CL2019001069A1 - Métodos para el tratamiento de atrofia muscular y enfermedad ósea con el uso de proteínas trap híbridas novedosas del ligando actriib. - Google Patents
Métodos para el tratamiento de atrofia muscular y enfermedad ósea con el uso de proteínas trap híbridas novedosas del ligando actriib.Info
- Publication number
- CL2019001069A1 CL2019001069A1 CL2019001069A CL2019001069A CL2019001069A1 CL 2019001069 A1 CL2019001069 A1 CL 2019001069A1 CL 2019001069 A CL2019001069 A CL 2019001069A CL 2019001069 A CL2019001069 A CL 2019001069A CL 2019001069 A1 CL2019001069 A1 CL 2019001069A1
- Authority
- CL
- Chile
- Prior art keywords
- candic
- disease
- methods
- subject
- treatment
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 101100437153 Rattus norvegicus Acvr2b gene Proteins 0.000 title abstract 3
- 208000020084 Bone disease Diseases 0.000 title abstract 2
- 201000000585 muscular atrophy Diseases 0.000 title abstract 2
- 239000003446 ligand Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 abstract 3
- 102000004196 processed proteins & peptides Human genes 0.000 abstract 3
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 3
- 208000035896 Twin-reversed arterial perfusion sequence Diseases 0.000 abstract 2
- 210000000056 organ Anatomy 0.000 abstract 2
- 208000023275 Autoimmune disease Diseases 0.000 abstract 1
- 208000024172 Cardiovascular disease Diseases 0.000 abstract 1
- 206010016654 Fibrosis Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 230000032683 aging Effects 0.000 abstract 1
- 208000007502 anemia Diseases 0.000 abstract 1
- 230000001363 autoimmune Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000016097 disease of metabolism Diseases 0.000 abstract 1
- 239000004744 fabric Substances 0.000 abstract 1
- 230000004761 fibrosis Effects 0.000 abstract 1
- 208000027866 inflammatory disease Diseases 0.000 abstract 1
- 208000019423 liver disease Diseases 0.000 abstract 1
- 208000030159 metabolic disease Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000008929 regeneration Effects 0.000 abstract 1
- 238000011069 regeneration method Methods 0.000 abstract 1
- 210000000130 stem cell Anatomy 0.000 abstract 1
- 210000001519 tissue Anatomy 0.000 abstract 1
- 238000002054 transplantation Methods 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/177—Receptors; Cell surface antigens; Cell surface determinants
- A61K38/179—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biophysics (AREA)
- Toxicology (AREA)
- Epidemiology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
LA PRESENTE DESCRIPCIÓN DESCRIBE POLIPÉPTIDOS HÍBRIDOS ACTRIIB-ECD SOLUBLES NOVEDOSOS. LA PRESENTE DESCRIPCIÓN PROPORCIONA MÉTODOS PARA EL TRATAMIENTO O LA PREVENCIÓN DE LA ATROFIA MUSCULAR, ENFERMEDAD ÓSEA, UNA ENFERMEDAD METABÓLICA, FIBROSIS, UNA ENFERMEDAD AUTOINMUNE/INFLAMATORIA, UNA ENFERMEDAD CARDIOVASCULAR, CÁNCER O CÁNCER, ENFERMEDAD RENAL CRÓNICA (CKD), ARTRITIS, ANOREXIA, ENFERMEDAD HEPÁTICA, RECHAZO DE TRASPLANTE DE ÓRGANOS O TEJIDOS, ANEMIA, DOLOR Y/O ENVEJECIMIENTO EN UN SUJETO QUE LO NECESITE. ADEMÁS, LA PRESENTE DESCRIPCIÓN PROPORCIONA MÉTODOS PARA INDUCIR EL CRECIMIENTO DE CÉLULAS MADRE PARA LA REPARACIÓN DE TEJIDOS O LA REGENERACIÓN DE ÓRGANOS EN UN SUJETO. LOS MÉTODOS ANTEMENCIONADOS COMPRENDEN LA ADMINISTRACIÓN AL SUJETO DE UNA CANTIDAD TERAPÉUTICAMENTE EFICAZ DE UN POLIPÉPTIDO TRAP HÍBRIDO DEL LIGANDO ACTRIIB. LA PRESENTE DESCRIPCIÓN PROPORCIONA TAMBIÉN COMPOSICIONES FARMACÉUTICAS QUE COMPRENDEN POLIPÉPTIDOS TRAP HÍBRIDOS DEL LIGANDO ACTRIIB.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662410595P | 2016-10-20 | 2016-10-20 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2019001069A1 true CL2019001069A1 (es) | 2019-08-23 |
Family
ID=62019496
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2019001069A CL2019001069A1 (es) | 2016-10-20 | 2019-04-18 | Métodos para el tratamiento de atrofia muscular y enfermedad ósea con el uso de proteínas trap híbridas novedosas del ligando actriib. |
Country Status (22)
| Country | Link |
|---|---|
| US (2) | US20190330307A1 (es) |
| EP (1) | EP3528833A4 (es) |
| JP (1) | JP2019535675A (es) |
| KR (1) | KR20190071758A (es) |
| CN (1) | CN109922821A (es) |
| AU (1) | AU2017345435B2 (es) |
| CA (1) | CA3039066A1 (es) |
| CL (1) | CL2019001069A1 (es) |
| CO (1) | CO2019005115A2 (es) |
| CR (1) | CR20190247A (es) |
| EA (1) | EA201990971A1 (es) |
| IL (1) | IL266032B2 (es) |
| JO (1) | JOP20190085A1 (es) |
| MA (1) | MA46585A (es) |
| MX (1) | MX2019004651A (es) |
| PE (1) | PE20190743A1 (es) |
| PH (1) | PH12019500853A1 (es) |
| SG (2) | SG11201903450YA (es) |
| TN (1) | TN2019000119A1 (es) |
| TW (1) | TWI826358B (es) |
| WO (1) | WO2018075747A1 (es) |
| ZA (1) | ZA201903105B (es) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT3280727T (pt) | 2015-04-06 | 2021-04-23 | Acceleron Pharma Inc | Proteínas de fusão do recetor de braço único do tipo i e tipo ii e respetivas utilizações |
| MA41919A (fr) | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| AU2016246708B2 (en) | 2015-04-06 | 2020-12-24 | Acceleron Pharma Inc. | ALK7:actRIIB heteromultimers and uses thereof |
| CA3039525A1 (en) | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
| BR112019006993A2 (pt) | 2016-10-05 | 2019-09-03 | Acceleron Pharma Inc | heteromultímeros de alk4:actriib e usos dos mesmos |
| JP7139326B2 (ja) | 2016-11-10 | 2022-09-20 | ケロス セラピューティクス インコーポレイテッド | アクチビンＩＩａ型受容体変異体および同変異体を含む医薬組成物 |
| US11484573B2 (en) | 2017-11-09 | 2022-11-01 | Keros Therapeutics, Inc. | Activin receptor type IIa variants and methods of use thereof |
| JP7510875B2 (ja) | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンｉｉｂ型受容体変異体および同変異体を含む医薬組成物 |
| CN116134049A (zh) * | 2020-02-03 | 2023-05-16 | 阿塞勒隆制药公司 | 变体actriib蛋白及其用途 |
| EP4121088A4 (en) * | 2020-03-20 | 2024-07-03 | Keros Therapeutics Inc | METHODS OF USING ACTIVIN TYPE IIB RECEPTOR VARIANTS |
| CA3176735A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Activin receptor type ii chimeras and methods of use thereof |
| WO2021189006A1 (en) * | 2020-03-20 | 2021-09-23 | Keros Therapeutics, Inc. | Methods of using activin receptor type iia variants |
| US20240181007A1 (en) * | 2021-01-08 | 2024-06-06 | Acceleron Pharma Inc. | Compositions and methods for treating pulmonary hypertension |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2332977T3 (en) * | 2004-07-23 | 2016-02-29 | Acceleron Pharma Inc | ActRII receptor polypeptides |
| TWI573802B (zh) * | 2007-03-06 | 2017-03-11 | 安美基公司 | 變異之活動素受體多肽及其用途 |
| US8501678B2 (en) * | 2007-03-06 | 2013-08-06 | Atara Biotherapeutics, Inc. | Variant activin receptor polypeptides and uses thereof |
| WO2013106175A1 (en) * | 2011-12-19 | 2013-07-18 | Amgen Inc. | Variant activin receptor polypeptides, alone or in combination with chemotherapy, and uses thereof |
| US8216997B2 (en) * | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| KR20180026795A (ko) * | 2009-06-12 | 2018-03-13 | 악셀레론 파마 인코포레이티드 | 절두된 ＡｃｔＲＩＩＢ-ＦＣ 융합 단백질 |
| CA2773494A1 (en) * | 2009-09-09 | 2011-03-17 | Acceleron Pharma Inc. | Actriib antagonists and dosing and uses thereof |
| CA2779472C (en) * | 2009-11-03 | 2021-03-16 | Acceleron Pharma Inc. | The use of a composition comprising an activin type iib receptor polypeptide in the treatment of fatty liver disease |
| GR1007832B (el) * | 2011-11-21 | 2013-02-14 | Ιδρυμα Ιατροβιολογικων Ερευνων Ακαδημιας Αθηνων, | Αδρανοποιητες της ακτιβινης και χρηση τους για την θεραπεια ασθενειων που σχετιζονται με παρεκκλινουσα ενεργοποιηση της "αμυντικης αποκρισης του ξενιστη" |
| MA41919A (fr) * | 2015-04-06 | 2018-02-13 | Acceleron Pharma Inc | Hétéromultimères alk4:actriib et leurs utilisations |
| BR112017022658A2 (pt) * | 2015-04-22 | 2018-07-17 | Alivegen Usa Inc | proteína isolada, molécula de ácido nucleico isolada, vetor recombinante, célula hospedeira, método de produção de uma proteína actriib híbrida, composição farmacêutica, métodos de tratamentos de distúrbios relacionados à miostatina ou relacionados à ativina a, de doença de desgaste dos músculos, de doença cardiovascular, de distúrbios metabólicos, de células cancerígenas, de doença renal, de doença inflamatória/autoimune, de uma doença de fibrose, de anemia, da dor, da condição de envelhecimento, de distúrbios ósseos, de um desgaste dos músculos ou distúrbio metabólico ou fibrótico ou inflamatório ou relacionado à ativina em indivíduos, e, método de indução do crescimento das células-tronco para o reparo de tecido ou regeneração do órgão em um indivíduo |
| WO2017192847A1 (en) * | 2016-05-04 | 2017-11-09 | University Of Cincinnati | Female fertility therapies |
| CA3039525A1 (en) * | 2016-10-05 | 2018-04-12 | Acceleron Pharma Inc. | Variant actriib proteins and uses thereof |
| JP7510875B2 (ja) * | 2018-01-12 | 2024-07-04 | ケロス セラピューティクス インコーポレイテッド | アクチビンｉｉｂ型受容体変異体および同変異体を含む医薬組成物 |
-
2017
- 2017-06-16 JO JOP/2019/0085A patent/JOP20190085A1/ar unknown
- 2017-10-18 TW TW106135727A patent/TWI826358B/zh active
- 2017-10-19 EA EA201990971A patent/EA201990971A1/ru unknown
- 2017-10-19 AU AU2017345435A patent/AU2017345435B2/en active Active
- 2017-10-19 WO PCT/US2017/057351 patent/WO2018075747A1/en active Application Filing
- 2017-10-19 MX MX2019004651A patent/MX2019004651A/es unknown
- 2017-10-19 TN TNP/2019/000119A patent/TN2019000119A1/en unknown
- 2017-10-19 JP JP2019521409A patent/JP2019535675A/ja active Pending
- 2017-10-19 CR CR20190247A patent/CR20190247A/es unknown
- 2017-10-19 MA MA046585A patent/MA46585A/fr unknown
- 2017-10-19 EP EP17861941.7A patent/EP3528833A4/en active Pending
- 2017-10-19 US US16/343,366 patent/US20190330307A1/en not_active Abandoned
- 2017-10-19 KR KR1020197014056A patent/KR20190071758A/ko not_active Application Discontinuation
- 2017-10-19 CA CA3039066A patent/CA3039066A1/en active Pending
- 2017-10-19 CN CN201780069411.8A patent/CN109922821A/zh active Pending
- 2017-10-19 SG SG11201903450YA patent/SG11201903450YA/en unknown
- 2017-10-19 IL IL266032A patent/IL266032B2/en unknown
- 2017-10-19 PE PE2019000842A patent/PE20190743A1/es unknown
- 2017-10-19 SG SG10201913301TA patent/SG10201913301TA/en unknown
-
2019
- 2019-04-17 PH PH12019500853A patent/PH12019500853A1/en unknown
- 2019-04-18 CL CL2019001069A patent/CL2019001069A1/es unknown
- 2019-05-17 ZA ZA2019/03105A patent/ZA201903105B/en unknown
- 2019-05-20 CO CONC2019/0005115A patent/CO2019005115A2/es unknown
-
2021
- 2021-12-07 US US17/544,579 patent/US20220332791A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019004651A (es) | 2019-10-09 |
| CN109922821A (zh) | 2019-06-21 |
| IL266032B2 (en) | 2024-06-01 |
| IL266032A (en) | 2019-06-30 |
| SG10201913301TA (en) | 2020-03-30 |
| KR20190071758A (ko) | 2019-06-24 |
| US20190330307A1 (en) | 2019-10-31 |
| US20220332791A1 (en) | 2022-10-20 |
| SG11201903450YA (en) | 2019-05-30 |
| MA46585A (fr) | 2019-08-28 |
| PH12019500853A1 (en) | 2019-12-02 |
| JP2019535675A (ja) | 2019-12-12 |
| CA3039066A1 (en) | 2018-04-26 |
| EA201990971A1 (ru) | 2019-10-31 |
| EP3528833A1 (en) | 2019-08-28 |
| CO2019005115A2 (es) | 2019-05-31 |
| PE20190743A1 (es) | 2019-05-27 |
| ZA201903105B (en) | 2023-03-29 |
| JOP20190085A1 (ar) | 2019-04-17 |
| EP3528833A4 (en) | 2020-11-25 |
| TN2019000119A1 (en) | 2020-10-05 |
| TW201827069A (zh) | 2018-08-01 |
| WO2018075747A1 (en) | 2018-04-26 |
| CR20190247A (es) | 2019-07-29 |
| AU2017345435B2 (en) | 2021-11-11 |
| AU2017345435A1 (en) | 2019-05-23 |
| TWI826358B (zh) | 2023-12-21 |
| IL266032B1 (en) | 2024-02-01 |
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