CO2017012974A2 - Anticuerpos de unión a tau - Google Patents
Anticuerpos de unión a tauInfo
- Publication number
- CO2017012974A2 CO2017012974A2 CONC2017/0012974A CO2017012974A CO2017012974A2 CO 2017012974 A2 CO2017012974 A2 CO 2017012974A2 CO 2017012974 A CO2017012974 A CO 2017012974A CO 2017012974 A2 CO2017012974 A2 CO 2017012974A2
- Authority
- CO
- Colombia
- Prior art keywords
- binding antibodies
- tau binding
- tau
- antibodies
- tauopathies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4711—Alzheimer's disease; Amyloid plaque core protein
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6893—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids related to diseases not provided for elsewhere
- G01N33/6896—Neurological disorders, e.g. Alzheimer's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/46—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans from vertebrates
- G01N2333/47—Assays involving proteins of known structure or function as defined in the subgroups
- G01N2333/4701—Details
- G01N2333/4703—Regulators; Modulating activity
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/28—Neurological disorders
- G01N2800/2814—Dementia; Cognitive disorders
- G01N2800/2821—Alzheimer
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Neurosurgery (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Cell Biology (AREA)
- Pathology (AREA)
- Peptides Or Proteins (AREA)
Abstract
La presente invención se refiere a anticuerpos de unión a Tau y fragmentos de unión de los mismos, métodos para hacer dicho anticuerpo y el uso de los mismos para el tratamiento y/o el diagnóstico de tauopatías tales como la enfermedad de Alzheimer (AD) y la supranuclear progresiva (PSP).
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP15175519 | 2015-07-06 | ||
PCT/EP2016/065809 WO2017005732A1 (en) | 2015-07-06 | 2016-07-05 | Tau-binding antibodies |
Publications (1)
Publication Number | Publication Date |
---|---|
CO2017012974A2 true CO2017012974A2 (es) | 2018-03-09 |
Family
ID=53524638
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CONC2017/0012974A CO2017012974A2 (es) | 2015-07-06 | 2017-12-18 | Anticuerpos de unión a tau |
Country Status (23)
Country | Link |
---|---|
US (4) | US10344081B2 (es) |
EP (1) | EP3319984A1 (es) |
JP (1) | JP6937289B2 (es) |
KR (1) | KR20180027566A (es) |
CN (1) | CN107849105B (es) |
AR (1) | AR105266A1 (es) |
AU (1) | AU2016289753C1 (es) |
BR (1) | BR112017028101A2 (es) |
CA (1) | CA2991264C (es) |
CL (1) | CL2018000042A1 (es) |
CO (1) | CO2017012974A2 (es) |
EA (1) | EA036821B1 (es) |
EC (1) | ECSP18000844A (es) |
IL (1) | IL256687B (es) |
MA (2) | MA41669A1 (es) |
MX (1) | MX2017015908A (es) |
PE (1) | PE20180499A1 (es) |
PH (1) | PH12017502180A1 (es) |
TN (1) | TN2017000543A1 (es) |
TW (1) | TWI748954B (es) |
UY (1) | UY36774A (es) |
WO (1) | WO2017005732A1 (es) |
ZA (1) | ZA201708128B (es) |
Families Citing this family (22)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
MX2017015464A (es) | 2015-06-05 | 2018-03-28 | Genentech Inc | Anticuerpos anti-tau y metodos de uso. |
KR20180027566A (ko) | 2015-07-06 | 2018-03-14 | 유씨비 바이오파마 에스피알엘 | 타우 결합 항체 |
MA42377A (fr) | 2015-07-06 | 2018-05-16 | Ucb Biopharma Sprl | Anticorps se liant à tau |
EP3452508A1 (en) | 2016-05-02 | 2019-03-13 | Prothena Biosciences Limited | Antibodies recognizing tau |
JP7170316B2 (ja) | 2016-05-02 | 2022-11-14 | プロセナ バイオサイエンシーズ リミテッド | タウ免疫療法 |
KR20230146126A (ko) | 2016-12-07 | 2023-10-18 | 제넨테크, 인크. | 항-타우 항체 및 이의 이용 방법 |
JP2020511937A (ja) | 2016-12-07 | 2020-04-23 | ジェネンテック, インコーポレイテッド | 抗tau抗体及び使用方法 |
WO2018148447A1 (en) * | 2017-02-08 | 2018-08-16 | Adimab, Llc | Antibody heavy chain variable domains targeting the nkg2d receptor |
CA3221995A1 (en) | 2017-02-08 | 2018-08-16 | Dragonfly Therapeutics, Inc. | Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer |
CA3053379A1 (en) | 2017-02-17 | 2018-08-23 | Denali Therapeutics Inc. | Anti-tau antibodies and methods of use thereof |
US11884732B2 (en) | 2017-02-20 | 2024-01-30 | Dragonfly Therapeutics, Inc. | Proteins binding HER2, NKG2D and CD16 |
JP2018139530A (ja) | 2017-02-27 | 2018-09-13 | 帝人ファーマ株式会社 | 認知症治療又は予防のためのヒト化抗体及びその製造方法、並びにそれを用いた認知症治療剤又は予防剤 |
SG11201910066QA (en) | 2017-05-02 | 2019-11-28 | Prothena Biosciences Ltd | Antibodies recognizing tau |
MX2020003857A (es) | 2017-10-16 | 2021-01-08 | Eisai R&D Man Co Ltd | Anticuerpos anti-tau y uso de los mismos. |
JP2021512630A (ja) | 2018-02-08 | 2021-05-20 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Nkg2d受容体を標的とする抗体可変ドメイン |
EP3894438A1 (en) * | 2018-12-13 | 2021-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | New anti tau svqivykpv epitope single domain antibody |
WO2020180819A1 (en) | 2019-03-03 | 2020-09-10 | Prothena Biosciences Limited | Antibodies recognizing tau |
AU2021251486A1 (en) * | 2020-04-08 | 2022-12-08 | Janssen Biotech, Inc. | Anti-PHF-TAU antibodies and uses thereof |
MX2022016322A (es) | 2020-06-25 | 2023-01-24 | Merck Sharp & Dohme Llc | Anticuerpos de alta afinidad dirigidos a tau fosforilada en la serina 413. |
WO2022144406A1 (en) * | 2020-12-29 | 2022-07-07 | Neurimmune Ag | Human anti-tau antibodies |
WO2023092004A1 (en) | 2021-11-17 | 2023-05-25 | Voyager Therapeutics, Inc. | Compositions and methods for the treatment of tau-related disorders |
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CN103992405B (zh) * | 2008-03-26 | 2016-08-17 | 宜康公司 | 抗-vegf抗体 |
CN101307108B (zh) * | 2008-06-25 | 2012-04-04 | 南京川博生物技术有限公司 | 抗磷酸化Tau蛋白抗体及其在AD症异常磷酸化Tau蛋白水平测定上的用途 |
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JP5917394B2 (ja) | 2009-06-10 | 2016-05-11 | ニューヨーク・ユニバーシティ | 病理学的タウタンパク質の免疫学的標的化方法 |
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CA2813493C (en) | 2010-10-11 | 2019-07-09 | University Of Zurich | Human anti-tau antibodies |
US8703137B2 (en) | 2011-01-31 | 2014-04-22 | Intellect Neurosciences Inc. | Treatment of tauopathies |
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CN104520322B (zh) | 2012-04-05 | 2019-11-15 | Ac免疫有限公司 | 人源化tau抗体 |
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MY176838A (en) * | 2012-08-16 | 2020-08-24 | Ipierian Inc | Methods of treating a tauopathy |
LT2935326T (lt) | 2012-12-21 | 2020-12-10 | Biogen Ma Inc. | Žmogaus antikūnai prieš tau baltymą |
CU24446B1 (es) | 2013-03-13 | 2019-10-04 | Prothena Biosciences Ltd | Un anticuerpo monoclonal humanizado que se une a tau |
KR102233349B1 (ko) | 2013-03-15 | 2021-03-31 | 에이씨 이뮨 에스.에이. | 항-타우(tau) 항체 및 사용 방법 |
MX2016007208A (es) | 2013-12-20 | 2016-07-21 | Hoffmann La Roche | Anticuerpos anti-tau(ps422) humanizados y metodos de uso. |
CA2874083C (en) * | 2014-12-05 | 2024-01-02 | Universite Laval | Tdp-43-binding polypeptides useful for the treatment of neurodegenerative diseases |
TWI669314B (zh) | 2015-02-26 | 2019-08-21 | 美國禮來大藥廠 | 針對tau之抗體及其用途 |
MX2017015464A (es) | 2015-06-05 | 2018-03-28 | Genentech Inc | Anticuerpos anti-tau y metodos de uso. |
KR20180027566A (ko) | 2015-07-06 | 2018-03-14 | 유씨비 바이오파마 에스피알엘 | 타우 결합 항체 |
MA42377A (fr) | 2015-07-06 | 2018-05-16 | Ucb Biopharma Sprl | Anticorps se liant à tau |
JO3711B1 (ar) | 2015-07-13 | 2021-01-31 | H Lundbeck As | أجسام مضادة محددة لبروتين تاو وطرق استعمالها |
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2016
- 2016-07-05 KR KR1020187003686A patent/KR20180027566A/ko not_active Application Discontinuation
- 2016-07-05 MX MX2017015908A patent/MX2017015908A/es unknown
- 2016-07-05 BR BR112017028101A patent/BR112017028101A2/pt active Search and Examination
- 2016-07-05 CA CA2991264A patent/CA2991264C/en active Active
- 2016-07-05 AU AU2016289753A patent/AU2016289753C1/en active Active
- 2016-07-05 TN TNP/2017/000543A patent/TN2017000543A1/en unknown
- 2016-07-05 WO PCT/EP2016/065809 patent/WO2017005732A1/en active Application Filing
- 2016-07-05 JP JP2018500422A patent/JP6937289B2/ja active Active
- 2016-07-05 EA EA201890169A patent/EA036821B1/ru not_active IP Right Cessation
- 2016-07-05 US US15/742,070 patent/US10344081B2/en active Active
- 2016-07-05 MA MA41669A patent/MA41669A1/fr unknown
- 2016-07-05 CN CN201680039813.9A patent/CN107849105B/zh active Active
- 2016-07-05 PE PE2017002758A patent/PE20180499A1/es unknown
- 2016-07-05 EP EP16736072.6A patent/EP3319984A1/en active Pending
- 2016-07-05 MA MA042380A patent/MA42380A/fr unknown
- 2016-07-06 AR ARP160102044A patent/AR105266A1/es unknown
- 2016-07-06 UY UY0001036774A patent/UY36774A/es not_active Application Discontinuation
- 2016-07-06 TW TW105121454A patent/TWI748954B/zh active
-
2017
- 2017-11-29 ZA ZA2017/08128A patent/ZA201708128B/en unknown
- 2017-11-29 PH PH12017502180A patent/PH12017502180A1/en unknown
- 2017-12-18 CO CONC2017/0012974A patent/CO2017012974A2/es unknown
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2018
- 2018-01-01 IL IL256687A patent/IL256687B/en unknown
- 2018-01-05 EC ECIEPI2018844A patent/ECSP18000844A/es unknown
- 2018-01-05 CL CL2018000042A patent/CL2018000042A1/es unknown
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2019
- 2019-07-01 US US16/458,217 patent/US10906966B2/en active Active
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2020
- 2020-12-29 US US17/136,440 patent/US11746145B2/en active Active
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2023
- 2023-06-30 US US18/344,930 patent/US20230331833A1/en active Pending
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