991A1 (en) | 2020-07-09 |
MX2020008103A (es) | 2020-09-25 |
EA202091486A1 (ru) | 2021-02-08 |
US20230365971A1 (en) | 2023-11-16 |
PH12020551195A1 (en) | 2021-08-16 |
US11512315B2 (en) | 2022-11-29 |
KR20200120624A (ko) | 2020-10-21 |
SG11202006021SA (en) | 2020-08-28 |
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