CL2017001353A1 - Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodona - Google Patents
Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodonaInfo
- Publication number
- CL2017001353A1 CL2017001353A1 CL2017001353A CL2017001353A CL2017001353A1 CL 2017001353 A1 CL2017001353 A1 CL 2017001353A1 CL 2017001353 A CL2017001353 A CL 2017001353A CL 2017001353 A CL2017001353 A CL 2017001353A CL 2017001353 A1 CL2017001353 A1 CL 2017001353A1
- Authority
- CL
- Chile
- Prior art keywords
- benzoic acid
- conjugates
- oxycodone
- heteroaryl carboxylic
- technology
- Prior art date
Links
- 150000001558 benzoic acid derivatives Chemical class 0.000 title abstract 2
- WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 title 2
- 239000005711 Benzoic acid Substances 0.000 title 1
- 235000010233 benzoic acid Nutrition 0.000 title 1
- 229960002085 oxycodone Drugs 0.000 title 1
- -1 oxycodone heteroaryl carboxylic acid Chemical class 0.000 title 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 229960005118 oxymorphone Drugs 0.000 abstract 2
- 150000001735 carboxylic acids Chemical class 0.000 abstract 1
- 230000003247 decreasing effect Effects 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- IPBVNPXQWQGGJP-UHFFFAOYSA-N phenyl acetate Chemical compound CC(=O)OC1=CC=CC=C1 IPBVNPXQWQGGJP-UHFFFAOYSA-N 0.000 abstract 1
- 238000001308 synthesis method Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
- A61K31/585—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin containing lactone rings, e.g. oxandrolone, bufalin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Addiction (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462084246P | 2014-11-25 | 2014-11-25 | |
| US201462084216P | 2014-11-25 | 2014-11-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CL2017001353A1 true CL2017001353A1 (es) | 2018-01-05 |
Family
ID=56075034
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CL2017001353A CL2017001353A1 (es) | 2014-11-25 | 2017-05-25 | Ácido benzoico, derivados de ácido benzoico, y conjugados de ácido carboxílico heteroarilo de oxicodona |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US9850252B2 (enExample) |
| EP (1) | EP3223819A4 (enExample) |
| JP (2) | JP6400848B2 (enExample) |
| KR (2) | KR20190049944A (enExample) |
| CN (1) | CN106999486A (enExample) |
| AU (1) | AU2015353502B2 (enExample) |
| BR (1) | BR112017011069A2 (enExample) |
| CA (1) | CA2967424C (enExample) |
| CL (1) | CL2017001353A1 (enExample) |
| CO (1) | CO2017005201A2 (enExample) |
| IL (1) | IL252470B (enExample) |
| MX (1) | MX2017006520A (enExample) |
| NZ (1) | NZ731591A (enExample) |
| PH (1) | PH12017500963A1 (enExample) |
| RU (1) | RU2683317C2 (enExample) |
| SG (1) | SG11201704178UA (enExample) |
| WO (1) | WO2016086113A1 (enExample) |
| ZA (1) | ZA201703154B (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
| US10849981B2 (en) | 2009-07-02 | 2020-12-01 | KemPham, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof |
| CA2967424C (en) | 2014-11-25 | 2023-05-02 | Kempharm, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone |
| US20200038383A1 (en) * | 2016-10-14 | 2020-02-06 | Kempharm, Inc. | Immediate-release abuse deterrent compositions or medicaments for treating pain, add, adhd and other syndromes or disorders |
| JP7369687B2 (ja) * | 2017-07-20 | 2023-10-26 | スーチョウ ランシンダタイ ファーマシューティクス エルティーディー シーオー． | 乱用防止長期作用型徐放性オピオイドプロドラッグ |
| EP3755704A1 (en) * | 2018-02-23 | 2020-12-30 | Rhodes Technologies Inc. | Novel opioid compounds and uses thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB320749A (enExample) | ||||
| US1731152A (en) | 1925-10-27 | 1929-10-08 | Firm C H Boehringer Sohn | Process for the manufacture of derivatives of dihydrocodeinone or its substitution products |
| AT229496B (de) | 1961-03-08 | 1963-09-25 | Lannacher Heilmittel | Verfahren zur Darstellung des neuen Nicotinsäureesters des Dihydrohydroxycodeinons |
| US4668685A (en) | 1984-07-05 | 1987-05-26 | E.I. Du Pont De Nemours And Company | Substituted benzoate ester prodrug derivatives of 3-hydroxymorphinans, which are analgesics or narcotic antagonists |
| SE9003665D0 (sv) | 1990-11-16 | 1990-11-16 | Kabivitrum Ab | Morphine prodrugs |
| GB9423542D0 (en) | 1994-11-22 | 1995-01-11 | Marples Brian A | Pharmaceutical compounds |
| US5869669A (en) | 1996-07-26 | 1999-02-09 | Penick Corporation | Preparation of 14-hydroxynormorphinones from normorphinone dienol acylates |
| JP2004501067A (ja) | 2000-01-28 | 2004-01-15 | ローム アンド ハース カンパニー | 高められた特性をもつ医薬 |
| IL158882A0 (en) | 2001-06-05 | 2004-05-12 | Control Delivery Sys Inc | Sustained-release analgesic compounds |
| US7375082B2 (en) | 2002-02-22 | 2008-05-20 | Shire Llc | Abuse-resistant hydrocodone compounds |
| EP2319540A1 (en) | 2002-02-22 | 2011-05-11 | Shire LLC | Sustained release pharmaceutical compounds to prevent abuse of controlled substances |
| US20040058946A1 (en) * | 2002-07-05 | 2004-03-25 | Buchwald Stephen L. | Abuse-resistant prodrugs of oxycodone and other pharmaceuticals |
| TW200500067A (en) | 2003-01-21 | 2005-01-01 | Control Delivery Sys Inc | Salts of codrugs and uses related thereto |
| DE602004024963D1 (de) | 2003-03-13 | 2010-02-25 | Controlled Chemicals Inc | Oxycodon- konjugate mit niedrigerem missbrauch- potential und ausgedehnter tätigkeitsdauer |
| EP1782834A3 (en) * | 2003-03-13 | 2007-08-01 | Controlled Chemicals, Inc. | Oxycodone conjugates with lower abuse potential and extended duration of action |
| NZ546226A (en) | 2003-09-30 | 2009-03-31 | Shire Llc | Oxycodone conjugates for prevention of overdose or abuse |
| WO2005034859A2 (en) | 2003-10-03 | 2005-04-21 | Elite Laboratories Inc. | Extended release formulations of opioids and method of use thereof |
| US20050203115A1 (en) * | 2004-03-10 | 2005-09-15 | Sancilio Frederick D. | Narcotic-NSAID ion pairs |
| PT1751087E (pt) | 2004-06-04 | 2012-09-10 | Xenoport Inc | Derivados de levodopa e as suas composições e utilizações |
| US7348430B2 (en) | 2005-01-21 | 2008-03-25 | Acura Pharmaceuticals, Inc. | Production of opioid analgesics |
| JP2009533443A (ja) * | 2006-04-10 | 2009-09-17 | シャイア エルエルシー | 一置換及び二置換のオキシコドン化合物及び組成物 |
| JP5371746B2 (ja) | 2006-05-26 | 2013-12-18 | ファーマコフォア， インコーポレイテッド | フェノール性オピオイドの制御放出 |
| US20080090771A1 (en) | 2006-10-06 | 2008-04-17 | Shire Llc | Abuse-resistant hydrocodone compounds, compositions and methods of using the same |
| WO2009079013A1 (en) | 2007-12-17 | 2009-06-25 | Mallinckrodt Inc. | Processes for the production of (+)-'nal' morphinan compounds |
| UA102916C2 (uk) | 2009-07-02 | 2013-08-27 | Кемфарм, Інк. | Композиція на основі кон'югату гідрокодону з бензойною кислотою, похідними бензойної кислоти або гетероарилкарбоновою кислотою, проліки, спосіб лікування від зловживань |
| US20120142720A1 (en) | 2009-07-02 | 2012-06-07 | Kempharm, Inc. | Phenylethanoic Acid, Phenylpropanoic Acid and Phenylpropenoic Acid Conjugates and Prodrugs of Hydrocodone, Methods of Making and Use Thereof |
| WO2011008636A1 (en) | 2009-07-15 | 2011-01-20 | Mallinckrodt Inc. | 3-oxy-hydromorphone derivatives |
| BR112013017296B1 (pt) * | 2011-01-11 | 2021-02-17 | Signature Therapeutics, Inc. | composto e composição compreendendo oxicodona, método para reduzir o abuso potencial da referida composição, unidade de dose e método para a sua preparação, e método para identificar um composto e um inibidor de tripsina |
| US8816083B2 (en) | 2011-10-26 | 2014-08-26 | Kempharm, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof |
| CA2967424C (en) | 2014-11-25 | 2023-05-02 | Kempharm, Inc. | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of oxycodone |
-
2015
- 2015-11-25 CA CA2967424A patent/CA2967424C/en active Active
- 2015-11-25 KR KR1020197012631A patent/KR20190049944A/ko not_active Withdrawn
- 2015-11-25 MX MX2017006520A patent/MX2017006520A/es unknown
- 2015-11-25 JP JP2017528967A patent/JP6400848B2/ja not_active Expired - Fee Related
- 2015-11-25 SG SG11201704178UA patent/SG11201704178UA/en unknown
- 2015-11-25 RU RU2017122144A patent/RU2683317C2/ru not_active IP Right Cessation
- 2015-11-25 US US14/952,348 patent/US9850252B2/en active Active
- 2015-11-25 CN CN201580064309.XA patent/CN106999486A/zh active Pending
- 2015-11-25 AU AU2015353502A patent/AU2015353502B2/en not_active Ceased
- 2015-11-25 EP EP15863639.9A patent/EP3223819A4/en not_active Withdrawn
- 2015-11-25 KR KR1020177017408A patent/KR101976101B1/ko not_active Expired - Fee Related
- 2015-11-25 NZ NZ731591A patent/NZ731591A/en not_active IP Right Cessation
- 2015-11-25 WO PCT/US2015/062637 patent/WO2016086113A1/en not_active Ceased
- 2015-11-25 BR BR112017011069A patent/BR112017011069A2/pt not_active Application Discontinuation
-
2017
- 2017-05-08 ZA ZA2017/03154A patent/ZA201703154B/en unknown
- 2017-05-23 IL IL252470A patent/IL252470B/en not_active IP Right Cessation
- 2017-05-25 PH PH12017500963A patent/PH12017500963A1/en unknown
- 2017-05-25 CO CONC2017/0005201A patent/CO2017005201A2/es unknown
- 2017-05-25 CL CL2017001353A patent/CL2017001353A1/es unknown
- 2017-11-14 US US15/812,730 patent/US10144740B2/en active Active
-
2018
- 2018-09-04 JP JP2018165325A patent/JP2018199719A/ja active Pending
- 2018-10-19 US US16/165,194 patent/US10544153B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2683317C2 (ru) | 2019-03-28 |
| CA2967424C (en) | 2023-05-02 |
| NZ731591A (en) | 2018-06-29 |
| US10544153B2 (en) | 2020-01-28 |
| JP6400848B2 (ja) | 2018-10-03 |
| ZA201703154B (en) | 2019-03-27 |
| CA2967424A1 (en) | 2016-06-02 |
| CO2017005201A2 (es) | 2017-08-31 |
| SG11201704178UA (en) | 2017-06-29 |
| JP2018199719A (ja) | 2018-12-20 |
| AU2015353502B2 (en) | 2018-09-27 |
| US20190048018A1 (en) | 2019-02-14 |
| US10144740B2 (en) | 2018-12-04 |
| US20160168160A1 (en) | 2016-06-16 |
| KR20170094249A (ko) | 2017-08-17 |
| WO2016086113A1 (en) | 2016-06-02 |
| IL252470B (en) | 2019-08-29 |
| PH12017500963A1 (en) | 2017-10-18 |
| EP3223819A1 (en) | 2017-10-04 |
| RU2017122144A3 (enExample) | 2018-12-26 |
| EP3223819A4 (en) | 2018-04-25 |
| CN106999486A (zh) | 2017-08-01 |
| RU2017122144A (ru) | 2018-12-26 |
| BR112017011069A2 (pt) | 2018-07-10 |
| IL252470A0 (en) | 2017-07-31 |
| US20180065975A1 (en) | 2018-03-08 |
| KR20190049944A (ko) | 2019-05-09 |
| KR101976101B1 (ko) | 2019-05-09 |
| AU2015353502A1 (en) | 2017-05-25 |
| MX2017006520A (es) | 2017-08-09 |
| US9850252B2 (en) | 2017-12-26 |
| JP2017535593A (ja) | 2017-11-30 |
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