CL2019001735A1 - Anticuerpos monoclonales anti-alfa-sinucleína para prevenir la agregación de tau. - Google Patents

Anticuerpos monoclonales anti-alfa-sinucleína para prevenir la agregación de tau.

Info

Publication number
CL2019001735A1
CL2019001735A1 CL2019001735A CL2019001735A CL2019001735A1 CL 2019001735 A1 CL2019001735 A1 CL 2019001735A1 CL 2019001735 A CL2019001735 A CL 2019001735A CL 2019001735 A CL2019001735 A CL 2019001735A CL 2019001735 A1 CL2019001735 A1 CL 2019001735A1
Authority
CL
Chile
Prior art keywords
alpha
monoclonal antibodies
tau aggregation
prevent tau
synuclein monoclonal
Prior art date
Application number
CL2019001735A
Other languages
English (en)
Inventor
Karina Fog
Jeppe Falsig Pedersen
Original Assignee
H Lundbeck As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H Lundbeck As filed Critical H Lundbeck As
Publication of CL2019001735A1 publication Critical patent/CL2019001735A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Hospice & Palliative Care (AREA)
  • Molecular Biology (AREA)
  • Psychology (AREA)
  • Endocrinology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

LA INVENCIÓN SE REFIERE A UN NUEVO USO DE ANTICUERPOS MONOCLONALES ANTI-ALFA-SINUCLEÍNA. LOS ANTICUERPOS PUEDEN USARSE PARA PREVENIR LA AGREGACIÓN DE TAU Y, POR LO TANTO, PARA TRATAR TAUPATÍAS TALES COMO LA ENFERMEDAD DE ALZHEIMER.
CL2019001735A 2016-12-22 2019-06-20 Anticuerpos monoclonales anti-alfa-sinucleína para prevenir la agregación de tau. CL2019001735A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA201600782 2016-12-22
DKPA201700016 2017-01-05

Publications (1)

Publication Number Publication Date
CL2019001735A1 true CL2019001735A1 (es) 2019-10-04

Family

ID=61022287

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2019001735A CL2019001735A1 (es) 2016-12-22 2019-06-20 Anticuerpos monoclonales anti-alfa-sinucleína para prevenir la agregación de tau.

Country Status (14)

Country Link
US (1) US10364286B2 (es)
EP (1) EP3558364A1 (es)
JP (1) JP7300990B2 (es)
KR (1) KR102584663B1 (es)
CN (1) CN110114088B (es)
AU (1) AU2017384681B2 (es)
BR (1) BR112018017172A2 (es)
CA (1) CA3046857A1 (es)
CL (1) CL2019001735A1 (es)
CO (1) CO2019006059A2 (es)
IL (1) IL267559A (es)
MX (1) MX2019007480A (es)
RU (1) RU2760334C2 (es)
WO (1) WO2018115225A1 (es)

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GB201512203D0 (en) 2015-07-13 2015-08-19 Lundbeck & Co As H Agents,uses and methods
JO3711B1 (ar) 2015-07-13 2021-01-31 H Lundbeck As أجسام مضادة محددة لبروتين تاو وطرق استعمالها
JOP20180117B1 (ar) 2016-07-12 2022-03-14 H Lundbeck As أجسام مضادة انتقائية لـ tau فائق المعالجة بفوسفوريلات وطرق لاستخدامها
EP3541836A1 (en) * 2016-11-15 2019-09-25 H. Lundbeck A/S Agents, uses and methods for the treatment of synucleinopathy
US11325968B2 (en) 2016-12-16 2022-05-10 H. Lundbeck A/S Alpha-synuclein antibodies
MA47205A (fr) 2017-01-04 2019-11-13 H Lundbeck As Anticorps spécifiques de la protéine tau hyperphosphorylée pour traiter des maladies oculaires
CN110506057B (zh) 2017-02-17 2023-09-29 百时美施贵宝公司 Alpha突触核蛋白抗体及其应用
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JP2022502369A (ja) * 2018-10-07 2022-01-11 ザ ユニヴァーシティ オブ ブリティッシュ コロンビア α−シヌクレインの立体配座特異的エピトープ、それに対する抗体、およびそれに関連する方法
EP3867270A1 (en) * 2018-10-19 2021-08-25 Janssen Vaccines & Prevention B.V. Anti-synuclein antibodies
KR102239512B1 (ko) * 2020-09-10 2021-04-12 서울대학교산학협력단 다중기능성 마이크로캡슐 조성물 및 그 제조방법
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CN113912716B (zh) * 2021-12-15 2022-03-01 北京凯祥弘康生物科技有限公司 针对α-突触核蛋白抗原的抗体及其应用

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Also Published As

Publication number Publication date
WO2018115225A1 (en) 2018-06-28
CN110114088B (zh) 2023-08-15
RU2019118922A (ru) 2021-01-22
EP3558364A1 (en) 2019-10-30
RU2760334C2 (ru) 2021-11-24
US20180179273A1 (en) 2018-06-28
CN110114088A (zh) 2019-08-09
AU2017384681B2 (en) 2024-06-13
AU2017384681A1 (en) 2019-07-04
US10364286B2 (en) 2019-07-30
BR112018017172A2 (pt) 2019-01-02
RU2019118922A3 (es) 2021-04-22
KR102584663B1 (ko) 2023-10-04
IL267559A (en) 2019-08-29
CO2019006059A2 (es) 2019-06-19
MX2019007480A (es) 2019-08-29
JP7300990B2 (ja) 2023-06-30
JP2020504729A (ja) 2020-02-13
CA3046857A1 (en) 2018-06-28
KR20190098976A (ko) 2019-08-23

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