CL2019001475A1 - Métodos para tratar afecciones inflamatorias. - Google Patents
Métodos para tratar afecciones inflamatorias.Info
- Publication number
- CL2019001475A1 CL2019001475A1 CL2019001475A CL2019001475A CL2019001475A1 CL 2019001475 A1 CL2019001475 A1 CL 2019001475A1 CL 2019001475 A CL2019001475 A CL 2019001475A CL 2019001475 A CL2019001475 A CL 2019001475A CL 2019001475 A1 CL2019001475 A1 CL 2019001475A1
- Authority
- CL
- Chile
- Prior art keywords
- methods
- present
- inflammatory conditions
- treat inflammatory
- signalized
- Prior art date
Links
- 230000004968 inflammatory condition Effects 0.000 title 1
- 239000005557 antagonist Substances 0.000 abstract 2
- 208000027866 inflammatory disease Diseases 0.000 abstract 2
- OVBICQMTCPFEBS-SATRDZAXSA-N (2s)-1-[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2s)-2-[[(2s)-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-acetamido-3-naphthalen-2-ylpropanoyl]amino]-3-(4-chlorophenyl)propanoyl]amino]-3-pyridin-3-ylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-6-[bi Chemical compound CC(O)=O.CC(O)=O.C([C@@H](C(=O)N[C@H](CCCCN=C(NCC)NCC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN=C(NCC)NCC)C(=O)N1[C@@H](CCC1)C(=O)N[C@H](C)C(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](CC=1C=NC=CC=1)NC(=O)[C@@H](CC=1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC=1C=C2C=CC=CC2=CC=1)NC(C)=O)C1=CC=C(O)C=C1 OVBICQMTCPFEBS-SATRDZAXSA-N 0.000 abstract 1
- 108090000978 Interleukin-4 Proteins 0.000 abstract 1
- 208000019693 Lung disease Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 108700032141 ganirelix Proteins 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/1793—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/02—Nasal agents, e.g. decongestants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Abstract
LA PRESENTE INVENCIÓN PROPORCIONA MÉTODOS PARA TRATAR AFECCIONES O ENFERMEDADES INFLAMATORIAS ASOCIADAS CON NIVELES ELEVADOS DE IL-33 E IL-4, O QUE SURGEN EN PARTE DE ESTOS, EN TRASTORNOS PULMONARES INFLAMATORIOS EN PARTICULAR. LOS MÉTODOS DE LA PRESENTE INVENCIÓN COMPRENDEN ADMINISTRARLE A UN SUJETO QUE LO NECESITA UNA O MÁS DOSIS TERAPÉUTICAMENTE EFICACES DE UN ANTAGONISTA DE IL-33 SOLO O EN COMBINACIÓN CON UNA O MÁS DOSIS TERAPÉUTICAMENTE EFICACES DE UN ANTAGONISTA DE IL-4R. EN DETERMINADAS MODALIDADES, LOS MÉTODOS DE LA PRESENTE INVENCIÓN INCLUYEN EL USO DE LOS ANTAGONISTAS PARA TRATAR CUALQUIER AFECCIÓN O ENFERMEDAD INFLAMATORIA MEDIADA EN PARTE POR UNA SEÑALIZACIÓN MEDIADA POR IL-33 O SEÑALIZACIÓN MEDIADA POR IL-4 MEJORADAS.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662428634P | 2016-12-01 | 2016-12-01 | |
US201762473738P | 2017-03-20 | 2017-03-20 | |
US201762567318P | 2017-10-03 | 2017-10-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
CL2019001475A1 true CL2019001475A1 (es) | 2019-08-16 |
Family
ID=60788696
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CL2019001475A CL2019001475A1 (es) | 2016-12-01 | 2019-05-30 | Métodos para tratar afecciones inflamatorias. |
Country Status (19)
Country | Link |
---|---|
US (2) | US10815305B2 (es) |
EP (1) | EP3548513A1 (es) |
JP (3) | JP7132220B2 (es) |
KR (2) | KR102645242B1 (es) |
CN (1) | CN110167963A (es) |
AU (1) | AU2017367691A1 (es) |
BR (1) | BR112019010646A2 (es) |
CA (1) | CA3044851A1 (es) |
CL (1) | CL2019001475A1 (es) |
CO (1) | CO2019005236A2 (es) |
CR (1) | CR20190311A (es) |
IL (1) | IL266770B2 (es) |
MA (1) | MA46954A (es) |
MX (2) | MX2019006177A (es) |
PH (1) | PH12019501120A1 (es) |
TN (1) | TN2019000172A1 (es) |
TW (2) | TWI784988B (es) |
UA (1) | UA127965C2 (es) |
WO (1) | WO2018102597A1 (es) |
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ES2900342T3 (es) | 2012-08-21 | 2022-03-16 | Sanofi Biotechnology | Métodos para tratar o prevenir el asma administrando un antagonista de IL-4R |
TWI784988B (zh) | 2016-12-01 | 2022-12-01 | 美商再生元醫藥公司 | 治療發炎症狀的方法 |
WO2018156180A1 (en) | 2017-02-24 | 2018-08-30 | Kindred Biosciences, Inc. | Anti-il31 antibodies for veterinary use |
SG11201909457XA (en) | 2017-04-13 | 2019-11-28 | Regeneron Pharma | Treatment and inhibition of inflammatory lung diseases in patients having risk alleles in the genes encoding il33 and il1rl1 |
JP2020527332A (ja) | 2017-06-12 | 2020-09-10 | ブルーフィン バイオメディシン, インコーポレイテッド | 抗−il1rap抗体および抗体薬物コンジュゲート |
US11352562B2 (en) | 2018-04-10 | 2022-06-07 | Showa Denko Materials Co., Ltd. | Epoxy resin, epoxy resin composition, epoxy resin cured product and composite material |
IL307286A (en) | 2018-04-11 | 2023-11-01 | Regeneron Pharma | Methods and preparations for quantification of IL-33 |
US11312778B2 (en) | 2018-11-21 | 2022-04-26 | Brian C. Machler | Method for treating allergic contact dermatitis |
CN111494625B (zh) | 2018-12-25 | 2022-06-21 | 江苏荃信生物医药股份有限公司 | 用于治疗il-4和/或il-13介导的信号转导相关的疾病的药物组合物 |
CN113557036A (zh) * | 2019-01-18 | 2021-10-26 | 奥泽生物疗法公司 | 基因编辑以改善关节功能 |
TW202102260A (zh) | 2019-03-21 | 2021-01-16 | 美商再生元醫藥公司 | 含有抗il-33抗體之穩定調配物 |
AU2020266593A1 (en) * | 2019-05-01 | 2021-11-11 | Regeneron Pharmaceuticals, Inc. | Methods for treating or preventing asthma by administering an IL-33 antagonist |
CN114786775A (zh) * | 2019-12-06 | 2022-07-22 | 赛诺菲生物技术公司 | 通过施用il-33拮抗剂治疗copd的方法 |
WO2021133776A1 (en) * | 2019-12-23 | 2021-07-01 | Sanofi Biotechnology | Methods for treating or preventing allergic asthma by administering an il-33 antagonist and/or an il-4r antagonist |
JP2023516497A (ja) | 2020-03-13 | 2023-04-19 | メドイミューン・リミテッド | Il33にリスクアレルを有する対象を治療するための治療方法 |
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CN113549151A (zh) * | 2020-04-24 | 2021-10-26 | 苏州康乃德生物医药有限公司 | 与人IL-4Rα中特定表位结合的抗体及其应用 |
CN111714619B (zh) * | 2020-07-15 | 2023-03-14 | 上海市浦东新区人民医院 | 成纤维生长因子6在制备缓解非酒精性脂肪性肝炎肝损伤的药物中的应用 |
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BR112019010646A2 (pt) | 2019-10-01 |
CO2019005236A2 (es) | 2019-05-31 |
JP7132220B2 (ja) | 2022-09-06 |
TWI784988B (zh) | 2022-12-01 |
JP2020513404A (ja) | 2020-05-14 |
MX2019006177A (es) | 2019-08-29 |
US10815305B2 (en) | 2020-10-27 |
JP7351989B2 (ja) | 2023-09-27 |
CN110167963A (zh) | 2019-08-23 |
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TW202332696A (zh) | 2023-08-16 |
PH12019501120A1 (en) | 2019-08-19 |
MX2023008368A (es) | 2023-07-26 |
IL266770A (en) | 2019-07-31 |
UA127965C2 (uk) | 2024-02-28 |
US20210079105A1 (en) | 2021-03-18 |
KR102645242B1 (ko) | 2024-03-13 |
JP2023175785A (ja) | 2023-12-12 |
KR20240033187A (ko) | 2024-03-12 |
AU2017367691A1 (en) | 2019-06-20 |
TW201827079A (zh) | 2018-08-01 |
CA3044851A1 (en) | 2018-06-07 |
MA46954A (fr) | 2019-10-09 |
IL266770B1 (en) | 2023-06-01 |
IL266770B2 (en) | 2023-10-01 |
WO2018102597A1 (en) | 2018-06-07 |
US11866503B2 (en) | 2024-01-09 |
US20180155436A1 (en) | 2018-06-07 |
EP3548513A1 (en) | 2019-10-09 |
JP2022174089A (ja) | 2022-11-22 |
TN2019000172A1 (en) | 2020-10-05 |
KR20190086471A (ko) | 2019-07-22 |
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