CL2018003021A1 - Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol - Google Patents

Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol

Info

Publication number
CL2018003021A1
CL2018003021A1 CL2018003021A CL2018003021A CL2018003021A1 CL 2018003021 A1 CL2018003021 A1 CL 2018003021A1 CL 2018003021 A CL2018003021 A CL 2018003021A CL 2018003021 A CL2018003021 A CL 2018003021A CL 2018003021 A1 CL2018003021 A1 CL 2018003021A1
Authority
CL
Chile
Prior art keywords
rent
halo
alcoxi
pyridazine
pyrimidine
Prior art date
Application number
CL2018003021A
Other languages
English (en)
Inventor
Paolo Tosatti
Jean-Yves Wach
Original Assignee
Elanco Tiergesundheit Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elanco Tiergesundheit Ag filed Critical Elanco Tiergesundheit Ag
Publication of CL2018003021A1 publication Critical patent/CL2018003021A1/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445Non condensed piperidines, e.g. piperocaine
    • A61K31/4523Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/14Ectoparasiticides, e.g. scabicides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Pyridine Compounds (AREA)

Abstract

LA PRESENTE INVENCIÓN PROPORCIONA COMPUESTOS DE FÓRMULA, EN DONDE: X ES O O S; Q1 Y Q2 SON INDEPENDIENTEMENTE CR5 O N, SIEMPRE QUE AL MENOS UNO DE Q1 Y Q2 SEA N; Y ES UN ENLACE DIRECTO O CH2; R1 ES H; ALQUILO C1-C6 OPCIONALMENTE SUSTITUIDO CON UN SUSTITUYENTE SELECCIONADO DE: CN, CONH2, COOH, NO2 Y -SI (CH3)3; HALOALQUILO C1-C6; ALQUENILO C2-C6; HALOALQUENILO C2-C6; ALQUINILO C2-C6; HALOALQUINILO C2-C6; CICLOALQUIL C3-C4-ALQUILO C1- C2 EN DONDE CICLOALQUILO C3-C4 ESTÁ OPCIONALMENTE SUSTITUIDO CON 1 O 2 ÁTOMOS HALO; OXETAN-3-IL-CH2; O BENCILO OPCIONALMENTE SUSTITUIDO CON HALO O HALOALQUILO C1-C3; R2 ES FENILO, PIRIDINA, PIRIMIDINA, PIRAZINA O PIRIDAZINA, EN DONDE EL FENILO, PIRIDINA, PIRIMIDINA, PIRAZINA O PIRIDAZINA ESTÁ OPCIONALMENTE SUSTITUIDO CON UNO A TRES SUSTITUYENTES, SIEMPRE QUE EL O LOS SUSTITUYENTES NO ESTÉN EN CARBONO ADYACENTE AL CARBONO UNIDO AL GRUPO CADA UNO INDEPENDIENTEMENTE SELECCIONADO DE: ALQUILO C1-C3, HALOALQUILO C1-C3, TIOHALOALQUILO C1-C3, ALCOXI C1-C3, HALOALCOXI C1-C3, HALO, NO2, SF5, CN, CONH2, COOH Y C(S)NH2; R3 ES ALQUILO C1-C3 O HALOALQUILO C1-C3; R4 ES PIRIDINA, PIRIMIDINA, PIRAZINA O PIRIDAZINA, EN DONDE LA PIRIDINA, PIRIMIDINA, PIRAZINA O PIRIDAZINA ESTÁ OPCIONALMENTE SUSTITUIDA CON UN SUSTITUYENTE SELECCIONADO DE: ALQUILO C1-C3, HALOALQUILO C1-C3, ALCOXI C1-C3, CICLOALQUILO C3-C4, HALO O HIDROXI; R5 ES H, ALQUILO C1-C3, HALOALQUILO C1-C3, CICLOALQUILO C3-C4, ALCOXI C1-C3, ALCOXI C1-C3C(O)- O (ALCOXI C1-C3)2CH-; O UNA SAL DEL MISMO.
CL2018003021A 2016-05-05 2018-10-24 Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol CL2018003021A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201662332004P 2016-05-05 2016-05-05

Publications (1)

Publication Number Publication Date
CL2018003021A1 true CL2018003021A1 (es) 2019-02-15

Family

ID=58672822

Family Applications (1)

Application Number Title Priority Date Filing Date
CL2018003021A CL2018003021A1 (es) 2016-05-05 2018-10-24 Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol

Country Status (20)

Country Link
US (2) US10287276B2 (es)
EP (1) EP3452460B1 (es)
JP (1) JP6370504B2 (es)
KR (1) KR102174828B1 (es)
CN (1) CN109311841B (es)
AR (1) AR108222A1 (es)
AU (1) AU2017261187B2 (es)
BR (1) BR112018069578B1 (es)
CA (1) CA3023208C (es)
CL (1) CL2018003021A1 (es)
CO (1) CO2018011825A2 (es)
DK (1) DK3452460T3 (es)
EA (1) EA036478B1 (es)
ES (1) ES2776850T3 (es)
MX (1) MX2018012951A (es)
NZ (1) NZ746361A (es)
PL (1) PL3452460T3 (es)
PT (1) PT3452460T (es)
TW (2) TWI696615B (es)
WO (1) WO2017192385A1 (es)

Families Citing this family (58)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2019229521A1 (en) * 2018-03-08 2020-09-03 Bayer Aktiengesellschaft Use of heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides in plant protection
MX2020010671A (es) * 2018-04-12 2020-10-28 Bayer Ag Derivados de n-(ciclopropilmetil)-5-(metilsulfonil)-n-11-[1-(pirim idin-2-il)-1h-1,2,4-triazol-5-il] etilibenzamida y los derivados de piridinacarboxamida correspondientes como plaguicidas.
UY38184A (es) * 2018-04-17 2019-10-31 Bayer Ag Compuestos heteroarilo-triazol y heteroarilo-tetrazol novedosos como plaguicidas
US20220002268A1 (en) 2018-04-20 2022-01-06 Bayer Aktiengesellschaft Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
SG11202010068VA (en) * 2018-04-25 2020-11-27 Bayer Ag Novel heteroaryl-triazole and heteroaryl-tetrazole compounds as pesticides
CN112087951A (zh) * 2018-05-08 2020-12-15 先正达农作物保护股份公司 施用某一种或多种杂芳基-1,2,4-三唑和杂芳基-四唑化合物来控制对植物、其繁殖材料和植物衍生产品的损害的方法
AU2019293690A1 (en) * 2018-06-29 2020-12-17 Syngenta Participations Ag Pesticidally active azole-amide compounds
UY38366A (es) 2018-09-13 2020-04-30 Syngenta Participations Ag Compuestos de azol-amida pesticidamente activos
TW202023386A (zh) * 2018-09-13 2020-07-01 瑞士商先正達合夥公司 殺有害生物活性唑-醯胺化合物
US20210395228A1 (en) * 2018-10-02 2021-12-23 Syngenta Participations Ag Pesticidally active benzene- and azine-amide compounds
ES2953567T3 (es) 2018-10-19 2023-11-14 Syngenta Participations Ag Compuestos de azol-amida plaguicidamente activos
EP3877380A1 (en) 2018-11-05 2021-09-15 Syngenta Participations Ag Pesticidally active azole-amide compounds
EP3696175A1 (en) 2019-02-18 2020-08-19 Syngenta Crop Protection AG Pesticidally active azole-amide compounds
BR112021017646A2 (pt) * 2019-03-08 2021-11-16 Syngenta Crop Protection Ag Compostos de azol-amida ativos em termos pesticidas
EP3941912B1 (en) * 2019-03-20 2023-12-13 Syngenta Crop Protection AG Pesticidally active azole amide compounds
EP3941915A1 (en) 2019-03-20 2022-01-26 Syngenta Crop Protection AG Pesticidally active azole amide compounds
BR112021018822A2 (pt) * 2019-03-22 2021-11-23 Syngenta Crop Protection Ag Derivados de n-[1-(5-bromo-2-pirimidin-2-il-1,2,4-triazol-3-il)etil]-2-ciclopropil-6-(trifluorometil)piridina-4-carboxamida e compostos relacionados como inseticidas
UY38623A (es) 2019-03-29 2020-10-30 Syngenta Crop Protection Ag Compuestos de diazina-amida activos como pesticidas
AU2020255265A1 (en) * 2019-04-05 2021-10-28 Syngenta Crop Protection Ag Pesticidally active diazine-amide compounds
MX2021012290A (es) * 2019-04-11 2021-11-12 Syngenta Crop Protection Ag Compuestos de diazina-amida activos como pesticidas.
EP3725788A1 (en) 2019-04-15 2020-10-21 Bayer AG Novel heteroaryl-substituted aminoalkyl azole compounds as pesticides
AU2020318590A1 (en) * 2019-07-23 2022-02-17 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
CA3148216A1 (en) * 2019-07-23 2021-01-28 Bayer Aktiengesellschaft Novel heteroaryl-triazole compounds as pesticides
EP4017851A1 (en) * 2019-08-23 2022-06-29 Syngenta Crop Protection AG Pesticidally active pyrazine-amide compounds
JP2023007504A (ja) * 2019-09-30 2023-01-19 日本農薬株式会社 イミン化合物またはその塩、および該化合物を有効成分として含有する有害生物防除剤並びに有害生物防除方法
BR112022006791A2 (pt) * 2019-10-09 2022-06-28 Bayer Ag Novos compostos heteroaril-triazol como pesticidas
BR112022006774A2 (pt) 2019-10-09 2022-06-28 Bayer Ag Compostos de heteroaril-triazol inovadores como pesticidas
WO2021068179A1 (en) * 2019-10-11 2021-04-15 Bayer Animal Health Gmbh Novel heteroaryl-substituted pyrazine derivatives as pesticides
TW202128650A (zh) 2019-10-11 2021-08-01 德商拜耳動物保健有限公司 作為殺蟲劑之新穎的雜芳基取代之吡𠯤衍生物
IL291996A (en) 2019-11-01 2022-06-01 Syngenta Crop Protection Ag Fused heteroaromatic bicyclic compounds are active as pesticides
TW202134226A (zh) 2019-11-18 2021-09-16 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
TW202136248A (zh) 2019-11-25 2021-10-01 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基-三唑化合物
BR112022012130A2 (pt) 2019-12-18 2022-08-30 Intervet Int Bv Compostos antelmínticos compreendendo uma estrutura azaindólica
US20230148316A1 (en) 2019-12-18 2023-05-11 Intervet Inc. Anthelmintic compounds comprising a quinoline structure
WO2021122645A1 (en) 2019-12-20 2021-06-24 Syngenta Crop Protection Ag Pesticidally active azole-amide compounds
BR112022016400A2 (pt) 2020-02-18 2022-10-25 Bayer Ag Compostos inovadores de heteroaril-triazol como pesticidas
CN115244036A (zh) * 2020-02-27 2022-10-25 先正达农作物保护股份公司 杀有害生物活性的二嗪-双酰胺化合物
TW202208347A (zh) 2020-05-06 2022-03-01 德商拜耳廠股份有限公司 作為殺蟲劑之新穎雜芳基三唑化合物
EP3909950A1 (en) 2020-05-13 2021-11-17 Basf Se Heterocyclic compounds for the control of invertebrate pests
WO2021228594A1 (en) 2020-05-13 2021-11-18 Basf Se Heterocyclic compounds for the control of invertebrate pests
EP3929189A1 (en) 2020-06-25 2021-12-29 Bayer Animal Health GmbH Novel heteroaryl-substituted pyrazine derivatives as pesticides
WO2022101265A1 (en) 2020-11-13 2022-05-19 Syngenta Crop Protection Ag Pesticidally active fused bicyclic heteroaromatic compounds
US20240043446A1 (en) 2020-12-11 2024-02-08 Intervet Inc. Anthelmintic compounds comprising a thienopyridine structure
BR112023022763A2 (pt) 2021-05-06 2024-01-02 Bayer Ag Imidazóis anulados substituídos por alquilamida e uso dos mesmos como inseticidas
EP4119547A1 (en) 2021-07-12 2023-01-18 Basf Se Triazole compounds for the control of invertebrate pests
WO2023285175A1 (en) 2021-07-12 2023-01-19 Basf Se Triazole compounds for the control of invertebrate pests
EP4377312A1 (en) 2021-07-29 2024-06-05 Syngenta Crop Protection AG Pesticidally active fused bicyclic heteroaromatic compounds
EP4140986A1 (en) 2021-08-23 2023-03-01 Basf Se Pyrazine compounds for the control of invertebrate pests
WO2023025602A1 (en) 2021-08-23 2023-03-02 Basf Se Pyrazine compounds for the control of invertebrate pests
AU2022335669A1 (en) 2021-08-25 2024-02-01 Bayer Aktiengesellschaft Novel pyrazinyl-triazole compounds as pesticides
IL310964A (en) 2021-08-27 2024-04-01 Basf Se Pyrazine compounds for the control of invertebrate pests
EP4140995A1 (en) 2021-08-27 2023-03-01 Basf Se Pyrazine compounds for the control of invertebrate pests
WO2023037249A1 (en) 2021-09-08 2023-03-16 Pi Industries Ltd. Sulfoximines/ sulfilimine containing aromatic caboxamide compounds and their use therof
WO2023041422A1 (en) 2021-09-20 2023-03-23 Basf Se Heterocyclic compounds for the control of invertebrate pests
EP4151631A1 (en) 2021-09-20 2023-03-22 Basf Se Heterocyclic compounds for the control of invertebrate pests
JPWO2023058748A1 (es) 2021-10-08 2023-04-13
EP4198033A1 (en) 2021-12-14 2023-06-21 Basf Se Heterocyclic compounds for the control of invertebrate pests
TW202341864A (zh) 2022-04-14 2023-11-01 美商富曼西公司 用於防治無脊椎有害生物之新型磺酸酯苯甲醯胺化合物

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EA011764B1 (ru) * 2004-03-05 2009-06-30 Ниссан Кемикал Индастриз, Лтд. Изоксазолинзамещённое производное бензамида и пестицид
US7271271B2 (en) 2004-06-28 2007-09-18 Amgen Sf, Llc Imidazolo-related compounds, compositions and methods for their use
DE102004041530A1 (de) * 2004-08-27 2006-03-02 Bayer Cropscience Ag Biphenylthiazolcarboxamide
JP5021734B2 (ja) * 2006-06-29 2012-09-12 エフ.ホフマン−ラ ロシュ アーゲー テトラゾール置換アリールアミド
JP2009544625A (ja) * 2006-07-20 2009-12-17 メーメット・カーラマン Rhoキナーゼのベンゾチオフェン阻害剤
AU2008337660B2 (en) * 2007-12-17 2014-02-06 F. Hoffmann-La Roche Ag Triazole-substituted arylamide derivatives and their use as P2X3 and /or P2X2/3 purinergic receptor antagonists
CN103261187B (zh) * 2010-06-15 2016-08-03 拜耳知识产权有限责任公司 制备四唑取代的邻氨基苯甲酰胺衍生物的方法以及这些衍生物的晶体多形体
UY33808A (es) * 2010-12-17 2012-07-31 Syngenta Participations Ag Compuestos insecticidas
CN105164124B (zh) * 2012-11-19 2017-03-15 诺华股份有限公司 用于治疗寄生虫疾病的化合物和组合物
CN105473558B (zh) * 2013-06-20 2019-04-19 拜耳作物科学股份公司 作为杀螨剂和杀昆虫剂的芳基硫化物衍生物和芳基硫氧化物衍生物
US9920017B2 (en) * 2014-03-06 2018-03-20 Bayer Cropscience Aktiengesellschaft Heterocyclic compounds as pesticides

Also Published As

Publication number Publication date
US10981897B2 (en) 2021-04-20
CN109311841A (zh) 2019-02-05
AU2017261187A1 (en) 2018-10-04
CO2018011825A2 (es) 2018-11-22
EA036478B1 (ru) 2020-11-16
WO2017192385A1 (en) 2017-11-09
EA201892191A1 (ru) 2019-04-30
TWI679197B (zh) 2019-12-11
BR112018069578B1 (pt) 2024-02-06
AU2017261187B2 (en) 2019-04-18
BR112018069578A2 (pt) 2019-01-22
CA3023208A1 (en) 2017-11-09
TW201938548A (zh) 2019-10-01
ES2776850T3 (es) 2020-08-03
MX2018012951A (es) 2019-01-21
KR20180132100A (ko) 2018-12-11
DK3452460T3 (da) 2020-03-16
US20180186778A1 (en) 2018-07-05
KR102174828B1 (ko) 2020-11-06
TW201803863A (zh) 2018-02-01
US20190256501A1 (en) 2019-08-22
US10287276B2 (en) 2019-05-14
PT3452460T (pt) 2020-03-24
AR108222A1 (es) 2018-08-01
NZ746361A (en) 2020-04-24
JP2018517716A (ja) 2018-07-05
CN109311841B (zh) 2021-04-27
CA3023208C (en) 2020-11-03
EP3452460A1 (en) 2019-03-13
EP3452460B1 (en) 2020-02-12
PL3452460T3 (pl) 2020-06-01
TWI696615B (zh) 2020-06-21
JP6370504B2 (ja) 2018-08-08

Similar Documents

Publication Publication Date Title
CL2018003021A1 (es) Compuestos heteroaril-1,2,4-triazol y heteroaril-tetrazol
PE20210004A1 (es) Inhibidores de mcl-1
CU24572B1 (es) Compuestos derivados de 1,2,4-triazolonas 2,4,5-trisustituidas
PE20181288A1 (es) Derivados de dihidroimidazopirazinona usados en el tratamiento del cancer
PE20161443A1 (es) Compuestos
AR109348A1 (es) Sulfonilureas y compuestos relacionados y sus usos
PE20200700A1 (es) Compuestos macrociclicos y usos de los mismos
MY182568A (en) Quaternary ammonium compounds and their use as fuel or lubricant additives
AR095708A1 (es) Indazoles sustituidos con diaminoheteroarilo
CO6440540A2 (es) Nuevas pirazol-4-n-alcoxicarboxamidas como microbicidas
CR20190423A (es) Nuevos compuestos biciclícos como inhibidores dobles de atx/ca
CO6150142A2 (es) Bezoxazoles y oxazolopiridinas que son utiles como inhibidores de las cinasas janus
PE20160992A1 (es) Inhibidores de quinasa relacionada con la tropomiosina (trk)
PE20141041A1 (es) Compuestos, metodos y formulaciones parasiticidas
EA201600403A1 (ru) N-ацилиминогетероциклические соединения
ES2587284T3 (es) 5-Fluoro-pirimidinas 2,4-disustituidas como inhibidores selectivos de CDK9
AR081421A1 (es) Carboxamidas utiles como microbicidas y composiciones que comprenden dichos compuestos
ECSP19043231A (es) Inhibidores de la tirosina quinasa de bruton
AR075975A1 (es) Compuestos heterociclicos y su uso como inhibidores de la glucogeno sintetasa quinasa 3
PE20190339A1 (es) 1h-pirazolo[4,3-b] piridinas como inhibidores de pde1
ES2630079T3 (es) Moduladores de la ruta del complemento y usos de los mismos
CL2019001041A1 (es) Compuestos terapéuticos y métodos para utilizarlos.
MX2016015641A (es) Compuesto de pirrolidina novedoso, y aplicación como agonista del receptor de melanocortina.
AR102544A1 (es) Compuestos derivados de dihidrohidantoína como herbicidas
CY1124908T1 (el) Παραγωγο μορφινανης